Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
Disclaimer>

Modeling the dynamics of a non-limited and a self-limited gene drive system in structured Aedes aegypti populations

Tags: , , ,
Legros, MX, C. G.; Morrison, A.; Scott, T. W.; Lloyd, A. L.; Gould, F.,  PLOS One,  8:e83354. 2013.
Recently there have been significant advances in research on genetic strategies to control populations of disease-vectoring insects. Some of these strategies use the gene drive properties of selfish genetic elements to spread physically linked anti-pathogen genes into local ...

Diversity and abundance of the abnormal chromosome 10 meiotic drive complex in Zea mays

Tags: ,
Kanizay, LBP, T.; Lowry, E. G.; Hufford, M. B.; Peterson, D. G.; Ross-Ibarra, J.; Dawe, R. K.,  Heredity,  110:570-577. 2013.
Maize Abnormal chromosome 10 (Ab10) contains a classic meiotic drive system that exploits the asymmetry of meiosis to preferentially transmit itself and other chromosomes containing specialized heterochromatic regions called knobs. The structure and diversity of the Ab10 meiotic ...

Transmission ratio distortion: review of concept and implications for genetic association studies

Tags:
Huang, LOL, A.; Infante-Rivard, C.,  Human Genetics,  132:245-263. 2013.
Transmission ratio distortion (TRD) occurs when one of the two alleles from either parent is preferentially transmitted to the offspring. This leads to a statistical departure from the Mendelian law of inheritance, which states that each of the two parental alleles is transmitted ...

Mutations to the piRNA Pathway Component Aubergine Enhance Meiotic Drive of Segregation Distorter in Drosophila melanogaster

Tags: , ,
Gell, SLR, R. A.,  Genetics,  193:771-784. 2013.
Diploid sexual reproduction involves segregation of allelic pairs, ensuring equal representation of genotypes in the gamete pool. Some genes, however, are able to "cheat" the system by promoting their own transmission. The Segregation distorter (Sd) locus in Drosophila ...

Guidance on the environmental risk assessment of genetically modified animals.

Tags: , , ,
EFSA GMO Panel (EFSA Panel on Genetically Modified Organisms),  EFSA Journal,  11:3200. 2013.
This document provides guidance for the environmental risk assessment (ERA) of living genetically modified (GM) animals, namely fish, insects and mammals and birds, to be placed on the European Union (EU) market in accordance with Regulation (EC) No 1829/2003 or Directive ...

Mechanism of meiotic drive in mammals

Tags: ,
Chmatal, LF, K.; Schultz, R. M.; Lampson, M. A.,  Molecular Biology of the Cell,  24:3775. 2013.
Meiotic drive is a phenomenon responsible for an unequal representation of alleles or whole chromosomes among gametes as a result of the mechanics of meiotic division (Sandler et Novitski 1957). When it drives segregation of Robertsonian translocations (Rb), a common chromosomal ...

The design and in vivo evaluation of engineered I-OnuI-based enzymes for HEG gene drive

Tags: , , ,
Chan, YST, R.; Jarjour, J.; Huen, D. S.; Stoddard, B. L.; Russell, S.,  PLOS One,  8:e74254. 2013.
The homing endonuclease gene (HEG) drive system, a promising genetic approach for controlling arthropod populations, utilises engineered nucleases to spread deleterious mutations that inactivate individual genes throughout a target population. Previous work with a naturally ...

Optimising homing endonuclease gene drive performance in a semi-refractory species: The Drosophila melanogaster experience

Tags: , , ,
Chan, YSH, D. S.; Glauert, R.; Whiteway, E.; Russell, S.,  PLOS One,  8:e54130. 2013.
Homing endonuclease gene (HEG) drive is a promising insect population control technique that employs meganucleases to impair the fitness of pest populations. Our previous studies showed that HEG drive was more difficult to achieve in Drosophila melanogaster than Anopheles gambiae ...

Natural variation of the Y chromosome suppresses sex ratio distortion and modulates testis-specific gene expression in Drosophila simulans

Tags: , , ,
Branco, ATT, Y.; Hartl, D. L.; Lemos, B.,  Heredity,  111:8-15. 2013.
X-linked sex-ratio distorters that disrupt spermatogenesis can cause a deficiency in functional Y-bearing sperm and a female-biased sex ratio. Y-linked modifiers that restore a normal sex ratio might be abundant and favored when a X-linked distorter is present. Here we ...

Local dynamics of a fast-evolving sex-ratio system in Drosophila simulans

Tags: , , , ,
Bastide, HG, P. R.; Ogereau, D.; Cazemajor, M.; Montchamp-Moreau, C.,  Molecular Ecology,  22:5352-5367. 2013.
By distorting Mendelian transmission to their own advantage, X-linked meiotic drive elements can rapidly spread in natural populations, generating a sex-ratio bias. One expected consequence is the triggering of a co-evolutionary arms race between the sex chromosome that carries ...

Germline excision of transgenes in Aedes aegypti by homing endonucleases

Tags: , ,
Aryan, AA, M. A. E.; Myles, K. M.; Adelman, Z. N.,  Scientific Reports,  3:1603. 2013.
Aedes (Ae.) aegypti is the primary vector for dengue viruses (serotypes1-4) and chikungunya virus. Homing endonucleases (HEs) are ancient selfish elements that catalyze double-stranded DNA breaks (DSB) in a highly specific manner. In this report, we show that the HEs Y2-I-AniI, ...

A Synthetic Gene Drive System for Local, Reversible Modification and Suppression of Insect Populations

Tags: , ,
Akbari, OSM, K. D.; Marshall, J. M.; Huang, H. X.; Ward, C. M.; Hay, B. A.,  Current Biology,  23:671-677. 2013.
Replacement of wild insect populations with genetically modified individuals unable to transmit disease provides a self-perpetuating method of disease prevention but requires a gene drive mechanism to spread these traits to high frequency [1-3]. Drive mechanisms requiring that ...

Ethical issues in field trials of genetically modified disease-resistant mosquitoes

Tags: , , , , , ,
D. B. Resnik,  Developing World Bioethics,  14:37-46. 2012.
Mosquito-borne diseases take a tremendous toll on human populations, especially in developing nations. In the last decade, scientists have developed mosquitoes that have been genetically modified to prevent transmission of mosquito-borne diseases, and field trials have been ...

The contribution of female meiotic drive to the evolution of neo-sex chromosomes

Tags: , ,
Yoshida, KK, J.,  Evolution,  66:3198-3208. 2012.
Sex chromosomes undergo rapid turnover in certain taxonomic groups. One of the mechanisms of sex chromosome turnover involves fusions between sex chromosomes and autosomes. Sexual antagonism, heterozygote advantage, and genetic drift have been proposed as the drivers for the ...

From genes to games: Cooperation and cyclic dominance in meiotic drive

Tags: , ,
Traulsen, AR, F. A.,  Journal of Theoretical Biology,  299:120-125. 2012.
Evolutionary change can be described on a genotypic level or a phenotypic level. Evolutionary game theory is typically thought of as a phenotypic approach, although it is frequently argued that it can also be used to describe population genetic evolution. Interpreting the ...

Genetic mapping a meiotic driver that causes sex ratio distortion in the mosquito Aedes aegypti

Tags: ,
Shin, DM, A.; Severson, D. W.,  Journal of Heredity,  103:303-307. 2012.
An endogenous meiotic driver in the dengue and yellow fever vector mosquito Aedes aegypti can cause highly male-biased sex ratio distortion in crosses from suitable genetic backgrounds. We previously selected a strain that carries a strong meiotic drive gene (D) linked with the ...

No evidence of mate discrimination against males carrying a sex ratio distorter in Drosophila pseudoobscura

Tags: , ,
Price, TARL, Z.; Smith, D. T.; Hurst, G. D. D.; Wedell, N.,  Behavioral Ecology and Sociobiology,  66:561-568. 2012.
Selfish genetic elements (SGEs) that spread by manipulating spermatogenesis often have highly deleterious effects on males that carry them. Females that mate with male carriers of SGEs can also suffer significant costs: they receive fewer and poorer-quality sperm, their offspring ...

Evaluating the evidence for transmission distortion in human pedigrees

Tags: , ,
Meyer, WKA, B.; Ober, C.; Ebner, T.; Tiemann-Boege, I.; Hudson, R. R.; Przeworski, M.,  Genetics,  191:215-232. 2012.
Children of a heterozygous parent are expected to carry either allele with equal probability. Exceptions can occur, however, due to meiotic drive, competition among gametes, or viability selection, which we collectively term "transmission distortion" (TD). Although there are ...

Confinement of gene drive systems to local populations: A comparative analysis

Tags: , , ,
Marshall, JMH, B. A.,  Journal of Theoretical Biology,  294:153-171. 2012.
Mosquito-borne diseases such as malaria and dengue fever pose a major health problem through much of the world. One approach to disease prevention involves the use of selfish genetic elements to drive disease-refractory genes into wild mosquito populations. Recently engineered ...

General principles of single-construct chromosomal gene drive

Tags: ,
Marshall, JMH, B. A.,  Evolution,  66:2150-2166. 2012.
Gene drive systems are genetic elements capable of spreading into a population even if they confer a fitness cost to their host. We consider a class of drive systems consisting of a chromosomally located, linked cluster of genes, the presence of which renders specific classes of ...

« First ‹ Previous 1 87 95 96 97 98 99 107 118 Next › Last »