Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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Analysis of two additional loci in Neurospora crassa related to Spore killer-2

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Turner, BC,  Fungal Genetics and Biology,  39:142-150. 2003.
Two new loci found in one strain of Neurospora crassa (P2604) collected in Malaya are related to the meiotic drive system Spore killer Sk-2. Sk-2 was found in Neurospora intermedia and introgressed into N. crassa. P2604 showed high resistance to killing when crossed to Sk-2. This ...

Common features of segregation distortion in plants and animals

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Taylor, DRI, P. K.,  Genetica,  117:27-35. 2003.
Segregation distortion is increasingly recognized as a potentially powerful evolutionary force. This runs counter to the perception that non-Mendelian genes are rare genetic curiosities, a view that seems to be supported by the near ubiquity of the Mendelian system of ...

Genetic dissection of hybrid incompatibilities between Drosophila simulans and D-mauritiana. III. Heterogeneous accumulation of hybrid incompatibilities, degree of dominance, and implications for Haldane’s rule

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Tao, YH, D. L.,  Evolution,  57:2580-2598. 2003.
The genetic basis of Haldane's rule was investigated through estimating the accumulation of hybrid incompatibilities between Drosophila simulans and D. mauritiana by means of introgression. The accumulation of hybrid male sterility (HMS) is at least 10 times greater than that of ...

Meiotic drive – Bickering genes shape evolution – Not all genes follow the rules of inheritance; now researchers are discovering how organisms adapt to the troublemakers

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Pennisi, E,  Science,  301:1837-1839. 2003.
Reproduction is supposed to be an equal opportunity event. Consider humans: In developing sperm, the sex chromosomes sort 50:50 such that half the sperm carry the male-defining Y chromosome and the rest sport an X. Only the randomness of fertilization leads to families of nine ...

The aging effect in the segregation distorter system of Drosophila melanogaster

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Oh, SCN, J. G.,  Korean Journal of Genetics,  25:237-242. 2003.
The SD/SD+ heterozygous male of Drosophila melanogaster transmits the SD second chromosome to its progeny in excess of the Mendelian frequency of 0.5. The k value is defined as the frequency of the SD chromosome recovered among progeny from such a male. This value has been shown ...

Transmission ratio distortion in mice

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Lyon, MF,  Annual Review of Genetics,  37:393-408. 2003.
The most studied example of transmission ratio distortion (TRD) in mice is that of the t-complex. This is a variant-region of Chromosome 17 which exists as a polymorphism in wild mice. Males heterozygous for a t-haplotype and a normal Chr 17 transmit-the t haplotype to >50% of ...

Closing the (Ran)GAP on segregation distortion in Drosophila

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Kusano, AS, C.; Chan, H. Y. E.; Ganetzky, B.,  Bioessays,  25:108-115. 2003.
Segregation Distorter (SD) is a meiotic drive system in Drosophila that causes preferential transmission of the SD chromosome from SD/SD+ males owing to induced dysfunction of SD+ spermatids. Since its discovery in 1956, SD and its mode of action have baffled biologists. ...

B chromosomes in plants: escapees from the A chromosome genome?

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Jones, NH, A.,  Trends in Plant Science,  8:417-423. 2003.
B chromosomes are dispensable elements that do not recombine with the A chromosomes of the regular complement and that follow their own evolutionary track. In some cases, they are known to be nuclear parasites with autonomous modes of inheritance, exploiting 'drive' to ensure ...

Responder (Rsp) alleles in the Segregation Distorter (SD) system of meiotic drive in Drosophila may represent a complex family of satellite repeat sequences

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Houtchens, KL, T. W.,  Genetica,  117:291-302. 2003.
In D. melanogaster males carrying Segregation Distorter (SD) second chromosomes, sperm receiving sensitive alleles of the Responder (Rsp) locus are subject to high rates of dysfunction. The Rsp region is located in 2R immediately adjacent to the centromere in heterochromatic band ...

General principles for risk assessment of living modified organisms: Lessons from chemical risk assessment

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Hill, RAS, C.,  Environ. Biosafety Res,  2:81-88. 2003.
Modern biotechnology has led to the development and use of Living Modified Organisms (LMOs) for agriculture and other purposes. Regulators at the national level are increasingly depending on risk assessment as a tool for assessing potential adverse effects of LMOs on the ...

Four loci on abnormal chromosome 10 contribute to meiotic drive in maize

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Hiatt, END, R. K.,  Genetics,  164:699-709. 2003.
We provide a genetic analysis of the meiotic drive system on maize abnormal chromosome 10 (Ab10) that causes preferential segregation of specific chromosomal regions to the reproductive megaspore. The data indicate that at least four chromosomal regions contribute to meiotic ...

The meiotic drive system on maize abnormal chromosome 10 contains few essential genes

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Hiatt, END, R. K.,  Genetica,  117:67-76. 2003.
In maize, a distal portion of abnormal chromosome 10 (Ab10) causes the meiotic drive of itself as well as many unlinked heterochromatic regions known as knobs. The Ab10 drive system, which encodes trans- as well as cis-acting components, occupies a large region of chromosome 10L ...

Sexual transmission of the Het-s prion leads to meiotic drive in Poldospora anserina

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Dalstra, HJPS, K.; Debets, A. J. M.; Saupe, S. J.; Hoekstra, R. F.,  Proceedings of the National Academy of Sciences of the United States of America,  100:6616-6621. 2003.
In the filamentous fungus Podospora anserina, two phenomena are associated with polymorphism at the het-s locus, vegetative incompatibility and ascospore abortion. Two het-s alleles occur naturally, het-s and het-S. The het-s encoded protein is a prion propagating as a ...

Site-specific selfish genes as tools for the control and genetic engineering of natural populations

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Burt, A,  Proceedings of the Royal Society B-Biological Sciences,  270:921-928. 2003.
Site-specific selfish genes exploit host functions to copy themselves into a defined target DNA sequence, and include homing endonuclease genes, group II introns and some LINE-like transposable elements. If such genes can be engineered to target new host sequences, then they can ...

Marcus Rhoades, preferential segregation and meiotic drive

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Birchler, JAD, R. K.; Doebley, J. F.,  Genetics,  164:835-841. 2003.
LONG before microarray biologists coined and promoted the term “discovery science,” maize geneticists were avid practitioners of this mode of investigation. In fact, one might say that for a number of years, the field of maize genetics basically operated as discovery science. ...

Overlapping deletions spanning the proximal two-thirds of the mouse t complex

Bergstrom, DEB, R. A.; Munroe, R. J.; Lee, B. K.; Browning, V. L.; You, Y.; Eicher, E. M.; Schimenti, J. C.,  Mammalian Genome,  14:817-829. 2003.
Chromosome deletion complexes in model organisms serve as valuable genetic tools for the functional and physical annotation of complex genomes. Among their many roles, deletions can serve as mapping tools for simple or quantitative trait loci (QTLs), genetic reagents for regional ...

Adaptation for horizontal transfer in a homing endonuclease

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Koufopanou, VG, M. R.; Burt, A.,  Molecular Biology and Evolution,  19:239-246. 2002.
Selfish genes of no function other than self-propagation are susceptible to degeneration if they become fixed in a population. and regular transfer to new species may be the only means for their long-term persistence. To test this idea we surveyed 24 species of yeast for VDE, a ...

Reciprocal crossover asymmetry and meiotic drive in a human recombination hot spot

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Jeffreys, AJN, R.,  Nature Genetics,  31:267-271. 2002.
Human DNA diversity arises ultimately from germline mutation that creates new haplotypes that can be reshuffled by meiotic recombination. Reciprocal crossover generates recombinant haplotypes but should not influence the frequencies of alleles in a population. We demonstrate ...

X chromosome effect on maternal recombination and meiotic drive in the mouse

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de la Casa-Esperon, EL-O, J. C.; de Villena, F. P. M.; Briscoe, T. L.; Malette, J. M.; Vaughan, J. E.; Morgan, K.; Sapienza, C.,  Genetics,  161:1651-1659. 2002.
We observed that maternal meiotic drive favoring the inheritance of DDK alleles at the Om locus on mouse chromosome 11 was correlated with the X chromosome inactivation phenotype of (C57BL/6Pgk1(a) X DDK)F-1 mothers. The basis for this unexpected observation appears to lie in the ...

Does Stellate cause meiotic drive in Drosophila melanogaster?

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Belloni, MT, P.; Bozzetti, M. P.; Palumbo, G.; Robbins, L. G.,  Genetics,  161:1551-1559. 2002.
Drosophila melanogaster males deficient for the crystal (cry) locus of the Y chromosome that carry between 15 and 60 copies of the X-linked Stellate (Ste) gene are semisterile, have elevated levels of nondisjunction, produce distorted sperm genotype ratios (meiotic drive), and ...

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