Fighting malaria with gene-drive technology

A team led by Imperial College London has created a genetic modification that distorts the sex ratio of a population of Anopheles gambiae mosquitoes using “gene drive” technology. The modification works by using a DNA-cutting enzyme to destroy the X chromosome during the production of sperm, which leads to predominantly male offspring, since females require two X chromosomes. The modification is coupled to a gene drive to allow it to spread through a population in a very effective way. A gene drive is a genetic engineering technology that propagates a particular modification by assuring that a specific form of a gene (or allele) will be transmitted with far more than the natural 50% probability.

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