Keywords: Target malaria

Who decides whether to use gene drives against malaria-carrying mosquitoes?

T. H. Saey,  ScienceNews,  2022.
The gene drive interferes with the insects’ ability to reproduce. It wiped out captive populations of mosquitoes in eight to 12 generations (SN: 10/27/18, p. 6) in a small lab study. In 2021, the technology worked in the large cages in Terni, Italy, too. Within as little as ...
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The sci-fi technology tackling malarial mosquitos

Anonymous,  The Star,  2022.
Environmental campaigner Liz O'Neill doesn't mince her words about gene drives - the next generation of genetic modification (GM) technology. "It is extremely worrying," says the director of UK anti-GM pressure group, GM Freeze. "To release something that has been specifically ...
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Importation of the non gene drive genetically modified male bias mosquito strain into Burkina Faso

A. Diabate,  Target Malaria,  2022.
On March 16 and 21, the team at the Institut de Recherche en Sciences de la Santé (IRSS), Target Malaria’s partner institution in Burkina Faso, received packages containing live genetically modified mosquito eggs from Italy. The National Biosafety Agency (ANB) officers were at ...
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The Financialisation of Malaria in Africa: Burkina Faso, rogue capital & GM/gene drive mosquitoes

S. Mentz-Lagrange and S. Swanepoel,  African Centre for Biodiversity,  2022.
This paper seeks to understand the financialisation of malaria as a vehicle for rogue capital in a context of a weakened state (through capture, corruption and coups) and the power that limits effective interventions. It shows how malaria, along with other diseases, is ...
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A multi-disciplinary approach for a building common understanding of genetic engineering for malaria control in Burkina Faso

L. Pare Toe, N. Barry, A. D. Ky, S. Kekele, W. I. Meda, K. Bayala, et al.,  Humanities and Social Sciences Communications,  9. 2022.
Genetic engineering is a complex topic, even for scientists working in other areas, and even more so for those who lack a formal scientific training. To help gene specialists and affected communities talk with one another, international guidance documents have been published that ...
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Mark-release-recapture experiment in Burkina Faso demonstrates reduced fitness and dispersal of genetically-modified sterile malaria mosquitoes

F. A. Yao, A.-A. Millogo, P. S. Epopa, A. North, F. Noulin, K. Dao, M. Drabo, C. Guissou, S. Kekele, M. Namountougou, R. K. Ouedraogo, L. Pare, N. Barry, R. Sanou, H. Wandaogo, R. K. Dabire, A. McKemey, F. Tripet and A. Diabaté,  Nature Communications,  13:796. 2022.
Every year, malaria kills approximately 405,000 people in Sub-Saharan Africa, most of them children under the age of five years. In many countries, progress in malaria control has been threatened by the rapid spread of resistance to antimalarial drugs and insecticides. Novel ...
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Articulating ethical principles guiding Target Malaria’s engagement strategy

A. J. Roberts and D. Thizy,  Malaria Journal,  21:35. 2022.
Progress in gene drive research has engendered a lively discussion about community engagement and the ethical standards the work hinges on. While there is broad agreement regarding ethical principles and established best practices for conducting clinical public health research, ...
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Gene Drives For Malaria Control And Elimination

Annonymous,  Health Tech,  2021.
There is notable ongoing research and prioritization of gene drive technology in Africa for Malaria control and elimination. Currently, there is ongoing gene drive mosquito research in Burkina Faso, Ghana, Mali and Uganda led by the Target Malaria consortium. While laboratory ...
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Two years of laboratory studies on the non gene drive genetically modified sterile male mosquitoes concluded successfully in Mali

M. Coulibaly,  Target Malaria,  2021.
The Target Malaria Mali team at the Malaria Research and Training Centre (MRTC) based at the University of Sciences, Techniques and Technologies of Bamako (USTTB) is proud to have been the first Malian research team to work on non gene drive genetically modified sterile male ...
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Small-scale release of non-gene drive mosquitoes in Burkina Faso: from engagement implementation to assessment, a learning journey

L. Pare Toe, N. Barry, A. D. Ky, S. Kekele, W. Meda, K. Bayala, M. Drabo, D. Thizy and A. Diabate,  Malaria Journal,  20:395. 2021.
This study provides a review of engagement activities relevant to field trials on non-gene drive genetically-modified mosquitoes as well as an assessment framework-using both qualitative and quantitative studies as well as an audit procedure. The latter was implemented to ...
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Gene drive revolution: How genetically tweaked mosquitoes could tip the balance in the battle to contain malaria

F. Okumu,  Genetic Literacy Project,  2021.
In 2016, a World Health Organisation (WHO) panel concluded that even with the best use of current approaches, there would still be 11 million malaria cases in 2050. What’s needed are longer-term integrated strategies to complement current methods. These may include large-scale ...
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Mobilizing Mutant Mosquitoes to Fight Malaria

D. Mclaughlin and J. Recht,  United Nations Foundation,  2021.
World Mosquito Day today marks the 1897 discovery by Sir Ronald Ross that female Anopheles mosquitoes spread malaria. Since that breakthrough, the world has fought this deadly disease through scientific research and new technology. While astounding progress has been made against ...
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Scientists eradicate malaria-transmitting mosquitos using genetic engineering which make females infertile in new study which takes one step closer to wiping out the disease worldwide.

C. Ciaccia,  Daily Mail,  2021.
Malaria kills nearly 500,000 people globally every year, but scientists have now figured out a way to use CRISPR gene-editing technology to make female mosquitoes infertile, described as a 'game-changer' for ending the deadly disease. Researchers from Imperial College London, ...
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GM mosquitoes to fight malaria

I. Khisa,  The INDEPENDENT,  2021.
Scientists at the Uganda Virus Research Institute (UVRI) plans to undertake a research on genetically engineered mosquitoes to tackle malaria. Dr. Jonathan Kayondo, the principal investigator Target Malaria Uganda and Senior Research Officer at UVRI had an email interview with ...
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Gene Drives – Engineering the Wild

L. Sharratt,  Sentinel,  2021.
So far, genetically engineered organisms have been mostly limited to agricultural use, with partial success. Around the world, a few major crops (mostly corn, soy, and cotton) are genetically engineered, predominantly for herbicide tolerance and insect resistance. However, the ...
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West African countries working together to develop framework to regulate genetically engineered mosquitos: Target Malaria

Anonymous,  Global News,  2021.
Abdoulaye Diabaté, principal investigator for Target Malaria, says West African countries like Burkina Faso, Mali and Benin are working with the New Partnership for Africa’s Development (NEPAD) to develop a pan-West African framework to regulate gene drive mosquitos.
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The ethical scientist in a time of uncertainty

L. Zoloth,  Cell,  184:1430-1439. 2021.
Using the example of gene drives for malaria control to explore the problem of deep uncertainty in biomedical research, I argue that profound uncertainty is an essential feature. Applying the language and presumptions of the discipline of philosophical ethics, I describe three ...
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In Uganda, genetically modified mosquitoes bring hope and fear

Anonymous,  africanews,  2021.
Scientists here are investigating whether populations of the malaria-carrying insects can be reduced by genetic modification. They're looking at the viability of releasing large numbers of genetically modified mosquitos into the wild to influence future generations. The study ...
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Experts oppose plan to breed mosquitoes

T. Abet,  Daily Monitor,  2021.
Environmentalists have opposed the plan to breed and release genetically modified mosquitoes in the country to curb malaria prevalence. They say the act presents substantial human and environmental health risks. Their objection follows last week’s announcement by scientists ...
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Genetically modified mosquitoes to curb malaria

T. Abet,  Daily Monitor,  2021.
Scientists at Uganda Virus Research Institute (UVRI) have started breeding mosquitoes with the aim of modifying their genetic materials and releasing them to the environment to curb malaria transmission. The genetically modified mosquitoes, according to the scientists, do not ...
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New genetically modified mosquitoes to help fight malaria

D. Zirimala,  Capital Radio FM,  2021.
According to Dr. Jonathan Kayondo, the principal investigator of the Target Malaria project, the genetically modified mosquitoes do not transmit malaria parasites when they bite. These are made infertile so that when they cross breed with the female anopheles mosquito, they are ...
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Proceedings of an expert workshop on community agreement for gene drive research in Africa – Co-organised by KEMRI, PAMCA and Target Malaria [version 1; peer review: awaiting peer review]

D. Thizy, L. Pare Toe, C. Mbogo, D. Matoke-Muhia, V. P. Alibu, S. K. Barnhill-Dilling, T. Chantler, G. Chongwe, J. Delborne, L. Kapiriri, E. Nassonko Kavuma, S. Koloi-Keaikitse, A. Kormos, K. Littler, D. Lwetoijera, R. Vargas de Moraes, N. Mumba, L. Muten,  Gates Open Research,  2021.
Target Malaria, the Kenya Medical Research Institute and the Pan African Mosquito Control Association co-organised a workshop with researchers and practitioners on this topic to question the model proposed by Target Malaria in its research so far that involved the release of ...
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Co‐developing a common glossary with stakeholders for engagement on new genetic approaches for malaria control in a local African setting

E. Chemonges Wanyama, B. Dicko, L. Pare Toe, M. B. Coulibaly, N. Barry, K. Bayala Traore, A. Diabate, M. Drabo, J. K. Kayondo, S. Kekele, S. Kodio, A. D. Ky, R. R. Linga, E. Magala, W. I. Meda, S. Mukwaya, A. Namukwaya, B. Robinson, H. Samoura, K. Sanogo,  Malaria Journal,  20:53. 2021.
Scientific terminologies are mainly lacking in local languages, yet when research activities involve international partnership, the question of technical jargon and its translation is crucial for effective and meaningful communication with stakeholders. Target Malaria, a ...
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The promise of CRISPR and gene drive systems to end malaria in Africa

E. Gomez-Diaz,  ARRIGE ORG,  2020.
Presentation by Elena Gómez Díaz (IPBLN-CSIC, Granada, Spain) at the ARRIGE 2020 meeting on "The promise of CRISPR and gene drive systems to end malaria in Africa". Discussion is included at the end of the Ruud de Maagd presentation.
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Brave New Planet: Reshaping Nature Through Gene Drives

E. Lander,  Brave New Planet,  2020.
A new technology, called gene drives, has the power to spread any genetic instructions you wish across an entire animal or plant species in the wild. It might let us restore ecosystems ravaged by invasive species, or help species adapt to climate change. And, it might save ...
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Interview with Professor Austin Burt: Role of gene drive technology in the context of the EU’s Biodiversity Strategy 2030

S. Dunphy,  European Scientist,  2020.
In view of these conditions, leading scientists are calling on EU institutions to continue to back research into gene drive as a potential tool to protect public health and deliver on Europe’s biodiversity goals. Experts believe gene drive technologies could be a vital and ...
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Driven to Exterminate

Z. Moloo and J. Thomas,  etc group,  2020.
Gates’s ‘let’s deploy it’ response may not seem out of character, but it was an unusually gung ho response given how risky the technology is widely acknowledged to be.
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Fighting malaria with genetically modified mosquitoes

E. Nakkazi,  BMJ,  370:m2172. 2020.
Could a bold project to genetically engineer mosquitoes curb the scourge of malaria in Africa? Finding out will require careful science—and public acceptance, writes Esther Nakkazi
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3 innovative technologies stopping malaria

B. Muni,  The Borgen Project,  2020.
Malaria has plummeted by 40% fifteen years after 2000. A report that NCBI published attributed this to mosquito preventative measures like bed netting and insecticides. These interventions and practices, like wearing light color clothing, help at-risk populations fight malaria. ...
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Fighting malaria with gene-drive technology

EarthWise,  earthwise radio,  2020.
A team led by Imperial College London has created a genetic modification that distorts the sex ratio of a population of Anopheles gambiae mosquitoes using “gene drive” technology. The modification works by using a DNA-cutting enzyme to destroy the X chromosome during the ...
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The development of complex and controversial innovations. Genetically modified mosquitoes for malaria eradication

V. Cisnetto and J. Barlow,  Research Policy,  49:103917. 2020.
e use a longitudinal process approach and qualitative system dynamics modelling to study the development of genetically modified (GM) mosquitoes for malaria eradication in an African country.
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‘We don’t want to be guinea pigs’: how one African community is fighting genetically modified mosquitoes

A. Pujol-Mazzini,  The Telegraph,  2019.
Researchers from the Target Malaria consortium, a not-for-profit research group funded by the Bill & Melinda Gates Foundation and various research institutions, have developed a mosquito in their laboratory that can kill off its own species by spreading a faulty gene. If it ...
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Scientists release sterile mosquitoes in Burkina to fight malaria

T. Ndiaga,  Reuters,  2019.
Scientists in Burkina Faso have deployed a new weapon in the fight against malaria, and waded into a thorny bioethics debate, by letting loose thousands of genetically sterilized mosquitoes.Their experiment is the first outside the lab to release genetically altered mosquitoes in ...
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Gene Drives in Africa: Civil Society Speaks Out

African Centre for Biodiversity,  African Centre for Biodiversity,  2019.
On Monday 1st July 2019, Target Malaria announced the release of genetically modified (GM) sterile male mosquitoes in Bana, a village in Burkina Faso – the first GM insect to be released in Africa. This is Phase I – by Phase III, Target Malaria aims to release gene drive ...
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For the first time, researchers will release genetically engineered mosquitoes in Africa

Ike Swetitz,  STAT,  2018.
The government of Burkina Faso granted scientists permission to release genetically engineered mosquitoes anytime this year or next, researchers announced Wednesday. It’s a key step in the broader efforts to use bioengineering to eliminate malaria in the region.
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A Revolutionary Genetic Experiment is Planned for a West African Village – If Residents Agree

Ike Swetitz,  STAT,  2017.
This small village of mud-brick homes in West Africa might seem the least likely place for an experiment at the frontier of biology. Yet scientists here are engaged in what could be the most promising, and perhaps one of the most frightening, biological experiments of our ...
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