Keywords: malaria

Genetic strategy reverses insecticide resistance

M. Aguilera,  Phys Org,  2022.
University of California San Diego biologists have now developed a method that reverses insecticide resistance using CRISPR/Cas9 technology. As described in Nature Communications, researchers Bhagyashree Kaduskar, Raja Kushwah and Professor Ethan Bier with the Tata Institute for ...
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Reversing insecticide resistance with allelic-drive in Drosophila melanogaster

B. Kaduskar, R. B. S. Kushwah, A. Auradkar, A. Guichard, M. Li, J. B. Bennett, A. H. F. Julio, J. M. Marshall, C. Montell and E. Bier,  Nature Communications,  13:291. 2022.
A recurring target-site mutation identified in various pests and disease vectors alters the voltage gated sodium channel (vgsc) gene (often referred to as knockdown resistance or kdr) to confer resistance to commonly used insecticides, pyrethroids and DDT. The ubiquity of kdr ...
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The Need for a Tiered Registry for US Gene Drive Governance

K. L. Warmbrod, A. L. Kobokovich, R. West, G. K. Gronvall and M. Montague,  Health Security,  2022.
A great deal of attention has been focused on the potential risks of gene drives, the kinds of biosafety protections they may require, and how they may be reversed; however, less attention has been paid to the systems that would be useful to have in place in the future, when ...
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Preparing an Insectary in Burkina Faso to Support Research in Genetic Technologies for Malaria Control

C. Guissou, M. M. Quinlan, R. Sanou, R. K. Ouédraogo, M. Namountougou and A. Diabaté,  Vector-Borne and Zoonotic Diseases,  2022.
The Institut de Recherche en Sciences de la Santé (IRSS) of Burkina Faso, West Africa, was the first African institution to import transgenic mosquitoes for research purposes. A shift from the culture of mosquito research to regulated biotechnology research and considerable ...
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Driving the Self-Destruction of Malaria-Transmitting Mosquitos

H. Aliouche,  News Medical Life Sciences,  2021.
Self-destruction of malaria-transmitting mosquitoes can be driven by gene drives deployed to manipulate natural populations. In particular, they can be used to reduce the number of individuals in a population or to modify their composition; this is particularly useful when such ...
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Integrated Management of Malaria Vectors in Africa

R. Mbabazi, K. Maredia, B. B. El-Sayed, A. K. Babumba, M. Savadogo and O. Akinbo,  Genetically Modified and other Innovative Vector Control Technologies,  2021.
Malaria disease is a major public health burden in Africa. The control of malaria vectors is a critical component for prevention, management, and eradication of malaria disease. This chapter presents information on the current status of malaria vector control in Africa with ...
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Measuring Public Attitudes to Releases of Transgenic Mosquitoes for Disease Control, with Special Reference to Dengue and Malaria

L. A. De Las Llagas and M. S. T. Gunigundo,  Genetically Modified and other Innovative Vector Control Technologies,  2021.
Since the advent of DDT in public health and agriculture, science leaped forward with revolutionary technology such as gene drive or editing, thus making it possible to develop alternative approaches to address vector-borne diseases. However, their utilization and sustenance in ...
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Safe Application of Genetically Modified Mosquito (GMM) to Combat Dengue and Chikungunya Depends on Socioeconomic Status and Social Acceptance in the Developing Countries: A Comprehensive Analysis

M. N. Islam,  Genetically Modified and other Innovative Vector Control Technologies,  2021.
The emerging and re-emerging vector-borne diseases are a serious public health problem throughout the world. It has been observed that more than 100 countries and approximately half of the world’s population are at risk on vector-borne diseases (VBDs). The global burden of the ...
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Malaria vector control tools in emergency settings: What do experts think? Results from a DELPHI survey

C. Boete, S. Burza, E. Lasry, S. Moriana and W. Robertson,  Conflict and Health,  15:11. 2021.
Background The use and implementation of novel tools for malaria control such as long lasting impregnated bednets (LLINs) and Indoor Residual Spraying (IRS) over the last decade has contributed to a substantial reduction in malaria burden globally. However numerous challenges ...
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Gene Drives For Malaria Control And Elimination

Annonymous,  Health Tech,  2021.
There is notable ongoing research and prioritization of gene drive technology in Africa for Malaria control and elimination. Currently, there is ongoing gene drive mosquito research in Burkina Faso, Ghana, Mali and Uganda led by the Target Malaria consortium. While laboratory ...
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Modeling impact and cost-effectiveness of driving-Y gene drives for malaria elimination in the Democratic Republic of the Congo

N. Metchanun, C. Borgemeister, G. Amzati, J. von Braun, M. Nikolov, P. Selvaraj and J. Gerardin,  Evolutionary Applications,  2021.
Malaria elimination will be challenging in countries that currently continue to bear high malaria burden. Sex-ratio distorting gene drives, such as driving-Y, could play a role in an integrated elimination strategy if they can effectively suppress vector populations. Using a ...
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The economic value of genetically engineered mosquitoes as a Malaria control strategy depends on local transmission rates

K. Lacy, K. A. Schaefer, D. P. Scheitrum and E. Y. Klein,  Biotechnology Journal,  10. 2021.
This paper assesses the economic value of genetically engineered (GE) Anopheles gambiae mosquitoes as a malaria control strategy. We use an epidemiological-economic model of malaria transmission to evaluate this technology for a range of village-level transmission settings. In ...
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The Potential for a Released Autosomal X-Shredder Becoming a Driving-Y Chromosome and Invasively Suppressing Wild Populations of Malaria Mosquitoes

Y. Alcalay, S. Fuchs, R. Galizi, F. Bernardini, R. E. Haghighat-Khah, D. B. Rusch, J. R. Adrion, M. W. Hahn, P. Tortosa, R. Rotenberry and P. A. Papathanos,  Frontiers in Bioengineering and Biotechnology,  9. 2021.
Sex-ratio distorters based on X-chromosome shredding are more efficient than sterile male releases for population suppression. X-shredding is a form of sex distortion that skews spermatogenesis of XY males towards the preferential transmission of Y-bearing gametes, resulting in a ...
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Scientists eye gene drive technology to combat malaria

S. Buguzi,  Sci Dev Net,  2021.
Scientists are hoping that adoption of gene drive technology could reduce mosquito populations as they call for new innovations in the fight against malaria, a fatal disease widespread in Sub-Saharan Africa. The World Health Organization (WHO) says the Africa region accounted ...
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Podcast: Malaria Gene Drive

S. Hartley, S. Neema and C. Opesen,  University of Exeter Business School,  2021.
Professor Sarah Hartley and her two colleagues in Uganda, Stella Neema and Chris Opesen discuss gene drive research for malaria control. Funded by British Academy and Wellcome trust, their work is to understand the social science challenges around the development of this kind of ...
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Gene drives in malaria control: what we need to know

R. Mudziwapasi, M. C. Changara, A. Ndudzo, T. Kaseke, F. Godobo, F. L. Mtemeli, R. Shoko, F. Songwe, S. Ndlovu and S. Sandra Mlambo,  Biotechnology and Biotechnological Equipment,  35:1623-1631. 2021.
Gene drives are being used to enhance a DNA sequence?s likelihood of passing between generations via sexual reproduction. Gene drives can be deployed to manipulate natural populations. They can be used to suppress populations by reducing the number of individuals in a population ...
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Two years of laboratory studies on the non gene drive genetically modified sterile male mosquitoes concluded successfully in Mali

M. Coulibaly,  Target Malaria,  2021.
The Target Malaria Mali team at the Malaria Research and Training Centre (MRTC) based at the University of Sciences, Techniques and Technologies of Bamako (USTTB) is proud to have been the first Malian research team to work on non gene drive genetically modified sterile male ...
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Malaria modeling and optimal control using sterile insect technique and insecticide-treated net

L. Cai, L. Bao, L. Rose, J. Summers and W. Ding,  Applicable Analysis,  2021.
We investigate a malaria transmission model with SEIR (susceptible-exposed-infected-recovered) classes for the human population, SEI (susceptible-exposed-infected) classes for the wild mosquitoes and an additional class for the sterile mosquitoes. The basic reproduction number ...
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Will freeing ourselves (forever) from mosquitoes soon be a realizable “dream”? Pros and cons of an epochal turning point – breaking latest news

Annonymous,  Breaking Latest News,  2021.
Also true for a dangerous insect like the mosquito: due to the pathologies of which vector, such as the malaria, the dengue o la yellow fever, every year in the world about 800 thousand people die. There are therefore quite a few reasons to want to get rid of it, not just the ...
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Population replacement gene drive characteristics for malaria elimination in a range of seasonal transmission settings: a modeling study

S. Leung, N. Windbichler, E. Wenger, C. Bever and P. Selvaraj,  bioRxiv,  2021.11.01.466856. 2021.
Genetically engineering mosquitoes is a promising new vector control strategy to reinvigorate the fight against malaria in Sub-Saharan Africa. Using an agent-based model of malaria transmission with vector genetics, we examine the impacts of releasing population-replacement gene ...
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Small-scale release of non-gene drive mosquitoes in Burkina Faso: from engagement implementation to assessment, a learning journey

L. Pare Toe, N. Barry, A. D. Ky, S. Kekele, W. Meda, K. Bayala, M. Drabo, D. Thizy and A. Diabate,  Malaria Journal,  20:395. 2021.
This study provides a review of engagement activities relevant to field trials on non-gene drive genetically-modified mosquitoes as well as an assessment framework-using both qualitative and quantitative studies as well as an audit procedure. The latter was implemented to ...
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Fighting the world’s most deadly animal: the mosquito

M. Rozenbaum,  Understanding Animal Research,  2021.
n the first, sterile male mosquitos are mass produced and released into the wild. These sterile males mate with wild females who then lay sterile eggs which will not hatch. This approach has been shown to reduce wild populations by as much as 90% in trials with Aedes aegypt. The ...
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Gene drive revolution: How genetically tweaked mosquitoes could tip the balance in the battle to contain malaria

F. Okumu,  Genetic Literacy Project,  2021.
In 2016, a World Health Organisation (WHO) panel concluded that even with the best use of current approaches, there would still be 11 million malaria cases in 2050. What’s needed are longer-term integrated strategies to complement current methods. These may include large-scale ...
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Stakeholders call for adoption of emerging technologies to fight Malaria

C. Muchira,  KBC,  2021.
Health stakeholders are calling for adoption of innovative and emerging technologies such as gene drive to change the focus of the war on malaria from just controlling its spread to actual elimination. The African Institute for Development Policy and other stakeholders have urged ...
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Microsporidia MB is found predominantly associated with Anopheles gambiae s.s and Anopheles coluzzii in Ghana

J. Akorli, E. A. Akorli, S. N. A. Tetteh, G. K. Amlalo, M. Opoku, R. Pwalia, M. Adimazoya, D. Atibilla, S. Pi-Bansa, J. Chabi and S. K. Dadzie,  Scientific Reports,  11:5. 2021.
A vertically transmitted microsporidian, Microsporidia MB, with the ability to disrupt Plasmodium development was reported in Anopheles arabiensis from Kenya, East Africa. To demonstrate its range of incidence, archived DNA samples from 7575 Anopheles mosquitoes collected from ...
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Mosquito transgenesis for malaria control

S. Dong, Y. Dong, M. L. Simões and G. Dimopoulos,  Trends in Parasitology,  2021.
Malaria is one of the deadliest diseases. Because of the ineffectiveness of current malaria-control methods, several novel mosquito vector-based control strategies have been proposed to supplement existing control strategies. Mosquito transgenesis and gene drive have emerged as ...
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Genetically changed mosquitoes could transform Africa’s long fight against malaria

L. Singh,  ForumIAS,  2021.
In nature, there’s a phenomenon called gene drive which operates in the process of reproduction. This is when a genetic element is able to increase the chance that it will be inherited by offspring. The general underlying principle of all gene drives is an organism that will ...
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Africa must not rest until Malaria rests: What is the role of emerging technologies?

R. Oronje,  AFIDEP,  2021.
As we mark the World Mosquito Day today, it is a sad reminder that Malaria still kills hundreds of thousands of people every year, majority of these people in Africa. According to the World Health Organisation (WHO), Malaria killed 409,000 people in 2019, and 94% of these deaths ...
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The Complex Lives of Mosquitoes: The Key for Malaria Control

F. Okumu,  ISGlobal,  2021.
Mosquitoes spread diseases to millions of people around the world, yet they remain poorly understood by most. Studying their biology and behaviours can help us combat, and eventually eliminate, dangerous diseases such as malaria and dengue fever.There are nearly 3,500 species of ...
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Mobilizing Mutant Mosquitoes to Fight Malaria

D. Mclaughlin and J. Recht,  United Nations Foundation,  2021.
World Mosquito Day today marks the 1897 discovery by Sir Ronald Ross that female Anopheles mosquitoes spread malaria. Since that breakthrough, the world has fought this deadly disease through scientific research and new technology. While astounding progress has been made against ...
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Identifying Sites for Testing Modified Mosquitoes as a Strategy to Eradicate Malaria

A. Fell,  UC Davis News,  2021.
In a newly published article in the journal Evolutionary Applications Professor Greg Lanzaro and his team at the Vector Genetics Laboratory, UC Davis School of Veterinary Medicine, set forth a framework for the selection of field sites in Africa best suited for testing ...
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New mosquito control tools are critical

L. Braack,  Open Access Government,  2021.
Globally, we are making slow headway in the fight against malaria, but there has been progress, nonetheless. Since 2000, 39 countries and territories have managed to rid themselves of malaria; the most recent is China. Existing tools can achieve local elimination, but the battle ...
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Scientists eradicate malaria-transmitting mosquitos using genetic engineering which make females infertile in new study which takes one step closer to wiping out the disease worldwide.

C. Ciaccia,  Daily Mail,  2021.
Malaria kills nearly 500,000 people globally every year, but scientists have now figured out a way to use CRISPR gene-editing technology to make female mosquitoes infertile, described as a 'game-changer' for ending the deadly disease. Researchers from Imperial College London, ...
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Breakthrough in non-GMO malaria control

C. Robinson and J. Matthews,  GM Watch,  2021.
A just-published study carried out in a high-security lab claims to show that a CRISPR gene drive (a way of forcing a heritable genetic modification through a whole species or population) can crash populations of malaria-spreading mosquitoes. But why crash mosquito populations ...
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Genetic engineering may rid world of malaria-transmitting mosquitoes

Y. Steinbuch,  New York Post,  2021.
Scientists have eradicated a population of malaria-transmitting mosquitoes by using genetic engineering to make the females infertile — in what the lead researcher called a possible “game-changer in bringing about malaria elimination.” A team of researchers — led by ...
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Gene-Drive Technology Could Decimate Malaria-Carrying Mosquitoes–Scientists Use CRISPR to Modify the Insects’ Genes

J. Henry,  Tech Times,  2021.
Gene-drive technology can now suppress the growing numbers of mosquitoes that carry malaria. A group of researchers discovered that this gene-editing technique can eradicate the vectors that could rapidly populate in a particular environment. A mosquito (Anopheles albimanus) is ...
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Malaria-carrying mosquitoes could be bred out of existence using ‘gene drive’ technology

A. Wilkins,  METRO,  2021.
Malaria-carrying mosquitoes have been eliminated using ‘gene drive’ technology in a nature-like environment, in a world-first study. By altering a gene that blocks female mosquito reproduction, and allowing that gene to spread, researchers found they could ensure complete ...
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Scientists reveal controversial genetically modified mosquitoes in high-security lab

The Frontier Post,  The Frontier Post,  2021.
Many years of additional research will be needed to prove the approach works and the mosquitoes would be safe to release into the wild. The project would also require regulatory approval and agreement by local residents in areas where those mosquitoes live, mostly in sub-Saharan ...
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Genetic engineering test with mosquitoes ‘may be game changer’ in eliminating malaria

L. Geddes,  The Guardian,  2021.
Scientists have successfully wiped out a population of malaria-transmitting mosquitoes by using a radical form of genetic engineering to render the females infertile – in the most advanced and largest ever test of use of the technology to fight the disease. As well as bringing ...
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How An Altered Strand Of DNA Can Cause Malaria-Spreading Mosquitoes To Self-Destruct

R. Stein,  NPR,  2021.
For the first time, scientists have shown that a new kind of genetic engineering can crash populations of malaria-spreading mosquitoes. In the landmark study, published Wednesday in the journal Nature Communications, researchers placed the genetically modified mosquitoes in a ...
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A lab experiment shows that we could engineer malaria-carrying mosquitoes to kill themselves off

A. Micu,  ZME Science,  2021.
A new paper showcases how genetic engineering can be used to cause populations of malaria-spreading mosquitoes to self-destroy. An international research effort has shown, in the context of a lab experiment, that male mosquitoes engineered to carry a certain strand of DNA can ...
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Malarial mosquitoes suppressed in experiments that mimic natural environments

H. Dunning,  Phys Org,  2021.
Researchers have shown "gene drive" technology, which spreads a genetic modification blocking female reproduction, works in natural-like settings. The team, led by researchers from Imperial College London, Polo GGB and Liverpool School of Tropical Medicine were able to suppress ...
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Horizontal Transmission of the Symbiont Microsporidia MB in Anopheles arabiensis

G. Nattoh, T. Maina, E. E. Makhulu, L. Mbaisi, E. Mararo, F. G. Otieno, T. Bukhari, T. O. Onchuru, E. Teal, J. Paredes, J. L. Bargul, D. M. Mburu, E. A. Onyango, G. Magoma, S. P. Sinkins and J. K. Herren,  Frontiers in Microbiology,  12. 2021.
The recently discovered Anopheles symbiont, Microsporidia MB, has a strong malaria transmission-blocking phenotype in Anopheles arabiensis, the predominant Anopheles gambiae species complex member in many active transmission areas in eastern Africa. The ability of Microsporidia ...
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Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field

A. Hammond, P. Pollegioni, T. Persampieri, A. North, R. Minuz, A. Trusso, A. Bucci, K. Kyrou, I. Morianou, A. Simoni, T. Nolan, R. Müller and A. Crisanti,  Nature Communications,  12:4589. 2021.
CRISPR-based gene-drives targeting the gene doublesex in the malaria vector Anopheles gambiae effectively suppressed the reproductive capability of mosquito populations reared in small laboratory cages. To bridge the gap between laboratory and the field, this gene-drive ...
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Selection of sites for field trials of genetically engineered mosquitoes with gene drive

G. C. Lanzaro, M. Campos, M. Crepeau, A. Cornel, A. Estrada, H. Gripkey, Z. Haddad, A. Kormos and S. Palomares,  Evolutionary Applications,  15. 2021.
Novel malaria control strategies using genetically engineered mosquitoes (GEMs) are on the horizon. Population modification is one approach wherein mosquitoes are engineered with genes rendering them refractory to the malaria parasite, Plasmodium falciparum, coupled with a ...
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GM mosquitoes to fight malaria

I. Khisa,  The INDEPENDENT,  2021.
Scientists at the Uganda Virus Research Institute (UVRI) plans to undertake a research on genetically engineered mosquitoes to tackle malaria. Dr. Jonathan Kayondo, the principal investigator Target Malaria Uganda and Senior Research Officer at UVRI had an email interview with ...
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Combating mosquito-borne diseases using genetic control technologies

G.-H. Wang, S. Gamez, R. R. Raban, J. M. Marshall, L. Alphey, M. Li, J. L. Rasgon and O. S. Akbari,  Nature Communications,  12:4388. 2021.
Mosquito-borne diseases, such as dengue and malaria, pose significant global health burdens. Unfortunately, current control methods based on insecticides and environmental maintenance have fallen short of eliminating the disease burden. Scalable, deployable, genetic-based ...
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Gene Drives – Engineering the Wild

L. Sharratt,  Sentinel,  2021.
So far, genetically engineered organisms have been mostly limited to agricultural use, with partial success. Around the world, a few major crops (mostly corn, soy, and cotton) are genetically engineered, predominantly for herbicide tolerance and insect resistance. However, the ...
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Africa Turning to Gene Drive Technology for Malaria Elimination

M. Hearty,  Science Africa,  2021.
With Africa accounting for nine out of ten malaria cases globally, the continent is turning to gene drive technology to control the disease. This is according to a decision made by African leaders at the 29th Summit of Heads of States and Governments of the African Union held in ...
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A new tool in the global fight against malaria

S. Laux,  Brighter World,  2021.
McMaster researchers with the Institute on Ethics & Policy for Innovation (IEPI) have played a key role in developing updated international guidelines that will inform research and development on genetically modified mosquitoes – an initiative that could significantly affect ...
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Fighting disease: How are genetically engineered mosquitoes regulated?

A. Julie,  Global News,  2021.
Mosquitoes have long been associated with the spread of diseases like malaria, dengue fever and the Zika virus. But scientists around the world have been exploring the possibility that mosquitoes could also be key to slowing the spread of disease. By genetically altering the DNA ...
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The (Losing) Battle Against Mosquitoes In Texas

J. Clayton,  Texas Public Radio,  2021.
Jerry Clayton: Mosquitoes are a fact of life in Texas, and the battle against the pesky biting insects is never ending. But there are some new weapons on the horizon. Zach Adleman is an associate professor of entomology at Texas A&M University. He joins us today. Thanks for being ...
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CRISPR-mediated knock-in of transgenes into the malaria vector Anopheles funestus

C. Quinn, A. Anthousi, C. Wondji and T. Nolan,  G3 Genes Genomes Genetics,  11. 2021.
The ability to introduce mutations, or transgenes, of choice to precise genomic locations has revolutionized our ability to understand how genes and organisms work. In many mosquito species that are vectors of various human diseases, the advent of CRISPR genome editing tools has ...
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Stable high-density and maternally inherited Wolbachia infections in Anopheles moucheti and Anopheles demeilloni mosquitoes

T. Walker, S. Quek, C. L. Jeffries, J. Bandibabone, V. Dhokiya, R. Bamou, M. Kristan, L. A. Messenger, A. Gidley, E. A. Hornett, E. R. Anderson, C. Cansado-Utrilla, S. Hegde, C. Bantuzeko, J. C. Stevenson, N. F. Lobo, S. C. Wagstaff, C. A. Nkondjio, S. R.,  Current Biology,  31:2310. 2021.
Wolbachia, a widespread bacterium that can reduce pathogen transmission in mosquitoes, has recently been reported to be present in Anopheles (An.) species. In wild populations of the An. gambiae complex, the primary vectors of Plasmodium malaria in Sub-Saharan Africa, Wolbachia ...
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European Parliament calls for ban on gene drive technology

Save Our Seeds,  Save Our Seeds,  2021.
The European Parliament yesterday confirmedi it‘s precautionary stance towards the use of a new genetic engineering technology called gene drive. In its report on the EU’s Biodiversity Strategy for 2030, adopted at the European Parliament’s plenary on 08.06.2021, ...
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Vector control: Discovery of Wolbachia in malaria vectors

P. A. Ross and A. A. Hoffmann,  Current Biology,  31:R738-R740. 2021.