Overcoming drug-resistant tumors with selection gene drives
Overcoming drug-resistant tumors with selection gene drives
Tags: Gene drive, Gene drive synthetic, Modeling, Synthetic biologyHui Wang, Mingqi Xie, Cell Genomics, 4. 2024.
Drug resistance is a major hurdle prohibiting effective treatment of many diseases, including cancer. Using model-guided designs, Leighow et al.1 engineered a dual-switch selection gene drive system custom designed to combat drug-resistant tumors. By demonstrating remarkable killing efficacies in preclinical models using human non-small lung cancer cells in vitro and in mice, this work describes an attractive mindset to develop next-generation anticancer therapies.
