Keywords: modeling

The effect of mating complexity on gene drive dynamics

P. Verma, R. G. Reeves, S. Simon, M. Otto and C. S. Gokhale,  bioRxiv,  2021.09.16.460618. 2022.
Gene drive technology promises to deliver on some of the global challenges humanity faces today in healthcare, agriculture and conservation. However, there is a limited understanding of the consequences of releasing self-perpetuating transgenic organisms into the wild populations ...
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Adversarial interspecies relationships facilitate population suppression by gene drive in spatially explicit models

Y. Liu, W. Teo, H. Yang and J. Champer,  bioRxiv,  2022.05.08.491087. 2022.
Suppression gene drives are designed to bias their inheritance and increase in frequency in a population, disrupting an essential gene in the process. When the frequency is high enough, the population will be unable to reproduce above the replacement level and could be ...
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A metapopulation approach to identify targets for Wolbachia-based dengue control

A. Reyna-Lara, D. Soriano-Paños, J. H. Arias-Castro, H. J. Martínez and J. Gómez-Gardeñes,  Chaos,  32:041105. 2022.
Over the last decade, the release of Wolbachia-infected Aedes aegypti into the natural habitat of this mosquito species has become the most sustainable and long-lasting technique to prevent and control vector-borne diseases, such as dengue, zika, or chikungunya. However, the ...
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Finding the strongest gene drive: Simulations reveal unexpected performance differences between Anopheles homing suppression drive candidates

S. E. Champer, I. K. Kim, A. G. Clark, P. W. Messer and J. Champer,  bioRxiv,  2022.03.28.486009. 2022.
Recent experiments have produced several Anopheles gambiae homing gene drives that disrupt female fertility genes, thereby eventually inducing population collapse. Such drives may be highly effective tools to combat malaria. One such homing drive, based on the zpg promoter ...
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Uniqueness and stability of periodic solutions for an interactive wild and Wolbachia-infected male mosquito model

R. Yan and Q. Sun,  Journal of Biological Dynamics,  2022.
We investigate a mosquito population suppression model, which includes the release of Wolbachia-infected males causing incomplete cytoplasmic incompatibility (CI). The model consists of two sub-equations by considering the density-dependent birth rate of wild mosquitoes. By ...
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Effects of Sterile Males and Fertility of Infected Mosquitoes on Mosquito-Borne Disease Dynamics

X. L. Sun, S. Q. Liu, Y. F. Lv and Y. Z. Pei,  Bulletin of Mathematical Biology,  84:33. 2022.
By studying an infection-age structured model, we consider the effects of releasing sterile males and the fertility of infected mosquitoes on the mosquito-borne diseases transmission including the extinction of mosquitoes, the elimination and persistence of diseases. Firstly, ...
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The prince, the mayor, and the U.S. fish that ate Japan

C. Elliot,  National Geographic,  2022.
When Crown Prince Akihito visited Chicago on October 3, 1960, his sole request was to visit Shedd Aquarium. Then Mayor Richard J. Daley, an avid angler, presented the prince with a gift that he scooped with a net from one of the tanks himself: 18 bluegills, the official Illinois ...
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Modeling CRISPR gene drives for suppression of invasive rodents using a supervised machine learning framework

S. E. Champer, N. Oakes, R. Sharma, P. García-Díaz, J. Champer and P. W. Messer,  PLoS Comput Biol,  17:e1009660. 2021.
Invasive rodent populations pose a threat to biodiversity across the globe. When confronted with these invaders, native species that evolved independently are often defenseless. CRISPR gene drive systems could provide a solution to this problem by spreading transgenes among ...
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Modeling impact and cost-effectiveness of driving-Y gene drives for malaria elimination in the Democratic Republic of the Congo

N. Metchanun, C. Borgemeister, G. Amzati, J. von Braun, M. Nikolov, P. Selvaraj and J. Gerardin,  Evolutionary Applications,  2021.
Malaria elimination will be challenging in countries that currently continue to bear high malaria burden. Sex-ratio distorting gene drives, such as driving-Y, could play a role in an integrated elimination strategy if they can effectively suppress vector populations. Using a ...
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Demographic feedbacks can hamper the spatial spread of a gene drive

L. Girardin and F. Débarre,  Journal of Mathematical Biology,  83:67. 2021.
This paper is concerned with a reaction–diffusion system modeling the fixation and the invasion in a population of a gene drive (an allele biasing inheritance, increasing its own transmission to offspring). In our model, the gene drive has a negative effect on the fitness of ...
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Quantifying the risk of vector-borne disease transmission attributable to genetically modified vectors

G. R. Hosack, A. Ickowicz and K. R. Hayes,  Royal Society Open Science,  8:201525. 2021.
The relative risk of disease transmission caused by the potential release of transgenic vectors, such as through sterile insect technique or gene drive systems, is assessed with comparison with wild-type vectors. The probabilistic risk framework is demonstrated with an assessment ...
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A confinable home and rescue gene drive for population modification

N. P. Kandul, J. Liu, J. B. Bennett, J. M. Marshall and O. S. Akbari,  eLife,  10:e65939. 2021.
Homing based gene drives, engineered using CRISPR/Cas9, have been proposed to spread desirable genes throughout populations. However, invasion of such drives can be hindered by the accumulation of resistant alleles. To limit this obstacle, we engineer a confinable population ...
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Design and analysis of CRISPR-based underdominance toxin-antidote gene drives

J. Champer, S. E. Champer, I. K. Kim, A. G. Clark and P. W. Messer,  Evolutionary Applications,  18. 2020.
We model drives which target essential genes that are either haplosufficient or haplolethal, using nuclease promoters with expression restricted to the germline, promoters that additionally result in cleavage activity in the early embryo from maternal deposition, and promoters ...
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Gene Drives across engineered fitness valleys: Modeling a design to prevent drive spillover.

F. J. H. de Haas and S. Otto,  bioRxiv,  2020.10.29.360404. 2020.
We model a proposed drive system that transitions in time from a low threshold drive system (homing-based gene drive) to a high threshold drive system (underdominance) using daisy chain technology. This combination leads to a spatially restricted drive strategy while maintaining ...
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Gene Drives: Dynamics and Regulatory Matters-A Report from the Workshop “Evaluation of Spatial and Temporal Control of Gene Drives,” April 4-5, 2019, Vienna

B. Giese, J. L. Friess, N. H. Barton, P. W. Messer, F. Debarre, M. F. Schetelig, N. Windbichler, H. Meimberg and C. Boete,  Bioessays,  41:3. 2019.
Gene Drives are regarded as future tools with a high potential for population control. Due to their inherent ability to overcome the rules of Mendelian inheritance, gene drives (GD) may spread genes rapidly through populations of sexually reproducing organisms. A release of ...
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