Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
Disclaimer>

Assessing the hybridization potential between a hypothetical gene drive-modified Drosophila suzukii strain and non-target Drosophila species

Tags: , , , ,
J. Romeis, S. Wolf, J. Collatz, J. Enkerli and F. Widmer,  IOBC-WPRS Bulletin,  163:108. 2023.
Genetically engineered gene drives (GD) are a potentially powerful tool to control pest insects by population suppression or even elimination. Before living GD modified insects can be released into the environment, they must pass an environmental risk assessment (ERA). A key ...

A male-killing gene encoded by a symbiotic virus of Drosophila

Tags: , , ,
D. Kageyama, T. Harumoto, K. Nagamine, A. Fujiwara, T. N. Sugimoto, A. Jouraku, M. Tamura, T. K. Katoh and M. Watada,  Nature Communications,  14:1357. 2023.
In most eukaryotes, biparentally inherited nuclear genomes and maternally inherited cytoplasmic genomes have different evolutionary interests. Strongly female-biased sex ratios that are repeatedly observed in various arthropods often result from the male-specific lethality ...

First report of natural Wolbachia infections in mosquitoes from Cuba

Tags: , , ,
A. Ruiz, G. Gutiérrez-Bugallo, R. Rodríguez-Roche, L. Pérez, R. González-Broche, L. A. Piedra, L. C. Martínez, Z. Menéndez, A. Vega-Rúa and J. A. Bisset,  Acta Tropica,  242:106891. 2023.
Mosquitoes are extensively responsible for the transmission of pathogens. Novel strategies using Wolbachia could transform that scenario, since these bacteria manipulate mosquito reproduction, and can confer a pathogen transmission-blocking phenotype in culicids. Here, we ...

CRISPR-based genetic control strategies for insect pests

Tags: , , , ,
Y. Yan, R. A. Aumann, I. Hacker and M. F. Schetelig,  Journal of Integrative Agriculture,  22:651-668. 2023.
Genetic control strategies such as the sterile insect technique have successfully fought insect pests worldwide. The CRISPR (clustered regularly interspaced short palindromic repeats) technology, together with high-quality genomic resources obtained in more and more species, ...

Modeling Sustained Transmission of Wolbachia among Anopheles Mosquitoes: Implications for Malaria Control in Haiti

Tags: , , ,
D. Florez, A. J. Young, K. J. Bernabé, J. M. Hyman and Z. Qu,  Trop Med Infect Dis,  8. 2023.
Wolbachia infection in Anopheles albimanus mosquitoes can render mosquitoes less capable of spreading malaria. We developed and analyzed a mechanistic compartmental ordinary differential equation model to evaluate the effectiveness of Wolbachia-based vector control strategies ...

A mosquito population suppression model with a saturated Wolbachia release strategy in seasonal succession

Tags: , , ,
Z. Zhang, L. Chang, Q. Huang, R. Yan and B. Zheng,  J Math Biol,  86:51. 2023.
Releasing Wolbachia-infected male mosquitoes to suppress wild female mosquitoes through cytoplasmic incompatibility has shown great promise in controlling and preventing mosquito-borne diseases. To make the release logistically and economically feasible, we propose a saturated ...

Analysing inhibition of dengue virus in Wolbachia-infected mosquito cells following the removal of Wolbachia

Tags: , ,
M. Hussain, K. Etebari and S. Asgari,  Virology,  581:48-55. 2023.
Wolbachia pipientis is known to block replication of positive sense RNA viruses. Previously, we created an Aedes aegypti Aag2 cell line (Aag2.wAlbB) transinfected with the wAlbB strain of Wolbachia and a matching tetracycline-cured Aag2.tet cell line. While dengue virus (DENV) ...

Genomic and cytogenetic analysis of the Ceratitis capitata temperature-sensitive lethal region

Tags: ,
G. Sollazzo, G. Gouvi, K. Nikolouli, R. A. Aumann, H. Djambazian, M. A. Whitehead, P. Berube, S.-H. Chen, G. Tsiamis, A. C. Darby, J. Ragoussis, M. F. Schetelig and K. Bourtzis,  G3-Genes Genomes Genetics,  13. 2023.
Genetic sexing strains (GSS) are an important tool in support of sterile insect technique (SIT) applications against insect pests and disease vectors. The yet unknown temperature-sensitive lethal (tsl) gene and the recently identified white pupae (wp) gene have been used as ...

Effects of Wolbachia on Transposable Element Expression Vary Between Drosophila melanogaster Host Genotypes

Tags: , ,
A. T. Eugénio, M. S. P. Marialva and P. Beldade,  Genome Biology Evolution,  15. 2023.
Transposable elements (TEs) are repetitive DNA sequences capable of changing position in host genomes, thereby causing mutations. TE insertions typically have deleterious effects but they can also be beneficial. Increasing evidence of the contribution of TEs to adaptive evolution ...

Genome evolution of dengue virus serotype 1 under selection by Wolbachia pipientis in Aedes aegypti mosquitoes

Tags: , , ,
D. Thi Hue Kien, K. Edenborough, D. da Silva Goncalves, T. Thuy Vi, E. Casagrande, H. Thi Le Duyen, V. Thi Long, L. Thi Dui, V. Thi Tuyet Nhu, N. Thi Giang, H. Thi Xuan Trang, E. Lee, I. a. Donovan-Banfield, H. Thi Thuy Van, N. Minh Nguyet, N. Thanh Phong,  Virus Evolution,  9:vead016. 2023.
The introgression of antiviral strains of Wolbachia into Aedes aegypti mosquito populations is a public health intervention for the control of dengue. Plausibly, dengue virus (DENV) could evolve to bypass the antiviral effects of Wolbachia and undermine this approach. Here, we ...

Wolbachia pipientis infections in populations of Aedes albopictus in the city of València (Spain): implications for mosquito control

Tags: , , ,
R. Bueno-Marí, R. Domínguez-Santos, M. Trelis, E. Garrote-Sánchez, M. Cholvi, F. Quero de Lera, M. Khoubbane, A. Marcilla and R. Gi,  Revista Española de Salud Pública,  97. 2023.
OBJECTIVE: The presence of Aedes albopictus, of high sanitary and social impact, was first reported in Valencia (Eastern Spain) in 2015. Innovative tools for its control include the use of the endosymbiotic bacterium Wolbachia pipientis. The release of mosquito males infected ...

Hybrid incompatibilities in the anopheles gambiae species complex

Tags: , , , , , , ,
A. Kriezis,  Imperial College London,  2023.
Malaria is an infectious disease caused by parasites of the genus Plasmodium which is responsible for approximately 400,000 deaths annually, primarily in sub-Saharan Africa. Malaria is transmitted by mosquitoes belonging to the Anopheles gambiae species complex. While progress ...

Satellite Rearing of Aedes Mosquito Eggs: Synchronized Empirical Test of a Novel Mass Rearing Model

Tags: , , ,
K. L. Dobson, K. Blore, J. A. Henke, K. Y. Hung, T. Morgan, T. Posey, S. Sun, O. Sypes, N. P. Tremblay and S. L. Dobson,  J Am Mosq Control Assoc,  39:12-17. 2023.
Mosquito suppression strategies based on "rear and release" of male mosquitoes are attracting renewed interest from governments, municipalities, and private businesses. These include irradiation-based sterile insect technique, Wolbachia-based technologies, and genetic ...

Ovarian Transcriptional Response to Wolbachia Infection in D. melanogaster in the Context of Between-Genotype Variation in Gene Expression

Tags: ,
S. I. Frantz, C. M. Small, W. A. Cresko and N. D. Singh,  G3-Genes Genomes Genetics,  2023.
Wolbachia is a maternally-transmitted endosymbiotic bacteria that infects a wide variety of arthropod and nematode hosts. The effects of Wolbachia on host biology are far-reaching and include changes in host gene expression. However, previous work on the host transcriptional ...

Alleviating the burden of malaria with gene drive technologies? A biocentric analysis of the moral permissibility of modifying malaria mosquitoes

Tags: , , , , ,
N. de Graeff, K. R. Jongsma and A. L. Bredenoord,  Journal of Medical Ethics,  2023.
Gene drive technologies (GDTs) have been proposed as a potential new way to alleviate the burden of malaria, yet have also raised ethical questions. A central ethical question regarding GDTs relates to whether it is morally permissible to intentionally modify or eradicate ...

Engagement on risk assessment for gene drive mosquitoes by EFSA and Target Malaria

Tags: , , , , , , ,
S. Hartley, A. Kokotovich, Y. Devos and J. Mumford,  Environmental Science and Policy,  142:183-193. 2023.
As engineered gene drive technologies continue to advance, many actors are actively considering how environmental risk assessments (RAs) for gene drive organisms should be conducted, and how stakeholder engagement opportunities should be provided. There is, however, a lack of ...

A toxin-antidote CRISPR gene drive system for regional population modification

Tags: , , ,
J. Champer, E. Lee, E. Yang, C. Liu, A. G. Clark and P. W. Messer,  Nature Communications,  11:1082. 2023.
Engineered gene drives based on a homing mechanism could rapidly spread genetic alterations through a population. However, such drives face a major obstacle in the form of resistance against the drive. In addition, they are expected to be highly invasive. Here, we introduce the ...

Simulations Reveal High Efficiency and Confinement of a Population Suppression CRISPR Toxin-Antidote Gene Drive

Tags: , , , , ,
Y. Zhu and J. Champer,  ACS Synthetic Biolog,  2023.
Though engineered gene drives hold great promise for spreading through and suppressing populations of disease vectors or invasive species, complications such as resistance alleles and spatial population structure can prevent their success. Additionally, most forms of suppression ...

Development of transgenic corn planthopper Peregrinus maidis that express the tetracycline transactivator

Tags: , ,
A. A. Patil, W. Klobasa, D. Espinoza-Rivera, O. Baars, M. D. Lorenzen and M. J. Scott,  Insect Molecular Biology,  32:363-375. 2023.
Abstract The corn planthopper, Peregrinus maidis, is a vector of several maize viruses and is consequently a significant agricultural pest in many tropical and subtropical regions. As P. maidis has developed resistance to insecticides, the aim of this study was to develop ...

Next-generation CRISPR gene-drive systems using Cas12a nuclease

Tags: , , ,
S. Sanz Juste, E. M. Okamoto, X. Feng and V. L. Del Amo,  bioRxiv,  2023.02.20.529271. 2023.
One method for reducing the impact of vector-borne diseases is through the use of CRISPR-based gene drives, which manipulate insect populations due to their ability to rapidly propagate desired genetic traits into a target population. However, all current gene drives employ a ...

« First ‹ Previous 1 20 28 29 30 31 32 40 118 Next › Last »