Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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Centromere drive: model systems and experimental progress

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D. Dudka and M. A. Lampson,  Chromosome Research,  2022.
Centromeres connect chromosomes and spindle microtubules to ensure faithful chromosome segregation. Paradoxically, despite this conserved function, centromeric DNA evolves rapidly and centromeric proteins show signatures of positive selection. The centromere drive hypothesis ...

Sensitivity of wMel and wAlbB Wolbachia infections in Aedes aegypti Puducherry (Indian) strains to heat stress during larval development

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K. Gunasekaran, C. Sadanandane, D. Panneer, A. Kumar, M. Rahi, S. Dinesh, B. Vijayakumar, M. Krishnaraja, S. K. Subbarao and P. Jambulingam,  Parasites and Vectors,  15:221. 2022.
BACKGROUND: ICMR-Vector Control Research Centre, Puducherry, India, developed two colonies of Aedes aegypti infected with wMel and wAlbB Wolbacia strains called Ae. aegypti (Pud) lines for dengue control. The sensitivity of wMel and wAlbB strains in Ae. aegypti (Pud) lines to ...

Sexual transmission of Anopheles gambiae densovirus (AgDNV) leads to disseminated infection in mated females

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K. L. Werling, R. M. Johnson, H. C. Metz and J. L. Rasgon,  Parasites and Vectors,  15:219. 2022.
Anopheles gambiae densovirus (AgDNV) is an insect-specific, single-stranded DNA virus that infects An. gambiae sensu stricto (s.s.), the major mosquito species responsible for transmitting malaria parasites throughout sub-Saharan Africa. AgDNV is a benign virus that is very ...

Hoisted with his own petard: how sex-ratio meiotic drive in <em>Drosophila affinis</em> creates resistance alleles that limit its spread

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W.-J. Ma, E. M. Knoles, K. B. Patch, M. M. Shoaib and R. L. Unckless,  bioRxiv,  2022.02.14.480432. 2022.
Meiotic drivers are selfish genetic elements that tinker with gametogenesis to bias their own transmission into the next generation of offspring. Such tinkering can have significant consequences on gametogenesis and end up hampering the spread of the driver. In Drosophila ...

DriverSEAT: A spatially-explicit stochastic modelling framework for the evaluation of gene drives in novel target species

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M. Legros and L. G. Barrett,  bioRxiv,  2022.06.13.496025. 2022.
Gene drives represent a potentially ground breaking technology for the control of undesirable species or the introduction of desirable traits in wild population, and there is strong interest in applying these technologies to a wide range of species across many domains including ...

Genetic Approaches for Controlling CRISPR-based Autonomous Homing Gene Drives

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P. R. Chennuri, Z. N. Adelman and K. M. Myles,  Frontiers in Bioengineering and Biotechnology,  10:897231. 2022.
CRISPR-based autonomous homing gene drives are a potentially transformative technology with the power to reduce the prevalence of, or even eliminate, vector-borne diseases, agricultural pests, and invasive species. However, there are a number of regulatory, ethical, ...

Natural and Engineered Sex Ratio Distortion in Insects

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A. Compton and Z. Tu,  Frontiers in Ecology and Evolution,  10. 2022.
Insects have evolved highly diverse genetic sex-determination mechanisms and a relatively balanced male to female sex ratio is generally expected. However, selection may shift the optimal sex ratio while meiotic drive and endosymbiont manipulation can result in sex ratio ...

Meiotic behavior, transmission and active genes of B chromosomes in the cichlid Astatotilapia latifasciata: new clues about nature, evolution and maintenance of accessory elements

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A. L. Cardoso, N. B. Venturelli, I. da Cruz, F. M. de Sá Patroni, D. de Moraes, R. A. de Oliveira, R. Benavente and C. Martins,  Molecular Genetics and Genomics,  2022.
Supernumerary B chromosomes (Bs) are dispensable genetic elements widespread in eukaryotes and are poorly understood mainly in relation to mechanisms of maintenance and transmission. The cichlid Astatotilapia latifasciata can harbor Bs in a range of 0 (named B -) and 1-2 (named ...

Generation of Gene Drive Mice for Invasive Pest Population Suppression

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M. D. Bunting, C. Pfitzner, L. Gierus, M. White, S. Piltz and P. Q. Thomas,  Applications of Genome Modulation and Editing,  2022.
Gene drives are genetic elements that are transmitted to greater than 50% of offspring and have potential for population modification or suppression. While gene drives are known to occur naturally, the recent emergence of CRISPR-Cas9 genome-editing technology has enabled ...

Selective targeting of biting females to control mosquito-borne infectious diseases

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B. B. Kojin, A. Compton, Z. N. Adelman and Z. Tu,  Trends in Parasitology,  2022.
Mosquitoes are vectors for a number of infectious diseases. Only females feed on blood to provision for their embryos and, in doing so, transmit pathogens to the associated vertebrate hosts. Therefore, sex is an important phenotype in the context of genetic control programs, both ...

Male-killing-associated bacteriophage WO identified from comparisons of Wolbachia endosymbionts of Homona magnanima

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H. Arai, H. Anbutsu, Y. Nishikawa, M. Kogawa, K. Ishii, M. Hosokawa, S.-R. Lin, M. Ueda, M. Nakai, Y. Kunimi, T. Harumoto, D. Kageyama, H. Takeyama and M. N. Inoue,  bioRxiv,  2022.
The origin and mechanism of male-killing, an advantageous strategy employed by maternally transmitted symbionts such as Wolbachia, remain unclear. We compared genomes of four Wolbachia strains derived from Homona magnanima, a male-killing strain wHm-t (1.5 Mb), and three ...

Iterative evolution of supergene-based social polymorphism in ants

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T. Kay, Q. Helleu and L. Keller,  Philos Trans R Soc Lond B Biol Sci,  377:20210196. 2022.
Species commonly exhibit alternative morphs, with individual fate being determined during development by either genetic factors, environmental cues or a combination thereof. Ants offer an interesting case study because many species are polymorphic in their social structure. Some ...

Unbalanced selection: the challenge of maintaining a social polymorphism when a supergene is selfish

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A. G. Tafreshi, S. P. Otto and M. Chapuisat,  Philos Trans R Soc Lond B Biol Sci,  377:20210197. 2022.
Supergenes often have multiple phenotypic effects, including unexpected detrimental ones, because recombination suppression maintains associations among co-adapted alleles but also allows the accumulation of recessive deleterious mutations and selfish genetic elements. Yet, ...

Supergene potential of a selfish centromere

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F. Finseth, K. Brown, A. Demaree and L. Fishman,  Philos Trans R Soc Lond B Biol Sci,  377:20210208. 2022.
Selfishly evolving centromeres bias their transmission by exploiting the asymmetry of female meiosis and preferentially segregating to the egg. Such female meiotic drive systems have the potential to be supergenes, with multiple linked loci contributing to drive costs or ...

Mendel’s First Law: partisan interests and the parliament of genes

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C. Veller,  Heredity,  2022.
Mendel’s First Law requires explanation because of the possibility of ‘meiotic drivers’, genes that distort fair segregation for selfish gain. The suppression of drive, and the restoration of fair segregation, is often attributed to genes at loci unlinked to the drive ...

Current Status of Mosquito Handling, Transporting and Releasing in Frame of the Sterile Insect Technique

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J. Guo, X. Zheng, D. Zhang and Y. Wu,  Insects,  13. 2022.
The sterile insect technique (SIT) and its related technologies are considered to be a powerful weapon for fighting against mosquitoes. As an important part of the area-wide integrated pest management (AW-IPM) programs, SIT can help reduce the use of chemical pesticides for ...

Active genetics comes alive

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V. M. Gantz and E. Bier,  BioEssays,  2022.
Abstract Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based ?active genetic? elements developed in 2015 bypassed the fundamental rules of traditional genetics. Inherited in a super-Mendelian fashion, such selfish genetic entities offered a variety of ...

Genetically Modified Mosquitoes to Fight Malaria in Nigeria, Burkina Faso, Mali and Uganda: What Legal Response?

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O. J. L. Tung,  Potchefstroom Electronic Law Journal,  25:1-42. 2022.
Advanced applied research on genetically modified (hereafter GM) insects is being undertaken to control insect vectors of human diseases such as mosquitoes. GM insect technologies are being developed in countries where there is a legal ...

Investigating CRISPR/Cas9 gene drive for production of disease-preventing prion gene alleles

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A. R. Castle, S. Wohlgemuth, L. Arce and D. Westaway,  PLoS One,  17:e0269342. 2022.
Prion diseases are a group of fatal neurodegenerative disorders that includes chronic wasting disease, which affects cervids and is highly transmissible. Given that chronic wasting disease prevalence exceeds 30% in some endemic areas of North America, and that eventual ...

Retraction Note: Selective inheritance of target genes from only one parent of sexually reproduced F1 progeny in Arabidopsis

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T. Zhang, M. Mudgett, R. Rambabu, B. Abramson, X. Dai, T. P. Michael and Y. Zhao,  Nature Communications,  13:3270. 2022.
Retraction to: Nature Communications https://doi-org.proxy-um.researchport.umd.edu/10.1038/s41467-021-24195-5, published online 22 June 2021.We retract the article cited above because genotyping results from recent experiments are not consistent with the conclusions presented in ...

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