Scholarly Literature
This is an aggregation of scholarly literature from peer-reviewed journals, bioRxiv , medRxiv and arXiv preprint servers focused on natural and engineered selfish genetic elements and genetic biocontrol. New citations are added as they appear. This content is intended for anyone interested in the scholarly literature on gene drive and genetic biocontrol.
A Wolbachia deubiquitylating enzyme induces cytoplasmic incompatibility
Tags: Cytoplasmic incompatibility, Toxin-antidote, WolbachiaBeckmann, J. F., J. A. Ronau and M. Hochstrasser, Nature Microbiology, 2:17007. 2017.
Wolbachia are obligate intracellular bacteria1 that infect arthropods, including approximately two-thirds of insect species2. Wolbachia manipulate insect reproduction by enhancing their inheritance through the female germline. The most common alteration is cytoplasmic ...
Daisyfield gene drive systems harness repeated genomic elements as a generational clock to limit spread
Tags: Gene drive synthetic, Modeling, Risk and safety, Self limitingJ. Min, C. Noble, D. Najjar and K. M. Esvelt, bioRxiv, 104877. 2017.
Here we describe a novel form of gene drive based on the introduction of multiple copies of an engineered ‘daisy’ sequence into repeated elements of the genome. Each introduced copy encodes guide RNAs that target one or more engineered loci carrying the CRISPR nuclease gene ...
Dodging silver bullets: good CRISPR gene-drive design is critical for eradicating exotic vertebrates
Tags: Gene drive mechanisms, Other mammalsProwse, TAAC, Phillip; Ross, Joshua V.; Pfitzner, Chandran; Wittmann, Talia A.; Thomas, Paul, Proceedings of the Royal Society B: Biological Sciences, 284:20170799. 2017.
Self-replicating gene drives that can spread deleterious alleles through animal populations have been promoted as a much needed but controversial ‘silver bullet’ for controlling invasive alien species. Homing-based drives comprise an endonuclease and a guide RNA (gRNA) that ...
How driving endonuclease genes can be used to combat pests and disease vectors
Tags: Evolution, Gene drive synthetic, Replicator/site directed nucleaseGodfray, HCJN, A.; Burt, A., BMC Biology, 15:81. 2017.
Driving endonuclease genes (DEGs) spread through a population by a non-Mendelian mechanism. In a heterozygote, the protein encoded by a DEG causes a double-strand break in the homologous chromosome opposite to where its gene is inserted and when the break is repaired using the ...
Is it time for synthetic biodiversity conservation?
Tags: Agriculture, Biodiversity/Conservation, Ecology, Evolution, Gene drive, Gene drive synthetic, Genetics, MalariaPiaggio, AJS, G.; Seddon, P. J.; Alphey, L.; Bennett, E. L.; Carlson, R. H.; Friedman, R. M.; Kanavy, D.; Phelan, R.; Redford, K. H.; Rosales, M.; Slobodian, L.; Wheeler, K., Trends in Ecology & Evolution, 32:97-107. 2017.
Evidence indicates that, despite some critical successes, current conservation approaches are not slowing the overall rate of biodiversity loss. The field of synthetic biology, which is capable of altering natural genomes with extremely precise editing, might offer the potential ...
Precaution: Open gene drive research
Tags: Gene drive syntheticEsvelt, KM, Science, 355:589-590. 2017.
IN THEIR POLICY Forum “Precaution and governance of emerging technologies” (11 November 2016, p. 710), G. E. Kaebnick and colleagues convincingly assert that precaution is consistent with support for science. However, they overlook one way to improve safety while hastening ...
Ethical implications of fighting malaria with CRISPR/Cas9
Tags: Ethics, Gene drive syntheticPatrão Neves, MD, Christiane, BMJ Global Health, 2:e000396. 2017.
Genome editing is a new, cheap and versatile technique which has great promise to combat vector-borne diseases. The current ethical debate worldwide is mainly concentrating on the dangers of germline intervention and less so on the potential for fighting vector-borne diseases. ; ...
Principles for gene drive research
Tags: Ethics, Gene drive synthetic, Risk and safetyEmerson, CJ, Stephanie; Littler, Katherine; Randazzo, Filippo, Science, 358:1135. 2017.
The recent outbreak of Zika virus in the Americas renewed attention on the importance of vector-control strategies to fight the many vector-borne diseases that continue to inflict suffering around the world. In 2015, there were ?212 million infections and a death every minute ...
Conditions for success of engineered underdominance gene drive systems
Tags: Gene drive synthetic, UnderdominanceEdgington, MPA, L. S., Journal of Theoretical Biology, 430:128-140. 2017.
Engineered underdominance is one of a number of different gene drive strategies that have been proposed for the genetic control of insect vectors of disease. Here we model a two-locus engineered underdominance based gene drive system that is based on the concept of mutually ...
wtf genes are prolific dual poison-antidote meiotic drivers
Tags: Agriculture, Gene drive mechanisms, Toxin-antidote, Transmission distortionNuckolls, NLN, M. A. B.; Eickbush, M. T.; Young, J. M.; Lange, J. J.; Yu, J. S.; Smith, G. R.; Jaspersen, S. L.; Malik, H. S.; Zanders, S. E., eLife, 6:e26033. 2017.
Meiotic drivers are selfish genes that bias their transmission into gametes, defying Mendelian inheritance. Despite the significant impact of these genomic parasites on evolution and infertility, few meiotic drive loci have been identified or mechanistically characterized. Here, ...
Evolutionary dynamics of CRISPR gene drives
Tags: Evolution, Gene drive syntheticNoble, CO, Jason; Esvelt, Kevin M.; Church, George M.; Nowak, Martin A., Science Advances, 3:e1601964. 2017.
The alteration of wild populations has been discussed as a solution to a number of humanity’s most pressing ecological and public health concerns. Enabled by the recent revolution in genome editing, clustered regularly interspaced short palindromic repeats (CRISPR) gene ...
Impact of mosquito gene drive on malaria elimination in a computational model with explicit spatial and temporal dynamics
Tags: Ecology, Gene drive synthetic, Replicator/site directed nucleaseEckhoff, PAW, E. A.; Godfray, H. C. J.; Burt, A., Proceedings of the National Academy of Sciences of the United States of America, 114:e255-e264. 2017.
The renewed effort to eliminate malaria and permanently remove its tremendous burden highlights questions of what combination of tools would be sufficient in various settings and what new tools need to be developed. Gene drive mosquitoes constitute a promising set of tools, with ...
CRISPR/Cas9 gene drives in genetically variable and nonrandomly mating wild populations
Tags: Evolution, Gene drive mechanisms, Gene drive synthetic, Risk and safetyDrury, DWD, A. L.; Siniard, D. J.; Zentner, G. E.; Wade, M. J., Science Advances, 3:e1601910. 2017.
Synthetic gene drives based on CRISPR/Cas9 have the potential to control, alter, or suppress populations of crop pests and disease vectors, but it is unclear how they will function in wild populations. Using genetic data from four populations of the flour beetle Tribolium ...
Genetic conflicts: the usual suspects and beyond
Tags: Evolution, Fruit fly, Genetic engineering, Transmission distortion, WolbachiaMcLaughlin, RNM, H. S., Journal of Experimental Biology, 220:6-17. 2017.
Selfishness is pervasive and manifests at all scales of biology, from societies, to individuals, to genetic elements within a genome. The relentless struggle to seek evolutionary advantages drives perpetual cycles of adaptation and counter-adaptation, commonly referred to as Red ...
B chromosome in Plantago lagopus Linnaeus, 1753 shows preferential transmission and accumulation through unusual processes
Tags: Chromosomal drive, Gene drive mechanismsDhar, MKK, G.; Kaul, S., Comparative Cytogenetics, 11:375-391. 2017.
Plantago lagopus is a diploid (2n = 2x = 12) weed belonging to family Plantaginaceae. We reported a novel B chromosome in this species composed of 5S and 45S ribosomal DNA and other repetitive elements. In the present work, presence of B chromosome(s) was confirmed through FISH ...
Engineering species-like barriers to sexual reproduction
Tags: Agriculture, Gene drive mechanisms, Gene drive synthetic, Risk and safetyMaselko, MH, Stephen C.; Chacón, Jeremy M.; Harcombe, William R.; Smanski, Michael J., Nature Communications, 8:883. 2017.
Controlling the exchange of genetic information between sexually reproducing populations has applications in agriculture, eradication of disease vectors, control of invasive species, and the safe study of emerging biotechnology applications. Here we introduce an approach to ...
Gene drives do not always increase in frequency: from genetic models to risk assessment
Tags: CRISPR, Evolution, Gene drive, Gene drive mechanisms, Replicator/site directed nuclease, Risk and safety, Transmission distortion, Vector controlde Jong, TJ, Journal Fur Verbraucherschutz Und Lebensmittelsicherheit-Journal of Consumer Protection and Food Safety, 12:299-307. 2017.
Homing genes encode endonucleases that make a double stranded break in the DNA, destroying a target site on the homologous chromosome. When the cell repairs the break the homing allele is copied, converting a heterozygote into a homozygote. This results in gene drive (GD), an ...
Sperm competition suppresses gene drive among experimentally evolving populations of house mice
Tags: Ecology, Evolution, Fruit fly, Gene drive, Population genetics/dynamics, Rodents, Transmission distortionManser, AL, A. K.; Simmons, L. W.; Firman, R. C., Molecular Ecology, 26:5784-5792. 2017.
Drive genes are genetic elements that manipulate the 50% ratio of Mendelian inheritance in their own favour, allowing them to rapidly propagate through populations. The action of drive genes is often hidden, making detection and identification inherently difficult. Yet drive ...
The promise and peril of CRISPR gene drives
Tags: CRISPR, Gene drive synthetic, Replicator/site directed nuclease, Self limiting, Transmission distortionZentner, GEW, Michael J. C., Bioessays, 39:1-9. 2017.
Gene drives are selfish genetic elements that use a variety of mechanisms to ensure they are transmitted to subsequent generations at greater than expected frequencies. Synthetic gene drives based on the clustered regularly interspersed palindromic repeats (CRISPR) genome editing ...
A bigger toolbox: Biotechnology in biodiversity conservation
Tags: Biodiversity/Conservation, Gene drive synthetic, Genetic engineering, GenomicsR. T. Corlett, Trends in Biotechnology, 35:55-65. 2017.
Conservation biology needs a bigger toolbox to meet unprecedented challenges. Genomics, fueled by declining sequencing costs, offers novel tools with increased precision for genetic questions previously answered with a few molecular markers, as well as completely new ...
Agricultural pest control with CRISPR-based gene drive: time for public debate: Should we use gene drive for pest control?
Tags: Ethics, Gene drive synthetic, Risk and safetyCourtier?Orgogozo, VM, Baptiste; Boëte, Christophe, EMBO Reports, 18:878-880. 2017.
Gene drive based on the CRISPR/Cas-9 gene editing system is a powerful technology that promotes the inheritance of the gene drive tool itself via sexual reproduction and can therefore spread quickly through a population. It holds great potential for public health and humanitarian ...
Gene Drive for Mosquito Control: Where Did It Come from and Where Are We Headed?
Tags: Other arthropodsMacias, VMO, J. R.; Rasgon, J. L., International Journal of Environmental Research and Public Health, 14:e1006. 2017.
Mosquito-borne pathogens place an enormous burden on human health. The existing toolkit is insufficient to support ongoing vector-control efforts towards meeting disease elimination and eradication goals. The perspective that genetic approaches can potentially add a significant ...
Unintended consequences of 21st century technology for agricultural pest management
Tags: Ethics, Regulation, Risk and safetyYoung, SL, EMBO reports, 18:1478-1478. 2017.
Comment on Agricultural pest control with CRISPR-based gene drive: time for public debate by Courtier-Orgogozo et al.
Adaptive risk management of gene drive experiments: Biosafety, biosecurity, and ethics
Tags: Policy, Regulation, Risk and safetyLunshof, JEB, A., Applied Biosafety, 22:97-103. 2017.
Emerging technologies in the life sciences call for new models of biosafety risk management. We examine the question of how to; address new developments in the life sciences and biosciences in a bottom-up manner—that is, from the concrete level of; biosafety practice with a ...
Introduction of a male-harming mitochondrial haplotype via ‘Trojan Females’ achieves population suppression in fruit flies
Tags: Gene drive mechanisms, Gene drive synthetic, Other arthropods, X chromosomeWolff, JNG, N. J.; Tompkins, D. M.; Dowling, D. K., eLife, 6:e23551. 2017.
Pests are a global threat to biodiversity, ecosystem function, and human health. Pest control approaches are thus numerous, but their implementation costly, damaging to non-target species, and ineffective at low population densities. The Trojan Female Technique (TFT) is a ...
Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations
Tags: Evolution, Gene drive mechanisms, Gene drive synthetic, Other arthropodsChamper, JR, Riona; Oh, Suh Yeon; Liu, Chen; Liu, Jingxian; Clark, Andrew G.; Messer, Philipp W., PLOS Genetics, 13:e1006796. 2017.
Author summary Gene drive systems provide a wide array of potential applications, including new strategies for the control of vector-borne diseases. For example, a functioning gene drive system could rapidly spread a genetically modified allele designed to reduce pathogen ...
A transatlantic perspective on 20 emerging issues in biological engineering
Tags: Gene drive, Gene drive synthetic, Genomics, Other Symbionts, Risk and safety, Synthetic biologyWintle, BCB, C. R.; Rhodes, C.; Molloy, J. C.; Millett, P.; Adam, L.; Breitling, R.; Carlson, R.; Casagrande, R.; Dando, M.; Doubleday, R.; Drexler, E.; Edwards, B.; Ellis, T.; Evans, N. G.; Hammond, R.; Haseloff, J.; Kahl, L.; Kuiken, T.; Lichman, B. R.; Matthewman, C. A.; Napier, J. A.; OhEigeartaigh, S. S.; Patron, N. J.; Perello, E.; Shapira, P.; Tait, J.; Takano, E.; Sutherland, W. J., eLife, 6:21. 2017.
Advances in biological engineering are likely to have substantial impacts on global society. To explore these potential impacts we ran a horizon scanning exercise to capture a range of perspectives on the opportunities and risks presented by biological engineering. We first ...
Gene Drive 101: A Basic Guidance Resource for Biosafety Professionals
Tags: Gene drive synthetic, Risk and safetyKrishnan, PG, David, Applied Biosafety, 22:181-184. 2017.
Biosafety risk assessment and containment framework strategies for research involving gene drives pose a challenge, as there are no published guidelines or regulatory information yet written specifically addressing biosafety and gene drive use. Since the risk is more at an ...
Teilhard de Chardin’s oeuvre within an ongoing discussion of a gene drive release for public health reasons
Tags: Ethics, Gene drive syntheticCartolovni, A, Life Sciences, Society and Policy, 13:18. 2017.
Within the domain of public health, vector-borne diseases are among the most vehemently discussed issues. Recent scientific breakthroughs in genome editing technology provided a solution to this issue in the form of a gene drive that might decrease and even eradicate vector-borne ...
A pooled sequencing approach identifies a candidate meiotic driver in Drosophila
Tags: Gene drive mechanisms, Other arthropods, Transmission distortionWei, KHCR, H. M.; Rathnam, C.; Lee, J.; Lin, D. A. N.; Ji, S. Q.; Mason, J. M.; Clark, A. G.; Barbash, D. A., Genetics, 206:451-465. 2017.
Meiotic drive occurs when a selfish element increases its transmission frequency above the Mendelian ratio by hijacking the asymmetric divisions of female meiosis. Meiotic drive causes genomic conflict and potentially has a major impact on genome evolution, but only a few drive ...
Recommendations for Laboratory Containment and Management of Gene Drive Systems in Arthropods
Tags: Gene drive synthetic, Risk and safetyBenedict, MQB, Austin; Capurro, Margareth L.; De Barro, Paul; Handler, Alfred M.; Hayes, Keith R.; Marshall, John M.; Tabachnick, Walter J.; Adelman, Zach N., Vector-Borne and Zoonotic Diseases, 18:2-13. 2017.
Versatile molecular tools for creating driving transgenes and other invasive genetic factors present regulatory, ethical, and environmental challenges that should be addressed to ensure their safe use. In this article, we discuss driving transgenes and invasive genetic factors ...
X chromosome drive in a widespread Palearctic woodland fly, Drosophila testacea
Tags: Evolution, Gene drive mechanisms, Other arthropods, X chromosomeKeais, GLH, M. A.; Gowen, B. E.; Perlman, S. J., Journal of Evolutionary Biology, 30:1185-1194. 2017.
Selfish genes that bias their own transmission during meiosis can spread rapidly in populations, even if they contribute negatively to the fitness of their host. Driving X chromosomes provide a clear example of this type of selfish propagation. These chromosomes have important ...
Evaluating strategies for reversing CRISPR-Cas9 gene drives
Tags: Gene drive synthetic, Risk and safetyVella, MRG, Christian E.; Lloyd, Alun L.; Gould, Fred, Scientific Reports, 7:11038. 2017.
A gene drive biases inheritance of a gene so that it increases in frequency within a population even when the gene confers no fitness benefit. There has been renewed interest in environmental releases of engineered gene drives due to recent proof of principle experiments with the ...
Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing
Tags: Evolution, Gene drive synthetic, Other arthropods, Replicator/site directed nucleaseBeaghton, AH, Andrew; Nolan, Tony; Crisanti, Andrea; Godfray, H. Charles J.; Burt, Austin, Genetics, 205:1587-1596. 2017.
There is a need for new interventions against the ongoing burden of vector-borne diseases such as malaria and dengue. One suggestion has been to develop genes encoding effector molecules that block parasite development within the vector, and then use the nuclease-based homing ...
Sry gene drive for rodent control: Reply to Gemmell and Tompkins
Tags: Fruit fly, Gene drive synthetic, Other mammals, Y-chromosomeKanavy, DS, M., Trends in Ecology & Evolution, 32:315-316. 2017.
We would like to thank Gemmell and Tompkins for their interest and comments onthe articlebyPiaggioet al. [1].Theissues raised by Gemmell and Tompkins [2] are very pertinent, and they correctly identified that the format of the article did not lend itself to a comprehensive ...
Eradicating Mosquitoes? The promise and peril of gene drive technologies.
Tags: Ethics, Gene drive synthetic, Other arthropodsJun, B-O, Eubios Journal of Asian and International Bioethics, 27:113-116. 2017.
This paper discusses the ethical issues associated with genetic modification of mosquito species that are human disease vectors. The Oxitec genetically changed mosquito—a variant of a species called Aedes aegypti, OX513A, is taken as an example. The benefits and risks are ...
Evolution of Resistance Against CRISPR/Cas9 Gene Drive
Tags: Ecology, Evolution, Gene drive syntheticUnckless, RLC, A. G.; Messer, P. W., Genetics, 205:827-841. 2017.
CRISPR/Cas9 gene drive (CGD) promises to be a highly adaptable approach for spreading genetically engineered alleles throughout a species, even if those alleles impair reproductive success. CGD has been shown to be effective in laboratory crosses of insects, yet it remains ...
Vector control with driving Y chromosomes: modelling the evolution of resistance
Tags: Evolution, Gene drive synthetic, Other arthropods, Y-chromosomeBeaghton, AB, P. J.; Burt, A., Malaria Journal, 16:286. 2017.
: The introduction of new malaria control interventions has often led to the evolution of resistance, both of the parasite to new drugs and of the mosquito vector to new insecticides, compromising the efficacy of the interventions. Recent progress in molecular and population ...
A large gene family in fission yeast encodes spore killers that subvert Mendel’s law
Tags: Evolution, Gene drive, Gene drive mechanisms, Toxin-antidoteHu, WJ, Z. D.; Suo, F.; Zheng, J. X.; He, W. Z.; Du, L. L., eLife, 6:e28567. 2017.
Spore killers in fungi are selfish genetic elements that distort Mendelian segregation in their favor. It remains unclear how many species harbor them and how diverse their mechanisms are. Here, we discover two spore killers from a natural isolate of the fission yeast ...
New Weapons in the Toad Toolkit: A Review of Methods to Control and Mitigate the Biodiversity Impacts of Invasive Cane Toads (Rhinella Marina)
Tags: Gene drive syntheticTingley, RW-F, Georgia; Schwarzkopf, Lin; Greenlees, Matthew J.; Phillips, Benjamin L.; Brown, Gregory; Clulow, Simon; Webb, Jonathan; Capon, Robert; Sheppard, Andy; Strive, Tanja; Tizard, Mark; Shine, Richard, The Quarterly Review of Biology, 92:123-149. 2017.
Our best hope of developing innovative methods to combat invasive species is likely to come from the study of high-profile invaders that have attracted intensive research not only into control, but also basic biology. Here we illustrate that point by reviewing current thinking ...
B Chromosomes – A matter of chromosome drive
Tags: Gene drive mechanisms, X chromosome, Y-chromosomeHouben, A, Frontiers in Plant Science, 8:210. 2017.
B chromosomes are supernumerary chromosomes which are often preferentially inherited, deviating from usual Mendelian segregation. The balance between the so-called chromosome drive and the negative effects that the presence of Bs applies on the fitness of their host determines ...
Spatial gene drives and pushed genetic waves
Tags: Gene drive mechanisms, Gene drive syntheticTanaka, HS, Howard A.; Nelson, David R., Proceedings of the National Academy of Sciences of the United States of America, 114:8452. 2017.
Gene constructs introduced into natural environments have been proposed to solve various ecological problems. The CRISPR-Cas9 technology greatly facilitates construction of gene drives that allow desired traits to rapidly replace wild types, even if these convey a selective ...
Towards the genetic control of invasive species
Tags: Aedes, Ecology, Fruit fly, Gene drive synthetic, Genetic biocontrol, Invasive species, Malaria, Pest managementHarvey-Samuel, TA, T.; Alphey, L., Biological Invasions, 19:1683-1703. 2017.
Invasive species remain one of the greatest threats to global biodiversity. Their control would be enhanced through the development of more effective and sustainable pest management strategies. Recently, a novel form of genetic pest management (GPM) has been developed in which ...
Results from the Workshop “Problem Formulation for the Use of Gene Drive in Mosquitoes”
Tags: Gene drive synthetic, Other arthropods, Risk and safetyRoberts, ADA, P. P.; Okumu, F.; Quemada, H.; Savadogo, M.; Singh, J. A.; James, S., American Journal of Tropical Medicine and Hygiene, 96:530-533. 2017.
Reducing the incidence of malaria has been a public health priority for nearly a century. New technologies and associated vector control strategies play an important role in the prospect of sustained reductions. The development of the CRISPR/Cas9 gene editing system has generated ...
The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito
Tags: Ecology, Evolution, Gene drive mechanisms, Gene drive synthetic, Other arthropodsHammond, AMK, Kyros; Bruttini, Marco; North, Ace; Galizi, Roberto; Karlsson, Xenia; Kranjc, Nace; Carpi, Francesco M.; D’Aurizio, Romina; Crisanti, Andrea; Nolan, Tony, PLOS Genetics, 13:e1007039. 2017.
Gene drives are selfish genetic elements that are able to bias their own inheritance among offspring. Starting from very low frequencies they can rapidly invade a population in just a few generations, even when imposing a fitness cost. Gene drives based on the precise DNA cutting ...
Advances in vector control science: Rear-and-release strategies show promise… but don’t forget the basics
Tags: Aedes, Gene drive synthetic, Risk and safety, WolbachiaRitchie, SAJ, B. J., Journal of Infectious Diseases, 215:S103-S108. 2017.
Both chikungunya and Zika viruses have recently swept from Africa across the Pacific to the Americas, causing major outbreaks of disease in humans. In the meantime, dengue epidemics continue throughout the tropics. Traditional vector control programs based on strategies from ...
CRISPR-based gene drive in agriculture will face technical and governance challenges
Tags: Gene drive synthetic, Regulation, Risk and safetyGutzmann, NE, Johanna E.; Barnes, Jessica Cavin; Baltzegar, Jennifer; Jones, Michael S.; Sudweeks, Jayce, EMBO reports, 18:1479-1480. 2017.
Comment on "Agricultural pest control with CRISPR-based gene drive: time for public debate" by Courtier-Orgogozo et al.
CRISPR/Cas9 gene drive: Growing pains for a new technology
Tags: Evolution, Gene drive syntheticReed, FA, Genetics, 205:1037-1039. 2017.
In this commentary, Floyd Reed discusses Unckless et al. (2017),; “Evolution of resistance against CRISPR/Cas9 gene drive,”; which was published in the February issue of GENETICS.
Potential of gene drives with genome editing to increase genetic gain in livestock breeding programs
Tags: Gene drive mechanisms, Gene drive synthetic, Transmission distortionGonen, SJ, J.; Gorjanc, G.; Mileham, A. J.; Whitelaw, C. B. A.; Hickey, J. M., Genetics Selection Evolution, 49:14. 2017.
This paper uses simulation to explore how gene drives can increase genetic gain in livestock breeding programs. Gene drives are naturally occurring phenomena that cause a mutation on one chromosome to copy itself onto its homologous chromosome. Methods: We simulated nine ...
The End of the GMO? Genome Editing, Gene Drives and New Frontiers of Plant Technology
Tags: Agriculture, CRISPR, Ethics, Gene drive synthetic, Gene editing, Genetically modified organisms, PolicyK. L. Hefferon and R. J. Herring, Review of Agrarian Studies, 7. 2017.
mprovements to agriculture will constitute one of the world’s greatest challenges in the coming century. Political and social controversies, as well as complications of plant breeding, intellectual property, and regulation, have compromised the promised impact of genetically ...
