Scholarly Literature
This is an aggregation of scholarly literature from peer-reviewed journals, bioRxiv , medRxiv and arXiv preprint servers focused on natural and engineered selfish genetic elements and genetic biocontrol. New citations are added as they appear. This content is intended for anyone interested in the scholarly literature on gene drive and genetic biocontrol.
Sex chromosome drive
Tags: Gene drive mechanisms, Other arthropods, Other mammals, Transmission distortion, X chromosome, Y-chromosomeHelleu, QG, P. R.; Montchamp-Moreau, C., Cold Spring Harbor Perspectives in Biology, 7:a017616. 2015.
Sex chromosome drivers are selfish elements that subvert Mendel's first law of segregation and therefore are over represented among the products of meiosis. The sex-biased progeny produced then fuels an extended genetic conflict between the driver and the rest of the genome. Many ...
Mating type and spore killing characterization of Fusarium verticillioides strains
Tags: Gene drive mechanisms, Transmission distortionGuo, LB, A. Z.; Geiser, D. M.; Jimenez-Gasco, M. D.; Kuldau, G. A., Mycological Progress, 14:1045. 2015.
Fusarium verticillioides is a heterothallic ascomycete causing maize ear rot, and produces fumonisin mycotoxins harmful to livestock and human health. A meiotic drive phenomenon called spore killing has been reported in several filamentous fungi including F. verticillioides. F. ...
Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi
Tags: Gene drive mechanisms, Gene drive synthetic, Other arthropodsGantz, VMJ, N.; Tatarenkova, O.; Fazekas, A.; Macias, V. M.; Bier, E.; James, A. A., Proceedings of the National Academy of Sciences of the United States of America, 112:e6736-e6743. 2015.
Genetic engineering technologies can be used both to create transgenic mosquitoes carrying antipathogen effector genes targeting human malaria parasites and to generate gene-drive systems capable of introgressing the genes throughout wild vector populations. We developed a highly ...
The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations
Tags: Gene drive mechanisms, Gene drive synthetic, Other arthropodsV. M. Gantz and E. Bier, Science, 348:442. 2015.
Loss-of-function mutations may only produce a mutant phenotype when both copies of the gene are mutated. Gantz and Bier developed a method they call mutagenic chain reaction (MCR) that autocatalytically produces homozygous mutations. MCR uses the initial mutated allele to cause a ...
Centromere-associated meiotic drive and female fitness variation in Mimulus
Tags: Ecology, Transmission distortionFishman, LK, J. K., Evolution, 69:1208-1218. 2015.
Female meiotic drive, in which chromosomal variants preferentially segregate to the egg pole during asymmetric female meiosis, is a theoretically pervasive but still mysterious form of selfish evolution. Like other selfish genetic elements, driving chromosomes may be maintained ...
Sex ratio meiotic drive as a plausible evolutionary mechanism for hybrid male sterility
Zhang, LBS, T. N.; Woldesellassie, F.; Xiao, H. L.; Tao, Y., PLOS Genetics, 11:e1005073. 2015.Biological diversity on Earth depends on the multiplication of species or speciation, which is the evolution of reproductive isolation such as hybrid sterility between two new species. An unsolved puzzle is the exact mechanism(s) that causes two genomes to diverge from their ...
Duplication and adaptive evolution of a key centromeric protein in Mimulus, a genus with female meiotic drive
Tags: Transmission distortionFinseth, FRD, Y. Z.; Saunders, A.; Fishman, L., Molecular Biology and Evolution, 32:2694-2706. 2015.
The fundamental asymmetry of female meiosis creates an arena for genetic elements to compete for inclusion in the egg, promoting the selfish evolution of centromere variants that maximize their transmission to the future egg. Such "female meiotic drive" has been hypothesized to ...
R2d2 and hyperdrive mechanisms (in Mouse meiosis)
Tags: Gene drive mechanisms, Transmission distortionZanders, SEM, H. S., PLOS Genetics, 11:1-4. 2015.
Mendelian transmission is established during meiosis, the cell division that generates haploidgametes (e.g., sperm and eggs) from diploid germ cells. Meiosis does not, however, have to befair. Selfish genetic elements, or meiotic drivers, have evolved to cheat this process in ...
Opinion: Is CRISPR-based gene drive a biocontrol silver bullet or global conservation threat?
Tags: Biodiversity/Conservation, Ethics, Gene drive synthetic, Risk and safetyWebber, BLR, S.; Edwards, O. R., Proceedings of the National Academy of Sciences of the United States of America, 112:10565-10567. 2015.
Scientists have recognized the potential for applying gene drive technologies to the control of invasive species for several years, yet debate about the application of gene drive has been primarily restricted to mosquitoes. Recent developments in clustered regularly interspaced ...
Safeguarding CRISPR-Cas9 gene drives in yeast
Tags: Gene drive synthetic, Risk and safetyDiCarlo, JEC, A.; Dietz, S. L.; Esvelt, K. M.; Church, G. M., Nature Biotechnology, 33:1250-1255. 2015.
RNA-guided gene drives capable of spreading genomic alterations made in laboratory organisms through wild populations could be used to address environmental and public health problems. However, the possibility of unintended genome editing occurring through the escape of strains ...
Gene drive overdrive
Tags: Gene drive synthetic, Risk and safetyDeFrancesco, L, Nature Biotechnology, 33:1019-1021. 2015.
The recent publication of a simple procedure for creating a CRISPR-Cas9-mediated gene drive has some researchers sounding the alarm. What are the risks to populations in the wild and what precautions are necessary? Laura DeFrancesco investigates.
Muddled genetic terms miss and mess the message
Vihinen, M, Trends in Genetics, 31:423-425. 2015.A critical aspect of science is the clear communication of complicated matters. However, language is often ambiguous, and the message can get lost in the telling. In particular, genetic terms can have different meanings for different people. Here, I discuss this problem and ...
Modeling the manipulation of natural populations by the mutagenic chain reaction
Tags: Gene drive syntheticUnckless, RLM, P. W.; Connallon, T.; Clark, A. G., Genetics, 201:425-431. 2015.
The use of recombinant genetic technologies for population manipulation has mostly remained an abstract idea due to the lack of a suitable means to drive novel gene constructs to high frequency in populations. Recently Gantz and Bier showed that the use of CRISPR/Cas9 technology ...
The next generation of rodent eradications: Innovative technologies and tools to improve species specificity and increase their feasibility on islands
Tags: Gene drive, Other mammalsCampbell, KJB, J.; Eason, C. T.; Glen, A. S.; Godwin, J.; Gould, F.; Holmes, N. D.; Howald, G. R.; Madden, F. M.; Ponder, J. B.; Threadgill, D. W.; Wegmann, A. S.; Baxter, G. S., Biological Conservation, 185:47-58. 2015.
Rodents remain one of the most widespread and damaging invasive alien species on islands globally. The current toolbox for insular rodent eradications is reliant on the application of sufficient anticoagulant toxicant into every potential rodent territory across an island. ...
Origin, evolution, and population genetics of the selfish Segregation Distorter gene duplication in European and African populations of Drosophila melanogaster
Tags: Ecology, Evolution, Gene drive mechanisms, Other arthropods, Transmission distortionBrand, CLL, A. M.; Presgraves, D. C., Evolution, 69:1271-1283. 2015.
Meiotic drive elements are a special class of evolutionarily selfish genes that subvert Mendelian segregation to gain preferential transmission at the expense of homologous loci. Many drive elements appear to be maintained in populations as stable polymorphisms, their equilibrium ...
Sex-ratio meiotic drive and Y-linked resistance in Drosophila affinis
Tags: Evolution, Gene drive mechanisms, Other arthropods, Transmission distortionUnckless, RLL, A. M.; Clark, A. G., Genetics, 199:831-840. 2015.
Genetic elements that cheat Mendelian segregation by biasing transmission in their favor gain a significant fitness benefit. Several examples of sex-ratio meiotic drive, where one sex chromosome biases its own transmission at the cost of the opposite sex chromosome, exist in ...
On the origin of sex chromosomes from meiotic drive
Tags: Evolution, X chromosome, Y-chromosomeUbeda, FP, M. M.; Wild, G., Proceedings of the Royal Society B-Biological Sciences, 282:20141932. 2015.
Most animals and many plants make use of specialized chromosomes (sex chromosomes) to determine an individual's sex. Best known are the XY and ZW sex-determination systems. Despite having evolved numerous times, sex chromosomes present something of an evolutionary puzzle. At ...
Safeguarding gene drive experiments in the laboratory
Tags: Gene drive synthetic, Risk and safetyAkbari, OSB, H. J.; Bier, E.; Bullock, S. L.; Burt, A.; Church, G. M.; Cook, K. R.; Duchek, P.; Edwards, O. R.; Esvelt, K. M.; Gantz, V. M.; Golic, K. G.; Gratz, S. J.; Harrison, M. M.; Hayes, K. R.; James, A. A.; Kaufman, T. C.; Knoblich, J.; Malik, H. S.; Matthews, K. A.; O'Connor-Giles, K. M.; Parks, A. L.; Perrimon, N.; Port, F.; Russell, S.; Ueda, R.; Wildonger, J., Science, 349:927-929. 2015.
Gene drive systems promote the spread of genetic elements through populations by assuring they are inherited more often than Mendelian segregation would predict (see the figure). Natural examples of gene drive from Drosophila include sex-ratio meiotic drive, segregation ...
Detrimental effects of an autosomal selfish genetic element on sperm competitiveness in house mice
Tags: Ecology, Fruit fly, Gene drive mechanisms, Other mammals, Rodents, Transmission distortionSutter, AL, A. K., Proceedings of the Royal Society B-Biological Sciences, 282:1-8. 2015.
Female multiple mating (polyandry) is widespread across many animal taxa and indirect genetic benefits are a major evolutionary force favouring polyandry. An incentive for polyandry arises when multiple mating leads to sperm competition that disadvantages sperm from genetically ...
Presence of segregation distortion in sheep
Tags: Evolution, Gene drive mechanisms, Other mammals, Transmission distortionRaed, MA, Research Journal of Biotechnology, 10:87-98. 2015.
The main objective of this project was the investigation of presence of segregation distortion (SD) and description of other relevant parameters of multilocus genetics in Australian Merino sheep. The SD cases investigated three flocks of 98, 79 and 92 offspring and their ...
Systematic evaluation of Drosophila CRISPR tools reveals safe and robust alternatives to autonomous gene drives in basic research
Tags: Gene drive mechanisms, Gene drive synthetic, Risk and safetyPort, FM, N.; Bullock, S. L., G3-Genes Genomes Genetics, 5:1493-1502. 2015.
The Clustered Regularly Interspaced Short Palindromic Repeat/CRISPR associated (CRISPR/Cas) technology allows rapid, site-specific genome modification in a wide variety of organisms. Proof-of-principle studies in Drosophila melanogaster have used various CRISPR/Cas tools and ...
Genetic Control of Mosquitoes.
Tags: Gene drive mechanisms, Gene drive synthetic, Mosquitoes, Oxitec, Sterile insect technique (SIT), Toxin-antidote, Transmission distortion, Underdominance, X chromosome, Y-chromosomeAlphey, L., Annual Review of Entomology, 59:205-224. 2014.
Genetics can potentially provide new, species-specific, environmentally friendly methods for mosquito control. Genetic control strategies aim either to suppress target populations or to introduce a harm-reducing novel trait. Different approaches differ considerably in their ...
Sperm traits of masculinized fish relative to wild-type males: a systematic review and meta-analyses
Tags: Fish, Population genetics/dynamics, Population suppression, Sex distorterA. M. Senior, S. L. Johnson and S. Nakagawa, Fish and Fisheries, 17:143-164. 2014.
Environmental sex reversal (ESR), whereby environmental effects (e.g. exogenous chemicals) override genetic sex determination, is a commonly used technique in aquaculture and physiology research. We performed a systematic review and meta-analyses of the literature that compares ...
Perceptions and recommendations by scientists for a potential release of genetically modified mosquitoes in Nigeria
Tags: Africa, Policy, Stakeholder engagementP. N. Okorie, J. M. Marshall, O. M. Akpa and O. G. Ademowo, Malaria Journal, 13:154. 2014.
The use of genetically modified mosquitoes (GMMs) for the control of malaria and other mosquito-borne diseases has been proposed in malaria-endemic countries, such as Nigeria, which has the largest burden in Africa. Scientists are major stakeholders whose opinions and perceptions ...
The Impact of Pyrethroid Resistance on the Efficacy of Insecticide-Treated Bed Nets against African Anopheline Mosquitoes: Systematic Review and Meta-Analysis.
Tags: Africa, Anopheles, Malaria, ResistanceC. Strode, S. Donegan, P. Garner, A. A. Enayati and J. Hemingway, PLOS Medicine, 11:e1001619. 2014.
This meta-analysis found that ITNs are more effective than UTNs regardless of resistance. There appears to be a relationship between resistance and the RD for mosquito mortality in laboratory and field studies. However, the substantive heterogeneity in the studies' results and ...
A critical component of meiotic drive in Neurospora is located near a chromosome rearrangement
Tags: Evolution, Gene drive mechanisms, Transmission distortionHarvey, AMR, D. G.; Groskreutz, K. M.; Kuntz, D. R.; Sharp, K. J.; Shiu, P. K. T.; Hammond, T. M., Genetics, 197:1165-1179. 2014.
Neurospora fungi harbor a group of meiotic drive elements known as Spore killers (Sk). Spore killer-2 (Sk-2) and Spore killer-3 (Sk-3) are two Sk elements that map to a region of suppressed recombination. Although this recombination block is limited to crosses between Sk and ...
Genes that bias Mendelian segregation
Tags: Gene drive mechanisms, Transmission distortionGrognet, PL, H.; Malagnac, F.; Silar, P., PLOS Genetics, 10:e1004387. 2014.
Mendel laws of inheritance can be cheated by Meiotic Drive Elements (MDs), complex nuclear genetic loci found in various eukaryotic genomes and distorting segregation in their favor. Here, we identify and characterize in the model fungus Podospora anserina Spok1 and Spok2, two ...
Genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast
Tags: Evolution, Gene drive mechanisms, Transmission distortion, Yeast and FungiZanders, SEE, M. T.; Yu, J. S.; Kang, J. W.; Fowler, K. R.; Smith, G. R.; Malik, H. S., eLife, 3:e02630. 2014.
Hybrid sterility is one of the earliest postzygotic isolating mechanisms to evolve between two recently diverged species. Here we identify causes underlying hybrid infertility of two recently diverged fission yeast species Schizosaccharomyces pombe and S. kambucha, which mate to ...
Dynamics of a combined medea-underdominant population transformation system
Tags: Gene drive mechanisms, Gene drive synthetic, Toxin-antidote, UnderdominanceGokhale, CSR, R. G.; Reed, F. A., BMC Evolutionary Biology, 14:98. 2014.
: Transgenic constructs intended to be stably established at high frequencies in wild populations have been demonstrated to "drive" from low frequencies in experimental insect populations. Linking such population transformation constructs to genes which render them unable to ...
Segregation distortion affected by transgenes in early generations of rice crop-weed hybrid progeny: Implications for assessing potential evolutionary impacts from transgene flow into wild relatives
Tags: Evolution, Gene drive mechanisms, Transmission distortionYang, CW, Z.; Yang, X.; Lu, B. R., Journal of Systematics and Evolution, 52:466-476. 2014.
The significant role of segregation distortion as a driving force of evolution has increasingly gained recognition worldwide. Segregation distortion of parental alleles is commonly reported in hybrid progeny between crops and wild relative species, which possibly influences the ...
A synthetic sex ratio distortion system for the control of the human malaria mosquito
Tags: Gene drive mechanisms, Gene drive synthetic, Other arthropods, Replicator/site directed nuclease, Y-chromosomeGalizi, RD, L. A.; Menichelli, M.; Bernardini, F.; Deredec, A.; Burt, A.; Stoddard, B. L.; Windbichler, N.; Crisanti, A., Nature Communications, 5:3977. 2014.
It has been theorized that inducing extreme reproductive sex ratios could be a method to suppress or eliminate pest populations. Limited knowledge about the genetic makeup and mode of action of naturally occurring sex distorters and the prevalence of co-evolving suppressors has ...
Biased transmission of sex chromosomes in the aphid Myzus persicae is not associated with reproductive mode
Tags: Gene drive mechanisms, Other arthropods, X chromosomeWilson, ACCD, R. N.; Vorburger, C., PLOS One, 9:1-12. 2014.
Commonly, a single aphid species exhibits a wide range of reproductive strategies including cyclical parthenogenesis and obligate parthenogenesis. Sex determination in aphids is chromosomal; females have two X chromosomes, while males have one. X chromosome elimination at male ...
Concerning RNA-guided gene drives for the alteration of wild populations
Tags: Ethics, PolicyEsvelt, KMS, Andrea L.; Catteruccia, Flaminia; Church, George M., eLife, 3:e03401. 2014.
Gene drives may be capable of addressing ecological problems by altering entire; populations of wild organisms, but their use has remained largely theoretical due to technical; constraints. Here we consider the potential for RNA-guided gene drives based on the CRISPR; nuclease ...
Sex-ratio meiotic drive and interspecific competition
Tags: X chromosome, Y-chromosomeUnckless, RLC, A. G., Journal of Evolutionary Biology, 27:1513-1521. 2014.
It has long been known that processes occurring within a species may impact the interactions between species. For example, as competitive ability is sensitive to parameters including reproductive rate, carrying capacity and competition efficiency, the outcome of interspecific ...
Genetic control of invasive fish: technological options and its role in integrated pest management
Tags: Biodiversity/Conservation, Biological control, Fish, Gene drive mechanisms, Gene drive synthetic, Genetic biocontrol, Sex distorter, Sterile insect technique (SIT)Thresher, REH, K.; Bax, N. J.; Teem, J.; Benfey, T. J.; Gould, F., Biological Invasions, 16:1201-1216. 2014.
Genetic options for the control of invasive fishes were recently reviewed and synthesized at a 2010 international symposium, held in Minneapolis/St. Paul, MN, USA. The only option currently available "off-the-shelf'' is triploidy, which can be used to produce sterile males for a ...
Male eyespan size is associated with meiotic drive in wild stalk-eyed flies (Teleopsis dalmanni)
Tags: Gene drive mechanisms, Other arthropods, Transmission distortion, X chromosomeCotton, AJF, M.; Cotton, S.; Pomiankowski, A., Heredity, 112:363-369. 2014.
This study provides the first direct evidence from wild populations of stalk-eyed flies to support the hypothesis that male eyespan is a signal of meiotic drive. Several stalk-eyed fly species are known to exhibit X-linked meiotic drive. A recent quantitative trait locus analysis ...
A selfish gene chastened: Tribolium castaneum Medea M (4) is silenced by a complementary gene
Tags: Gene drive mechanisms, Other arthropods, Toxin-antidoteThomson, MS, Genetica, 142:161-167. 2014.
Maternal-effect dominant embryonic arrest (Medea) of Tribolium castaneum are autosomal factors that act maternally to cause the death of any progeny that do not inherit them. This selfish behavior is thought to result from a maternally expressed poison and zygotically expressed ...
Centromere strength provides the cell biological basis for meiotic drive and karyotype evolution in mice
Tags: Evolution, Gene drive mechanisms, Genetics, Other mammals, Rodents, Transmission distortionChmatal, LG, S. I.; Mitsainas, G. P.; Martinez-Vargas, J.; Ventura, J.; Searle, J. B.; Schultz, R. M.; Lampson, M. A., Current Biology, 24:2295-2300. 2014.
Mammalian karyotypes (number and structure of chromosomes) can vary dramatically over short evolutionary time frames [1-3]. There are examples of massive karyotype conversion, from mostly telocentric (centromere terminal) to mostly metacentric (centromere internal), in 102-10 s ...
An X-linked sex ratio distorter in Drosophila simulans that kills or incapacitates both noncarrier sperm and sons
Tags: Gene drive mechanisms, Toxin-antidote, Transmission distortionRice, WR, G3-Genes Genomes Genetics, 4:1837-1848. 2014.
Genomic conflict occurs when a genomic component gains a reproductive advantage at the expense of the organism as a whole. X-linked segregation distorters kill or incapacitate Y-bearing sperm, thereby gaining a transmission advantage but also reducing male fertility and ...
Heritable strategies for controlling insect vectors of disease
Tags: Gene drive synthetic, Other arthropodsBurt, A, Philosophical Transactions of the Royal Society B-Biological Sciences, 369:20130432. 2014.
Mosquito-borne diseases are causing a substantial burden of mortality, morbidity and economic loss in many parts of the world, despite current control efforts, and new complementary approaches to controlling these diseases are needed. One promising class of new interventions ...
Meiotic drive impacts expression and evolution of X-linked genes in stalk-eyed flies
Tags: Gene drive mechanisms, Other arthropods, Transmission distortion, X chromosomeReinhardt, JAB, C. L.; Paczolt, K. A.; Johns, P. M.; Baker, R. H.; Wilkinson, G. S., PLOS Genetics, 10:e1004362. 2014.
Although sex chromosome meiotic drive has been observed in a variety of species for over 50 years, the genes causing drive are only known in a few cases, and none of these cases cause distorted sex-ratios in nature. In stalk-eyed flies (Teleopsis dalmanni), driving X chromosomes ...
Regulatory experience and challenges for the release of GM insects
Tags: Aedes, Agriculture, Dengue, Gene editing, Genetic biocontrol, Other arthropods, Pest management, Policy, Regulation, Risk and safety, Risk assessmentBeech, C, Journal Fur Verbraucherschutz Und Lebensmittelsicherheit-Journal of Consumer Protection and Food Safety, 9:S71-S76. 2014.
Genetically modified (GM) insects are a potentially valuable new tool for the biological control of insect pests of humans, animals and plants. Considerable progress has been made recently in transfer of GM insects from the laboratory to release and evaluation in the environment. ...
Analysis of segregation distortion and its relationship to hybrid barriers in rice
Tags: Ecology, Evolution, Gene drive mechanisms, Transmission distortionReflinur, K, B.; Jang, S. M.; Chu, S. H.; Bordiya, Y.; Akter, M. B.; Lee, J.; Chin, J. H.; Koh, H. J., Rice, 7:3. 2014.
Segregation distortion (SD) is a frequently observed occurrence in mapping populations generated from crosses involving divergent genotypes. In the present study, ten genetic linkage maps constructed from reciprocal F-2 and BC1F1 mapping populations derived from the parents ...
Novel synthetic Medea selfish genetic elements drive population replacement in Drosophila: A theoretical exploration of Medea-dependent population suppression
Tags: Gene drive synthetic, Other arthropods, Toxin-antidoteAkbari, OSC, C. H.; Marshall, J. M.; Huang, H. X.; Antoshechkin, I.; Hay, B. A., ACS Synthetic Biology, 3:915-928. 2014.
Insects act as vectors for diseases of plants, animals, and humans. Replacement of wild insect populations with genetically modified individuals unable to transmit disease provides a potentially self-perpetuating method of disease prevention. Population replacement requires a ...
Multiple sex chromosomes in the light of female meiotic drive in amniote vertebrates
Tags: Birds, Evolution, Gene drive mechanisms, Other mammals, Transmission distortionPokorna, MA, M.; Kratochvil, L., Chromosome Research, 22:35-44. 2014.
It is notable that the occurrence of multiple sex chromosomes differs significantly between major lineages of amniote vertebrates. In this respect, birds are especially conspicuous, as multiple sex chromosomes have not been observed in this lineage so far. On the other hand, in ...
Meiotic drive influences the outcome of sexually antagonistic selection at a linked locus
Tags: Fruit fly, Gene drive mechanisms, Transmission distortionPatten, MM, Journal of Evolutionary Biology, 27:2360-2370. 2014.
Most meiotic drivers, such as the t-haplotype in Mus and the segregation distorter (SD) in Drosophila, act in a sex-specific manner, gaining a transmission advantage through one sex although suffering only the fitness costs associated with the driver in the other. Their ...
Regulating gene drives
Tags: Policy, Regulation, Risk and safetyOye, KAE, K.; Appleton, E.; Catteruccia, F.; Church, G.; Kuiken, T.; Lightfoot, S. B. Y.; McNamara, J.; Smidler, A.; Collins, J. P., Science, 345:626-628. 2014.
Regulatory gaps must be filled before gene drives could be used in the wild
Feasible introgression of an anti-pathogen transgene into an urban mosquito population without using gene-drive
Tags: Gene drive syntheticOkamoto, KWR, M. A.; Gould, F.; Lloyd, A. L., PLOS Neglected Tropical Diseases, 8:e2827. 2014.
Introgressing anti-pathogen constructs into wild vector populations could reduce disease transmission. It is generally assumed that such introgression would require linking an anti-pathogen gene with a selfish genetic element or similar technologies. Yet none of the proposed ...
Transmission distortion affecting human noncrossover but not crossover recombination: A hidden source of meiotic drive
Tags: Gene drive mechanisms, Other mammals, Transmission distortionOdenthal-Hesse, LB, I. L.; Veselis, A.; Jeffreys, A. J.; May, C. A., PLOS Genetics, 10:e1004106. 2014.
Author Summary Meiosis is an essential feature of sexual reproduction that maintains chromosome number over generations. This specialised form of cell division creates gametes containing a single copy of each chromosome so that each parent contributes half their genetic ...
Evidence for meiotic drive as an explanation for karyotype changes in fishes
Tags: Evolution, FishMolina, WFM, P. A.; Bertollo, L. A. C.; Bidau, C. J., Marine Genomics, 15:29-34. 2014.
The process of preferential chromosome segregation during meiosis has been suggested to be responsible for the predominance of certain chromosome types in the karyotypes of mammals, birds and insects. We developed an extensive analysis of the fixation of mono- or bibrachial ...
