Natural selfish genetic elements should not be defined as gene drives

M. A. Wells and R. A. Steinbrecher,  Proceedings of the National Academy of Sciences,  119:e2201142119. 2022.

Gene drives are increasingly discussed in the political realm, and how the term is defined therefore has important impli-cations. The opinion piece from Alphey et al. (1) identifies alack of consensus on the definition and makes explicit changes in how the terminology is being used by some researchers. As such it is a timely invitation for debate. The definition of the term “gene drive” Alphey et al. (1)propose would include naturally occurring selfish genetic elements (SGEs) and natural processes causing biased inheritance. We disagree with this aspect of the proposal, which does not reflect the original use of the term, which related to engineered system

More related to this: