Gene Drive in the News
A curated collection of articles from the popular press
Driving the Self-Destruction of Malaria-Transmitting Mosquitos
19948H. Aliouche, News Medical Life Sciences, 2021-12-22 09:36:57.
Self-destruction of malaria-transmitting mosquitoes can be driven by gene drives deployed to manipulate natural populations. In particular, they can be used to reduce the number of individuals in a population or to modify their composition; this is particularly useful when such species are vectors of disease. The use of genetic engineering tools is becoming increasingly widespread and enables the deployment of natural and synthetic gene drivers that can propagate a particular subset of genetic expressions population through the biasing of Mendelian inheritance laws.
Gene Drives For Malaria Control And Elimination
19693Annonymous, Health Tech, 2021-12-16 19:01:30.
There is notable ongoing research and prioritization of gene drive technology in Africa for Malaria control and elimination. Currently, there is ongoing gene drive mosquito research in Burkina Faso, Ghana, Mali and Uganda led by the Target Malaria consortium. While laboratory research has demonstrated that gene drive techniques are effective in altering the Anopheles mosquito populations so that they can no longer transmit Malaria parasites and crashing entire mosquito populations, this research still has a long way to go in testing the effectiveness of gene drive mosquitoes in controlling Malaria. Initiated in 2018, Target Malaria’s work in Uganda is led by the Uganda Virus Research Institute (UVRI). The work in Uganda is still in early stages, focusing on entomological mosquito collections from field sites on islands within Lake Victoria and mainland sites. In Burkina Faso, Target Malaria’s initiated exploratory gene drive research in in 2012, led by the Institut de Recherche en Sciences de la Santé (IRSS) in Bobo-Dioulasso. In 2019, the team released genetically modified sterile male mosquitoes in Bana village. The mosquitoes were genetically-modified to be sterile, which means they died without any offspring. These were not gene drive mosquitoes, and their release was not to test these as a vector control tool.
Oxitec wraps mosquito trials for the season
19698T. O'Hara, Keynews.com, 2021-12-15 19:12:16.
The private bio-tech company Oxitec has wrapped up its test release of genetically modified mosquitoes in the Florida Keys
How Israelis help the world fight mosquito-borne diseases
19690A. K. Leichman, ISRAEL21c, 2021-12-14 18:22:37.
Israeli scientists and entrepreneurs understand the problems and risks and have been developing a series of ingenious remedies to this growing problem. Prof. Philippos Aris Papathanos, head of Hebrew University’s Insect Genetics Lab, was awarded a Bill & Melinda Gates Foundation grant to develop new genetic approaches for controlling malaria mosquito populations. “We’re building a modern variant of an old idea that has been around since the 1950s: to control mosquitoes by modifying and manipulating their genetics,” Papathanos tells ISRAEL21c. He explains that sterilizing and releasing individual male mosquitoes theoretically leads to the collapse of the population. But this tactic has proven difficult to upscale to the necessary level of a whole city, country or continent. Instead of sterilization, Papathanos’ lab is using cutting-edge CRISPR technology to modify male malaria mosquitoes’ Y chromosome so that they produce only male babies, and those sons inherit the altered chromosome. Over time, there will be no more females and hence no more disease-transmitting bites.“This method can suppress the population in a stronger way because the genes are designed to spread through the population. We don’t need to upscale if we make the system more efficient with the least number of insects released,” says Papathanos.
No, genetically engineered mosquitoes aren’t about to be released in Berkeley
19619K. D. Rauch, Berkeleyside, 2021-12-13 21:34:24.
Judith Pierce, public outreach coordinator for the Alameda County Mosquito Abatement District, would like to make one thing clear: A release of genetically engineered mosquitoes is not coming to Berkeley — or anywhere in Alameda County — in the near future. Not to her knowledge, anyway, and if it were official, she would know. The Berkeley City Council’s robust discussion of this at a council meeting in early November was based partially on misleading information, said Pierce.The council, at its Nov. 9 meeting, considered whether to send a letter to the Environmental Protection Agency (EPA) opposing a potential California pilot study of mosquitoes engineered to combat Zika, dengue, chikungunya, yellow fever and other diseases.Councilmember Ben Bartlett sponsored the item, sending out an email to constituents ahead of time urging them to take action to prevent the EPA from “releasing billions of genetically engineered mosquitoes across California, specifically in Alameda County.” The sample letter Bartlett presented to the council was focused statewide, but background information he shared, as well as discussion at the meeting, focused on keeping the mosquitoes out of the county.
Gene editing used to create all-male or all-female litters of mice
19542J. Goodyer, Science Focus, 2021-12-06 20:26:39.
As males are unable to produce milk or lay eggs, the ability to breed cows and hens that produce all-female litters is likely to be high on most poultry and dairy farmers’ wish lists. Now, scientists at the Francis Crick Institute and the University of Kent have come a step closer to realising this goal after successfully using CRISPR gene editing techniques to produce all-female or all-male litters of mice. The technique could also be used to improve animal welfare in areas of scientific research in which only male or only female animals are required for studies, the researchers say. To make the breakthrough the researchers took advantage of the fact that CRISPR consists of two parts – the Cas9 enzyme, which cuts the DNA and enables scientists to alter specific regions of genes, and the guide RNA, which carries the Cas9 enzyme to the desired region on the genome.
Gene editing used to create all-male or all-female mice litters
19502A. Reis, European Scientist, 2021-12-04 17:04:50.
Researchers from the Francis Crick Institute and the University of Kent used gene-editing technologies to create male-only and female-only mice litters, according to a study published in Nature Communications (1). The authors also suggested ways in which this method could be used to improve animal welfare in scientific research and agriculture. There are many situations in research and agriculture where it would be desirable to have just females or just males. For example, reproductive studies require only animals of the gender being studied, while in farming, egg and milk production needs only female animals. Sadly, in many cases, the unwanted animals end up being culled. “This work could have an immediate and valuable impact in scientific laboratories, as we’ve shown how it is safe and effective in mice, a common mammal used in medical and scientific research. While a lot of research needs both sexes, there are areas of study where only one is needed. For example, when studying the reproductive system, sex-specific diseases, or certain hormones”, said James Turner, group leader of the Sex Chromosome Biology Laboratory at the Crick says:
Gene-editing used to create single sex mice litters
19504The Francis Crick Institute, Phys Org, 2021-12-03 17:09:04.
Scientists at the Francis Crick Institute, in collaboration with University of Kent, have used gene editing technology to create female-only and male-only mice litters with 100% efficiency. This proof of principle study, published in Nature Communications today, demonstrates how the technology could be used to improve animal welfare in scientific research and perhaps also agriculture. In scientific research and also farming, there is often a need for either male or female animals. For example, laboratory research into male or female reproduction requires only animals of the sex being studied. And in farming, only female animals are required for egg production and in dairy herds. This means it is common practice for animals of the unrequired sex to be culled after birth. The researchers' new method uses a two-part genetic system to inactivate embryos shortly after fertilisation, allowing only the desired sex to develop. Such a genetically-based method to control the sex of offspring could drastically reduce culling in both industries. The embryo selection is based on the fact that there are two elements of CRISPR-Cas9—the Cas9 enzyme that cuts the DNA, allowing scientists to alter specific regions, and the guide RNA which carries the Cas9 to the right location on the genome. The team placed one element of the system on the father's X or Y chromosome, meaning that it will only be inherited by female or male embryos respectively. The other element is contributed by the mother, and is inherited by all embryos.
Single-sex mice litters were created with 100% efficiency using gene editing.
19498R. Silman, Brinkwire, 2021-12-03 17:00:12.
The Francis Crick Institute, in partnership with the University of Kent, has employed gene editing technology to construct 100% efficient female-only and male-only mouse litters. This proof-of-concept study, which was published today (Friday, December 3rd, 2021) in Nature Communications, shows how the technique could be used to improve animal wellbeing in scientific research and possibly agriculture. Male and female animals are frequently required in scientific research and husbandry. Laboratory research into male or female reproduction, for example, necessitates only animals of the examined sex. In addition, only female animals are needed for egg production and dairy herds in farming. This means that animals of the unrequired sex are routinely culled after birth.
Scientists eye gene drive technology to combat malaria
19496S. Buguzi, Sci Dev Net, 2021-12-03 16:55:44.
Scientists are hoping that adoption of gene drive technology could reduce mosquito populations as they call for new innovations in the fight against malaria, a fatal disease widespread in Sub-Saharan Africa. The World Health Organization (WHO) says the Africa region accounted for around 94 per cent of all global malaria cases and deaths in 2019. Over two-thirds of deaths were among children under the age of five. Gene drive technology — genetic engineering that modifies malaria mosquitoes so they can pass their genes on to large mosquito populations — could potentially contribute to malaria elimination in Africa, according to Krystal Birungi, a field entomology coordinator at the not-for-profit research consortium Target Malaria, Uganda. “There is a sense in which our best tools today are also our oldest, which implies that innovation needs to be scaled up.” Fredros Okumu, entomologist and director of science, Ifakara Health Institute, Tanzania “It is a cost-effective way to cut down malaria vectors, and is simple to implement because the mosquitoes themselves do the work,” said Birungi during a Roll Back Malaria Partnership virtual boot camp on malaria control innovation on 15 November. Although the technology is not on the market, and is yet to gain public acceptance, if rolled out it could complement existing malaria interventions such as insecticide-treated nets and indoor residual spray, helping reduce malaria cases, according to Birungi.
Lab animals: Gene-editing technology is used to create female-only and male-only mice litters
19493todayuknews, Today UK News, 2021-12-03 16:50:32.
Single-sex litters of mice — comprising only either female or male pups — have been produced by means of so-called CRISPR-Cas9 gene editing technology. The technique, developed by experts at the Francis Crick Institute and the University of Kent, works by inactivating embryos of one sex shortly after fertilisation. It could be used to improve animal welfare in both laboratory and agricultural settings where, for various reasons, only female or male animals are needed. It is common for animals of the unrequired sex to be culled — a practice which could be drastically reduced by controlling the sex of the animals prior to birth. As the technique requires the genetic modification of both parents to work, however, the approach would not be suitable for forcing the sex of designer babies. Single-sex litters of mice — comprising only either female or male pups — have been produced by means of so-called CRISPR-Cas9 gene editing technology. Pictured: the mice that were bred to create single-sex litters. The black parts of their coat are caused by the genetically modified cells, while the white parts come from the non-modified parts of their genome
Gene editing produces all-male or all-female litters of mice
19491E. Pennisi, Science, 2021-12-03 16:41:41.
In some farmers’ ideal world, cows would birth only females, sows would bear no boars, and chicks would all grow up to be hens. Such sex ratios would stop them from killing millions of male animals, which don’t produce eggs or milk. Now, scientists are a step closer to this reality. Researchers have harnessed the gene editor CRISPR to produce litters of mice all of one sex. That’s a potential boon to agriculture and may offer a more immediate advantage in scientific research. “The paper shows a state-of-the-art solution to producing single-sex species,” with “impressive results,” says Ehud Qimron, a CRISPR expert at Tel Aviv University who was not involved with the work. The impact for lab animals may be huge. “In the past 5 years around 25,000 papers were published using mice in sex-specific research studies,” says study co-author James Turner, a molecular geneticist at the Francis Crick Institute. “If we could prevent the generation of the unstudied sex, the number [saved] would be in the hundreds of thousands.” Other methods exist to skew the male/female ratio of newborn animals. Scientists can sort sperm by the weight of the sex chromosome, or cause embryos of one sex to die before birth. In a study published 2 years ago, researchers using the gene editor CRISPR managed to produce altered mice in which four of five litters were all female.
Podcast: Malaria Gene Drive
19474S. Hartley, S. Neema and C. Opesen, University of Exeter Business School, 2021-11-25 15:15:30.
Professor Sarah Hartley and her two colleagues in Uganda, Stella Neema and Chris Opesen discuss gene drive research for malaria control. Funded by British Academy and Wellcome trust, their work is to understand the social science challenges around the development of this kind of technology and to consider how governance and ethics should be managed when dealing with a scientific breakthrough such as this.
Major phase of Florida Keys GMO mosquito release complete, company says
19393D. Goodhue, Miami Herald, 2021-11-23 17:29:49.
A British biotechnology company and the Florida Keys Mosquito Control District on Tuesday announced they have “successfully concluded” a major phase in a controversial trial project aimed at wiping out an invasive species of mosquito known to spread dangerous diseases like dengue fever, Zika and chikungunya. In April, the company, Oxitec, placed up to 130 boxes, each filled with millions of genetically altered male Aedes aegypti mosquito larvae, in several locations in the Middle and Lower Keys — hoping they would fly away after hatching and breeding with the naturally occurring local females in the area. Scientists designed a “death mechanism” in the males meant to ensure no viable female offspring would result from the mating. The male offspring, according to Oxitec, will pass on a “self-limiting gene” to half of their young, with the goal of Aedes aegypti breeding themselves out of existence in the Keys, according to the company.
Science Has Given Us the Power to Undermine Nature’s Deadliest Creature: Should We Use It?
19304E. Herold, leaps.org, 2021-11-16 13:32:15.
British biotech company Oxitec has engineered male mosquitoes to have a genetic "kill-switch" that could potentially crash the local population of Aedes aegypti, at least in the short-term. The modified males that are being released are intended to mate with wild females. Males don't bite; it's the female that's deadly, always seeking out blood to gorge on to help mature her eggs. After settling her filament-thin legs on her prey, she sinks a needlelike proboscis into the skin and sucks the blood until her translucent belly is bloated and glowing red. The kill-switch will ensure that the female offspring die before they reach maturity and thus, be unable to reproduce. Should a small number of them survive, they will be rendered unable to bite. The genetic modification means the proboscis, the sickle-like needle that pierces the skin, won't form properly. The idea is that the lack of females for the males to mate with, over a few generations, will collapse the local population of Aedes aegypti. The modified mosquitoes are the second genetically engineered insect to be released in the U.S. by Oxitec. The first was a modified diamondback moth, an agricultural pest that doesn't bite humans. But with the mosquitoes, there are many questions about the long-term effects on wild ecosystems, other species in the food chain, and human health. With the Keys initiative, there has been vociferous opposition from environmental groups and some local residents, but some scientists and public health experts say that genetically modified insects pose less of a risk than the diseases they carry and the powerful, indiscriminant pesticides used to combat them.
The drone, the tool of the future to combat its spread
19234T. Thompson, Your Decommissioning News, 2021-11-09 22:01:19.
Drones could become a promising tool in the fight against the tiger mosquito, according to a study published Tuesday by French researchers. French researchers said on Tuesday that drones could, within a few years, integrate into the arsenal of the fight against the tiger mosquito, an invasive species that appeared on mainland France about fifteen years ago, revealing the results of an experiment conducted in Montpellier. The tiger mosquito, Aedes albopictus, now detected in 65 French departments, grows at 80% in individuals, mainly in standing water in gardens. It is more harmful because it stings constantly during the day and can transmit viral diseases such as dengue, chikungunya or Zika if it has been stung by a previous patient. Therefore the first preventive measure against this insect, whose reproduction is preferred by high temperatures, is to systematically empty and overturn containers that may contain water, such as a simple ashtray. But additional methods have emerged in recent years, including the so-called “sterile insect technique” (TIS), which consists of raising male mosquitoes in laboratories, sterilizing them, and then releasing them into the field, where wild females are sterilized. which will not have offspring.
Two years of laboratory studies on the non gene drive genetically modified sterile male mosquitoes concluded successfully in Mali
19224M. Coulibaly, Target Malaria, 2021-11-09 21:44:38.
The Target Malaria Mali team at the Malaria Research and Training Centre (MRTC) based at the University of Sciences, Techniques and Technologies of Bamako (USTTB) is proud to have been the first Malian research team to work on non gene drive genetically modified sterile male mosquitoes. The team has just published the results of the two years we spent studying these mosquitoes in our laboratory. Thanks to this research, we have gained new knowledge and developed cutting-edge skills in the areas of entomology, molecular biology and genetics, allowing us to sustain a colony containing both local and genetically modified mosquitoes. This research was made possible thanks to an authorisation from the Malian Ministry of Environment, Sanitation and Sustainable Development (MEADD) issued on 21 June 2019 to import a strain of non gene drive genetically modified sterile male mosquitoes and study them in a contained environment. Initially designed at Imperial College London1, the genetically modified mosquitoes were then tested at Polo d’Innovazione di Genomica, Genetica e Biologia (PoloGGB) in Terni, Italy, before being transported to Mali. The mosquito eggs arrived by plane on 4 September 2019. They were kept in the insectarium renovated by the Target Malaria project.
Will freeing ourselves (forever) from mosquitoes soon be a realizable “dream”? Pros and cons of an epochal turning point – breaking latest news
19160Annonymous, Breaking Latest News, 2021-11-05 14:34:10.
Also true for a dangerous insect like the mosquito: due to the pathologies of which vector, such as the malaria, the dengue o la yellow fever, every year in the world about 800 thousand people die. There are therefore quite a few reasons to want to get rid of it, not just the itchy summer bites, and thanks to the technique developed by Professor Crisanti it would seem possible, in a not too distant future. It starts from a premise: Not that we want to get rid of all mosquitoes. There are around 3,500 species of mosquitoes and fortunately only a few transmit parasitic diseases such as malaria or others that cause diseases such as zika and dengue. So if I want to get rid of malaria I have to attack malaria. Traditionally this has been done with insecticides which have shown all their limits and dangers. These measures, which are apparently simple, require sustainability over time, require resources and political continuity. All this is missing today. Hence biotechnology, the idea of making mosquitoes themselves do this job. If we manage to modify the genetic characteristics of mosquitoes, we can theoretically create mosquitoes that do not reproduce or that do not transmit the infection.
New Zealand wants to get rid of stoats with genetic engineering
19157C. Weerasinghe, Cyber Layman, 2021-11-05 14:23:23.
The principle of the “gene drive” is to modify a specific gene in a group of specimens of a species and then let the gene spread throughout the population by inheritance, through reproduction. If, as in this case, the aim is to reduce the population of animals, for example, we can make sure that only males are born. New Zealand stoats are not the only animals on which the technique of “gene drive” is thought to be used: for example, there are similar plans for mosquitoes that transmit malaria. The first time the technique proved effective was in 2015, when it was tested on a population of fruit flies; then it was tested on some species of yeast, insects and mice (for which, however, the effectiveness of the technique has not yet been demonstrated), never on an animal as large as an ermine. New Zealand may be the first country to experience such a thing domestically.
Oxitec Announces Ground-breaking Commercial Launch of Its Friendly™ Aedes aegypti Solution in Brazil
19395Oxitec, COSION, 2021-11-03 17:40:43.
Oxitec, the leading developer of biological solutions to control pests, announced today the landmark commercial launch of its Friendly™ Aedes aegypti solution designed specifically for use by homeowners, businesses, and communities to control the dengue-spreading Aedes aegypti mosquito. This launch represents the first time globally that the benefits of using biologically engineered mosquito control technology that can be purchased directly by consumers. Having received full biosafety commercial approval in 2020 from the Brazilian government's biosafety authority, CTNBio, the company is making its just-add-water solution available for delivery directly to customers' doorsteps starting in the State of São Paulo. Available for purchase online, the product comprises durable outer boxes and Friendly™ male mosquito egg refill packs. Once delivered, customers need only to add water to the Friendly™ box, place it in a garden, patio, or around a home or business, and the boxes will produce Oxitec's non-biting male mosquitoes over time, which disperse to find and mate with invasive, biting Aedes aegypti females. Their female offspring cannot survive, which means fewer biting female mosquitoes in the following generations. While the Friendly™ Aedes aegypti males pursue and mate with female Aedes aegypti, customers need only reactivate the easy-to-use box once per month. This technology controls the pest without harming beneficial species like bees and butterflies and does not persist in the environment.
Contact Us
Alex Sullivan
Foundation for the
National Institutes of Health
geneconvenevi@fnih.org