Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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Sperm competition and the dynamics of X chromosome drive: Stability and extinction

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Taylor, JEJ, J.,  Genetics,  160:1721-1731. 2002.
Several empirical studies of sperm competition in populations polymorphic for a driving X chromosome have revealed that Sex-ratio males (those carrying a driving X) are at a disadvantage relative to Standard males. Because the frequency of the driving X chromosome determines the ...

Sex-ratio drive in Drosophila simulans: Variation in segregation ratio of X chromosomes from a natural population

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Montchamp-Moreau, CC, M.,  Genetics,  162:1221-1231. 2002.
The sex-ratio trait that exists in a dozen Drosophila species is a case of naturally occurring X chromosome drive that causes males to produce female-biased progeny. Autosomal and Y polymorphism for suppressors are known to cause variation in drive expression, but the X ...

Segregation distortion induced by wild-type RanGAP in Drosophila

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Kusano, AS, C.; Ganetzky, B.,  Proceedings of the National Academy of Sciences of the United States of America,  99:6866-6870. 2002.
Segregation Distorter (SD) is a meiotic drive system in Drosophila that causes preferential transmission of the SD chromosome from SD/SD+ males owing to the induced dysfunction of SD+ spermatids. The key distorter locus, Sid, is a dominant neomorphic allele encoding a truncated, ...

Sperm development, age and sex chromosome meiotic drive in the stalk-eyed fly, Cyrtodiopsis whitei

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Wilkinson, GSS, M. I.,  Heredity,  87:17-24. 2001.
The cytological basis of X chromosome meiotic drive or sex ratio (SR) has been reported for several species of Drosophila but not for other species. Here we describe how sperm development in the stalk-eyed fly, Cyrtodiopsis whitei, influences progeny sex proportion, in order to ...

Meiotic drive alters sperm competitive ability in stalk-eyed flies

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Wilkinson, GSF, C. L.,  Proceedings of the Royal Society B-Biological Sciences,  268:2559-2564. 2001.
Meiotic drive results when sperm carrying a driving chromosome preferentially survive development. Meiotic drive should therefore influence sperm competition because drive males produce fewer sperm than non-drive males. Whether meiotic drive also influences the competitive ...

Selection and segregation distortion in a sex-differentiated population

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Weissing, FJvB, M.,  Theoretical Population Biology,  60:327-341. 2001.
We extend the classical model for selection at an autosomal locus in a sex-differentiated population to include segregation distortion. The equations remain the same, but the fitness parameters are interpreted differently and refer to alleles instead of genotypes. We derive ...

Competition at the Mouse t Complex: Rare Alleles Are Inherently Favored

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van Boven, MW, Franz J.,  Theoretical Population Biology,  60:343-358. 2001.
We investigate the competition between alleles at a segregation distorter locus. The focus is on the invasion prospects of rare mutant distorter alleles in a population in which a wildtype and a resident distorter allele are present. The parameters are chosen to reflect the ...

Sex-ratio segregation distortion associated with reproductive isolation in Drosophila

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Tao, YH, D. L.; Laurie, C. C.,  Proceedings of the National Academy of Sciences of the United States of America,  98:13183-13188. 2001.
Sex-ratio distortion is the most common form of non-Mendelian segregation observed in natural populations. It may occur even more frequently than direct observations suggest, because the dysgenic population consequences of a biased sex ratio are expected to result in the rapid ...

Sex chromosome meiotic drive

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Jaenike, J,  Annual Review of Ecology and Systematics,  32:25-49. 2001.
Sex chromosome drive refers to the unequal transmission of X and Y chromosomes from individuals of the heterogametic sex, resulting in biased sex ratios among progeny and within populations, The presence of driving sex chromosomes can reduce mean fitness within a population, ...

The role of selfish genetic elements in eukaryotic evolution

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Hurst, GDDW, J. H.,  Nature Reviews Genetics,  2:597-606. 2001.
'Selfish genetic elements', such as transposons, homing endonucleases, meiotic drive chromosomes and heritable microorganisms, are common features of eukaryotes. However, their importance in the evolution of eukaryotic genomes is still controversial. In this review, we discuss ...

An unusual sex-determination system in South American field mice (genus Akodon): The role of mutation, selection, and meiotic drive in maintaining XY females

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Hoekstra, HEH, J. M.,  Evolution,  55:190-197. 2001.
The mechanism of sex determination in mammals appears highly conserved: the presence of a Y chromosome triggers the male developmental pathway, whereas the absence of a Y chromosome results in a default female phenotype. However, if the Y chromosome fails to initiate the male ...

Outcrossed sex allows a selfish gene to invade yeast populations

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Goddard, MRG, D.; Burt, A.,  Proceedings of the Royal Society B-Biological Sciences,  268:2537-2542. 2001.
Homing endonuclease genes (HEGs) in eukaryotes are optional genes that have no obvious effect on host phenotype except for causing chromosomes not containing a cop), of the gene to be cut, thus causing them to be inherited at a greater than Mendelian rate via gene conversion. ...

Nonrandom segregation during meiosis: the unfairness of females

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de Villena, FPMS, C.,  Mammalian Genome,  12:331-339. 2001.
Most geneticists assume that chromosome segregation during meiosis is Mendelian (i.e., each allele at each locus is represented equally in the gametes). The great majority of reports that discuss non-Mendelian transmission have focused on systems of gametic selection, such as the ...

Transmission ratio distortion due to the bl gene in table beet

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Austin, DG, I. L.,  Journal of the American Society for Horticultural Science,  126:340-343. 2001.
The bl gene conditions a blotchy phenotype (irregular sectors of red and white root color) in table beet (Beta vulgaris ssp, vulgaris). Segregation of the bl gene was found to be consistent with a single recessive gene, however, some evidence for a departure from a single gene ...

Success in Zanzibar: Eradication of tsetse

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A. R. Msangi, N. Kiwia, I. I. Malele, F. Mramba, K. M. Saleh, W. A. Mussa, K. G. Juma, V. A. Dyck, M. J. B. Vreysen, A. G. Parker, U. Feldmann, Z. R. Zhu and H. Pan,  Area-Wide Control of Fruit Flies and Other Insect Pests,  2000.
There are about 22 species of tsetse flies found nowhere else in the world except in 36 countries of sub-Saharan Africa Tsetse flies transmit a debilitating and often fatal disease, trypanosomosis, which causes tremendous losses of livestock, and severely limits agricultural ...

Glossina austeni (Diptera: Glossinidae) Eradicated on the Island of Unguja, Zanzibar, Using the Sterile Insect Technique

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M. J. B. Vreysen, K. M. Saleh, M. Y. Ali, A. M. Abdulla, Z.-R. Zhu, K. G. Juma, V. A. Dyck, A. R. Msangi, P. A. Mkonyi and H. U. Feldmann,  Journal of Economic Entomology,  123-135. 2000.
An area-wide integrated tsetse eradication project was initiated in Zanzibar in 1994 by the International Atomic Energy Agency and the governments of Tanzania and Zanzibar, to eradicate Glossina austeni Newstead from Unguja Island (Zanzibar) using the sterile insect technique. ...

Co-existence of hosts and sex ratio distorters in structured populations

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Hatcher, MJD, A. M.; Tofts, C.,  Evolutionary Ecology Research,  2:185-205. 2000.
Vertically transmitted parasites occur in several invertebrate species, and alter host reproduction by a variety of mechanisms, including sex ratio distortion via feminization. Efficient feminizers are predicted to drive homogenous host populations extinct due to the absence of ...

Persistence of selfish genetic elements: population structure and conflict

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Hatcher, MJ,  Trends in Ecology & Evolution,  15:271-277. 2000.
Selfish genetic elements are vertically transmitted factors that spread by obtaining a transmission advantage relative to the rest of the genome of their host organism, often with a cost to overall host fitness. In many cases, conventional population genetics theory predicts them ...

Non-Mendelian segregation of sex chromosomes in heterospecific Drosophila males

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Dermitzakis, ETM, J. P.; Waldrip, H. M.; Clark, A. G.,  Genetics,  154:687-694. 2000.
Interspecific hybrids and backcrossed organisms generally suffer from reduced viability and/or fertility. To identify and genetically map these defects, we introgressed regions of the Drosophila sechellia genome into the D. simulans genome. A female-biased sex ratio was observed ...

A genetic test to determine the origin of maternal transmission ratio distortion: Meiotic drive at the mouse Om locus

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de Villena, FPMdlC-E, E.; Briscoe, T. L.; Sapienza, C.,  Genetics,  154:333-342. 2000.
We have shown previously that the progeny of crosses between heterozygous females and C57BL/G males show transmission ratio distortion at the Om locus on mouse chromosome 11. This result has been replicated in several independent experiments. Here we show that the distortion maps ...

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