Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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Heritability of the maternal meiotic drive system linked to Om and high-resolution mapping of the Responder locus in mouse

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de Villena, FPMdlC-E, E.; Williams, J. W.; Malette, J. M.; Rosa, M.; Sapienza, C.,  Genetics,  155:283-289. 2000.
Matings between (C57BL/6 X DDK)F-1 females and C57BL/6 males result in a significant excess of offspring inheriting maternal DDK alleles in the central region of mouse chromosome 11 due to meiotic drive at the second meiotic division. We have shown previously that the locus ...

Sex-ratio meiotic drive in Drosophila simulans is related to equational nondisjunction of the Y chromosome

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Cazemajor, MJ, D.; Montchamp-Moreau, C.,  Genetics,  154:229-236. 2000.
The sex-ratio trait, an example of naturally occurring X-linked meiotic drive, has been reported in a dozen Drosophila species. Males carrying a sex-ratio X chromosome produce an excess of female offspring caused by a deficiency of Y-bearing sperm. In Drosophila simulans, such ...

Spore-killing meiotic drive factors in a natural population of the fungus Podospora anserina

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van der Gaag, MD, A. J. M.; Oosterhof, J.; Slakhorst, M.; Thijssen, Jagm; Hoekstra, R. F.,  Genetics,  156:593-605. 2000.
In fungi, meiotic drive is observed as spore killing. In the secondarily homothallic ascomycete Podospora anserina it is characterized by the abortion of two of the four spores in the ascus. We have identified seven different types of meiotic drive elements (Spore killers). Among ...

Chromosomally-induced meiotic drive in Drosophila males: Checkpoint or fallout?

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Tomkiel, JE,  Genetica,  109:95-103. 2000.
In male Drosophila melanogaster, anomalies in sex chromosome pairing at meiosis often lead to complete or partial sperm dysfunction. This observation has led to the suggestion that defects in either the efficiency or configuration of chromosome pairing at metaphase trigger a ...

Segregation distortion of mouse t-haplotypes: The molecular basis emerges

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Schimenti, J,  Trends in Genetics,  16:240-243. 2000.
The t haplotype is an ancestral version of proximal mouse chromosome 17 that has evolved mechanisms to persist as an intact genomic variant in mouse populations. t haplotypes contain mutations that affect embryonic development, male fertility and male transmission ratio ...

Physical mapping of male fertility and meiotic drive quantitative trait loci in the mouse t complex using chromosome deficiencies

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Planchart, AY, Y.; Schimenti, J. C.,  Genetics,  155:803-812. 2000.
The t complex spans 20 cM of the proximal region of mouse chromosome 17. A variant form, the t haplotype (t), exists at significant frequencies in wild mouse populations and is characterized by the presence of inversions that suppress recombination with Mild-type (+) chromosomes. ...

Nonrandom segregation of the mouse univalent X chromosome: Evidence of spindle-mediated meiotic drive

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LeMaire-Adkins, RH, P. A.,  Genetics,  156:775-783. 2000.
A fundamental principle of Mendelian inheritance is random segregation of alleles to progeny; however, examples of distorted transmission either of specific alleles or of whole chromosomes have been described in a variety of species. In humans and mice, a distortion in chromosome ...

A male-biased primary sex ratio and larval mortality in Eucheira socialis (Lepidoptera : Pieridae)

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Underwood, DLAS, A. M.,  Evolutionary Ecology Research,  1:703-717. 1999.
We investigated the sex ratio and sex-biased mortality in the Mexican pierid butterfly, Eucheira socialis westwoodi. We studied two populations between 1990 and 1997 along Mexico Highway 40, which runs from Mazatlan, Sinaloa to Durango, Durango, Populations occurring between km ...

Genetic and molecular characterization of sting, a gene involved in crystal formation and meiotic drive in the male germ line of Drosophila melanogaster

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Schmidt, AP, G.; Bozzetti, M. P.; Tritto, P.; Pimpinelli, S.; Schafer, U.,  Genetics,  151:749-760. 1999.
The sting mutation, caused by a P element inserted into polytene region 32D, was isolated by a screen for male sterile insertions in Drosophila melanogaster. This sterility is correlated with the presence of crystals in spermatocytes and spermatids that are structurally ...

Meiotic drive and evolution of female choice

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Reinhold, KE, L.; Misof, B.; Kurtz, J.,  Proceedings of the Royal Society B-Biological Sciences,  266:1341-1345. 1999.
As a special version of the good-genes hypothesis, it was recently proposed that females could benefit from choosing drive-resistant males in a meiotic drive system. Here, we examine with a three-locus, six-allele population genetic model whether female choice for drive ...

Transmission ratio distortion in females on chromosome 10p11-p15

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Paterson, ADP, A.,  American Journal of Medical Genetics,  88:657-661. 1999.
A number of recent reports of linkage of markers on chromosome 10p to schizophrenia, and evidence for linkage in one study to bipolar affective disorder, provide encouragement for psychiatric genetics, after nonreplication of linkage findings at other chromosomal regions, The ...

Truncated RanGAP encoded by the Segregation Distorter locus of Drosophila

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Merrill, CB, L.; Kusano, A.; Ganetzky, B.,  Science,  283:1742-1745. 1999.
Segregation Distorter (SD) in Drosophila melanogaster is a naturally occurring meiotic drive system in which the SD chromosome is transmitted from SD/SD+ males in vast: excess over its homolog owing to the induced dysfunction of SD+-bearing spermatids. The Sd Locus is the key ...

Models of sex-ratio meiotic drive and sexual selection in stalk-eyed flies

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Lande, RW, G. S.,  Genetics Research,  74:245-253. 1999.
Hypertrophied sexually dimorphic eye stalks have evolved independently in several families of Diptera, with the eyespan of males exceeding their total body length in some species. These structures function in intermale contests for territories and in mate attraction, the ...

How common are meiotically driving sex chromosomes in insects?

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Jiggins, FMH, G. D. D.; Majerus, M. E. N.,  American Naturalist,  154:481-483. 1999.
In summary, we argue that the hypothesis that sex chromosome; meiotic drive is common within the insects is in; fact not proved. We feel that, although it is unlikely that; it will be found exclusively in the Diptera, there is a case; to be made that the Diptera are a hot spot ...

Suppression of sex-ratio meiotic drive and the maintenance of Y-chromosome polymorphism in Drosophila

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Jaenike, J,  Evolution,  53:164-174. 1999.
Like several other species of Drosophila, D. quinaria is polymorphic for X-chromosome meiotic drive; matings involving males that carry a "sex-ratio" X chromosome (X(SR)) result in the production of strongly female-biased offspring sex ratios (Jaenike 1996). A survey of isofemale ...

Invasion of one insect species, Adalia bipunctata, by two different male-killing bacteria

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Hurst, GDDvdS, J. H. G.; Majerus, T. M. O.; Bertrand, D.; Zakharov, I. A.; Baungaard, J.; Volkl, W.; Stouthamer, R.; Majerus, M. E. N.,  Insect Molecular Biology,  8:133-139. 1999.
Male-killing bacteria, which are inherited through the female line and kill male progeny only, are known from five different orders of insect. Our knowledge of the incidence of these elements has stemmed from discovery of their phenotype in different species, Our estimate of the ...

Population dynamics under parasitic sex ratio distortion

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Hatcher, MJT, D. E.; Dunn, A. M.; Tofts, C.,  Theoretical Population Biology,  56:11-28. 1999.
We analyse the population dynamic effects of sex ratio distortion by vertically transmitted, feminizing parasites, We show that, for diploid hosts, sex ratio distortion may lead to extinction as males become too rare to maintain the host population through reproduction. ...

Recurrent invasion and extinction of a selfish gene

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Goddard, MRB, A.,  Proceedings of the National Academy of Sciences of the United States of America,  96:13880-13885. 1999.
Homing endonuclease genes show super-Mendelian inheritance, which allows them to spread in populations even when they are of no benefit to the host organism. To test the idea that regular horizontal transmission is necessary for the long-term persistence of these genes, we ...

Transmission ratio distortion at the INS-IGF2 VNTR

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Eaves, IAB, S. T.; Forster, P.; Ferber, K. M.; Ehrmann, D.; Wilson, A. J.; Bhattacharyya, S.; Ziegler, A. G.; Brinkmann, B.; Todd, J. A.,  Nature Genetics,  22:324-325. 1999.
Transmission ratio distortion (TRD) is defined as a statistically significant departure from mendelian transmission. So far, evidence of this in humans has been limited or controversial1,2,3,4, and the few established examples involve chromosome rearrangements in lower ...

Are Drosophila SR drive chromosomes always balanced?

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Carvalho, ABV, S. C.,  Heredity,  83:221-228. 1999.
SR chromosomes are the best-known case of sex chromosome meiotic drive. These X chromosomes cause the production of female-biased progenies in several Drosophila species; Due to their meiotic drive advantage, they are expected to spread and become fixed, resulting in population ...

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