Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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Insect control by genetic manipulation of natural populations

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M. J. Whitten,  Science,  171:682. 1971.
The possible use of chromosome rearrangements is considered as a means for introducing genes into insect populations for their own control. The release of laboratory-constructed strains differing from the field population for a number of chromosome interchanges should create an ...

The Sterile-Male Technique Against Tsetse Flies, Glossina Spp

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D. A. Dame and C. H. Schmidt,  16,  24-30. 1970.
Simpson (1958) discussed the relationship between the biological characteristics of the genus Glossina and the use of the sterile-male technique in the control of this vector of trypanosomiasis, as did Knipling in an informal report in 1963 on Practical Role of the Sterility ...

Mechanisms of meiotic drive

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Zimmering, SS, L.; Nicoletti, B.,  Annual Review of Genetics,  4:409-436. 1970.
Meiotic drive has been defined by Sandler & Novitski (157) as any alteration of the normal process of meiosis with the consequence that a heterozygote for two genetic alternatives produces an effective gametic pool with an excess of one type; such a pattern of behavior ...

Analysis of a general population genetic model of meiotic drive

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Hartl, DL,  Evolution,  24:538-545. 1970.
The purpose of this article is to present the detailed solution of a model of meiotic drive which Lewontin (1968) has suggested would be helpful in understanding the evo- lutionary dynamics of the t-alleles in the house mouse. Because mice tend to breed in small endogamous family ...

Meiotic drive in natural populations of Drosophila melanogaster 9: Suppressors of segregation distorter in wild populations

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Hartl, DL,  Canadian Journal of Genetics and Cytology,  12:594-600. 1970.
A population of Drosophila melanogaster in Madison, Wisconsin, has been screened for suppressors of segregation distorter (SD), an autosomal meiotic drive element found in the same population. Three kinds of suppressors were tested for: (1) Y-linked suppressors, none were found, ...

Possible use of translocations to fix desirable genes in insect populations.

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Curtis, CF,  Nature,  218:368-369. 1968.
Chromosome translocation heterozygotes (T/+) are usually semisterile, but translocation homozygotes (T/T) if viable are usually fully fertile. If such a viable translocation were produced in an insect pest, T/T insects could be reared in captivity and released into the wild, ...

Meiotic drive and visible polarity in Drosophila spermatocytes

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Yanders, AFB, J. G.; Peacock, W. J.; Goodchild, D. J.,  Genetics,  59:245-253. 1968.
The model for meiotic drive presented by PEACOCK and ERICKSON (1965) demands that an intracellular differentiation exists at the time of the first meiotic division in spermatocytes. As a result of this differentiation, one of the spindle poles at anaphase I will lead to the ...

Eradication of Culex pipiens fatigans through cytoplasmic incompatibility.

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H. Laven,  Nature,  216:383. 1967.
Culex pipiens fatigans is the chief vector of filariasis in south-east Asia. Urbanization has often caused the numbers of this mosquito-and with it the danger of filariasis infection-to increase alarmingly. The natural vigour, tolerance and fast development of resistance to ...

Extraordinary sex ratios

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W. D. Hamilton,  Science,  156:477-488. 1967.
The two sexes are usually produced in approximately equal numbers. Fisher (1) was the first to explain why, under natural selection, this should be so, irrespective of the particular mechanism of sex determination. His rather tersely expressed argument has been clarified by ...

Genetic distortion of sex ratio in a mosquito Aedes aegypti

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Hickey, WAC, G. B.,  Genetics,  53:1177-1196. 1966.
CRAIG, HICKEY and VANDEHEY (1960) reported that a hereditary factor transmitted by males was responsible for high male ratios in A. aegypti. This phenomenon was designated as male-producing or MP. Males from high maleproducing families produced a high proportion of males in their ...

Meiotic drive in Drosophila involving chromosome breakage

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Erickson, J,  Genetics,  51:555-571. 1965.
In ordinary genetic systems the members of a pair of unlike alleles, or of a pair of unlike chromosomes, are recovered in equal numbers among the off spring, barring complications affecting viability. Contrary to this expectation, in a number of studies it has been found that one ...

Aanalysis of case of meiotic drive in Drosophila melanogaster

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Hanks, GD,  Genetics,  50:123-130. 1964.
IN the past ten years there has been a renewed interest in the abnormal recovery of chromosomes after meiosis; see for example DUNN (1953); NOVITSKI and SANDLER (1957) ; SANDLER and NOVITSKI ( 1957) ; LINDSLEY and SANDLER (1958); NOVITSKI and HANKS (1961); and MAGUIRE (1963). ...

Applications of genetic technology to mosquito rearing

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G. B. Craig,  Bulletin of the World Health Organization,  29:89-97. 1963.
Since the development of insecticide-resistance and the consequent partial failure of the chemical approach to the control of disease vectors, interest in the biological approach has re-awakened. An aspect of the latter approach that is of great current interest is " autocidal ...

On the role of lethal mutants in the control of populations

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R. C. Von Borstel and A. A. Buzzati-Traverso,  Radioisotopes and Radiation in Entomology: Proceedings of a Symposium, Bombay, 5-9 December, 1960,  1962:273-278. 1962.
On the role of lethal. mutants in the control of populations. Population control by release of irradiated males requires that the sperm must be damaged by radiation. The type of damage induced by radiation imposes a restriction on which species may be controlled because if the ...

Meiotic drive in natural populations of Drosophila melanogaster .7. Conditional segregation distortion – a possible nonallelic conversion

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Sandler, LH, Y.,  Genetics,  46:585-604. 1961.
Males, heterozygous for the Segregation-distorter (SD) allele (located in or near the centromeric heterochromatin of the right arm of chromosome 11) and a standard tester second chromosome, regularly produce a preponderance of functional SD-bearing sperm ( SANDLER, HIRAIZUMI and ...

Meiotic drive in natural populations of Drosophila melanogaster .8. A heritable aging effect on phenomenon of segregation distortion

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Sandler, LH, Y.,  Canadian Journal of Genetics and Cytology,  3:34-46. 1961.
Second chromosomes have been found in natural populations of Drosophila melanogaster that contain an abnormal centromere region which conditions a highly aberrant segregation ratio in heterozygous males (Sandler, Hiraizumi, and Sandler, 1959). In particular, when a chromosome ...

Analysis of irradiated Drosophila populations for meiotic drive

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Novitski, EH, G. D.,  Nature,  190:989-990. 1961.
The existence of chromosomes or alleles that are represented in the gametes of a heterozygote with a frequency greater than the expected 50 percent is now well established for a variety of species. The immediate population result of introducing such a chromosome or allele must ...

Meiotic drive in natural populations of Drosophila melanogaster .6: A preliminary report on presence of segregation-distortion in a Baja california population

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Mange, EJ,  American Naturalist,  95:87-96. 1961.
Meiotic drive is a term coined by Sandler and Novitski (1957) to describe; the situation whereby a heterozygote produces gametes containing an excess; of one allele, rather than the expected equality. As a consequence of such; aberrant segregations, gene frequencies within a ...

Time of temperature sensitivity of meiotic drive in Drosophila melanogaster

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Erickson, JH, G. D.,  American Naturalist,  95:247-250. 1961.
In a line of Drosophila melanogaster demonstrating meiotic drive, it was found that the high recovery rate of the X-chromosome could be nearly nullified by temperature treatment. A series of experiments were carried out to determine at what stage of the life-cycle this treatment ...

Inherited male-producing factor in Aedes aegypti

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G. B. Craig, W. A. Hickey and R. C. Vandehey,  Science,  132:1887-1889. 1960.
An inherited factor causes a predominance of males in certain strains and in progeny of single pairs of Aedes aegypti L. This factor appears to be transmitted only by males and is not due to differential mortality, at least in postgametic stages. Mass release of male-producing ...

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