Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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Effects of a blood-free mosquito diet on fitness and gonotrophic cycle parameters of laboratory reared Anopheles gambiae sensu stricto

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Mosi, F.A., Rutha, I., Velez, R. et al.,  Parasites and Vectors,  17. 2024.
The current rise of new innovative tools for mosquito control, such as the release of transgenic mosquitoes carrying a dominant lethal gene and Wolbachia-based strategies, necessitates a massive production of mosquitoes in the insectary. However, currently laboratory rearing ...

Culex-Transmitted Diseases: Mechanisms, Impact, and Future Control Strategies using Wolbachia

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Madhav, M.; Blasdell, K.R.; Trewin, B.; Paradkar, P.N.; López-Denman, A.J.,  Viruses,  16:1134. 2024.
Mosquitoes of the Culex genus are responsible for a large burden of zoonotic virus transmission globally. Collectively, they play a significant role in the transmission of medically significant diseases such as Japanese encephalitis virus and West Nile virus. Climate change, ...

Assessing CRISPR/Cas9 potential in SDG3 attainment: malaria elimination—regulatory and community engagement landscape

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Snuzik, A.,  Malaria Journal,  23. 2024.
Elimination of malaria has become a United Nations member states target: Target 3.3 of the sustainable development goal no. 3 (SDG3). Despite the measures taken, the attainment of this goal is jeopardized by an alarming trend of increasing malaria case incidence. Globally, there ...

Programming tumor evolution with selection gene drives to proactively combat drug resistance

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Leighow, S.M., Reynolds, J.A., Sokirniy, I. et al.,  Nature Biotechnology,  2024.
Most targeted anticancer therapies fail due to drug resistance evolution. Here we show that tumor evolution can be reproducibly redirected to engineer therapeutic opportunity, regardless of the exact ensemble of pre-existing genetic heterogeneity. We develop a selection gene ...

Revisiting Wolbachia detections: Old and new issues in Aedes aegypti mosquitoes and other insects

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Perran A. Ross, Ary A. Hoffmann,  Ecology and Evolution,  14. 2024.
Wolbachia continue to be reported in species previously thought to lack them, particularly Aedes aegypti mosquitoes. The presence of Wolbachia in this arbovirus vector is considered important because releases of mosquitoes with transinfected Wolbachia are being used around the ...

Mark–Release–Recapture (MRR) of Sterile Male Aedes albopictus (Skuse) in Sri Lanka: Field Performance of Sterile Males and Estimation of the Wild Mosquito Population Density

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Hapugoda, Menaka, Nilmini Silva Gunawardena, Tharaka Ranathunge, Jeremy Bouyer, Hamidou Maiga, Kankanige Karunathilake, Gayan Parakrama Withanage, Indika Weerasinghe, Bazoumana B. D. Sow, and Jeevanie Harishchandra,  Insects,  15:466. 2024.
Dengue is an important mosquito-borne disease in Sri Lanka. The Sterile Insect Technique (SIT) is an environment-friendly and novel method that can suppress dengue vector mosquitoes in Sri Lanka. This study aimed to evaluate the field performance of sterile males and the density ...

No Such Thing as Containment? Gene Drives for Conservation and the (Im)possibility of an Island

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Boersma, K., Bovenkerk, B. and Ludwig, D.,  Philosophy and Technology,  37:75. 2024.
This article explores the use of islands as tools of geographical and intellectual containment - or what we call “islanding” - in the scientific and policy literature about gene drive technologies in conservation. In the first part of the article, we explore the narrative of ...

Escalation of genome defense capacity enables control of an expanding meiotic driver

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Peiwei Chen, Katherine C. Pan, Eunice H. Park, Yicheng Luo, Yuh Chwen G. Lee, Alexei A. Aravin,  bioRxiv,  2024.
From RNA interference to chromatin silencing, diverse genome defense pathways silence selfish genetic elements to safeguard genome integrity1,2. Despite their diversity, different defense pathways share a modular organization, where numerous specificity factors identify diverse ...

Modeling the Evolution of S. pombe Populations with Multiple Killer Meiotic Drivers

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José Fabricio López Hernández, Boris Y Rubinstein, Robert L Unckless, Sarah E Zanders,  G3 Genes|Genomes|Genetics,  2024.
Meiotic drivers are selfish genetic loci that can be transmitted to more than half of the viable gametes produced by a heterozygote. This biased transmission gives meiotic drivers an evolutionary advantage that can allow them to spread over generations until all members of a ...

Exploration of the potential of a boosted sterile insect technique to control fruit flies in mango orchards

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Esther Gnilane Diouf, Thierry Brévault, Saliou Ndiaye, Cyril Piou,  Pest Management Science,  2024.
An innovative version of the sterile insect technique (SIT) for pest control, called boosted SIT, relies on the use of sterile males coated with a biocide to control a target wild pest population of the same species. The objective of the present study was to assess the relevance ...

Eliminating malaria vectors with precision-guided sterile males

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Reema A. Apte, Andrea L. Smidler, James J. Pai, et al,  Applied Biological Sciences,  121. 2024.
Controlling the principal African malaria vector, the mosquito Anopheles gambiae, is considered essential to curtail malaria transmission. However, existing vector control technologies rely on insecticides, which are becoming increasingly ineffective. Sterile insect technique ...

Germline Cas9 promoters with improved performance for homing gene drive

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Du, J., Chen, W., Jia, X. et al.,  Nature Communications,  15:4560. 2024.
Gene drive systems could be a viable strategy to prevent pathogen transmission or suppress vector populations by propagating drive alleles with super-Mendelian inheritance. CRISPR-based homing gene drives convert wild type alleles into drive alleles in heterozygotes with Cas9 and ...

Upscaling irradiation protocols of Aedes albopictus pupae within an SIT program in Reunion Island

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Marquereau, L., Yamada, H., Damiens, D. et al.,  Scientific Reports,  14. 2024.
The implementation of the sterile insect technique against Aedes albopictus relies on many parameters, in particular on the success of the sterilization of males to be released into the target area in overflooding numbers to mate with wild females. Achieving consistent sterility ...

Simulation-based economic evaluation of the Wolbachia method in Brazil: a cost-effective strategy for dengue control

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Ivan Ricardo Zimmermann, Ricardo Ribeiro Alves Fernandes, Márcia Gisele Santos da Costa, et al,  The Lancet Regional Health - Americas,  35. 2024.
Dengue virus (DENV) is an arbovirus transmitted by Aedes aegypti mosquitoes, which can cause severe conditions such as hemorrhagic fever and dengue shock syndrome. These conditions are associated with adverse social, clinical, and economic consequences in Brazil. Herein, the ...

Curing mosquitoes with genetic approaches for malaria control

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Mary Kefi, Victor Cardoso-Jaime, Sally A. Saab, George Dimopoulos,  Trends in Parasitology,  2024.
Malaria remains a persistent global public health challenge because of the limitations of current prevention tools. The use of transgenic mosquitoes incapable of transmitting malaria, in conjunction with existing methods, holds promise for achieving elimination of malaria and ...

Transformation of meiotic drive into hybrid sterility in Drosophila

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Jackson Bladen, Hyuck-Jin Nam, Nitin Phadnis,  bioRxiv,  2024.
Hybrid male sterility is one of the fastest evolving intrinsic reproductive barriers between recently isolated populations. A leading explanation for the evolution of hybrid male sterility involves genomic conflicts with meiotic drivers in the male germline. There are, however, ...

A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae

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Ignacio Tolosana, Katie Willis, Austin Burt, Matthew Gribble, Tony Nolan, Andrea Crisanti, Federica Bernardini,  bioRxiv,  2024.
Genetic control – the deliberate introduction of genetic traits to control a pest or vector population – offers a powerful tool to augment conventional mosquito control tools that have been successful in reducing malaria burden but that are compromised by a range of ...

A small-molecule approach to restore female sterility phenotype targeted by a homing suppression gene drive in the fruit pest Drosophila suzukii

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Ma S, Ni X, Chen S, Qiao X, Xu X, Chen W, et al.,  PLoS Genetics,  2024.
CRISPR-based gene drives offer promising prospects for controlling disease-transmitting vectors and agricultural pests. A significant challenge for successful suppression-type drive is the rapid evolution of resistance alleles. One approach to mitigate the development of ...

Wolbachia symbionts control sex in a parasitoid wasp using a horizontally acquired gene

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Li C, Li CQ, Chen ZB, Liu BQ, Sun X, Wei KH, Li CY, Luan JB.,  Current Biology,  2024.
Host reproduction can be manipulated by bacterial symbionts in various ways. Parthenogenesis induction is the most effective type of reproduction manipulation by symbionts for their transmission. Insect sex is determined by regulation of doublesex (dsx) splicing through ...

Wolbachia infection-responsive immune genes suppress Plasmodium falciparum infection in Anopheles stephensi

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Vandana V, Dong S, Sheth T, Sun Q, Wen H, Maldonado A, et al.,  PLoS Pathogens,  20. 2024.
Wolbachia, a maternally transmitted symbiotic bacterium of insects, can suppress a variety of human pathogens in mosquitoes, including malaria-causing Plasmodium in the Anopheles vector. However, the mechanistic basis of Wolbachia-mediated Plasmodium suppression in mosquitoes is ...

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