Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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Comparing the long-term persistence of different Wolbachia strains after the release of bacteria-carrying mosquitoes

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Jose L. Orozco-Gonzales, Antone dos Santos Benedito, Daiver Cardona-Salgado et al.,  Mathematical Biosciences,  372. 2024.
This paper proposes a bidimensional modeling framework for Wolbachia invasion, assuming imperfect maternal transmission, incomplete cytoplasmic incompatibility, and direct infection loss due to thermal stress. Our model adapts to various Wolbachia strains and retains all ...

A naturally isolated symbiotic bacterium suppresses flavivirus transmission by Aedes mosquitoes

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Liming Zhang et al.,  Science,  384. 2024.
Flavivirus diseases are increasing in incidence and prevalence owing to the urban proclivities of its Aedes mosquito vector species. Extirpation of mosquitoes is considered key for the control of several human diseases but often involves toxic chemicals that prompt mosquito ...

Economic optimization of Wolbachia-infected Aedes aegypti release to prevent dengue

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Hollingsworth BD, Cho C, Vella M, Roh H, Sass J, Lloyd AL, Brown ZS.,  Pest Management Science,  2024.
Dengue virus, primarily transmitted by the Aedes aegypti mosquito, is a major public health concern affecting ≈3.83 billion people worldwide. Recent releases of Wolbachia-transinfected Ae. aegypti in several cities worldwide have shown that it can reduce dengue transmission. ...

Altering traits and fates of wild populations with Mendelian DNA sequence modifying Allele Sails

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Michelle L. Johnson, Bruce A. Hay, Maciej Maselko,  Nature Communications,  15. 2024.
Population-scale genome editing can be used to alter the composition or fate of wild populations. One approach to achieving these aims utilizes a synthetic gene drive element—a multi-gene cassette—to bring about an increase in the frequency of an existing allele. However, the ...

Genetic and geographic population structure in the malaria vector, Anopheles farauti, provides a candidate system for pioneering confinable gene-drive releases

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Ambrose, L., Allen, S.L., Iro’ofa, C. et al.,  Heredity,  2024.
Indoor insecticide applications are the primary tool for reducing malaria transmission in the Solomon Archipelago, a region where Anopheles farauti is the only common malaria vector. Due to the evolution of behavioural resistance in some An. farauti populations, these ...

The Perpetual Vector Mosquito Threat and Its Eco-Friendly Nemeses

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Miranda, L.S.; Rudd, S.R.; Mena, O.; Hudspeth, P.E.; Barboza-Corona, J.E.; Park, H.-W.; Bideshi, D.K.,  Biology,  13:182. 2024.
Aedes, Culex, and Anopheles mosquitoes are the most prolific arthropod vectors of viral and parasitic agents of debilitating and lethal diseases in humans and animals. Despite some success in integrated pest management programs to control vectors, mosquito-borne diseases, such as ...

Wolbachia Infection through Hybridization to Enhance an Incompatible Insect Technique-Based Suppression of Aedes albopictus in Eastern Spain

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Cholvi M, Trelis M, Bueno-Marí R, Khoubbane M, Gil R, Marcilla A, Moretti R.,  Insects,  15. 2024.
Wolbachia bacteria occur naturally as symbionts of many insect species and are responsible for various phenomena that modify the hosts’ reproductive biology. Among them, cytoplasmic incompatibility (CI) refers to the sterility of eggs produced by crosses between infected males ...

Detection and quantification of natural Wolbachia in Aedes aegypti in Metropolitan Manila, Philippines using locally designed primers

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Reyes JIL, Suzuki T, Suzuki Y, Watanabe K.,  Frontiers in Cellular and Infection Microbiology,  2024.
The Philippines bears health and economic burden caused by high dengue cases annually. Presently, the Philippines still lack an effective and sustainable vector management. The use of Wolbachia, a maternally transmitted bacterium, that mitigate arbovirus transmission has been ...

Talking About Gene Drive in Uganda: The Need for Science Communication to Underpin Engagement

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Hartley, S., Stelmach, A., Opesen, C., Openjuru, G. L., and Neema, S.,  Science Communication,  2024.
Uganda may host the world’s first field trials of gene drive mosquitoes for malaria control. Global North discourses pre-suppose African publics have access to information about gene drive and are ready to make decisions about its governance. We explore assumptions about the ...

Monitoring Aedes populations for arboviruses, Wolbachia, insecticide resistance and its mechanisms in various agroecosystems in Benin

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S. Ateutchia-Ngouanet, F. Nanfack-Minkeu, K. Mavridis, S. Wanji, M. Demanou, J. Vontas, R. Djouaka,  Acta Tropica,  253. 2024.
The susceptibility of arbovirus vectors to insecticides and the microbiome of Aedes species are understudied in Benin.

Between the lab and the Wild: Establishing the Potential of Gene Drive Mosquitoes for Malaria Control

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Mäkelin, M.,  Science as Culture,  2024.
Malaria control has been one of the defining goals in global health.

Wolbachia strain wAlbB shows favourable characteristics for dengue control use in Aedes aegypti from Burkina Faso

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Maria Vittoria Mancini, Shivan M. Murdochy, Etienne Bilgo, Thomas H. Ant, Daniel Gingell, Edounou Jacques Gnambani, Anna-Bella Failloux, Abdoulaye Diabate, Steven P. Sinkins,  Environmental Microbiology,  26. 2024.
Dengue represents an increasing public health burden worldwide.

Alpha-mannosidase-2 modulates arbovirus infection in a pathogen- and Wolbachia-specific manner in Aedes aegypti mosquitoes

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Nadya Urakova, Renuka E. Joseph, Allyn Huntsinger, Vanessa M. Macias, Matthew J. Jones, Leah T. Sigle, Ming Li, Omar S. Akbari, Zhiyong Xi, Konstantinos Lymperopoulos, Richard T. Sayre, Elizabeth A. McGraw, Jason L. Rasgon,  Insect Molecular Biology,  2024.
Multiple Wolbachia strains can block pathogen infection, replication and/or transmission in Aedes aegypti mosquitoes under both laboratory and field conditions.

Prophage proteins alter long noncoding RNA and DNA of developing sperm to induce a paternal-effect lethality

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Rupinder Kaur et al.,  Science,  383:1111-1117. 2024.
Many arthropods carry symbiotic bacteria. Some, including Wolbachia strains, have the capacity to cause male sterility.

Comparative analysis of Wolbachia maternal transmission and localization in host ovaries

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Michael T.J. Hague, Timothy B. Wheeler, Brandon S. Cooper,  bioRxiv,  2024.

Scientism, trust, value alignment, views of nature, and U.S. public opinion about gene drive mosquitos

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Evans, J. H., & Schairer, C. E.,  Public Understanding of Science,  2024.
Gene drive could be a powerful tool for addressing problems of conservation, agriculture, and human health caused by insect and animal pests but is likely to be controversial as it involves the release of genetically modified organisms. This study examined the social determinants ...

Acceptability of emergent Aedes aegypti vector control methods in Ponce, Puerto Rico: A qualitative assessment

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Pérez-Guerra CL, Rosado-Santiago C, Ramos SA, Marrero-Santos KM, González-Zeno G, Partridge SK, et al.,  PLoS Global Public Health,  2024.
Aedes aegypti control has been fraught with challenges in Puerto Rico. The government has implemented commonly used vector control methods, but arboviral epidemics still occur. It is necessary to explore new Ae. aegypti control methods. This study aimed to understand the ...

Efficacy of Wolbachia-based mosquito control: Predictions of a spatially discrete mathematical model

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David Dye, John W. Cain,  PLoS One,  19. 2024.
Wolbachia is an endosymbiont bacterium present in many insect species. When Wolbachia-carrying male Aedes aegypti mosquitoes mate with non-carrier females, their embryos are not viable due to cytoplasmic incompatibility. This phenomenon has been exploited successfully for the ...

Aedes aegypti Controls Ae. aegypti: SIT and IIT—An Overview

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Robert L. Aldridge; Seth Gibson; Kenneth J. Linthicum,  Journal of the American Mosquito Control Association,  20:32-49. 2024.
The sterile insect technique (SIT) and the incompatible insect technique (IIT) are emerging and potentially revolutionary tools for controlling Aedes aegypti (L.), a prominent worldwide mosquito vector threat to humans that is notoriously difficult to reduce or eliminate in ...

DENV-1 Titer Impacts Viral Blocking in wMel Aedes aegypti with Brazilian Genetic Background

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Corrêa-Antônio, Jessica, Mariana R. David, Dinair Couto-Lima, Gabriela Azambuja Garcia, Milan S. G. Keirsebelik, Rafael Maciel-de-Freitas, and Márcio Galvão Pavan.,  Viruses,  16. 2024.
Several countries have been using Wolbachia deployments to replace highly competent native Aedes aegypti populations with Wolbachia-carrying mosquitoes with lower susceptibility to arboviruses such as dengue, Zika, and chikungunya. In Rio de Janeiro, Wolbachia deployments started ...

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