Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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High-efficiency gene editing in Anopheles sinensis using ReMOT control

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X.-l. Yang, X. Ling, Q. Sun, P.-p. Qiu, K. Xiang, u.-f. JHong, S.-l. He, J. Chen, X. Ding, H. Hu, Z.-b. He, C. Zhou, B. Chen and L. Qiao,  bioRxiv,  2023.08.29.555096. 2023.
CRISPR/Cas9-mediated gene editing provides an effective method for deciphering the molecular mechanisms underlying mosquito development and mosquito-borne disease transmission, as well as for exploring genetic control strategies. However, delivering the Cas9 ribonucleoprotein ...

A recombinant Aspergillus oryzae fungus transmitted from larvae to adults of Anopheles stephensi mosquitoes inhibits malaria parasite oocyst development

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L. Kianifard, A. M. Rafiqi, O. Akcakir, A. S. I. Aly, P. F. Billingsley and S. Uysal,  Scientific Reports,  13:12177. 2023.
The control of malaria parasite transmission from mosquitoes to humans is hampered by decreasing efficacies of insecticides, development of drug resistance against the last-resort antimalarials, and the absence of effective vaccines. Herein, the anti-plasmodial transmission ...

Female meiotic drive in plants: mechanisms and dynamics

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F. Finseth,  Current Opinion in Genetics and Development,  82:102101. 2023.
Female meiosis is fundamentally asymmetric, creating an arena for genetic elements to compete for inclusion in the egg to maximize their transmission. Centromeres, as mediators of chromosomal segregation, are prime candidates to evolve via ‘female meiotic drive’. According to ...

Influence of environmental conditions on mass rearing parameters of tsetse flies at the Bobo-Dioulasso insectary (Burkina Faso): retrospective study

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K. S. M. Dera, B. A. Kaboré, S. Pagabeleguem, A. A. Ouedraogo, A. I. Toé, M. Ira, A. M. G. Belem and G. M. S. O. Sanou,  International Journal of Biological and Chemical Sciences,  17:1020-1032. 2023.
With the goal of eradicating tsetse flies and trypanosomiasis in Africa, several control methods have been developed. One of this is the biological control through the application of the sterile insect technique (SIT) as a part of an area-wide integrated pest management. This ...

Female meiotic drive shapes the distribution of rare inversion polymorphisms in Drosophila melanogaster

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S. A. Koury,  Genetics,  2023.
In all species, new chromosomal inversions are constantly being formed by spontaneous rearrangement and then stochastically eliminated from natural populations. In Drosophila, when new chromosomal inversions overlap with a pre-existing inversion in the population, their rate of ...

Gene drives for invasive wasp control: Extinction is unlikely, with suppression dependent on dispersal and growth rates

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P. J. Lester, D. O'Sullivan and G. L. W. Perry,  Ecological Applications,  2023.
Abstract Gene drives offer a potentially revolutionary method for pest control over large spatial extents. These genetic modifications spread deleterious variants through a population and have been proposed as methods for pest suppression or even eradication. We examined the ...

Proliferation and dissemination of killer meiotic drive loci

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E. C. Lai and A. A. Vogan,  Current Opinion in Genetics and Development,  82:102100. 2023.
Killer meiotic drive elements are selfish genetic entities that manipulate the sexual cycle to promote their own inheritance via destructive means. Two broad classes are sperm killers, typical of animals and plants, and spore killers, which are present in ascomycete fungi. Killer ...

Wolbachia has subtle effects on thermal preference in highly inbred Drosophila melanogaster which vary with life stage and environmental conditions

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A. Strunov, C. Schoenherr and M. Kapun,  Scientific Reports,  13:13792. 2023.
Temperature fluctuations are challenging for ectotherms which are not able to regulate body temperature by physiological means and thus have to adjust their thermal environment via behavior. However, little is yet known about whether microbial symbionts influence thermal ...

Effect of the Sterile Insect Technique and Augmentative Parasitoid Releases in a Fruit Fly Suppression Program in Mango-Producing Areas of Southeast Mexico

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J. Cancino, P. Montoya, F. O. Gálvez, C. Gálvez and P. Liedo,  Insects,  14. 2023.
The Sterile Insect Technique (SIT), by means of sterile male releases of Anastrepha ludens (Loew), coupled with Augmentative Biological Control (ABC), by releasing the parasitoid Diachasmimorpha longicaudata (Ashmead), was evaluated in a commercial mango production area for one ...

The impact of predators of mosquito larvae on Wolbachia spreading dynamics

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Z. Zhu, Y. Hui and L. Hu,  Journal of Biological Dynamics,  17:2249024. 2023.
Dengue fever creates more than 390 million cases worldwide yearly. The most effective way to deal with this mosquito-borne disease is to control the vectors. In this work we consider two weapons, the endosymbiotic bacteria Wolbachia and predators of mosquito larvae, for combating ...

wMel Wolbachia alters female post-mating behaviors and physiology in the dengue vector mosquito Aedes aegypti

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J. Osorio, S. Villa-Arias, C. Camargo, L. F. Ramírez-Sánchez, L. M. Barrientos, C. Bedoya, G. Rúa-Uribe, S. Dorus, C. Alfonso-Parra and F. W. Avila,  Communications Biology,  6:865. 2023.
Globally invasive Aedes aegypti disseminate numerous arboviruses that impact human health. One promising method to control Ae. aegypti populations is transinfection with Wolbachia pipientis, which naturally infects ~40–52% of insects but not Ae. aegypti. Transinfection of Ae. ...

Optimizing the delivery of self-disseminating vaccines in fluctuating wildlife populations

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C. Schreiner, A. Basinski, C. Remien and S. Nuismer,  PLOS Neglected Tropical Diseases,  17:e0011018. 2023.
Author summary Pathogens such as Ebola, rabies, and Lassa virus that usually infect wildlife can jump to the human population. In the worst case, this can lead to outbreaks or pandemics such as happened in 2014 with Ebola and 2019 with SARS-CoV-2. One approach to mitigate the ...

Wolbachia infection at least partially rescues the fertility and ovary defects of several new Drosophila melanogaster bag of marbles protein-coding mutants

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W. Miwa and F. A. Charles,  bioRxiv,  2023.03.20.532813. 2023.
The D. melanogaster protein coding gene bag of marbles (bam) plays a key role in early male and female reproduction by forming complexes with partner proteins to promote differentiation in gametogenesis. Like another germline gene, Sex lethal, bam genetically interacts with the ...

Single-cell profiling of Anopheles gambiae spermatogenesis defines the onset of meiotic silencing and premeiotic overexpression of the X chromosome

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N. Page, C. Taxiarchi, D. Tonge, J. Kuburic, E. Chesters, A. Kriezis, K. Kyrou, L. Game, T. Nolan and R. Galizi,  Commun Biol,  6:850. 2023.
Understanding development and genetic regulation in the Anopheles gambiae germline is essential to engineer effective genetic control strategies targeting this malaria mosquito vector. These include targeting the germline to induce sterility or using regulatory sequences to drive ...

Bioinformatic and literature assessment of toxicity and allergenicity of a CRISPR-Cas9 engineered gene drive to control Anopheles gambiae the mosquito vector of human malaria

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A. Qureshi and J. B. Connolly,  Malaria Journal,  22:234. 2023.
Population suppression gene drive is currently being evaluated, including via environmental risk assessment (ERA), for malaria vector control. One such gene drive involves the dsxFCRISPRh transgene encoding (i) hCas9 endonuclease, (ii) T1 guide RNA (gRNA) targeting the doublesex ...

Assessing the suitability of YY males and ZZ females as an invasive species population control method across life histories

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R. A. Erickson, H. M. Thompson, S. A. Kageyama, G. M. Andriacchi, A. R. Cupp, R. Patiño and J. J. Amberg,  Biological Invasions,  25:3737-3751. 2023.
Natural resource managers use tools to control invasive species. In theory, stocking YY males or ZZ females would allow managers to skew sex ratios until populations collapse. In combination with other suppression methods, such as removal, this approach could be incorporated into ...

Paternal genome elimination: patterns and mechanisms of drive and silencing

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M. Herbette and L. Ross,  Current Opinion in Genetics and Development,  81. 2023.
In thousands of arthropod species, males inherit, but subsequently eliminate the entire haploid genome of their father. However, why this peculiar reproductive strategy evolved repeatedly across diverse species and what mechanisms are involved in paternal genome elimination (PGE) ...

Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes

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W. Huang, J. Rodrigues, E. Bilgo, J. R. Tormo, J. D. Challenger, C. De Cozar-Gallardo, I. Pérez-Victoria, F. Reyes, P. Castañeda-Casado, E. J. Gnambani, D. F. d. S. Hien, M. Konkobo, B. Urones, I. Coppens, A. Mendoza-Losana, L. Ballell, A. Diabate, T. S.,  Science,  381:533-540. 2023.
Malaria control demands the development of a wide range of complementary strategies. We describe the properties of a naturally occurring, non?genetically modified symbiotic bacterium, Delftia tsuruhatensis TC1, which was isolated from mosquitoes incapable of sustaining the ...

Suppression Trial through an Integrated Vector Management of Aedes albopictus (Skuse) Based on the Sterile Insect Technique in a Non-Isolated Area in Spain

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C. Tur, D. Almenar, M. Zacarés, S. Benlloch-Navarro, I. Pla and V. Dalmau,  Insects,  14. 2023.
In recent years, Aedes albopictus (Skuse, 1984) has expanded its distribution globally due to its high ecological plasticity. This expansion has increased the population’s susceptibility to contracting diseases such as dengue, Zika, and chikungunya, among others, which are ...

wMel replacement of dengue-competent mosquitoes is robust to near-term change

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V. N. Vásquez, L. M. Kueppers, G. Rašić and J. M. Marshall,  Nature Climate Change,  13:848-855. 2023.
Rising temperatures are impacting the range and prevalence of mosquito-borne diseases. A promising biocontrol technology replaces wild mosquitoes with those carrying the virus-blocking Wolbachia bacterium. Because the most widely used strain, wMel, is adversely affected by heat ...

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