Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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Meiotic drive adaptive testes enlargement during early development in the stalk-eyed fly

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S. L. Bradshaw, L. Meade, J. Tarlton-Weatherall and A. Pomiankowski,  Biology Letters,  18:20220352. 2022.
The sex ratio (SR) X-linked meiotic drive system in stalk-eyed flies destroys Y-bearing sperm. Unlike other SR systems, drive males do not suffer fertility loss. They have greatly enlarged testes which compensate for gamete killing. We predicted that enlarged testes arise from ...

Does severe hypoxia during irradiation of Aedes aegypti pupae improve sterile male performance?

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D. A. Tussey, K. J. Linthicum and D. A. Hahn,  Parasites and Vectors,  15:446. 2022.
The yellow fever mosquito, Aedes aegypti, vectors several pathogens responsible for human diseases. As a result, this mosquito species is a priority for control by mosquito control districts in Florida. With insecticide resistance development becoming a concern, alternative ...

Engineering stringent genetic biocontainment of yeast with a protein stability switch

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S. A. Hoffmann and Y. Cai,  bioRxiv,  2022.11.24.517818. 2022.
Synthetic biology holds immense promise to tackle key problems we are facing, for instance in resource use, environmental health, and human health care. However, comprehensive safety measures are needed to deploy genetically engineered microorganisms in open-environment ...

Developing radiation-based sterile insect technique (SIT) for controlling Aedes aegypti: identification of a sterilizing dose

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C. Chen, R. L. Aldridge, S. Gibson, J. Kline, V. Aryaprema, W. Qualls, R.-d. Xue, L. Boardman, K. J. Linthicum and D. A. Hahn,  Pest Management Science,  2022.
Abstract Background The sterile insect technique (SIT) is emerging as a tool to supplement traditional pesticide-based control of Aedes aegypti, a prominent mosquito vector of microbes that have increased the global burden of human morbidity and mortality over the past 50?years. ...

Modeling-informed Engineered Genetic Incompatibility strategies to overcome resistance in the invasive Drosophila suzukii

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A. Sychla, N. R. Feltman, W. D. Hutchison and M. J. Smanski,  Frontiers in Insect Science,  2. 2022.
Engineered Genetic Incompatibility (EGI) is an engineered extreme underdominance genetic system wherein hybrid animals are not viable, functioning as a synthetic speciation event. There are several strategies in which EGI could be leveraged for genetic biocontrol of pest ...

A CRISPR endonuclease gene drive reveals distinct mechanisms of inheritance bias

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S. A. N. Verkuijl, E. Gonzalez, M. Li, J. X. D. Ang, N. P. Kandul, M. A. E. Anderson, O. S. Akbari, M. B. Bonsall and L. Alphey,  Nature Communications,  13:7145. 2022.
CRISPR/Cas gene drives can bias transgene inheritance through different mechanisms. Homing drives are designed to replace a wild-type allele with a copy of a drive element on the homologous chromosome. In Aedes aegypti, the sex-determining locus is closely linked to the white ...

The effect of mating complexity on gene drive dynamics

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P. Verma, R. G. Reeves, S. Simon, M. Otto and C. S. Gokhale,  The American Naturalist,  2022.
Gene drive technology promises to deliver on some of the global challenges humanity faces today in health care, agriculture, and conservation. However, there is a limited understanding of the consequences of releasing self-perpetuating transgenic organisms into wild populations ...

Driving lessons: a brief (personal) history of centromere drive

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H. S. Malik,  Genetics,  2022.
Meiosis is an important specialized cell division in many eukaryotic species, including fungi, plants, and animals. Meiosis results in the production of haploid gametes starting from a diploid cell via 1 round of replication and 2 rounds of cell division. In an influential ...

CRISPR-Mediated Cassette Exchange (CriMCE): A Method to Introduce and Isolate Precise Marker-Less Edits

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I. Morianou, A. Crisanti, T. Nolan and A. M. Hammond,  The CRISPR Journal,  2022.
The introduction of small unmarked edits to the genome of insects is essential to study the molecular underpinnings of important biological traits, such as resistance to insecticides and genetic control strategies. Advances in CRISPR genome engineering have made this possible, ...

A Wolbachia factor for male killing in lepidopteran insects

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S. Katsuma, K. Hirota, N. Matsuda-Imai, T. Fukui, T. Muro, K. Nishino, H. Kosako, K. Shoji, H. Takanashi, T. Fujii, S.-i. Arimura and T. Kiuchi,  Nature Communications,  13:6764. 2022.
Bacterial symbionts, such as Wolbachia species, can manipulate the sexual development and reproduction of their insect hosts. For example, Wolbachia infection induces male-specific death in the Asian corn borer Ostrinia furnacalis by targeting the host factor Masculinizer (Masc), ...

Independent evaluation of Wolbachia infected male mosquito releases for control of Aedes aegypti in Harris County, Texas, using a Bayesian abundance estimator

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S. Lozano, K. Pritts, D. Duguma, C. Fredregill and R. Connelly,  PLOS Neglected Tropical Diseases,  16:e0010907. 2022.
Among disease vectors, Aedes aegypti (L.) (Diptera: Culicidae) is one of the most insidious species in the world. The disease burden created by this species has dramatically increased in the past 50 years, and during this time countries have relied on pesticides for control and ...

Centromere drive: chromatin conflict in meiosis

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P. Talbert and S. Henikoff,  Current Opinion in Genetics and Development,  77:102005. 2022.
Centromeres are essential loci in eukaryotes that are necessary for the faithful segregation of chromosomes in mitosis and meiosis. Centromeres organize the kinetochore, the protein machine that attaches sister chromatids or homologous chromosomes to spindle microtubules and ...

Influence of public hesitancy and receptivity on reactive behaviours towards releases of male Wolbachia-Aedes mosquitoes for dengue control

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M. O. Lwin, Z. Ong, C. Panchapakesan, A. Sheldenkar, L. T. Soh, I. Chen, X. Li, W. Niah, K. Vasquez, S. Sim and L.-C. Ng,  PLOS Neglected Tropical Diseases,  16:e0010910. 2022.
Singapore, a highly urbanized Asian tropical country that experiences periodic dengue outbreaks, is piloting field releases of male Wolbachia-carrying Aedes aegyptimosquitoes with the aim of suppressing urban populations of the primary dengue vector Aedes aegypti. This study ...

Wolbachia inhibits ovarian formation and increases blood feeding rate in female Aedes aegypti

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M.-J. Lau, P. A. Ross, N. M. Endersby-Harshman, Q. Yang and A. A. Hoffmann,  PLOS Neglected Tropical Diseases,  16:e0010913. 2022.
Author summary Wolbachia bacteria reduce the transmission of dengue and other arboviruses transmitted by their mosquito hosts once they have invaded host populations. This invasion process is being undertaken in Aedes aegypti mosquito populations throughout the world but can be ...

Leveraging a natural murine meiotic drive to suppress invasive populations

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L. Gierus, A. Birand, M. D. Bunting, G. I. Godahewa, S. G. Piltz, K. P. Oh, A. J. Piaggio, D. W. Threadgill, J. Godwin, O. Edwards, P. Cassey, J. V. Ross, T. A. A. Prowse and P. Q. Thomas,  Proceedings of the National Academy of Sciences,  119:e2213308119. 2022.
Invasive rodents are a major cause of environmental damage and biodiversity loss, particularly on islands. Unlike insects, genetic biocontrol strategies including population-suppressing gene drives with biased inheritance have not been developed in mice. Here, we demonstrate a ...

Gene drive technologies: navigating the ethical landscape

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N. d. Graeff,  Utrecht University,  2022.
Gene drives are technologies that modify a particular genetic element in animals or insects so that this genetic element does not follow the typical rules of heredity, and is passed onto future generations with an increased likelihood. Gene drive technologies could be used to ...

Making waves: Comparative analysis of gene drive spread characteristics in a continuous space model

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M. Pan and J. Champer,  bioRxiv,  2022.11.01.514650. 2022.
With their ability to rapidly increase in frequency, gene drives can be used to modify or suppress target populations after an initial release of drive-containing individuals. Recent advances in this field have revealed many possibilities for different types of drives, and ...

Asymmetric Inheritance: The Diversity and Evolution of Non-Mendelian Reproductive Strategies

L. Ross, A. J. Mongue, C. N. Hodson and T. Schwander,  Annual Review of Ecology, Evolution, and Systematics,  53:1-23. 2022.
The ability to reproduce is the key trait that distinguishes living organisms from inorganic matter, and the strategies used to achieve successful reproduction are almost as diverse as the organisms themselves. In animals, the most widespread form of reproduction involves ...

GMOs in Africa: Status, adoption and public acceptance

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L. A. Gbadegesin, E. A. Ayeni, C. K. Tettey, V. A. Uyanga, O. O. Aluko, J. K. Ahiakpa, C. O. Okoye, J. I. Mbadianya, M. A. Adekoya, R. O. Aminu, F. P. Oyawole and P. Odufuwa,  Food Control,  141:109193. 2022.
Globally, genetically modified (GM) crops contribute to food security by increasing crop yield, quality and shelf-life. The commercialisation and adoption of GM crops in many developed countries raised hope of improving food security and livelihood. Africa, a developing continent ...

A sterile insect technique pilot trial on Captiva Island: defining mosquito population parameters for sterile male releases using mark–release–recapture

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D. O. Carvalho, R. Morreale, S. Stenhouse, D. A. Hahn, M. Gomez, A. Lloyd and D. Hoel,  Parasites and Vectors,  15:405. 2022.
The sterile insect technique (SIT), which involves area-wide inundative releases of sterile insects to suppress the reproduction of a target species, has proven to be an effective pest control method. The technique demands the continuous release of sterilized insects in ...

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