Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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Stability properties of underdominance in finite subdivided populations

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Altrock, PMT, A.; Reed, F. A.,  PLOS Computational Biology,  7:10. 2011.
In isolated populations underdominance leads to bistable evolutionary dynamics: below a certain mutant allele frequency the wildtype succeeds. Above this point, the potentially underdominant mutant allele fixes. In subdivided populations with gene flow there can be stable states ...

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

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Windbichler, NM, M.; Papathanos, P. A.; Thyme, S. B.; Li, H.; Ulge, U. Y.; Hovde, B. T.; Baker, D.; Monnat, R. J.; Burt, A.; Crisanti, A.,  Nature,  473:212-215. 2011.
Genetic methods of manipulating or eradicating disease vector populations have long been discussed as an attractive alternative to existing control measures because of their potential advantages in terms of effectiveness and species specificity(1-3). The development of ...

Selfish genetic elements, genetic conflict, and evolutionary innovation

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Werren, JH,  Proceedings of the National Academy of Sciences of the United States of America,  108:10863-10870. 2011.
Genomes are vulnerable to selfish genetic elements (SGEs), which enhance their own transmission relative to the rest of an individual's genome but are neutral or harmful to the individual as a whole. As a result, genetic conflict occurs between SGEs and other genetic elements in ...

Transcript profiling of the meiotic drive phenotype in testis of Aedes aegypti using suppressive subtractive hybridization

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Shin, DYJ, L. Z.; Lobo, N. F.; Severson, D. W.,  Journal of Insect Physiology,  57:1220-1226. 2011.
The meiotic drive gene in Aedes aegypti is tightly linked with the sex determination locus on chromosome 1, and causes highly male-biased sex ratios. We prepared cDNA libraries from testes from the Ae. aegypti 137 strain (driving) and RED strain (non-driving), and used ...

A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion in C. elegans

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Seidel, HSA, M.; Li, J. L.; van Oudenaarden, A.; Rockman, M. V.; Kruglyak, L.,  PLOS Biology,  9:e1001115. 2011.
The evolutionary fate of an allele ordinarily depends on its contribution to host fitness. Occasionally, however, genetic elements arise that are able to gain a transmission advantage while simultaneously imposing a fitness cost on their hosts. We previously discovered one such ...

Semele: A Killer-male, rescue-female system for suppression and replacement of insect disease vector populations

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Marshall, JMP, G. W.; Buchman, A. B.; Hay, B. A.,  Genetics,  187:535-551. 2011.
Two strategies to control mosquito-borne diseases, such as malaria and dengue fever, are reducing mosquito population sizes or replacing populations with disease-refractory varieties. We propose a genetic system, Semele, which may be used for both. Semele consists of two ...

Inverse Medea as a novel gene drive system for socal population replacement: A theoretical analysis

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Marshall, JMH, B. A.,  Journal of Heredity,  102:336-341. 2011.
One strategy to control mosquito-borne diseases, such as malaria and dengue fever, on a regional scale is to use gene drive systems to spread disease-refractory genes into wild mosquito populations. The development of a synthetic Medea element that has been shown to drive ...

Gene-drive into insect populations with age and spatial structure: a theoretical assessment

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Huang, YXL, A. L.; Legros, M.; Gould, F.,  Evolutionary Applications,  4:415-428. 2011.
The potential benefits and risks of genetically engineered gene-drive systems for replacing wild pest strains with more benign strains must be assessed prior to any field releases. We develop a computer simulation model to assess the feasibility of using engineered underdominance ...

Selective microspore abortion correlated with aneuploidy: an indication of meiotic drive

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Furness, CAR, P. J.,  Sexual Plant Reproduction,  24:1-8. 2011.
Selective megaspore abortion (monomegaspory) probably arose once in seed plants and occurs routinely in more than 70% of angiosperm species, representing one of the key characters of a heterosporous life history. In contrast, selective microspore abortion leading to pollen ...

Polar bodies–more a lack of understanding than a lack of respect

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S. Schmerler and G. M. Wessel,  Molecular Reproduction and Development,  78:3-8. 2010.
Polar bodies are as diverse as the organisms that produce them. Although in many animals these cells often die following meiotic maturation of the oocyte, in other organisms they are an essential and diverse part of embryonic development. Here we highlight some of this diversity ...

On the Well Posedness and Refined Estimates for the Global Attractor of the TYC Model

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R. D. Parshad and J. B. Gutierrez,  Boundary Value Problems,  2010.
The Trojan Y Chromosome strategy (TYC) is a theoretical method for eradication of invasive species. It requires constant introduction of artificial individuals into a target population, causing a shift in the sex ratio that ultimately leads to local extinction. In this work we ...

Problem formulation in the environmental risk assessment for genetically modified plants

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Wolt, JDK, Paul; Raybould, Alan; Fitzpatrick, Julie W.; Burachik, Moisés; Gray, Alan; Olin, Stephen S.; Schiemann, Joachim; Sears, Mark; Wu, Felicia,  Transgenic Research,  19:425-436. 2010.
Problem formulation is the first step in environmental risk assessment (ERA) where policy goals, scope, assessment endpoints, and methodology are distilled to an explicitly stated problem and approach for analysis. The consistency and utility of ERAs for genetically modified (GM) ...

Changes in sperm tail development associated with Y chromosome meiotic drive leading to an excess of males in the medfly Ceratitis capitata (Diptera: Tephritidae)

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Rendon, PAB, R. D.; Wood, R. J.,  Biological Journal of the Linnean Society,  101:351-359. 2010.
The Mediterranean fruit fly Ceratitis capitata (Wied.) normally produces the sexes in equal ratio but strains carrying the Y chromosome meiotic drive MP (male-producing) factor show an excess of males. This is associated with a loss of sperm, and abnormal sperm structure in terms ...

The role of meiotic drive in hybrid male sterility

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McDermott, SRN, M. A. F.,  Philosophical Transactions of the Royal Society B-Biological Sciences,  365:1265-1272. 2010.
Meiotic drive causes the distortion of allelic segregation away from Mendelian expected ratios, often also reducing fecundity and favouring the evolution of drive suppressors. If different species evolve distinct drive-suppressor systems, then hybrid progeny may be sterile as a ...

Segregation distortion and the evolution of sex-determining mechanisms

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Kozielska, MW, F. J.; Beukeboom, L. W.; Pen, I.,  Heredity,  104:100-112. 2010.
Segregation distorters are alleles that distort normal segregation in their own favour. Sex chromosomal distorters lead to biased sex ratios, and the presence of such distorters, therefore, may induce selection for a change in the mechanism of sex determination. The evolutionary ...

Games in tetrads: Segregation, recombination, and meiotic drive

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Haig, D,  American Naturalist,  176:404-413. 2010.
The two alleles at a heterozygous locus segregate during meiosis, sometimes at meiosis I and sometimes at meiosis II. The timing of segregation is determined by the pattern of crossing-over between a locus and its attached centromeres. Genes near centromeres can exploit this ...

Segregation analysis of a sex ratio distortion locus in congenic mice

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Casellas, JF, C. R.; Verdugo, R. A.; Medrano, J. F.,  Journal of Heredity,  101:351-359. 2010.
The congenic HG.CAST-(D17Mit196-D17Mit190) (HQ17(hg/hg)) mouse strain showed a significant departure on the expected 50%/50% offspring sex ratio in more than 2400 progeny (55.7% females). The entire pedigree file included data from 13 nonoverlapping purebred generations and an ...

Segregation distortion in chicken and the evolutionary consequences of female meiotic drive in birds

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Axelsson, EA, A.; Van, A. P.; Li, L.; Megens, H. J.; Vereijken, A. L. J.; Crooijmans, Rpma; Groenen, M. A. M.; Ellegren, H.; Willerslev, E.; Nielsen, R.,  Heredity,  105:290-298. 2010.
As all four meiotic products give rise to sperm in males, female meiosis result in a single egg in most eukaryotes. Any genetic element with the potential to influence chromosome segregation, so that it is preferentially included in the egg, should therefore gain a transmission ...

Using underdominance to bi-stably transform local populations

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Altrock, PMT, A.; Reeves, R. G.; Reed, F. A.,  Journal of Theoretical Biology,  267:62-75. 2010.
Underdominance refers to natural selection against individuals with a heterozygous genotype. Here, we analyze a single-locus underdominant system of two large local populations that exchange individuals at a certain migration rate. The system can be characterized by fixed points ...

On the global attractor of the Trojan Y chromosome model.

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R. D. Parshad and J. B. Gutierrez,  Communications on Pure and Applied Analysis,  10:339-359. 2010.
We consider the Trojan Y Chromosome (TYC) model for eradication of invasive species in population dynamics. We present global estimates for the TYC system in a spatial domain. In this work we prove the existence of a global attractor for the system. We derive uniform estimates to ...

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