Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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Putting the brake on drive: meiotic drive of t haplotypes in natural populations of mice

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Ardlie, KG,  Trends in Genetics,  14:189-193. 1998.
Mouse t haplotypes are a 'selfish' form of chromosome 17 that show non-mendelian transmission from heterozygous +/t males. The considerable transmission bias in favour of t haplotypes should result in very high frequencies of these chromosomes in natural populations, but they ...

Polymorphism for Y-linked suppressors of sex-ratio in two natural populations of Drosophila mediopunctata

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Carvalho, ABV, S. C.; Klaczko, L. B.,  Genetics,  146:891-902. 1997.
In several Drosophila species there is a trait known as ''sex-ratio'': males carrying certain X chromosomes (called ''SR'') produce female biased progenies due to X-Y meiotic drive. In Drosophila mediopunctata this trait has a variable expression due to Y-linked suppressors of ...

Identification of a male meiosis-specific gene, Tcte2, which is differentially spliced in species that form sterile hybrids with laboratory mice and deleted in t chromosomes showing meiotic drive

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Braidotti, GB, D. P.,  Developmental Biology,  186:85-99. 1997.
Tcte2 (t complex testes expressed 2) is a male meiosis-specific gene that maps to band 3.3 of mouse chromosome 17. Two distinct male fertility defects, hybrid sterility and transmission ratio distortion, have previously been mapped to this region. Hybrid sterility arises in ...

The sex-ratio trait in Drosophila simulans: Geographical distribution of distortion and resistance

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Atlan, AM, H.; Landre, C.; Montchamp-Moreau, C.,  Evolution,  51:1886-1895. 1997.
The sex-ratio trait we describe here in Drosophila simulans results from X-linked meiotic drive. Males bearing a driving X chromosome can produce a large excess of females (about 90%) in their progeny. This is, however, rarely the case in the wild, where resistance factors, ...

Non-Mendelian transmission at the Machado-Joseph disease locus in normal females: Preferential transmission of alleles with smaller CAG repeats

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Rubinsztein, DCL, J.,  Journal of Medical Genetics,  34:234-236. 1997.
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is a neurodegenerative disorder which is associated with a CAG repeat expansion in the MJD1 gene on chromosome 14q32.1. A recent study reported an excess of transmission of disease chromosomes relative to ...

Sex chromosome meiotic drive in stalk-eyed flies

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Presgraves, DCS, E.; Wilkinson, G. S.,  Genetics,  147:1169-1180. 1997.
Meiotically driven sex chromosomes can quickly spread to fixation and cause population extinction unless balanced by selection or suppressed by genetic modifiers. We report results of genetic analyses that demonstrate that extreme female-biased sex ratios in two sister species of ...

Variation in Y chromosome meiotic drive in Aedes aegypti (Diptera: Culicidae): a potential genetic approach to mosquito control

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OwusuDaaku, KOW, R. J.; Butler, R. D.,  Bulletin of Entomological Research,  87:617-623. 1997.
Reciprocal crosses between strains of Aedes aegypti (Linnaeus) from different geographical areas have revealed an unexpectedly complex pattern of holandrically inherited male biased sex ratios in F2. The variation has been interpreted in terms of a web of X-Y interactions in F1, ...

Selected lines of Aedes aegypti with persistently distorted sex ratios

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OwusuDaaku, KOW, R. J.; Butler, R. D.,  Heredity,  79:388-393. 1997.
A breeding scheme to isolate X chromosomes sensitive to drive by the T8 (Trinidad) Y chromosome of Aedes aegypti (the MD haplotype) is reported. Crosses with an Australian strain Th.I (Thursday Island) revealed not only sensitive and resistant X chromosomes but also some with the ...

Abnormal spermiogenesis is associated with the X-linked sex-ratio trait in Drosophila simulans

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MontchampMoreau, CJ, D.,  Heredity,  79:24-30. 1997.
The sex-ratio trait, known in several Drosophila species, results from X-linked meiotic drive that affects Y-bearing sperm and causes males to produce female-biased progeny. We describe spermiogenesis in three types of D, simulans males: wild-type, sex-ratio, and males that bear ...

Meiotic drive at the myotonic dystrophy and the cone-rod dystrophy loci on chromosome 19q13.3

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Inglehearn, CFG, C. Y.,  American Journal of Human Genetics,  60:1562-1563. 1997.
The apparently conflicting observations of a high new mutation rate at the myotonic dystrophy (DM) locus on chromosome 19q13.3 and of a founder effect for DM chromosomes led researchers to invoke the influence of meiotic drive at this locus. Two studies (Carey et al. 1994; ...

Segregation distortion in unstructured and structured populations: Competition between ‘sterile’ t haplotypes

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VanBoven, MW, F. J.,  Netherlands Journal of Zoology,  46:216-226. 1996.
By means of two simple models we investigate the competition between sex-specific segregation distorters in unstructured and structured populations. The models are motivated by the t complex of the house mouse. Some variants at this gene complex, the t haplotypes, distort ...

Competition between segregation distorters: Coexistence of ”superior” and ”inferior” haplotypes at the t complex

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vanBoven, MW, F. J.; Heg, D.; Huisman, J.,  Evolution,  50:2488-2498. 1996.
By means of population genetical models, we investigate the competition between sex-specific segregation distorters. Although the models are quite general, they are motivated by a specific example, the t complex of the house mouse. Some variants at this gene complex, the t ...

Genetic control of B chromosome transmission rate in Zea mays ssp mays (Poaceae)

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Rosato, MC, A. M.; Naranjo, C. A.; Puertas, M. J.; Poggio, L.,  American Journal of Botany,  83:1107-1112. 1996.
We selected genotypes of high and low B chromosome transmission rate (TR) in a native race of maize (Pisingallo) from northwest Argentina. We made 20 female 0B x male 1B and 20 f.1B x m.0B crosses. The former (G0m) showed a large variation of B TR, with a mean of TR +/- SE = 0.52 ...

Measuring meiotic drive

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Robbins, LGP, G.; Bonaccorsi, S.; Pimpinelli, S.,  Genetics,  142:645-647. 1996.
LAURENCE HURST’S (1996) letter re-examines our data on the effect of Stellate copy number on the meiotic parameters of Mystal- (= su(ste)-) males (PALUMBO et al. 1994). In our analysis, we found a tight correlation of fertility and disjunction with Stellate copy number, with ...

Meiotic drive in fungi: Chromosomal elements that cause fratricide and distort genetic ratios

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Raju, NB,  Journal of Genetics,  75:287-296. 1996.
Fungal Spore killers (Sk), studied most extensively in Neurospora and to a lesser extent in Podospora, Gibberella and Cochliobolus, cause the death of ascospores (= meiospores) that do not contain the killer (Sk(K)) element. When a Spore killer is heterozygous (Sk(K) x Sk(S)) in ...

Epistatic control of non-mendelian inheritance in mouse interspecific crosses

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Montagutelli, XT, R.; Nadeau, J. H.,  Genetics,  143:1739-1752. 1996.
Strong deviation of allele frequencies from Mendelian inheritance favoring Mus spretus-derived alleles has been described previously for X-linked loci in four mouse interspecific crosses. We reanalyzed data for three of these crosses focusing on the location of the gene(s) ...

The effect of B chromosomes on mating success of the grasshopper Eyprepocnemis plorans

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Martin, SA, P.; HenriquesGil, N.,  Genetica,  97:197-203. 1996.
The mating ability of E. plorans was tested in laboratory conditions in six experimental units composed of ten males and fifteen females during 31 days. When significant differences were found (three from the six cages, and in totals) they involved a decrease of matings involving ...

Analysis of meiotic segregation, using single-sperm typing: Meiotic drive at the myotonic dystrophy locus

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Leeflang, EPM, M. S.; Arnheim, N.,  American Journal of Human Genetics,  59:896-904. 1996.
Meiotic drive at the myotonic dystrophy (DM) locus has recently been suggested as being responsible for maintaining the frequency, in the human population, of DM chromosomes capable of expansion to the disease state. In order to test this hypothesis, we have studied samples of ...

The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein

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King, SMD, J. F.; Benashski, S. E.; Lye, R. J.; PatelKing, R. S.; Pfister, K. K.,  Journal of Biological Chemistry,  271:32281-32287. 1996.
Mammalian brain cytoplasmic dynein contains three light chains of M(r) = 8,000, 14,000, add 22,000 (King, S. M., Barbarese, E., Dillman, J. F., III, Patel-King, R. S., Carson, J. H., and Pfister, K. Kr (1996) J. Biol. Chem. 271, 19358-19366). Peptide sequence data (16/16 residues ...

Further evidence consistent with Stellate’s involvement in meiotic drive

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Hurst, LD,  Genetics,  142:641-643. 1996.
STELLATE is an X-linked multicopy gene found in Drosophila melanogaster and is one of the most bizarre gene arrays yet described (for details see HARDY et al. 1984; LIVAK 1984, 1990; DANILEVSKAYA et al. 1991; BAW~REVA et al. 1992; SHEVELYOV 1992; PALUMBO et al. 1994). The ...

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