Scholarly Literature
This is an aggregation of scholarly literature from peer-reviewed journals, bioRxiv , medRxiv and arXiv preprint servers focused on natural and engineered selfish genetic elements and genetic biocontrol. New citations are added as they appear. This content is intended for anyone interested in the scholarly literature on gene drive and genetic biocontrol.
Gene Editing and Genetic Control of Hemipteran Pests: Progress, Challenges and Perspectives
Tags: CRISPR, Gene editing, Genetic biocontrol, Genetically modified organismsI. D. Pacheco, L. L. Walling and P. W. Atkinson, Frontiers in Bioengineering and Biotechnology, 10. 2022.
The origin of the order Hemiptera can be traced to the late Permian Period more than 230 MYA, well before the origin of flowering plants 100 MY later in during the Cretaceous period. Hemipteran species consume their liquid diets using a sucking proboscis; for phytophagous ...
Beware the Unknown: Views on Genetic Technology in Conservation
H. G. W. Dixson, J. Balanovic, F. Medvecky, E. D. Edwards and E. A. MacDonald, Narrative Inquiry in Bioethics, 12. 2022.Artificial Gene Drive (GD) may offer a number of transformative impacts on society. Despite potential usage in the area of conservation, GD remains largely unfamiliar to the public and little is known about their views. In our study, participants from New Zealand were placed in ...
Establishment of Wolbachia infection in Aedes aegypti from Pakistan via embryonic microinjection and semi-field evaluation of general fitness of resultant mosquito population
Tags: Aedes, Cytoplasmic incompatibility, Genetic biocontrol, Incompatible insect technique, WolbachiaM. S. Sarwar, N. Jahan, A. Ali, H. K. Yousaf and I. Munzoor, Parasites and Vectors, 15:191. 2022.
BACKGROUND: Dengue is a mosquito-borne viral disease that is mainly spread by Aedes aegypti. It is prevalent on five continents, predominantly in tropical and sub-tropical zones across the world. Wolbachia bacteria have been extensively used in vector control strategies ...
Non-Mendelian segregation and transmission drive of B chromosomes
Tags: Chromosomal drive, Selfish genetic elements, Transmission distortionJ. P. M. Camacho, Chromosome Research, 2022.
Selfish genetic elements (SGE) get a transmission advantage (drive) thanks to their non-Mendelian inheritance. Here I identify eight steps during the reproductive cycle that can be subverted by SGEs to thrive in natural populations. Even though only three steps occur during ...
The maize abnormal chromosome 10 meiotic drive haplotype: a review
Tags: Agriculture, Chromosomal driveR. K. Dawe, Chromosome Research, 2022.
The maize abnormal chromosome 10 (Ab10) haplotype encodes a meiotic drive system that converts heterochromatic knobs into centromere-like bodies that are preferentially segregated through female meiosis. Ab10 was first described in the 1940s and has been intensively studied. Here ...
Testing non-autonomous antimalarial gene drive effectors using self-eliminating drivers in the African mosquito vector Anopheles gambiae
Tags: Anopheles, Gene drive synthetic, Malaria, Population modification/replacementD. A. Ellis, G. Avraam, A. Hoermann, C. A. S. Wyer, Y. X. Ong, G. K. Christophides and N. Windbichler, PLOS Genetics, 18:e1010244. 2022.
Author summary Gene drive is a method that allows the genetic modification of entire populations of harmful organisms. Their application to tackle invasive species, agricultural pests or insect disease vectors has been suggested. For example, they could reduce the capacity of ...
Modifying mosquitoes to suppress disease transmission: Is the long wait over?
Tags: Aedes, Anopheles, Dengue, Genetic biocontrol, Genetically modified mosquitoes, Malaria, WolbachiaJ. R. Powell, Genetics, 2022.
For more than 50 years it has been a dream of medical entomologists and public health workers to control diseases like malaria and dengue fever by modifying, through genetics and other methods, the arthropods that transmit them to humans. A brief synopsis of the history of ...
A meiotic driver alters sperm form and function in house mice: a possible example of spite
Tags: Rodents, Transmission distortionL. Winkler and A. K. Lindholm, Chromosome Research, 2022.
The ability to subvert independent assortment of chromosomes is found in many meiotic drivers, such as the t haplotype in house mice Mus musculus, in which the t-bearing chromosomal homolog is preferentially transmitted to offspring. This is explained by a poison-antidote system, ...
Wolbachia interacts with the microbiome to shape fitness-associated traits during seasonal adaptation in Drosophila melanogaster
Tags: Incompatible insect technique, Other Symbionts, Population modification/replacement, Population suppression, WolbachiaL. P. Henry, M. Fernandez, S. Wolf and J. Ayroles, bioRxiv, 2022.05.31.494239. 2022.
The microbiome contributes to many different host traits, but its role in host adaptation remains enigmatic. The fitness benefits of the microbiome often depend on ecological conditions, but fluctuations in both the microbiome and environment modulate these fitness benefits. ...
Exploring value change
Tags: Ethics, Gene drive synthetic, Policy, Stakeholder engagementT. E. de Wildt and V. J. Schweizer, Prometheus, 38. 2022.
This article aims to explore the use of cross-impact balances (CIB) to identify scenarios of value change. The possibility of value change has received little attention in the literature on value-sensitive design (VSD). Examples of value change include the emergence of new values ...
Modeling the impact of genetically modified male mosquitoes in the spatial population dynamics of Aedes aegypti
Tags: Aedes, Arbovirus, Dengue, Genetic biocontrol, ModelingM. R. da Silva, P. H. G. Lugão, F. Prezoto and G. Chapiro, Scientific Reports, 12:9112. 2022.
The mosquito Aedes aegypti is the primary vector of diseases such as dengue, Zika, chikungunya, and yellow fever. Improving control techniques requires a better understanding of the mosquito’s life cycle, including spatial population dynamics in endemic regions. One of the most ...
Combined Trojan Y Chromosome Strategy and Sterile Insect Technique to Eliminate Mosquitoes: Modelling and Analysis
Tags: Modeling, Sex distorter, Sterile insect technique (SIT)J. Lyu, M. Gu, S. Wang and K. Cheng, Mathematical Problems in Engineering, 2022:2373350. 2022.
Sterile insect technique has been successfully applied in the control of agricultural pests; however, it has a limited ability to control mosquitoes. A promising alternative approach is the Trojan Y Chromosome strategy, which works by manipulating the sex ratio of a population ...
Optimization of Aedes albopictus (Diptera: Culicidae) Mass Rearing through Cost-Effective Larval Feeding
Tags: Sterile insect technique (SIT)M. Kavran, A. Puggioli, S. Šiljegović, D. Čanadžić, N. Laćarac, M. Rakita, A. Ignjatović Ćupina, F. Balestrino, D. Petrić and R. Bellini, Insects, 13. 2022.
Aedes (Stegomyia) albopictus (Skuse, 1895) is an invasive important medical and veterinary pest species. The sterile insect technique (SIT) involves the mass rearing of males, and their sterilization and release into the habitat to compete with wild males. Our research objective ...
Reply to: Assessing the efficiency of Verily’s automated process for production and release of male Wolbachia-infected mosquitoes
Tags: Aedes, Incompatible insect technique, Sterile insect technique (SIT), WolbachiaJ. E. Crawford, K. C. Hopkins, A. Buchman, T. Zha, P. Howell, E. Kakani, J. R. Ohm, N. Snoad, L. Upson, J. Holeman, P. Massaro, S. L. Dobson, F. S. Mulligan and B. J. White, Nature Biotechnology, 2022.
We appreciate the comments from Bouyer et al. under their mandate as a United Nations agency program (‘to promote the safe and appropriate use of nuclear techniques and related technologies in food and agriculture’) on our paper1 . The centuries-old fight against ...
Assessing the efficiency of Verily’s automated process for production and release of male Wolbachia-infected mosquitoes
Tags: Aedes, Incompatible insect technique, Sterile insect technique (SIT), WolbachiaJ. Bouyer, H. Maiga and M. J. B. Vreysen, Nature Biotechnology, 2022.
A paper by Crawford et al.1 titled ‘Efficient production of male Wolbachia-infected Aedes aegypti mosquitoes enables large-scale suppression of wild populations’ reports a mosquito control suppression trial carried out from2017 to 2018 in Fresco Country, California, USA1 . ...
Recommendations for environmental risk assessment of gene drive applications for malaria vector control
Tags: Gene drive synthetic, Malaria, Modeling, Population suppression, Risk and safety, Stakeholder engagement, Vector controlJ. B. Connolly, J. D. Mumford, D. C. M. Glandorf, S. Hartley, O. T. Lewis, S. W. Evans, G. Turner, C. Beech, N. Sykes, M. B. Coulibaly, J. Romeis, J. L. Teem, W. Tonui, B. Lovett, A. Mankad, A. Mnzava, S. Fuchs, T. D. Hackett, W. G. Landis, J. M. Marshall, Malar J, 21:152. 2022.
Building on an exercise that identified potential harms from simulated investigational releases of a population suppression gene drive for malaria vector control, a series of online workshops identified nine recommendations to advance future environmental risk assessment of gene ...
Perplexing dynamics of Wolbachia proteins for cytoplasmic incompatibility
Tags: Cytoplasmic incompatibility, Modeling, Toxin-antidote, WolbachiaT. Harumoto and T. Fukatsu, PLOS Biology, 20:e3001644. 2022.
The mechanism of symbiont-induced cytoplasmic incompatibility has been a long-lasting mystery. This Primer explores a new study on Wolbachia’s Cif proteins in PLOS Biology that provides supportive evidence for the “Host-Modification Model,” although the alternative ...
A nickase Cas9 gene-drive system promotes super-Mendelian inheritance in Drosophila
Tags: CRISPR, Fruit fly, Gene drive syntheticV. L. Del Amo, S. S. Juste and V. M. Gantz, Cell Rep, 39:110843. 2022.
CRISPR-based gene-drives have been proposed for managing insect populations, including disease-transmitting mosquitoes, due to their ability to bias their inheritance toward super-Mendelian rates (>50%). Current technologies use a Cas9 that introduces DNA double-strand breaks ...
The Cif proteins from Wolbachia prophage WO modify sperm genome integrity to establish cytoplasmic incompatibility
Tags: Cytoplasmic incompatibility, Transmission distortion, WolbachiaR. Kaur, B. A. Leigh, I. T. Ritchie and S. R. Bordenstein, PLOS Biology, 20:e3001584. 2022.
In Drosophila melanogaster, germline expression of the Wolbachia proteins CifA and CifB causes cytoplasmic incompatibility, but how this impairs male reproduction remains unclear. This study shows how Cif proteins encoded by the endosymbiont prophage invade the fly’s gametic ...
Wolbachia 16S rRNA haplotypes detected in wild Anopheles stephensi in eastern Ethiopia
Tags: Anopheles, Genetic biocontrol, Invasive species, Mosquitoes, Population modification/replacement, Population suppression, WolbachiaE. Waymire, S. Duddu, S. Yared, D. Getachew, D. Dengela, S. R. Bordenstein, M. Balkew, S. Zohdy, S. R. Irish and T. E. Carter, Parasites and Vectors, 15:178. 2022.
About two out of three Ethiopians are at risk of malaria, a disease caused by the parasites Plasmodium falciparum and Plasmodium vivax. Anopheles stephensi, an invasive vector typically found in South Asia and the Middle East, was recently found to be distributed across eastern ...
Strategies to Mitigate Establishment under the Wolbachia Incompatible Insect Technique
Tags: Cytoplasmic incompatibility, Genetic biocontrol, Incompatible insect technique, Population suppression, Sterile insect technique (SIT), WolbachiaS. Soh, S. H. Ho, J. Ong, A. Seah, B. S. Dickens, K. W. Tan, J. R. Koo, A. R. Cook, S. Sim, C. H. Tan, L. C. Ng and J. T. Lim, Viruses, 14. 2022.
The Incompatible Insect Technique (IIT) strategy involves the release of male mosquitoes infected with the bacterium Wolbachia. Regular releases of male Wolbachia-infected mosquitoes can lead to the suppression of mosquito populations, thereby reducing the risk of transmission of ...
Novel molecular approaches to combat vectors and vector-borne viruses: Special focus on RNA interference (RNAi) mechanisms
Tags: Arbovirus, Genetic biocontrolA. Agarwal, D. K. Sarma, D. Chaurasia and H. S. Maan, Acta Tropica, 2022.
Vector-borne diseases, such as dengue, chikungunya, zika, yellow fever etc pose significant burden among the infectious diseases globally, especially in tropical and sub-tropical regions. Globalization, deforestation, urbanization, climate change, uncontrolled population growth, ...
Quality Control and Mating Performance of Irradiated Glossina palpalis gambiensis Males
Tags: Genetic biocontrol, Other arthropods, Sterile insect technique (SIT)K. Ilboudo, K. Camara, E. W. Salou and G. Gimonnea, Insects, 13. 2022.
The biological quality of sterile male insects produced in a mass-rearing facility is a prerequisite for the success of the SIT, which is a component of area-wide integrated pest management (AW-IPM). Indeed, sterile male insects released in the field must have a good mating ...
Elimination of a closed population of the yellow fever mosquito, Aedes aegypti, through releases of self-limiting male mosquitoes
Tags: Aedes, Asia, Dengue, Oxitec, Sterile insect technique (SIT)P. B. Patil, S. K. Dasgupta, K. Gorman, A. Pickl-Herk, M. Puinean, A. McKemey, B. Char, U. B. Zehr and S. R. Barwale, PLOS Neglected Tropical Diseases, 16:e0010315. 2022.
Author summary Aedes aegypti L. species is the primary vector responsible for transmission of the dengue virus worldwide including chikungunya, yellow fever and Zika virus. The experiment presented in the manuscript represents a study undertaken to demonstrate suppression of the ...
Bayesian network-based risk assessment of synthetic biology: Simulating CRISPR-Cas9 gene drive dynamics in invasive rodent management
Tags: Gene drive synthetic, Invasive species, Pest management, Risk assessment, Rodents, Synthetic biologyE. A. Brown, S. R. Eikenbary and W. G. Landis, Risk Analysis, 2022.
Gene drive technology has been proposed to control invasive rodent populations as an alternative to rodenticides. However, this approach has not undergone risk assessment that meets criteria established by Gene Drives on the Horizon, a 2016 report by the National Academies of ...
Aquatic invasive species specialists’ perceptions on the importance of genetic tools and concepts to inform management
Tags: Fish, Gene drive synthetic, Genetic biocontrol, Invasive species, Pest management, Sex distorterT. A. Bernos, K. M. Jeffries and N. E. Mandrak, Biological Invasions, 24:1863-1879. 2022.
Perceptions related to the importance of genetic research influence the mobilization of genetic tools and concepts to inform conservation actions. Research characteristics, stakeholders’ perspectives, knowledge, and social linkages with geneticists influence the outcome of ...
Simple, sensitive, and cost-effective detection of wAlbB Wolbachia in Aedes mosquitoes, using loop mediated isothermal amplification combined with the electrochemical biosensing method
Tags: Aedes, Dengue, Field trials, WolbachiaP. Thayanukul, B. Lertanantawong, W. Sirawaraporn, S. Charasmongkolcharoen, T. Chaibun, R. Jittungdee and P. Kittayapong, PLOS Neglected Tropical Diseases, 16:e0009600. 2022.
Author summary Mosquito-borne diseases such as dengue, chikungunya, zika, and yellow fever are transmitted to humans mainly by the bites of Aedes aegypti mosquitoes. Controlling the vectors of these diseases relies mostly on the use of insecticides. However, the efficiency has ...
Intronic gRNAs for the Construction of Minimal Gene Drive Systems
Tags: CRISPR, Fruit fly, Gene drive syntheticA. Nash, P. Capriotti, A. Hoermann, P. A. Papathanos and N. Windbichler, Frontiers in Bioengineering and Biotechnology, 10. 2022.
Gene drives are promising tools for the genetic control of insect vector or pest populations. CRISPR-based gene drives are generally highly complex synthetic constructs consisting of multiple transgenes and their respective regulatory elements. This complicates the generation of ...
Lessons learned from the introduction of genetically engineered crops: relevance to gene drive deployment in Africa
Tags: Africa, Gene drive syntheticH. Quemada, Transgenic Res, 2022.
The application of gene drives to achieve public health goals, such as the suppression of Anopheles gambiae populations, or altering their ability to sustain Plasmodium spp. infections, has received much attention from researchers. If successful, this genetic tool can contribute ...
Double-tap gene drive uses iterative genome targeting to help overcome resistance alleles
Tags: CRISPR, Gene drive synthetic, Replicator/site directed nuclease, ResistanceA. L. Bishop, V. López Del Amo, E. M. Okamoto, Z. Bodai, A. C. Komor and V. M. Gantz, Nat Commun, 13:2595. 2022.
Homing CRISPR gene drives could aid in curbing the spread of vector-borne diseases and controlling crop pest and invasive species populations due to an inheritance rate that surpasses Mendelian laws. However, this technology suffers from resistance alleles formed when the ...
Adversarial interspecies relationships facilitate population suppression by gene drive in spatially explicit models
Tags: Gene drive, Gene drive synthetic, Modeling, Mosquitoes, Population suppression, Replicator/site directed nucleaseY. Liu, W. Teo, H. Yang and J. Champer, bioRxiv, 2022.05.08.491087. 2022.
Suppression gene drives are designed to bias their inheritance and increase in frequency in a population, disrupting an essential gene in the process. When the frequency is high enough, the population will be unable to reproduce above the replacement level and could be ...
Local adaptation of Aedes aegypti mosquitoes to Wolbachia-induced fitness costs
Tags: Genetic biocontrol, Mosquito husbandry, Population modification/replacement, WolbachiaP. A. Ross and A. A. Hoffmann, bioRxiv, 2022.05.06.490959. 2022.
Aedes aegypti mosquito eggs can remain quiescent for many months before hatching, allowing populations to persist through unfavorable conditions. Aedes aegypti infected with the Wolbachia strain wMel have been released in tropical and subtropical regions for dengue control. wMel ...
The principles driving gene drives for conservation
Tags: Biodiversity/Conservation, Gene drive synthetic, Governance, Invasive species, PolicyS. Hartley, R. Taitingfong and P. Fidelman, Environmental Science and Policy, 135:36-45. 2022.
Gene drive technology is an emerging biotechnology with the potential to address some of the most intractable global biodiversity conservation issues. Scientists are exploring potential gene drive applications for managing invasive species and building resilience in keystone ...
Transient Introgression of Wolbachia into Aedes aegypti Populations Does Not Elicit an Antibody Response to Wolbachia Surface Protein in Community Members
Tags: Aedes, Arbovirus, Dengue, WolbachiaE. Lee, T. Hien Nguyen, T. Yen Nguyen, S. Nam Vu, N. Duong Tran, L. Trung Nghia, Q. Mai Vien, T. Dong Nguyen, R. Kriiger Loterio, I. Iturbe-Ormaetxe, H. A. Flores, S. L. O'Neill, D. Anh Dang, C. P. Simmons and J. E. Fraser, Pathogens, 11. 2022.
Wolbachia is an endosymbiotic bacterium that can restrict the transmission of human pathogenic viruses by Aedes aegypti mosquitoes. Recent field trials have shown that dengue incidence is significantly reduced when Wolbachia is introgressed into the local Ae. aegypti population. ...
New weapons to fight malaria transmission: A historical view
Tags: Gene drive synthetic, History, Malaria, Other SymbiontsW. Huang, S.-J. Cha and M. Jacobs-Lorena, Entomological Research, 2022.
The stagnation of our fight against malaria in recent years, mainly due to the development of mosquito insecticide resistance, argues for the urgent development of new weapons. The dramatic evolution of molecular tools in the last few decades led to a better understanding of ...
International shipments of Wolbachia-infected mosquito eggs: towards the scaling-up of World Mosquito Program operations
Tags: Aedes, Dengue, Oceania, WolbachiaJ. A. Denton, D. A. Joubert, A. A. Goundar and J. R. L. Gilles, Scientific and Technical Review, 41:91-99. 2022.
The Wolbachia insect control method, employed by the World Mosquito Program (WMP), relies on introgressing Wolbachia through target Aedes aegypti populations to reduce the incidence of dengue. Since 2010, the WMP has been producing Wolbachia-infected mosquitoes at numerous sites ...
The fate of a suppressed X-linked meiotic driver: experimental evolution in Drosophila simulans
Tags: Fruit fly, Population suppression, Sex distorter, Transmission distortionH. Bastide, D. Ogereau, C. Montchamp-Moreau and P. R. Gérard, Chromosome Research, 2022.
Sex-ratio (SR) meiotic drivers are X-linked selfish genetic elements that promote their own transmission by preventing the production of Y-bearing sperm, which usually lowers male fertility. The spread of SR drivers in populations is expected to trigger the evolution of unlinked ...
Epistatic selection on a selfish Segregation Distorter supergene: drive, recombination, and genetic load
Tags: Evolution, Genomics, Transmission distortionB. Navarro-Dominguez, C.-H. Chang, C. L. Brand, C. A. Muirhead, D. C. Presgraves and A. M. Larracuente, eLife, 11:e78981. 2022.
In this work, we investigate the evolution and genomic consequences of an autosomal, multilocus, male meiotic drive system, Segregation Distorter (SD) in the fruit fly, Drosophila melanogaster. In African populations, the predominant SD chromosome variant, SD-Mal, is ...
CRISPR/Cas9 mediates efficient site-specific mutagenesis of the odorant receptor co-receptor (Orco) in the malaria vector Anopheles sinensis
Tags: Anopheles, CRISPR, Genetic biocontrolY. Wang, X. F. He, L. Qiao, Z. R. Yu, B. Chen and Z. B. He, Pest Management Science, 11. 2022.
BACKGROUND Anopheles sinensis is the most widely distributed mosquito species and is the main transmitter of Plasmodium vivax malaria in China. Most previous research has focused on the mechanistic understanding of biological processes in An. sinensis and novel ways of ...
Engineering a self-eliminating transgene in the yellow fever mosquito, Aedes aegypti
Tags: Aedes, Gene drive synthetic, Genetically modified mosquitoesK. Chae, C. Dawson, C. Valentin, B. Contreras, J. Zapletal, K. M. Myles and Z. N. Adelman, PNAS Nexus, 2022.
Promising genetics-based approaches are being developed to reduce or prevent the transmission of mosquito-vectored diseases. Less clear is how such transgenes can be removed from the environment, a concern that is particularly relevant for highly invasive gene drive transgenes. ...
A New Approach to Develop Resistant Cultivars Against the Plant Pathogens: CRISPR Drives
Tags: CRISPR, Gene drive syntheticM. I. Tek and K. Budak, Frontiers in Plant Science, 13. 2022.
CRISPR drive is a recent and robust tool that allows durable genetic manipulation of the pest population like human disease vectors such as malaria vector mosquitos. In recent years, it has been suggested that CRISPR drives can also be used to control plant diseases, pests, and ...
Pilot trial using mass field-releases of sterile males produced with the incompatible and sterile insect techniques as part of integrated Aedes aegypti control in Mexico
Tags: Aedes, Incompatible insect technique, Mosquito husbandry, Sterile insect technique (SIT), WolbachiaA. Martín-Park, A. Che-Mendoza, Y. Contreras-Perera, S. Pérez-Carrillo, H. Puerta-Guardo, J. Villegas-Chim, G. Guillermo-May, A. Medina-Barreiro, H. Delfín-González, R. Méndez-Vales, S. Vázquez-Narvaez, J. Palacio-Vargas, F. Correa-Morales, G. Ayora-Tal, PLoS Negl Trop Dis, 16:e0010324. 2022.
We implemented a controlled before-and-after quasi-experimental study in two suburban localities of Yucatan (Mexico): San Pedro Chimay (SPC), which received IIT-SIT, and San Antonio Tahdzibichén used as control. Release of wAlbB Ae. aegypti males at SPC extended for 6 months ...
Recent advancements in CRISPR/Cas technology for accelerated crop improvement
Tags: Agriculture, Gene drive synthetic, Gene editingD. Das, D. L. Singha, R. R. Paswan, N. Chowdhury, M. Sharma, P. S. Reddy and C. Chikkaputtaiah, Planta, 255:109. 2022.
The likelihood of reduced agricultural production due to highly turbulent climatic conditions increases as the global population expands. The second paradigm of stress-resilient crops with enhanced tolerance and increased productivity against various stresses is paramount to ...
Biotechnological Road Map for Innovative Weed Management
Tags: Agriculture, CRISPR, Gene drive synthetic, Genetic biocontrolA. C. S. Wong, K. Massel, Y. Lam, J. Hintzsche and B. S. Chauhan, Frontiers in Plant Science, 13. 2022.
In most agriculture farmlands, weed management is predominantly reliant on integrated weed management (IWM) strategies, such as herbicide application. However, the overuse and misuse of herbicides, coupled with the lack of novel active ingredients, has resulted in the uptrend of ...
The evolutionary significance of meiotic drive
Tags: Evolution, Sex distorter, Transmission distortionJ. B. Searle and F. P.-M. de Villena, Heredity, 2022.
In this essay, we will focus on‘true meiotic drive’ where the distorted transmission does arise within meiosis itself (Zanders and Unckless2019),specifically in females. Here, the non-transmission of one of the products of meiotic division is inherent in the gametogenic ...
Role of CRISPR Technology in Gene Editing of Emerging and Re-emerging Vector Borne Disease
Tags: Dengue, Gene drive synthetic, Genetic biocontrol, Malaria, Vector controlK. K. Mahto, P. Prasad, M. Kumar, H. Dubey and A. Ranjan, Recent Advances in Pathogen Interactions, Immunity, and Vector Control Strategies, 2022.
Vector borne diseases are rampant across the world. Due to spread and estab-lishment of vector species in different geographical areas, vector adaptation and resistance towards many insecticides the only option left is vector control for vari-ous vector borne diseases. Recent ...
Wolbachia endosymbionts in two Anopheles species indicates independent acquisitions and lack of prophage elements
Tags: Anopheles, Genomics, Other Symbionts, Population modification/replacement, WolbachiaS. Quek, L. Cerdeira, C. L. Jeffries, S. Tomlinson, T. Walker, G. L. Hughes and E. Heinz, Microbial Genomics, 8. 2022.
Wolbachia is a genus of obligate bacterial endosymbionts that infect a diverse range of arthropod species as well as filarial nematodes, with its single described species, Wolbachia pipientis, divided into several ‘supergroups’ based on multilocus sequence typing. Wolbachia ...
Aedes aegypti abundance and insecticide resistance profiles in the applying Wolbachia to eliminate dengue trial
Tags: Aedes, Dengue, Population modification/replacement, WolbachiaW. Tantowijoyo, S. K. Tanamas, I. Nurhayati, S. Setyawan, N. Budiwati, I. Fitriana, I. Ernesia, D. S. Wardana, E. Supriyati, E. Arguni, Y. Meitika, E. Prabowo, B. Andari, B. R. Green, L. Hodgson, E. Rancès, P. A. Ryan, S. L. O'Neill, K. L. Anders, M. R. A, PLOS Neglected Tropical Diseases, 16:e0010284. 2022.
The Applying Wolbachia to Eliminate Dengue (AWED) trial was a parallel cluster randomised trial that demonstrated Wolbachia (wMel) introgression into Ae. aegypti populations reduced dengue incidence. In this predefined substudy, we compared between treatment arms, the relative ...
A metapopulation approach to identify targets for Wolbachia-based dengue control
Tags: Aedes, Arbovirus, Dengue, Modeling, Population modification/replacement, WolbachiaA. Reyna-Lara, D. Soriano-Paños, J. H. Arias-Castro, H. J. Martínez and J. Gómez-Gardeñes, Chaos, 32:041105. 2022.
Over the last decade, the release of Wolbachia-infected Aedes aegypti into the natural habitat of this mosquito species has become the most sustainable and long-lasting technique to prevent and control vector-borne diseases, such as dengue, zika, or chikungunya. However, the ...
Environmental factors influence the local establishment of Wolbachia in Aedes aegypti mosquitoes in two small communities in central Vietnam [version 2]
Tags: Aedes, Population modification/replacement, WolbachiaN. T. Hien, D. D. Anh, N. H. Le, N. T. Yen, T. V. Phong, V. S. Nam, T. N. Duong, N. B. Nguyen, D. T. T. Huong, L. Q. Hung, C. N. T. Trinh, N. V. Hoang, V. Q. Mai, L. T. Nghia, N. T. Dong, L. H. Tho, S. Kutcher, T. P. Hurst, J. L. Montgomery, M. Woolfit, E, Gates Open Research, 5:147. 2022.
Background: The wMel strain of Wolbachia has been successfully introduced into Aedes aegypti mosquitoes and subsequently shown to reduce transmission of dengue and other pathogens, under both laboratory and field conditions. Here we describe the entomological outcomes of wMel ...
