Scholarly Literature
This is an aggregation of scholarly literature from peer-reviewed journals, bioRxiv , medRxiv and arXiv preprint servers focused on natural and engineered selfish genetic elements and genetic biocontrol. New citations are added as they appear. This content is intended for anyone interested in the scholarly literature on gene drive and genetic biocontrol.
Adult mosquito predation and potential impact on the sterile insect technique
Tags: Aedes, Ecology, Risk and safety, Sterile insect technique (SIT)N. S. Bimbilé Somda, H. Maïga, W. Mamai, T. Bakhoum, T. Wallner, S. B. Poda, H. Yamada and J. Bouyer, Scientific Reports, 12:2561. 2022.
The sterile insect technique is a promising environmentally friendly method for mosquito control. This technique involves releasing laboratory-produced sterile males into a target field site, and its effectiveness may be affected by the extent of adult mosquito predation. Sterile ...
C-type lectin 4 regulates broad-spectrum melanization-based refractoriness to malaria parasites
Tags: Anopheles, Genetic biocontrol, Malaria, Mosquitoes, Population modification/replacementM. L. Simões, Y. Dong, G. Mlambo and G. Dimopoulos, PLOS Biology, 20:e3001515. 2022.
Anopheles gambiae melanization-based refractoriness to the human malaria parasite Plasmodium falciparum has rarely been observed in either laboratory or natural conditions, in contrast to the rodent model malaria parasite Plasmodium berghei that can become completely melanized by ...
Mark-release-recapture experiment in Burkina Faso demonstrates reduced fitness and dispersal of genetically-modified sterile malaria mosquitoes
Tags: Africa, Gene drive synthetic, Genetically modified mosquitoes, Mosquito husbandry, Target malariaF. A. Yao, A.-A. Millogo, P. S. Epopa, A. North, F. Noulin, K. Dao, M. Drabo, C. Guissou, S. Kekele, M. Namountougou, R. K. Ouedraogo, L. Pare, N. Barry, R. Sanou, H. Wandaogo, R. K. Dabire, A. McKemey, F. Tripet and A. Diabaté, Nature Communications, 13:796. 2022.
Every year, malaria kills approximately 405,000 people in Sub-Saharan Africa, most of them children under the age of five years. In many countries, progress in malaria control has been threatened by the rapid spread of resistance to antimalarial drugs and insecticides. Novel ...
Quality Control Methods for Aedes albopictus Sterile Male Transportation
Tags: Aedes, Invasive species, Mosquito husbandry, Mosquitoes, Sterile insect technique (SIT)G. D. Mastronikolos, A. Kapranas, G. K. Balatsos, C. Ioannou, D. P. Papachristos, P. G. Milonas, A. Puggioli, I. Pajović, D. Petrić, R. Bellini, A. Michaelakis and N. T. Papadopoulos, Insects, 2022.
Genetic based mosquito control methods have been gaining ground in recent years for their potential to achieve effective suppression or replacement of vector populations without hampering environments or causing any public health risk. These methods require the mass rearing of ...
The spore killers, fungal meiotic driver elements
Tags: Gene drive synthetic, Transmission distortion, Yeast and FungiA. A. Vogan, I. Martinossi-Allibert, S. L. Ament-Velásquez, J. Svedberg and H. Johannesson, Mycologia, 2022.
During meiosis, both alleles of any given gene should have equal chances of being inherited by the progeny. There are a number of reasons why, however, this is not the case, with one of the most intriguing instances presenting itself as the phenomenon of meiotic drive. Genes that ...
Gene-drive mosquitoes, a prospect for future malaria control
Tags: Africa, Anopheles, Gene drive synthetic, Malaria, Replicator/site directed nucleaseS. A. Monawwer, A. O. I. Alzubaidi, F. Yasmin, S. M. Q. Haimour, S. M. I. Shay and I. Ullah, Pan African Medical Journal, 41:2-6. 2022.
Despite major developments in malaria control over the past two decades, the disease continues to scourge the human population across the globe. Rising concerns such as insecticide resistance amongst vector mosquitoes are a cause of huge fear amongst healthcare providers and ...
Articulating ethical principles guiding Target Malaria’s engagement strategy
Tags: Ethics, Gene drive synthetic, Stakeholder engagement, Target malariaA. J. Roberts and D. Thizy, Malaria Journal, 21:35. 2022.
Progress in gene drive research has engendered a lively discussion about community engagement and the ethical standards the work hinges on. While there is broad agreement regarding ethical principles and established best practices for conducting clinical public health research, ...
Quality over quantity: unraveling the contributions to cytoplasmic incompatibility caused by two coinfecting Cardinium symbionts
Tags: Cytoplasmic incompatibility, Other Symbionts, WolbachiaM. R. Doremus, C. M. Stouthamer, S. E. Kelly, S. Schmitz-Esser and M. S. Hunter, Heredity, 2022.
Cytoplasmic incompatibility (CI) is a common form of reproductive sabotage caused by maternally inherited bacterial symbionts of arthropods. CI is a two-step manipulation: first, the symbiont modifies sperm in male hosts which results in the death of fertilized, uninfected ...
piggyBac-based transgenic RNAi of serine protease 2 results in male sterility in Hyphantria cunea
Tags: Genetic biocontrol, Sterile insect technique (SIT)X. Li, Q. Liu, H. Bi, Y. Wang, X. Xu, W. Sun, Z. Zhang and Y. Huang, Insect Biochemistry and Molecular Biology, 103726. 2022.
Fall webworm, Hyphantria cunea, is a global invasive forest pest that causes serious damage to the economy and ecosystem of agriculture and forestry. Due to the extent of the problem and the difficulty of conventional chemical control, new technologies must be pursued, such as ...
Endosymbionts moderate constrained sex allocation in a haplodiploid thrips species in a temperature-sensitive way
Tags: Cytoplasmic incompatibility, Fruit fly, Selfish genetic elements, Sex distorter, WolbachiaA. Katlav, D. T. Nguyen, J. L. Morrow, R. N. Spooner-Hart and M. Riegler, Heredity, 9. 2022.
Maternally inherited bacterial endosymbionts that affect host fitness are common in nature. Some endosymbionts colonise host populations by reproductive manipulations (such as cytoplasmic incompatibility; CI) that increase the reproductive fitness of infected over uninfected ...
Assessing Aedes aegypti candidate genes during viral infection and Wolbachia-mediated pathogen blocking
Tags: Aedes, Arbovirus, Dengue, WolbachiaL. T. Sigle, M. Jones, M. Novelo, S. A. Ford, N. Urakova, K. Lymperopoulos, R. T. Sayre, Z. Xi, J. L. Rasgon and E. A. McGraw, Insect Molecular Biology, 2022.
Abstract One approach to control dengue virus transmission is the symbiont Wolbachia, that limits viral infection in mosquitoes. Despite plans for its widespread use in Aedes aegypti, Wolbachia's mode of action remains poorly understood. Many studies suggest that the mechanism is ...
Genetically engineered insects with sex-selection and genetic incompatibility enable population suppression
Tags: Fruit fly, Genetic biocontrol, Genetic incompatibilities, Incompatible insect technique, Sterile insect technique (SIT)A. Upadhyay, N. R. Feltman, A. Sychla, A. Janzen, S. R. Das, M. Maselko and M. Smanski, eLife, 11. 2022.
Engineered Genetic Incompatibility (EGI) is a method to create species-like barriers to sexual reproduction. It has applications in pest control that mimic Sterile Insect Technique when only EGI males are released. This can be facilitated by introducing conditional ...
A flavivirus-inducible gene expression system that modulates broad-spectrum antiviral activity against dengue and Zika viruses
Tags: Aedes, Dengue, Genetic biocontrol, Genetically modified mosquitoesS.-C. Weng, Y.-X. Zhou and S.-H. Shiao, Insect Biochemistry and Molecular Biology, 142:103723. 2022.
Incidence of dengue virus (DENV) and Zika virus (ZIKV), two mosquito-borne flaviviruses, is increasing in large parts of the world. Vaccination and medication for these diseases are unsatisfactory. Here, we developed a novel antiviral approach, using a virus-inducible gene ...
Paternal transmission of the Wolbachia CidB toxin underlies cytoplasmic incompatibility
Tags: Culex, Cytoplasmic incompatibility, Fruit fly, Toxin-antidote, WolbachiaB. Horard, K. Terretaz, A. S. Gosselin-Grenet, H. Sobry, M. Sicard, F. Landmann and B. Loppin, Current Biology, 2022.
Wolbachia are widespread endosymbiotic bacteria that manipulate the reproduction of arthropods through a diversity of cellular mechanisms. In cytoplasmic incompatibility (CI), a sterility syndrome originally discovered in the mosquito Culex pipiens, uninfected eggs fertilized by ...
Conditions for Investment in Genetic Biocontrol of Pest Vertebrates in Australia
Tags: Genetic biocontrol, Governance, Oceania, Risk and safety, Stakeholder engagementL. Carter, A. Mankad, S. Campbell, W. Ruscoe, K. P. Oh, P. R. Brown, M. Byrne, M. Tizard and T. Strive, Frontiers in Agronomy, 3. 2022.
Managing pest vertebrate species in Australia is a significant challenge for government, industry, research sectors and land-managers. Innovative tools such as genetic biocontrol offers decision-makers a potentially effective means of reducing the impact of pest species ...
Could Sterile Aedes albopictus Male Releases Interfere with Aedes aegypti Population in Reunion Island?
Tags: Aedes, Sterile insect technique (SIT)H. F. Andrianjakarivony, D. Damiens, L. Marquereau, B. Gaudillat, N. Habchi-Hanriot and L.-C. Gouagna, Insects, 13. 2022.
In Reunion Island, the feasibility of an Aedes albopictus control program using the Sterile Insect Technique (SIT) is studied. Because, in some regions, Ae. albopictus is living in sympatry with Aedes aegypti, the impact of releasing millions of sterile male Ae. albopictus on ...
Self-limiting fall armyworm: a new approach in development for sustainable crop protection and resistance management
Tags: Genetic biocontrol, Moths, Oxitec, Sterile insect technique (SIT)C. E. Reavey, A. S. Walker, S. P. Joyce, L. Broom, A. Willse, K. Ercit, M. Poletto, Z. H. Barnes, T. Marubbi, B. J. Troczka, D. Treanor, K. Beadle, B. Granville, V. de Mello, J. Teal, E. Sulston, A. Ashton, L. Akilan, N. Naish, O. Stevens, N. Humphreys-Jo, BMC Biotechnology, 22:5. 2022.
Here, we describe the first germline transformation of the fall armyworm and the development of a genetically engineered male-selecting self-limiting strain, OX5382G, which exhibits complete female mortality in the absence of an additive in the larval diet. Laboratory experiments ...
Gene Drives in the U.K., U.S., and Australian Press (2015–2019): How a New Focus on Responsibility Is Shaping Science Communication
Tags: Ethics, Gene drive synthetic, Policy, Stakeholder engagementA. Stelmach, B. Nerlich and S. Hartley, Science Communication, 10755470211072245. 2022.
Gene drive is a controversial biotechnology for pest control. Despite a commitment from gene drive researchers to responsibility and the key role of the media in debates about science and technology, little research has been conducted on media reporting of gene drive. We employ ...
Monitoring Needs for Gene Drive Mosquito Projects: Lessons From Vector Control Field Trials and Invasive Species
Tags: Field trials, Gene drive synthetic, Genetic biocontrol, Invasive species, Oxitec, Population modification/replacement, Population suppression, WolbachiaG. Rašić, N. F. Lobo, E. H. Jeffrey Gutiérrez, C. H. Sánchez and J. M. Marshall, Frontiers in Genetics, 12:780327. 2022.
As gene drive mosquito projects advance from contained laboratory testing to semi-field testing and small-scale field trials, there is a need to assess monitoring requirements to: i) assist with the effective introduction of the gene drive system at field sites, and ii) detect ...
A gene drive does not spread easily in populations of the honey bee parasite Varroa destructor
Tags: Agriculture, Gene drive synthetic, Genetic biocontrol, Modeling, Other arthropods, Population suppressionN. R. Faber, A. B. Meiborg, G. R. McFarlane, G. Gorjanc and B. A. Harpur, Apidologie, 52:1112-1127. 2022.
Varroa mites (Varroa destructor) are the most significant threat to beekeeping worldwide. They are directly or indirectly responsible for millions of colony losses each year. Beekeepers are somewhat able to control varroa populations through the use of physical and chemical ...
Gene drives for vertebrate pest control: realistic spatial modelling of eradication probabilities and times for island mouse populations
Tags: Biodiversity/Conservation, CRISPR, Gene drive synthetic, Modeling, Other mammals, Replicator/site directed nucleaseA. Birand, P. Cassey, J. V. Ross, J. C. Russell, P. Thomas and T. A. A. Prowse, Molecular Ecology, 2022.
Abstract Invasive alien species continue to threaten global biodiversity. CRISPR-based gene drives, which can theoretically spread through populations despite imparting a fitness cost, could be used to suppress or eradicate pest populations. We develop an individual-based, ...
A natural fungal gene drive enacts killing through targeting DNA
Tags: Yeast and FungiA. S. Urquhart and D. M. Gardiner, bioRxiv, 2022.01.19.477016. 2022.
Fungal spore-killers are a class of selfish genetic elements that positively bias their own inheritance by killing non-inheriting gametes following meiosis. As killing takes place specifically within the developing fungal ascus, a tissue which is experimentally difficult to ...
Recently introduced Wolbachia reduces bacterial species richness and reshapes bacterial community structure in Nilaparvata lugens
Tags: Incompatible insect technique, Other Symbionts, WolbachiaT.-P. Li, C.-Y. Zhou, J.-T. Gong, Z. Xi and X.-Y. Hong, Pest Management Science, 2022.
BACKGROUND Wolbachia has been developed as an effective tool to suppress insect pests and arbovirus transmission. Recently, the brown planthopper Nilaparvata lugens, a serious agricultural pest, has been successfully transinfected with Wolbachia strain wStri from Laodelphax ...
Ethical Considerations for Gene Drive: Challenges of Balancing Inclusion, Power and Perspectives
Tags: Ethics, Gene drive synthetic, Policy, Stakeholder engagementA. Kormos, G. C. Lanzaro, E. Bier, V. Santos, L. Nazare, J. Pinto, A. A. dos Santos and A. James, Frontiers in Bioengineering and Biotechnology, 2022.
Progress in gene-drive research has stimulated discussion and debate on ethical issues including community engagement and consent, policy and governance, and decision-making involved in development and deployment. Many organizations, academic institutions, foundations, and ...
IMPACTOS AMBIENTAIS DA TÉCNICA DE GENE DRIVE PARA O CONTROLE DE EPIDEMIAS: ALCANCES E LIMITES DO PRINCÍPIO DA PRECAUÇÃO
Tags: Gene drive, Policy, Risk and safety, Risk assessment, South/Central AmericaN. R. Furtado, PERI Revista de Filosofia, 13. 2022.
The paper discusses the application of the precautionary principle in the management of environmental risks arising from the use of gene drives to control epidemics. Gene drives consist of a technique for creating genetically modified organisms, which are released into an ...
Analysis of a Cas12a-based gene-drive system in budding yeast
Tags: CRISPR, Gene drive synthetic, Yeast and FungiI. C. Lewis, Y. Yan and G. C. Finnigan, Access Microbiol, 3:000301. 2022.
The discovery and adaptation of CRISPR/Cas systems within molecular biology has provided advances across biological research, agriculture and human health. Genomic manipulation through use of a CRISPR nuclease and programmed guide RNAs has become a common and widely accessible ...
Effects of Sterile Males and Fertility of Infected Mosquitoes on Mosquito-Borne Disease Dynamics
Tags: Aedes, Modeling, Mosquitoes, Sterile insect technique (SIT)X. L. Sun, S. Q. Liu, Y. F. Lv and Y. Z. Pei, Bulletin of Mathematical Biology, 84:33. 2022.
By studying an infection-age structured model, we consider the effects of releasing sterile males and the fertility of infected mosquitoes on the mosquito-borne diseases transmission including the extinction of mosquitoes, the elimination and persistence of diseases. Firstly, ...
Gene drive communication: exploring experts’ lived experience of metaphor use
Tags: Gene drive synthetic, Stakeholder engagementB. Nerlich and A. Stelmach, New Genetics and Society, 2022.
Metaphors have been crucial in making genetics and genomics public, fromthe code and the book of life to genetic scissors and gene surgery. A newfield is emerging called“gene drive”–a range of controversial technologiesthat can potentially be used for the eradication or ...
Insect Allies – Assessment of a Viral Approach to Plant Genome Editing
Tags: Agriculture, CRISPR, Gene drive synthetic, Gene editing, Policy, Regulation, Risk and safetyK. Pfeifer, J. L. Frieß and B. Giese, Integrated Environmental Assessment and Management, 2022.
The DARPA program Insect Allies has already sparked scientific debate concerning technology assessment-related issues, among which the most prevalent is that of dual use potential. As apart from the issues concerning peaceful applications, the technology also provides the ...
Characterization of the first Wolbachia from the genus Scaptodrosophila, a male-killer from the rainforest species S. claytoni
Tags: Sex distorter, WolbachiaK. M. Richardson, M. Schiffer, P. A. Ross, J. A. Thia and A. A. Hoffmann, Insect Science, 2022.
Abstract The Scaptodrosophila genus represents a large group of drosophilids with a worldwide distribution and a predominance of species in Australia, but there is little information on the presence and impacts of Wolbachia endosymbionts in this group. Here we describe the first ...
Reversing insecticide resistance with allelic-drive in Drosophila melanogaster
Tags: CRISPR, Gene drive synthetic, Malaria, Mosquitoes, ResistanceB. Kaduskar, R. B. S. Kushwah, A. Auradkar, A. Guichard, M. Li, J. B. Bennett, A. H. F. Julio, J. M. Marshall, C. Montell and E. Bier, Nature Communications, 13:291. 2022.
A recurring target-site mutation identified in various pests and disease vectors alters the voltage gated sodium channel (vgsc) gene (often referred to as knockdown resistance or kdr) to confer resistance to commonly used insecticides, pyrethroids and DDT. The ubiquity of kdr ...
The prince, the mayor, and the U.S. fish that ate Japan
Tags: Aedes, Fish, Gene drive synthetic, Genetic biocontrol, Invasive species, Modeling, Mosquitoes, Sterile insect technique (SIT)C. Elliot, National Geographic, 2022.
When Crown Prince Akihito visited Chicago on October 3, 1960, his sole request was to visit Shedd Aquarium. Then Mayor Richard J. Daley, an avid angler, presented the prince with a gift that he scooped with a net from one of the tanks himself: 18 bluegills, the official Illinois ...
Introgression of the Aedes aegypti red-eye genetic sexing strains into different genomic backgrounds for sterile insect technique applications
Tags: Aedes, Mosquitoes, Sterile insect technique (SIT)A. A. Augustinos , K. Nikolouli , L. D. De La Fuente , M. Misbah-Ul-Haq, D. O. Carvalho and K. Bourtzis, Frontiers in Bioengineering and Biotechnology, 2022.
Aedes aegypti is an invasive mosquito species and major vector of human arboviruses. A wide variety of control methods have been employed to combat mosquito populations. One of them is the sterile insect technique (SIT) that has recently attracted considerable research efforts ...
iGEM and Gene Drives: A Case Study for Governance
Tags: Gene drive synthetic, Governance, Regulation, Risk and safetyP. Millett, T. Alexanian, M. J. Palmer, S. W. Evans, T. Kuiken and K. Oye, Health Security, 2022.
Gene drives have already challenged governance systems. In this case study, we explore the International Genetically Engineered Machine (iGEM) competition's experiences in gene drive-related research and lessons in developing, revising, and implementing a governance system. ...
Lab-scale characterization and semi-field trials of Wolbachia Strain wAlbB in a Taiwan Wolbachia introgressed Ae. aegypti strain
Tags: Dengue, Incompatible insect technique, Mosquito husbandry, Mosquitoes, Population modification/replacement, Population suppression, WolbachiaW. L. Liu, H. Y. Yu, Y. X. Chen, B. Y. Chen, S. N. Leaw, C. H. Lin, M. P. Su, L. S. Tsai, Y. Chen, S. H. Shiao, Z. Y. Xi, A. C. C. Jang and C. H. Chen, PLOS Neglected Tropical Diseases, 16:24. 2022.
Author summaryPrior to open field release, new genetic approaches that interfere with mosquito abilities and reduce mosquito population density require progressive evaluation both in the laboratory and contained field trials. Trials in contained outdoor systems are thus an ...
The Need for a Tiered Registry for US Gene Drive Governance
Tags: Gene drive synthetic, Malaria, Mosquitoes, Policy, Regulation, Risk and safetyK. L. Warmbrod, A. L. Kobokovich, R. West, G. K. Gronvall and M. Montague, Health Security, 2022.
A great deal of attention has been focused on the potential risks of gene drives, the kinds of biosafety protections they may require, and how they may be reversed; however, less attention has been paid to the systems that would be useful to have in place in the future, when ...
Effect of aneuploidy of a nonessential chromosome on gene expression in maize
Tags: Agriculture, Chromosomal driveX. Shi, H. Yang, C. Chen, J. Hou, T. Ji, J. Cheng and J. A. Birchler, Plant Journal, 2022.
The nonessential supernumerary maize B chromosome (B) has recently been shown to contain active genes and be capable of impacting gene expression of the A chromosomes. However, the effect of the B chromosome on gene expression is still unclear. In addition, it is unknown whether ...
An Introduction to Containment Recommendations for Gene Drive Mosquitoes and the Laboratory Rearing of Genetically Engineered Mosquitoes in Africa
Tags: Containment, Gene drive synthetic, Genetic biocontrol, Genetically modified mosquitoes, Policy, Regulation, Risk and safetyS. Higgs, Vector-Borne and Zoonotic Diseases, 2022.
The prospect of using genetically engineered arthropods to reduce the incidence of vector-borne diseases either indirectly by suppressing vector populations or directly by replacing wild-type vector species with less competent ones has long been discussed; however, only in the ...
Preparing an Insectary in Burkina Faso to Support Research in Genetic Technologies for Malaria Control
Tags: Africa, Containment, Gene drive synthetic, Genetic biocontrol, Genetically modified mosquitoes, MalariaC. Guissou, M. M. Quinlan, R. Sanou, R. K. Ouédraogo, M. Namountougou and A. Diabaté, Vector-Borne and Zoonotic Diseases, 2022.
The Institut de Recherche en Sciences de la Santé (IRSS) of Burkina Faso, West Africa, was the first African institution to import transgenic mosquitoes for research purposes. A shift from the culture of mosquito research to regulated biotechnology research and considerable ...
Beyond the eye: Kynurenine pathway impairment causes midgut homeostasis dysfunction and survival and reproductive costs in blood-feeding mosquitoes
Tags: Aedes, Anopheles, Culex, Genetic biocontrol, Mosquito husbandryV. Bottino-Rojas, I. Ferreira, R. D. Nunes, X. Feng, T. B. Pham, A. Kelsey, R. Carballar-Lejarazú, V. Gantz, P. L. Oliveira and A. A. James, Insect Biochemistry and Molecular Biology, 103720. 2022.
Insect ommochrome biosynthesis pathways metabolize tryptophan to generate eye-color pigments and naturally occurring alleles of pathway genes are useful phenotypic markers in transgenesis studies. Pleiotropic effects of mutations in some genes exert a load on both survival and ...
Integrated control of Aedes albopictus in Southwest Germany supported by the Sterile Insect Technique
Tags: Genetic biocontrol, Sterile insect technique (SIT)N. Becker, S. M. Langentepe-Kong, A. T. Rodriguez, T. T. Oo, D. Reichle, R. Luhken, J. Schmidt-Chanasit, P. Luthy, A. Puggioli and R. Bellini, Parasites and Vectors, 15:19. 2022.
Background: The invasive species Aedes albopictus, commonly known as the Asian tiger mosquito, has undergone extreme range expansion by means of steady introductions as blind passengers in vehicles traveling from the Mediterranean to south-west Germany. The more than 25 ...
Stakeholder engagement to inform the risk assessment and governance of gene drive technology to manage spotted-wing drosophila
Tags: Fruit fly, Gene drive synthetic, Genetic biocontrol, Governance, Invasive species, Risk assessment, Stakeholder engagementA. E. Kokotovich, S. K. Barnhill-Dilling, J. E. Elsensohn, R. Li, J. A. Delborne and H. Burrack, Journal of Environmental Management, 307:114480. 2022.
Emerging biotechnologies, such as gene drive technology, are increasingly being proposed to manage a variety of pests and invasive species. As one method of genetic biocontrol, gene drive technology is currently being developed to manage the invasive agricultural pest ...
Intervention of Modern Genetic Tools for Managing Insect Pests of Fruit Crops
Tags: Gene drive synthetic, Genetic biocontrol, Incompatible insect technique, Sterile insect technique (SIT)G. S. Miglani, S. Singh, Z. Li and R. K. Sandhu, Genetic Methods and Tools for Managing Crop Pests, 2022.
Merits and demerits of select modern genetic tools as sterile insect technique, repressible dominant lethal, engineering insect pests, transgenic crops, primary resistance management, gene silencing RNA interference, genome-editing-based methods, autocidal insect control ...
Newer Genetic Tools, Techniques, Vectors, Promoters, and Molecular Markers for Genetic Engineering of Herbivorous Insects
Tags: Genetic biocontrol, Genetically modified organismsD. D. Rani, S. Subhash, H. R. Gopalkrishna and A. K. Chakravarthy, Genetic Methods and Tools for Managing Crop Pests, 2022.
Insects can transmit major infectious diseases to crop plants. Recent advances in insect genomics and transformation technology provide new strategies for the control of insect-borne pathogen transmission and insect pest management. One such strategy is the genetic modification ...
Stakeholder Views on Engagement, Trust, Performance, and Risk Considerations About Use of Gene Drive Technology in Agricultural Pest Management
Tags: Agriculture, Gene drive synthetic, Policy, Regulation, Risk and safety, Stakeholder engagementC. L. Goldsmith, K. E. Kang, E. Heitman, Z. N. Adelman, L. W. Buchman, D. Kerns, X. Liu, R. F. Medina and A. Vedlitz, Health Security, 2021.
Gene drive is an experimental technique that may make it possible to alter the genetic traits of whole populations of a species through the genetic modification of a relatively small number of individuals. This technology is sufficiently new that literature on the understanding ...
Facilitating the Conversation: Gene Drive Classification
Tags: Gene drive synthetic, Policy, Regulation, Risk and safety, Stakeholder engagementJ. Overcash and A. Golnar, Health Security, 2021.
Gene drives are an emerging technology with tremendous potential to impact public health, agriculture, and conservation. While gene drives can be described simply as selfish genetic elements (natural or engineered) that are inherited at non-Mendelian rates, upon closer ...
Modeling CRISPR gene drives for suppression of invasive rodents using a supervised machine learning framework
Tags: Gene drive synthetic, Invasive species, Modeling, Replicator/site directed nuclease, RodentsS. E. Champer, N. Oakes, R. Sharma, P. García-Díaz, J. Champer and P. W. Messer, PLoS Comput Biol, 17:e1009660. 2021.
Invasive rodent populations pose a threat to biodiversity across the globe. When confronted with these invaders, native species that evolved independently are often defenseless. CRISPR gene drive systems could provide a solution to this problem by spreading transgenes among ...
Cytoplasmic incompatibility in hybrid zones: infection dynamics and resistance evolution
Tags: Cytoplasmic incompatibility, Evolution, Modeling, WolbachiaE. S. Røed and J. Engelstädter, Journal of Evolutionary Biology, 2021.
Cytoplasmic incompatibility is an endosymbiont-induced mating incompatibility common in arthropods. Unidirectional cytoplasmic incompatibility impairs crosses between infected males and uninfected females, whereas bidirectional cytoplasmic incompatibility occurs when two host ...
Determinants of stakeholders’ attitudes and intentions toward supporting the use of Wolbachia-infected Aedes mosquitoes for dengue control
Tags: Aedes, Dengue, Incompatible insect technique, Stakeholder engagement, WolbachiaA. F. Arham, L. Amin, M. A. C. Mustapa, Z. Mahadi, M. Yaacob and M. Ibrahim, BMC Public Health, 21:2314. 2021.
BACKGROUND: A recent approach in controlling dengue is by using the Wolbachia-infected Aedes mosquito (WiAM). The approach has been reported to be more effective than traditional methods, such as fogging. Therefore, it is imperative to assess the factors predicting its acceptance ...
From Wolbachia genomics to phenotype: molecular models of cytoplasmic incompatibility must account for the multiplicity of compatibility types
Tags: Cytoplasmic incompatibility, WolbachiaA. Namias, M. Sicard, M. Weill and S. Charlat, Current Opinion in Insect Science, 2021.
Wolbachia endosymbionts commonly induce cytoplasmic incompatibility, making infected males’ sperm lethal to the embryos unless these are rescued by the same bacterium, inherited from their mother. Causal genes were recently identified but two families of mechanistic models are ...
