Scholarly Literature
This is an aggregation of scholarly literature from peer-reviewed journals, bioRxiv , medRxiv and arXiv preprint servers focused on natural and engineered selfish genetic elements and genetic biocontrol. New citations are added as they appear. This content is intended for anyone interested in the scholarly literature on gene drive and genetic biocontrol.
Alternative Techniques and Options for Risk Reduction of Gene Drives
Tags: Gene drive synthetic, Policy, Regulation, Risk assessmentBernd Giese, Arnim von Gleich and Johannes L. Frieß, Gene Drives at Tipping Points, 2020.
In this chapter, we analyse and compare different types of gene drives as well as promising alternative approaches that may provide a reduced risk.
Limits of Knowledge and Tipping Points in the Risk Assessment of Gene Drive Organisms
Tags: Gene drive synthetic, Risk assessmentArnim von Gleich and Winfried Schröder, Gene Drives at Tipping Points, 2020.
New challengesTipping point in the risk assessment of genetically engineered (GE) organisms are expected to emerge in the context of so-called ‘gene drives’. Based on a review of findings from current knowledge of GE organisms, it is concluded that the risk assessment of gene ...
Steps Towards a Precautionary Risk Governance of SPAGE Technologies Including Gene-Drives
Tags: Gene drive synthetic, Risk assessmentArnim von Gleich, Gene Drives at Tipping Points, 2020.
In view of the rapid dynamics of genetic engineering development (in particular regarding the ‘new gene-technologies’ gene editing, self-propagating artificial genetic elements (SPAGESelf-Propagating Artificial Genetic Elements (SPAGE)) and synthetic biology), the question is ...
Model Concepts for Gene Drive Dynamics
Tags: Gene drive syntheticJohnannes L. Frieß, Merle Preu and Broder Breckling, Gene Drives at Tipping Points, 2020.
The GeneTip project works on the conception and design modeling of population dynamics influenced by gene drives. In this pursuit, multiple different approaches and concepts have been developed to on one hand, be able to cover a broad perspective on the topic but on the other ...
Case Study 2: Oilseed Rape (Brassica napus L.)
Tags: Agriculture, Gene drive synthetic, Risk assessmentJohnannes L. Frieß, Broder Breckling, Kathrin Pascher and Windfried Schröder, Gene Drives at Tipping Points, 2020.
SPAGESelf-Propagating Artificial Genetic Elements (SPAGE) (Self-Propagating Artificial Genetic Element) technologies allow for a proliferation of genetic information on the populationPopulation level at a higher rate than usual Mendelian inheritanceMendelian inheritance. ...
Case Study 1: Olive Fruit Fly (Bactrocera oleae)
Tags: Gene drive synthetic, Population genetics/dynamicsMerle Preu, Johannes L. Frieß, Broder Breckling and Winfried Schröder, Gene Drives at Tipping Points, 2020.
The olive fruit fly Bactrocera oleae is a phytophagous insect associated to olive trees (Olea europaea, Oleaceae). Its larvae monophagously feed on olive fruits, the fly is therefore considered the most severe pest of olive cultivation causing tremendous economic losses. The ...
Vulnerability Analysis of Ecological Systems
Tags: Gene drive synthetic, Policy, Regulation, Risk assessmentCarina R. Lalyer, Arnim von gleich, Bernd Giese, Gene Drives at Tipping Points, 2020.
Vulnerability analysis can be seen as the counterpart to technology characterization. Technology characterisation scrutinises the intervening technology. Vulnerability analyses potentially affected systems. That may be socio-ecological, socio-technical, socio-economic or other ...
Gene Drives Touching Tipping Points
Tags: Gene drive synthetic, Regulation, Risk assessmentBrodee Breckling, Arnim von Gleich,, Gene Drives at Tipping Points, 2020.
Tipping points and tipping elements, phase transitions and similar critical phenomena are widely discussed in scientific as well as socio-economic contexts as components to understand unforeseen far reaching changes and critical transitions from one stage into another in complex ...
Technology Characterisation
Tags: Gene drive syntheticJohannes L. Frieß, Bernd Giese, Arnim von Gleich, Gene Drives at Tipping Point, 2020.
In recent years, innovation in genetic engineering brought forth a number of technologies to manipulate the fate of entire wild typeWild type populations. These technologies rely on the dissemination of synthetic genetic elements within a population of sexually reproducing ...
Gene Drives at Tipping Points
Tags: Gene drive synthetic, Policy, Regulation, Risk assessmentAmin von Gleich and Winfried Schroder, Gene Drives at Tipping Points, 2020.
This open access book reports on a pilot project aiming at collecting information on the socio-ecological risks that could arise in the event of an uncontrolled spread of genetically engineered organisms into the environment. The researchers will, for instance, be taking a closer ...
The Enterprise: A massive transposon carrying Spokt meiotic drive genes
Tags: Selfish genetic elements, Toxin-antidote, Transmission distortion, Yeast and FungiA. A. Vogan, S. L. Ament-Velásquez, E. Bastiaans, O. Wallerman, S. J. Saupe, A. Suh and H. Johannesson, bioRxiv, 2020.03.25.007153. 2020.
Previously, we described a large genomic feature called the Spok block which is notable due to the presence of meiotic drive genes of the Spok gene family. The Spok block ranges from 110 kb to 247 kb and can be present in at least four different genomic locations within P. ...
The yeast mating-type switching endonuclease HO is a domesticated member of an unorthodox homing genetic element family
Tags: Replicator/site directed nuclease, Yeast and FungiA. Y. Coughlan, L. Lombardi, S. Braun-Galleani, A. A. R. Martos, V. Galeote, F. Bigey, S. Dequin, K. P. Byrne and K. H. Wolfe, eLife, 9:e55336. 2020.
The mating-type switching endonuclease HO plays a central role in the natural life cycle of Saccharomyces cerevisiae, but its evolutionary origin is unknown. HO is a recent addition to yeast genomes, present in only a few genera close to Saccharomyces. Here we show that HO is ...
Mosquito-Borne Diseases Emergence/Resurgence and How to Effectively Control It Biologically
Tags: Aedes, Anopheles, Pest management, Resistance, Vector control, WolbachiaH. Dahmana and O. Mediannikov, Pathogens, 9:26. 2020.
Deadly pathogens and parasites are transmitted by vectors and the mosquito is considered the most threatening vector in public health, transmitting these pathogens to humans and animals. We are currently witnessing the emergence/resurgence in new regions/populations of the most ...
Opinions of key stakeholders on alternative interventions for malaria control and elimination in Tanzania
Tags: Gene drive synthetic, Malaria, Mosquitoes, Stakeholder engagement, Vector controlM. F. Finda, N. Christofides, J. Lezaun, B. Tarimo, P. Chaki, A. H. Kelly, N. Kapologwe, P. Kazyoba, B. Emidi and F. O. Okumu, Malaria Journal, 19:164. 2020.
Malaria control in Tanzania currently relies primarily on long-lasting insecticidal nets and indoor residual spraying, alongside effective case management and behaviour change communication. This study explored opinions of key stakeholders on the national progress towards malaria ...
Development and testing of a novel killer–rescue self-limiting gene drive system in Drosophila melanogaster
Tags: Fruit fly, Gene drive synthetic, Toxin-antidoteS. H. Webster, M. R. Vella and M. J. Scott, Proceedings of the Royal Society B: Biological Sciences, 287:20192994. 2020.
Here we report the development and testing of a novel self-limiting gene drive system, Killer–Rescue (K–R), in Drosophila melanogaster. This system is composed of an autoregulated Gal4 Killer (K) and a Gal4-activated Gal80 Rescue (R). Overexpression of Gal4 is lethal, but in ...
Selfish genes and sexual selection: the impact of genomic parasites on host reproduction
Tags: Genomics, Population genetics/dynamics, Resistance, Selfish genetic elements, Transmission distortion, WolbachiaN. Wedell, Journal of Zoology, 311:1-12. 2020.
Selfish genetic elements (SGEs) such as replicating mobile elements, segregation distorters and maternally inherited endosymbionts, bias their transmission success relative to the rest of the genome to increase in representation in subsequent generations. As such, they generate ...
Spatio-temporal controllability and environmental risk assessment of genetically engineered gene drive organisms from the perspective of EU GMO Regulation
Tags: Gene drive synthetic, Policy, Regulation, Risk assessmentC. Then, K. Kawall and N. Valenzuela, Integrated Environmental Assessment and Management, 2020.
Gene drive organisms are a recent development created by using methods of genetic engineering; they inherit genetic constructs that are passed on to future generations with a higher probability than with Mendelian inheritance. There are some specific challenges inherent to the ...
Natural gene drives offer potential pathogen control strategies in plants
Tags: Gene drive synthetic, Yeast and FungiD. M. Gardiner, A. Rusu, L. Barrett, G. C. Hunter and K. Kazan, bioRxiv, 2020.
Globally, fungal pathogens cause enormous crop losses and current control practices are not always effective, economical or environmentally sustainable. Tools enabling genetic management of wild pathogen populations could potentially solve many problems associated with plant ...
Efficient production of male Wolbachia-infected Aedes aegypti mosquitoes enables large-scale suppression of wild populations
Tags: Aedes, Incompatible insect technique, Sterile insect technique (SIT), WolbachiaJ. E. Crawford, D. W. Clarke, V. Criswell, M. Desnoyer, D. Cornel, B. Deegan, K. Gong, K. C. Hopkins, P. Howell, et al., Nature Biotechnology, 38:482-492. 2020.
The range of the mosquito Aedes aegypti continues to expand, putting more than two billion people at risk of arboviral infection. The sterile insect technique (SIT) has been used to successfully combat agricultural pests at large scale, but not mosquitoes, mainly because of ...
Engineering multiple species-like genetic incompatibilities in insects
Tags: Fruit fly, Gene drive synthetic, Genetic incompatibilities, Regulation, Toxin-antidote, UnderdominanceM. Maselko, N. Feltman, A. Upadhyay, A. Hayward, S. Das, N. Myslicki, A. J. Peterson, M. B. O’Connor and M. J. Smanski, bioRxiv, 2020.
Speciation constrains the flow of genetic information between populations of sexually reproducing organisms. Gaining control over mechanisms of speciation would enable new strategies to manage wild populations of disease vectors, agricultural pests, and invasive species. ...
Bioethical issues in genome editing by CRISPR-Cas9 technology
Tags: Ethics, Gene drive, Gene editingF. B. Ayanoglu, A. E. Elcin and Y. M. Elcin, Turkish Journal of Biology, 44:110-120. 2020.
Genome editing technologies have led to fundamental changes in genetic science. Among them, CRISPR-Cas9 technology particularly stands out due to its advantages such as easy handling, high accuracy, and low cost. It has made a quick introduction in fields related to humans, ...
Auditing preparedness for vector control field studies
Tags: Gene drive synthetic, Gene editing, Risk assessmentC. M. Collins and M. M. Quinlan, American Journal of Tropical Medicine and Hygiene, 102:707-710. 2020.
The value of baseline entomological data to any future area-wide release campaign relies on the application of consistent methods to produce results comparable across different times and places in a stepwise progression to larger releases. Traditionally, standard operating ...
Engineering a minimal gene drive system for integral replacement in Drosophila melanogaster
Tags: Fruit fly, Gene drive synthetic, Population modification/replacementA. Nash, Imperial College London, 2020.
Gene drives represent a powerful tool for the control of vector-borne diseases. By suppressing or replacing vector populations, laboratory studies have highlighted the potential for this group of tools to make a powerful impact on the burden of zoonotic disease. Current genetic ...
Development of control and sterilization technology for bluegill by genome editing
Tags: Fish, Gene drive synthetic, Genetic biocontrol, Invasive species, Sterile insect technique (SIT)M. A. Madsen, Nippon Suisan Gakkaishi, 86:100-100. 2020.
This article is in Japanese
Male-biased adult production of the striped fruit fly, Zeugodacus scutellata, by feeding dsRNA fpecific to Transformer-2
Tags: Genetic engineering, Sterile insect technique (SIT)M. A. Al Baki, M. Vatanparast and Y. Kim, Insects, 11:211. 2020.
Sterile insect release technique (SIT) is effective for eradicating quarantine insects including various tephritid fruit flies. When SIT is used for fruit flies, it is challenging to remove females from sterile males due to oviposition-associated piercing damage. This study ...
The value of existing regulatory frameworks for the environmental risk assessment of agricultural pest control using gene drive
Tags: Biological control, Gene drive synthetic, Genetically modified organisms, Incompatible insect technique, Regulation, Risk assessment, Sterile insect technique (SIT)J. Romeis, J. Collatz, D. C. M. Glandorf and M. B. Bonsall, Environmental Science & Policy, 108:19-36. 2020.
The application of (synthetic) gene drives is a powerful tool to control populations of insects that are agricultural pests, vectors of diseases, or a threat to biodiversity potentially leading to the local or global eradication of a species. The potential use of gene drive ...
Editorial Expression of Concern: Transgenic Aedes aegypti Mosquitoes Transfer Genes into a Natural Population
Tags: Aedes, Arbovirus, Dengue, Genetic biocontrol, Genetically modified mosquitoes, Oxitec, Risk and safety, South/Central America, Sterile insect technique (SIT)B. R. Evans, P. Kotsakiozi, A. L. Costa-Da-Silva, R. S. Ioshino, L. Garziera, M. C. Pedrosa, A. Malavasi, J. F. Virginio, M. L. Capurro and J. R. Powell, Scientific Reports, 10:2. 2020.
Shortly after publication of this Article in September 2019, the Editors were alerted to concerns regarding the interpretation of the data and some of the conclusions.
Experimental manipulation of selfish genetic elements links genes to microbial community function
Tags: Gene drive mechanisms, Population genetics/dynamicsS. D. Quistad, G. Doulcier and P. B. Rainey, Philosophical Transactions of the Royal Society B-Biological Sciences, 375:12. 2020.
Microbial communities underpin the Earth's biological and geochemical processes, but their complexity hampers understanding. Motivated by the challenge of diversity and the need to forge ways of capturing dynamical behaviour connecting genes to function, biologically independent ...
Can a population targeted by a CRISPR-based homing gene drive be rescued?
Tags: CRISPR, Gene drive synthetic, Replicator/site directed nuclease, Risk assessmentN. O. Rode, V. Courtier-Orgogozo and F. Débarre, bioRxiv, 2020.03.17.995829. 2020.
CRISPR-based homing gene drive is a genetic control technique aiming to modify or eradicate natural populations through the release of individuals carrying an engineered piece of DNA that can be inherited by all their progeny. Developing countermeasures is important to control ...
Simulating effects of fitness and dispersal on the use of Trojan sex chromosomes for the management of invasive species
Tags: Biological control, Fish, Genetic biocontrol, Modeling, Pest management, Sex distorter, Y-chromosomeC. C. Day, E. L. Landguth, R. K. Simmons, W. P. Baker, A. R. Whiteley, P. M. Lukacs and A. Bearlin, Journal of Applied Ecology, 2020.
The use of Trojan Y chromosomes (TYC) for controlling invasive species involves manipulating the sex chromosomes of captive-raised individuals. Following release, the offspring of these individuals consist of only one sex, thereby skewing the sex ratio of the invasive population ...
Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs
Tags: CRISPR, Gene drive synthetic, Replicator/site directed nuclease, ResistanceS. E. Champer, S. Y. Oh, C. Liu, Z. Wen, A. G. Clark, P. W. Messer and J. Champer, Science Advances, 6:eaaz0525. 2020.
The rapid evolution of resistance alleles poses a major obstacle for genetic manipulation of populations with CRISPR homing gene drives. One proposed solution is using multiple guide RNAs (gRNAs), allowing a drive to function even if some resistant target sites are present. Here, ...
Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies
Tags: CRISPR, Gene drive mechanisms, Gene drive syntheticMarino, N. D., Pinilla-Redondo, R. , Csorgo, B., Bondy-Denomy, J., Nature Methods, 2020.
Clustered, regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) genes, a diverse family of prokaryotic adaptive immune systems, have emerged as a biotechnological tool and therapeutic. The discovery of protein inhibitors of CRISPR-Cas systems, ...
Abundance of conserved CRISPR-Cas9 target sites within the highly polymorphic genomes of Anopheles and Aedes mosquitoes
Tags: Anopheles, Gene drive synthetic, Genetics, Population genetics/dynamics, ResistanceH. Schmidt, T. C. Collier, M. J. Hanemaaijer, P. D. Houston, Y. Lee and G. C. Lanzaro, Nature Communications, 11. 2020.
ere we report the results of a survey of 1280 genomes of the mosquitoes Anopheles gambiae, An. coluzzii, and Aedes aegypti in which we determine that similar to 90% of all protein-encoding CGD target genes in natural populations include at least one target site with no DRAs at a ...
A fly model establishes distinct mechanisms for synthetic CRISPR/Cas9 sex distorters
Tags: Fruit fly, Gene drive synthetic, Other arthropods, Y-chromosomeB. Fasulo, A. Meccariello, M. Morgan, C. Borufka, P. A. Papathanos and N. Windbichler, PLOS Genetics, 16:e1008647. 2020.
Author summary Harmful insect populations can be eliminated for a lack of females if they are made to produce mostly male offspring. There are genes that occur naturally that make males produce mostly sons and, although we don’t know exactly how they work, this appears to ...
Performance analysis of novel toxin-antidote CRISPR gene drive systems
Tags: Gene drive synthetic, Replicator/site directed nuclease, Resistance, Toxin-antidoteJ. Champer, I. K. Kim, S. E. Champer, A. G. Clark and P. W. Messer, BMC Biology, 18:27. 2020.
CRISPR gene drive systems allow the rapid spread of a genetic construct throughout a population. Such systems promise novel strategies for the management of vector-borne diseases and invasive species by suppressing a target population or modifying it with a desired trait. ...
Stakeholder workshop “Problem formulation for the environmental risk assessment of gene drive modified insects” (15 May 2019, Brussels)
Tags: Biodiversity/Conservation, Gene drive synthetic, PolicyEuropean Food Safety, A., Devos, Y., Gallani, B. & Firbank, L. G, A. European Food Safety, Y. Devos, B. Gallani and L. G. Firbank, 17:1819E. 2020.
Recent advances in molecular and synthetic biology are enabling the engineering of gene drives that spread genes of interest through interbreeding populations at a frequency greater than the rate expected by simple Mendelian inheritance. At present, insects represent the most ...
Toward the definition of efficacy and safety criteria for advancing gene drive-modified mosquitoes to field testing
Tags: Gene drive synthetic, Policy, Risk and safetyS. L. James, J. M. Marshall, G. K. Christophides, F. O. Okumu and T. Nolan, Vector Borne and Zoonotic Diseases, 20:237. 2020.
Mosquitoes containing gene drive systems are being developed as complementary tools to prevent transmission of malaria and other mosquito-borne diseases. As with any new tool, decision makers and other stakeholders will need to balance risks (safety) and benefits (efficacy) when ...
Population-level multiplexing: A promising strategy to manage the evolution of resistance against gene drives targeting a neutral locus
Tags: CRISPR, Gene drive synthetic, Genetic engineering, Population genetics/dynamicsM. P. Edgington, T. Harvey-Samuel and L. Alphey, Evolutionary Applications, 10. 2020.
CRISPR-based gene drives bias inheritance in their favour by inducing double-stranded breaks (DSBs) at wild-type homologous loci and using the drive transgene as a repair template-converting drive heterozygotes into homozygotes. Recent studies have shown that alternate ...
A unifying approach to gene drive
Tags: Gene drive syntheticP. Verma, R. Reeves and C. S. Gokhale, bioRxiv, 2020.02.28.970103. 2020.
Synthetic gene drive technologies aim to spread transgenic constructs into wild populations even when they impose organismal fitness disadvantages. The properties of gene drive constructs are diverse and depend on their molecular construction, and differential selection pressure ...
Public health concerns over gene-drive mosquitoes: will future use of gene-drive snails for schistosomiasis control gain increased level of community acceptance?
Tags: Gene drive synthetic, Mosquitoes, Other invertebratesD. O. Famakinde, Pathogens and Global Health, 2020.
With the advent of CRISPR (clustered regularly interspaced short palindromic repeat)-based gene drive, present genetic research in schistosomiasis vector control envisages the breeding and release of transgenic schistosome-resistant (TSR) snail vectors to curb the spread of the ...
Gene Drives: New and Improved
Tags: Gene drive synthetic, Policy, RegulationR. M. Friedman, J. M. Marshall and O. S. Akbari, Issues in Science and Technology, 36:1-7. 2020.
Our goal here is to describe the various options under development in nontechnical terms for a policy-making audience, review how far along each is, and examine the broader context of how this new suite of technologies compares with other available alternatives. Early engagement ...
Genome engineering in insects: focus on the CRISPR/Cas9 system
Tags: CRISPR, Gene drive synthetic, Gene editingHillary, V. Edwin Ceasar, Stanislaus Antony Ignacimuthu, S., Genome Engineering via CRISPR-Cas9 System, 2020.
Genome engineering is a precise tool used to alter the genome of desired organism. Zinc finger nuclease (ZFN), transcription activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeats (CRISPR), and the CRISPR-associated RNA guided ...
Modeling the impacts of a simple meiotic gene drive on small, homeostatic populations
Tags: Evolution, Gene drive synthetic, Transmission distortionK. R. Pilkiewicz and M. L. Mayo, Physical Review E, 101:11. 2020.
Gene drives offer unprecedented control over the fate of natural ecosystems by leveraging non-Mendelian inheritance mechanisms to proliferate synthetic genes across wild populations. However, these benefits are offset by a need to avoid the potentially disastrous consequences of ...
Dramatically diverse Schizosaccharomyces pombe wtf meiotic drivers all display high gamete-killing efficiency
Tags: Toxin-antidote, Transmission distortion, Yeast and FungiM. A. Bravo Núñez, I. M. Sabbarini, M. T. Eickbush, Y. Liang, J. J. Lange, A. M. Kent and S. E. Zanders, PLOS Genetics, 16:e1008350. 2020.
During gametogenesis, the two gene copies at a given locus, known as alleles, are each transmitted to 50% of the gametes (e.g. sperm). However, some alleles cheat so that they are found in more than the expected 50% of gametes, often at the expense of fertility. This selfish ...
Progress towards engineering gene drives for population control
Tags: Gene drive synthetic, Transmission distortion, UnderdominanceR. R. Raban, J. M. Marshall and O. S. Akbari, The Journal of Experimental Biology, 223:jeb208181. 2020.
Vector-borne diseases, such as dengue, Zika and malaria, are a major cause of morbidity and mortality worldwide. These diseases have proven difficult to control and currently available management tools are insufficient to eliminate them in many regions. Gene drives have the ...
Vector genetics, insecticide resistance and gene drives: an agent-based modeling approach to evaluate malaria transmission and elimination
Tags: Africa, Evolution, Gene drive mechanisms, Gene drive synthetic, Malaria, Modeling, MosquitoesP. Selvaraj, E. A. Wenger, D. Bridenbecker, N. Windbichler, J. R. Russell, J. Gerardin, C. A. Bever and M. Nikolov, bioRxiv, 2020.01.27.920421. 2020.
Vector control has been a key component in the fight against malaria for decades, and chemical insecticides are critical to the success of vector control programs worldwide. However, increasing resistance to insecticides threatens to undermine these efforts. Understanding the ...
Phased Conditional Approach for Mosquito Management Using Sterile Insect Technique
Tags: Regulation, Sterile insect technique (SIT)J. Bouyer, H. Yamada, R. Pereira, K. Bourtzis and M. J. B. Vreysen, Trends in Parasitology, 2020.
Mosquito-borne diseases represent a major threat to humankind. Recently, the incidence of malaria has stopped decreasing while that of dengue is increasing exponentially. Alternative mosquito-control methods are urgently needed. The sterile insect technique (SIT) has seen ...
Genetic Variation and Potential for Resistance Development to the tTA Overexpression Lethal System in Insects
Tags: Fruit fly, Oxitec, Resistance, Sterile insect technique (SIT)K. E. Knudsen, W. R. Reid, T. M. Barbour, L. M. Bowes, J. Duncan, E. Philpott, S. Potter and M. J. Scott, G3: Genes|Genomes|Genetics, Early Online:g3.400990.2020. 2020.
Release of insect pests carrying the dominant lethal tetracycline transactivator (tTA) overexpression system has been proposed as a means for population suppression. High levels of the tTA transcription factor are thought to be toxic due to either transcriptional squelching or ...
Engineered symbionts activate honey bee immunity and limit pathogens
Tags: Genetic biocontrol, Other arthropods, Other SymbiontsP. Leonard Sean, J. E. Powell, J. Perutka, P. Geng, C. Heckmann Luke, D. Horak Richard, W. Davies Bryan, D. Ellington Andrew, E. Barrick Jeffrey and A. Moran Nancy, Science, 367:573-576. 2020.
Honey bees are essential pollinators threatened by colony losses linked to the spread of parasites and pathogens. Here, we report a new approach for manipulating bee gene expression and protecting bee health. We engineered a symbiotic bee gut bacterium, Snodgrassella alvi, to ...
Gene technologies in weed management: a technical feasibility analysis
Tags: Agriculture, Gene drive synthetic, Replicator/site directed nuclease, ResistanceN. Kumaran, A. Choudhary, M. Legros, A. W. Sheppard, L. G. Barrett, D. M. Gardiner and S. Raghu, Current Opinion in Insect Science, 38:6-14. 2020.
With the advent of new genetic technologies such as gene silencing and gene drive, efforts to develop additional management tools for weed management is gaining significant momentum. These technologies promise novel ways to develop sustainable weed control options because gene ...
