Scholarly Literature
This is an aggregation of scholarly literature from peer-reviewed journals, bioRxiv , medRxiv and arXiv preprint servers focused on natural and engineered selfish genetic elements and genetic biocontrol. New citations are added as they appear. This content is intended for anyone interested in the scholarly literature on gene drive and genetic biocontrol.
Meiotic Cas9 expression mediates gene conversion in the male and female mouse germline
Tags: CRISPR, Gene drive synthetic, RodentsA. J. Weitzel, H. A. Grunwald, C. Weber, R. Levina, V. M. Gantz, S. M. Hedrick, E. Bier and K. L. Cooper, PLOS Biology, 19:e3001478. 2021.
Highly efficient gene conversion systems have the potential to facilitate the study of complex genetic traits using laboratory mice and, if implemented as a “gene drive,” to limit loss of biodiversity and disease transmission caused by wild rodent populations. We previously ...
Weakly deleterious natural genetic variation amplifies probability of resistance in multiplexed gene drive systems
Tags: Gene drive, Gene drive synthetic, Modeling, ResistanceB. S. Khatri and A. Burt, bioRxiv, 2021.12.23.473701. 2021.
Evolution of resistance is a major barrier to successful deployment of gene drive systems to suppress natural populations. Multiplexed guide RNAs that require resistance mutations in all target cut sites is a promising strategy to overcome resistance. Using novel stochastic ...
Interaction Between Entomology and Gene Technology: Bt-transgenic and Gene Drives for Pests Control .
Tags: Agriculture, Gene drive synthetic, Genetic biocontrolJ. C. Ndayıragıje, T. Özek, H. Çevik and İ. Karaca, Türk Bilim ve Mühendislik Dergisi, 3:108-115. 2021.
Pest control is the major agricultural activity for increasing crop productivity thus insuring food security. Recent pest management programs are depending too much on chemical pesticides, which are a threat to our health and environment. One of the greatest entomological ...
chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche
Tags: Transmission distortionC. Y. Tseng, M. Burel, M. Cammer, S. Harsh, M. S. Flaherty, S. Baumgartner and E. A. Bach, Developmental Cell, 2021.
Niches maintain a finite pool of stem cells via restricted space and short-range signals. Stem cells compete for limited niche resources, but the mechanisms regulating competition are poorly understood. Using the Drosophila testis model, we show that germline stem cells (GSCs) ...
Temporal Viability of Aedes aegypti and Aedes albopictus Eggs Using Two Hygroscopic Substances as Preservatives under a Sterile Insect Technique (SIT) Program in Southern Mexico
Tags: Aedes, Mosquito husbandry, Mosquitoes, Sterile insect technique (SIT)E. N. Martínez-García, E. E. Díaz-González, C. F. Marina, J. G. Bond, J. J. Rodríguez-Rojas, G. Ponce-García, R. M. Sánchez-Casas and I. Fernández-Salas, Insects, 13. 2021.
Dengue and other Aedes-borne diseases have dramatically increased over the last decades. The Sterile Insect Technique (SIT) has been successfully used as part of integrated pest strategies to control populations of insect-plant and livestock pests and is currently being tested as ...
Three Decades of Malaria Vector Control in Sudan: The Plausible Role of Sterile Insect Technique (SIT)
Tags: Anopheles, Sterile insect technique (SIT)A. Elaagip and A. Adedapo, Genetically Modified and other Innovative Vector Control Technologies, 2021.
In Northern State, Sudan, a feasibility study for sterile insect technique (SIT) in an area-wide integrated pest management was established for the first time in an African country. The aim of the study was to see whether it is feasible, from a technical, an economical and a ...
Perspectives into Genetic Manipulations for Control of Dengue Vector (Aedes aegypti Linnaeus, 1762) with Reference to Progress in Indian Experiments
Tags: Aedes, Gene drive synthetic, Genetic biocontrol, Incompatible insect technique, Sterile insect technique (SIT)R. Chatterjee, S. Bhattacharya and B. K. Tyagi, Genetically Modified and other Innovative Vector Control Technologies, 2021.
Vector-borne diseases like malaria, dengue, chikungunya, Japanese encephalitis, Zika and others claim millions of lives across the globe annually, and as such their control has become an ardent necessity. Past attempts over the decades have introduced vector control through ...
Aedes Control Using Sterile Insect Technique (SIT) in Malaysia
Tags: Aedes, Dengue, Sterile insect technique (SIT)W. A. Nazni, G.-N. Teoh, S. I. Shaikh Norman Hakimi, M. A. Muhammad Arif, M. Tanusshni, M. A. Nuradila, A. Nurfarahin Hanini, I. A. Shazia, A.-M. Tan, H. Rabizah, M. D. Ahmad Zainuri, A. Hasnor Hadi, Y.-L. Cheong, A. Norazah, H. Maiga, R. S. Lees and L. H, Genetically Modified and other Innovative Vector Control Technologies, 2021.
The continued occurrence of massive outbreaks of Aedes-borne viral diseases of dengue, chikungunya, Zika and yellow fever, in spite of intensive and extensive application of conventional control measures, necessitates application of new tools, such as sterile insect technique ...
Integrated Management of Malaria Vectors in Africa
Tags: Genetic biocontrol, Malaria, Mosquitoes, Policy, Regulation, Risk assessment, Stakeholder engagementR. Mbabazi, K. Maredia, B. B. El-Sayed, A. K. Babumba, M. Savadogo and O. Akinbo, Genetically Modified and other Innovative Vector Control Technologies, 2021.
Malaria disease is a major public health burden in Africa. The control of malaria vectors is a critical component for prevention, management, and eradication of malaria disease. This chapter presents information on the current status of malaria vector control in Africa with ...
Engineering RNA Interference-Based Dengue Virus Resistance in the Mosquito Vector Aedes aegypti: The Current Status and Future Directions
Tags: Aedes, Dengue, Genetic biocontrol, Genetic engineeringS. D. Denipitiyage, Y. I. N. S. Gunawardene, Z. Federico and R. S. Dassanayake, Genetically Modified and other Innovative Vector Control Technologies, 2021.
Dengue is an acute, febrile disease caused by the dengue viruses (DENV) comprising four serotypes and transmitted by the mosquito vector Ae. aegypti. DENV are single-stranded, positive-sense RNA viruses of the family Flaviviridae. Dengue is declared as a current significant ...
Wolbachia: Biological Control Strategy Against Arboviral Diseases
Tags: Aedes, Arbovirus, Genetic biocontrol, Population modification/replacement, WolbachiaI. Mohanty, A. Rath and R. K. Hazra, Genetically Modified and other Innovative Vector Control Technologies, 2021.
Arboviral diseases like dengue, chikungunya, and Zika are among the major causes of mortality and morbidity in human population. The limited control methods together with lack of antiviral therapies and effective vaccines have paved way for new approaches. One such approach to ...
Wolbachia Endosymbiont and Mosquito Vectors, with Emphasis on Lymphatic Filariasis Elimination
Tags: Culex, Cytoplasmic incompatibility, Incompatible insect technique, Population modification/replacement, WolbachiaI. P. Sunish, Genetically Modified and other Innovative Vector Control Technologies, 2021.
Wolbachia are maternally inherited intracellular bacteria, known to alter early development and mitotic processes in their hosts. They are frequently observed as a reproductive parasite, capable of inducing feminization, parthenogenesis, male killing, or cytoplasmic ...
Laboratory Biosafety in Handling Genetically Modified Mosquitoes
Tags: Containment, Genetically modified mosquitoes, Policy, Regulation, Risk and safety, Risk assessmentJ. Charles, Genetically Modified and other Innovative Vector Control Technologies, 2021.
One of the novel approaches in controlling vector-borne diseases is to release genetically modified mosquitoes in nature. Trial studies are done in different phases by the researches, both in the laboratory and in the fields. Before a GM mosquito is validated to be ready for ...
Safety Assessment of Novel Genetic Technologies for Vector Control: National and International Perspectives
Tags: Asia, Genetically modified mosquitoes, Policy, Regulation, Risk and safety, Risk assessmentV. Ahuja, Genetically Modified and other Innovative Vector Control Technologies, 2021.
Novel genetic technologies provide an alternative approach for control of vectors particularly those carrying deadly pathogens. Genetic control technologies aim to either suppress target populations or modify the vector by introducing a heritable factor that reduces or blocks ...
Measuring Public Attitudes to Releases of Transgenic Mosquitoes for Disease Control, with Special Reference to Dengue and Malaria
Tags: Dengue, Genetic biocontrol, Genetically modified mosquitoes, Malaria, Policy, Regulation, Risk and safety, Risk assessment, Stakeholder engagementL. A. De Las Llagas and M. S. T. Gunigundo, Genetically Modified and other Innovative Vector Control Technologies, 2021.
Since the advent of DDT in public health and agriculture, science leaped forward with revolutionary technology such as gene drive or editing, thus making it possible to develop alternative approaches to address vector-borne diseases. However, their utilization and sustenance in ...
Experiences and Outcomes from a Worldwide Training Programme on Genetically Modified Vectors (GMVs) Related Biosafety for Human Health and the Environment
Tags: Genetic biocontrol, Genetically modified mosquitoesB. K. Tyagi, Genetically Modified and other Innovative Vector Control Technologies, 2021.
Partial to virtual lack of any impact on control of vectors of human diseases, especially mosquitoes, warranted urgent search for new alternate technologies which will be safe, economical and environment-friendly, on one hand, and integrate with other tools and methodologies of ...
Advances in Aedes Mosquito Vector Control Strategies Using CRISPR/Cas9
Tags: Aedes, Dengue, Gene drive synthetic, Genetic biocontrol, MosquitoesP. D. S. U. Wickramasinghe, G. N. Silva, Y. I. N. Silva Gunawardene and R. S. Dassanayake, Genetically Modified and other Innovative Vector Control Technologies, 2021.
Advancements in genetic engineering have resulted in the development of mosquitoes with impaired vector competence, thereby limiting acquisition and transmission of pathogens. The main dengue (DENV) vector, Aedes aegypti, is an invasive species that have spread unwittingly across ...
Genetic Improvements to the Sterile Insect Technique (SIT) for the Control of Mosquito Population
Tags: Genetic biocontrol, Mosquitoes, Sterile insect technique (SIT)P. V. D. Dilani, Y. I. N. S. Gunawardene and R. S. Dassanayake, Genetically Modified and other Innovative Vector Control Technologies, 2021.
Mosquito-borne diseases are becoming a major health problem worldwide. At present, the principal method of controlling these diseases entirely depends on the mosquito vector control strategies. However, traditional control methods which are focussed on reducing mosquito ...
Field Trials of Gene Drive Mosquitoes: Lessons from Releases of Genetically Sterile Males and Wolbachia-infected Mosquitoes
Tags: Field trials, Gene drive synthetic, Incompatible insect technique, Mosquitoes, Sterile insect technique (SIT), WolbachiaJ. M. Marshall and V. N. Vásquez, Genetically Modified and other Innovative Vector Control Technologies, 2021.
The discovery of CRISPR-based gene editing and its application to homing-based gene drive has been greeted with excitement, for its potential to control mosquito-borne diseases on a wide scale, and concern, for the invasiveness and potential irreversibility of a release. At the ...
Arthropods of Medical Importance: Need for Genetic and Other Innovative Vector Control Technologies, with Emphasis on Eco-biosocial and Environmental Considerations.
Tags: Gene drive synthetic, Genetic biocontrol, Incompatible insect technique, Mosquitoes, Policy, Risk and safety, Stakeholder engagement, Sterile insect technique (SIT), WolbachiaB. K. Tyagi, Genetically Modified and other Innovative Vector Control Technologies, 2021.
Among the world’s known vector groups, viz. arthropods, snails and rodents, the most important vectors originate from arthropods, the jointed legs. Arthropods are doubtlessly regarded as the most dominant creatures on the Earth due largely to their remarkable structural and ...
The Effects of Boric Acid Sugar Bait on Wolbachia Trans-Infected Male Aedes albopictus (ZAP Males®) in Laboratory Conditions
Tags: Genetic biocontrol, Incompatible insect technique, WolbachiaV. S. Aryaprema, W. A. Qualls, K. L. Dobson, S. L. Dobson and R.-D. Xue, Insects, 13. 2021.
The field release of Wolbachia trans-infected male mosquitoes, as well as the use of toxic sugar baits, is a novel and promising candidate technique for integrated mosquito management programs. However, the methods of action of the two techniques may not be complementary, because ...
Genetically Modified and other Innovative Vector Control Technologies
Tags: Gene drive synthetic, Genetic biocontrol, Incompatible insect technique, Mosquitoes, Policy, Risk and safety, Stakeholder engagement, Sterile insect technique (SIT), WolbachiaB. K. Tyagi, SpringerLink, 2021.
This book comprehensively covers the latest development in developing and deploying the genetically modified vectors, particularly Anopheles and Aedes mosquitoes responsible for transmitting malaria parasites and dengue viruses, the most deadly and/or debilitating among all the ...
Safe Application of Genetically Modified Mosquito (GMM) to Combat Dengue and Chikungunya Depends on Socioeconomic Status and Social Acceptance in the Developing Countries: A Comprehensive Analysis
Tags: Dengue, Genetic biocontrol, Genetically modified mosquitoes, Malaria, Policy, Regulation, Risk and safety, Risk assessment, Stakeholder engagementM. N. Islam, Genetically Modified and other Innovative Vector Control Technologies, 2021.
The emerging and re-emerging vector-borne diseases are a serious public health problem throughout the world. It has been observed that more than 100 countries and approximately half of the world’s population are at risk on vector-borne diseases (VBDs). The global burden of the ...
Malaria vector control tools in emergency settings: What do experts think? Results from a DELPHI survey
Tags: Genetically modified mosquitoes, Malaria, Policy, Stakeholder engagementC. Boete, S. Burza, E. Lasry, S. Moriana and W. Robertson, Conflict and Health, 15:11. 2021.
Background The use and implementation of novel tools for malaria control such as long lasting impregnated bednets (LLINs) and Indoor Residual Spraying (IRS) over the last decade has contributed to a substantial reduction in malaria burden globally. However numerous challenges ...
Gene Editing in the Wild: Shaping Decisions through Broad Public Deliberation
Tags: Ethics, Gene drive synthetic, Gene editing, Stakeholder engagementM. K. Gusmano, G. E. Kaebnick, K. J. Maschke, C. P. Neuhaus and B. C. Wills, The Hastings Center Report, 51. 2021.
The essays in this special report grew out of a project funded by the National Science Foundation (with NSF award number 1827935). Gregory E. Kaebnick and Michael K. Gusmano were co-principal investigators on the project, and Karen J. Maschke and Carolyn P. Neuhaus were ...
Genetic Control in Historical Perspective: The Legacy of India’s Genetic Control of Mosquitoes Unit
Tags: Asia, Genetic biocontrol, History, Sterile insect technique (SIT)R. Wilbanks, Hastings Center Report, 51:S11-S18. 2021.
Abstract In the early 1970s, a World Health Organization-initiated and United States-funded project released lab-reared mosquitoes outside New Delhi in the first large-scale field trials of the genetic control of mosquitoes. Despite partnering with the Indian Council of Medical ...
Deficits of Public Deliberation in U.S. Oversight for Gene Edited Organisms
Tags: Ethics, Gene editing, Regulation, Stakeholder engagementJ. Kuzma, Hastings Center Report, 51 Suppl 2:S25-s33. 2021.
Environmental releases of gene edited (GEdOs) and gene drive organisms (GDOs) will likely occur under conditions of high uncertainty and in complex socioecological systems. Therefore, public deliberation is especially important to account for diverse interpretations of safety, ...
Public Deliberation about Gene Editing in the Wild
Tags: Ethics, Gene drive, Gene editing, Stakeholder engagementM. K. Gusmano, G. E. Kaebnick, K. J. Maschke, C. P. Neuhaus and B. C. Wills, Hastings Center Report, 51 Suppl 2:S2-s10. 2021.
Genetic editing technologies have long been used to modify domesticated nonhuman animals and plants. Recently, attention and funding have also been directed toward projects for modifying nonhuman organisms in the shared environment-that is, in the "wild." Interest in gene editing ...
Empowering Indigenous Knowledge in Deliberations on Gene Editing in the Wild
Tags: Ethics, Gene drive, Genetic engineering, Stakeholder engagementR. Taitingfong and A. Ullah, Hastings Center Report, 51 Suppl 2:S74-s84. 2021.
Proposals to release genetically engineered organisms in the wild raise complex ethical issues related to their safe and equitable implementation. While there is broad agreement that community and public engagement is vital to decision-making in this context, more discussion is ...
The Decision Phases Framework for Public Engagement: Engaging Stakeholders about Gene Editing in the Wild
Tags: Ethics, Gene drive synthetic, Gene editing, Stakeholder engagementS. K. Barnhill-Dilling, A. Kokotovich and J. A. Delborne, Hastings Center Report, 51 Suppl 2:S48-s61. 2021.
Some experts and advocates propose environmental biotechnologies such as genetic engineering, gene drive systems, and synthetic biology as potential solutions to accelerating rates of species loss. While these tools may offer hope for a seemingly intractable problem, they also ...
Diverse mating phenotypes impact the spread of wtf meiotic drivers in Schizosaccharomyces pombe
Tags: Transmission distortionJ. F. L. Hernandez, R. M. Helston, J. J. Lange, R. B. Billmyre, S. H. Schaffner, M. T. Eickbush, S. McCroskey and S. E. Zanders, Elife, 10:30. 2021.
Meiotic drivers are genetic elements that break Mendel's law of segregation to be transmitted into more than half of the offspring produced by a heterozygote. The success of a driver relies on outcrossing (mating between individuals from distinct lineages) because drivers gain ...
Exploiting a Y chromosome-linked Cas9 for sex selection and gene drive
Tags: Chromosomal drive, CRISPR, Gene drive synthetic, Sex distorterS. Gamez, D. Chaverra-Rodriguez, A. Buchman, N. P. Kandul, S. C. Mendez-Sanchez, J. B. Bennett, C. H. Sánchez, T. Yang, I. Antoshechkin, J. E. Duque, P. A. Papathanos, J. M. Marshall and O. S. Akbari, Nature Communications, 7202. 2021.
CRISPR-based genetic engineering tools aimed to bias sex ratios, or drive effector genes into animal populations, often integrate the transgenes into autosomal chromosomes. However, in species with heterogametic sex chromsomes (e.g. XY, ZW), sex linkage of endonucleases could be ...
Evolution of B Chromosomes: From Dispensable Parasitic Chromosomes to Essential Genomic Players
Tags: Chromosomal driveM. Johnson Pokorná and R. Reifová, Frontiers in Genetics, 12:727570. 2021.
B chromosomes represent additional chromosomes found in many eukaryotic organisms. Their origin is not completely understood but recent genomic studies suggest that they mostly arise through rearrangements and duplications from standard chromosomes. They can occur in single or ...
Genomic insertion locus and Cas9 expression in the germline affect CRISPR/Cas9-based gene drive performance in the yellow fever mosquito Aedes aegypti
Tags: Aedes, Arbovirus, CRISPR, Dengue, Gene drive synthetic, Population modification/replacement, ResistanceW. R. Reid, J. Lin, A. E. Williams, R. Juncu, K. E. Olson and A. W. E. Franz, bioRxiv, 2021.12.08.471839. 2021.
The yellow fever mosquito Aedes aegypti is a major vector of arthropod-borne viruses, including dengue, chikungunya, and Zika. A novel approach to mitigate arboviral infections is to generate mosquitoes refractory to infection by overexpressing antiviral effector molecules. Such ...
Modeling impact and cost-effectiveness of driving-Y gene drives for malaria elimination in the Democratic Republic of the Congo
Tags: Anopheles, Gene drive synthetic, Malaria, Modeling, Replicator/site directed nucleaseN. Metchanun, C. Borgemeister, G. Amzati, J. von Braun, M. Nikolov, P. Selvaraj and J. Gerardin, Evolutionary Applications, 2021.
Malaria elimination will be challenging in countries that currently continue to bear high malaria burden. Sex-ratio distorting gene drives, such as driving-Y, could play a role in an integrated elimination strategy if they can effectively suppress vector populations. Using a ...
Genetic conversion of a split-drive into a full-drive element
Tags: CRISPR, Fruit fly, Gene drive, Gene drive synthetic, Self limitingG. Terradas, J. B. Bennett, Z. Li, J. M. Marshall and E. Bier, bioRxiv, 2021.12.05.471291. 2021.
Gene-drive systems offer an important new avenue for spreading beneficial traits into wild populations. Their core components, Cas9 and guide RNA (gRNA), can either be linked within a single cassette (full gene drive, fGD) or provided in two separate elements (split gene drive, ...
Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects
Tags: Fruit fly, Transmission distortionA. Mirsalehi, D. N. Markova, M. Eslamieh and E. Betrán, BMC Genomics, 22:876. 2021.
We find that most of the nuclear transport duplications in Drosophila are of a few classes of nuclear transport genes, RNA mediated and fast evolving. We also retrieve many pseudogenes for the Ran gene. Some of the duplicates are relatively young and likely contributing to the ...
The economic value of genetically engineered mosquitoes as a Malaria control strategy depends on local transmission rates
Tags: Gene drive synthetic, Genetically modified mosquitoes, Malaria, Oxitec, Sterile insect technique (SIT)K. Lacy, K. A. Schaefer, D. P. Scheitrum and E. Y. Klein, Biotechnology Journal, 10. 2021.
This paper assesses the economic value of genetically engineered (GE) Anopheles gambiae mosquitoes as a malaria control strategy. We use an epidemiological-economic model of malaria transmission to evaluate this technology for a range of village-level transmission settings. In ...
Towards Integrated Management of Dengue in Mumbai
Tags: Asia, Dengue, Mosquitoes, WolbachiaP. N. Paradkar, P. R. Sahasrabudhe, M. Ghag Sawant, S. Mukherjee and K. R. Blasdell, Viruses, 13. 2021.
With increasing urbanisation, the dengue disease burden is on the rise in India, especially in large cities such as Mumbai. Current dengue surveillance in Mumbai includes municipal corporation carrying out specific activities to reduce mosquito breeding sites and the use of ...
A flurry of sex-ratio distorters
Tags: Transmission distortionA. A. Vogan, Nature Ecology and Evolution, 2021.
Two analyses of long-read sequencing show that the Winters sex-ratio distorter of Drosophila has been a part of a recent gene family expansion, coupled to the appearance of suppressors, in a genomic arms race driven by satellite DNA.
Rapid evolutionary dynamics of an expanding family of meiotic drive factors and their hpRNA suppressors
Tags: Evolution, Fruit fly, Transmission distortionJ. Vedanayagam, C. J. Lin and E. C. Lai, Nature Ecology and Evolution, 2021.
Meiotic drivers are a class of selfish genetic elements whose existence is frequently hidden due to concomitant suppressor systems. Accordingly, we know little of their evolutionary breadth and molecular mechanisms. Here, we trace the evolution of the Dox meiotic drive system in ...
CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes
Tags: CRISPR, Gene drive synthetic, Rodents, Sex distorter, X chromosome, Y-chromosomeC. Douglas, V. Maciulyte, J. Zohren, D. M. Snell, S. K. Mahadevaiah, O. A. Ojarikre, P. J. I. Ellis and J. M. A. Turner, Nature Communications, 12:6926. 2021.
Animals are essential genetic tools in scientific research and global resources in agriculture. In both arenas, a single sex is often required in surplus. The ethical and financial burden of producing and culling animals of the undesired sex is considerable. Using the mouse as a ...
Public Perceptions Regarding Genomic Technologies Applied to Breeding Farm Animals: A Qualitative Study
Tags: Agriculture, Gene editing, Genetic biocontrol, Stakeholder engagementF. Z. Naab, D. Coles, E. Goddard and L. J. Frewer, BioTech, 10. 2021.
The societal acceptability of different applications of genomic technologies to animal production systems will determine whether their innovation trajectories will reach the commercialisation stage. Importantly, technological implementation and commercialisation trajectories, ...
CRISPR gene-drive systems based on Cas9 nickases promote super-Mendelian inheritance in Drosophila
Tags: CRISPR, Fruit fly, Gene drive syntheticV. Lopez del Amo, S. Sanz Juste and V. M. Gantz, bioRxiv, 2021.12.01.470847. 2021.
CRISPR-based gene drive systems can be used to modify entire wild populations due to their ability to bias their own inheritance towards super-Mendelian rates (>100%). Current gene drives contain a Cas9 and a gRNA gene inserted at the location targeted by the gRNA. These ...
Gene drive that results in addiction to a temperature-sensitive version of an essential gene triggers population collapse in Drosophila
Tags: Fruit fly, Gene drive synthetic, Population modification/replacement, Population suppression, Selfish genetic elements, Toxin-antidoteG. Oberhofer, T. Ivy and B. A. Hay, Proceedings of the National Academy of Sciences, 118:e2107413118. 2021.
One strategy for population suppression seeks to use gene drive to spread genes that confer conditional lethality or sterility, providing a way of combining population modification with suppression. Stimuli of potential interest could be introduced by humans, such as an otherwise ...
Applying functional genomics to the study of lamprey development and sea lamprey population control
Tags: CRISPR, Fish, Gene drive synthetic, Genetic biocontrolJ. R. York, R. E. Thresher and D. W. McCauley, Journal of Great Lakes Research, 47:S639-S649. 2021.
Lampreys are one of the few survivors of an ancient lineage of jawless vertebrates and have become an important study organism in numerous disciplines in the biological sciences, including evolutionary biology, embryology, ecology, physiology and biomedicine. At the same time, ...
New Arthropod Containment Recommendations Provide Essential Guidance for Safety of Gene Drive Research
Tags: Containment, Gene drive synthetic, Genetically modified mosquitoes, PolicyS. James and D. O’Brochta, The American Journal of Tropical Medicine and Hygiene, tpmd211148. 2021.
Gene drive technologies have not yet been field tested, however, there are no data on the possible environmental or health effects of releasing gene drive–modified organisms. For this reason, there have been widespread calls for additional guidance on risk assessment and ...
New molecular genetic techniques: regulatory and societal considerations
Tags: Gene drive synthetic, Genetic biocontrol, Incompatible insect technique, Policy, Regulation, Risk and safety, Risk assessment, Stakeholder engagement, Sterile insect technique (SIT)Nielsen, K. M., AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application, 2021.
A rapidly expanding toolbox of techniques available for genome editing provides the basis for a new continuum in types of modifications that can be introduced into a genome and blur the bimodal GMO vs. non-GMO (genetically modified organism) divide. Site-directed nucleases (SDN) ...
Genome editing and its applications for insect pest control: Curse or blessing?
Tags: CRISPR, Gene drive synthetic, Gene editing, Genetic biocontrol, Genetically modified mosquitoes, Policy, Regulation, Risk and safety, Stakeholder engagementHacker, I. , and Schetelig, M. F, AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application, 2021.
Gene and genome editing are described as cutting-edge research tools with the potential to tackle urgent global challenges in the management of agricultural pests and human disease vectors such as mosquitoes. The field is defined by the chances and challenges to interlink the ...
Area-wide management of fruit flies in a tropical mango growing area integrating the sterile insect technique and biological control: From a research to an operational programme
Tags: Biological control, Fruit fly, Pest management, Sterile insect technique (SIT)Liedo, P., Montoya, P. , and Toledo, J., AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application, 2021.
The Sterile Insect Technique (SIT) has been successfully used for the control of fruit flies in a number of places in the world. One requirement for its successful application is that wild populations should be at low densities to achieve effective sterile to wild fly ...
