Scholarly Literature
This is an aggregation of scholarly literature from peer-reviewed journals, bioRxiv , medRxiv and arXiv preprint servers focused on natural and engineered selfish genetic elements and genetic biocontrol. New citations are added as they appear. This content is intended for anyone interested in the scholarly literature on gene drive and genetic biocontrol.
RISCOS BIOTECNOLÓGICOS AMBIENTAIS E PARTICIPAÇÃO SOCIAL: POR UMA GESTÃO DEMOCRÁTICA DA BIOTECNOLOGIA GENE DRIVE NA ATUAÇÃO DA CTNBIO
Tags: Gene drive synthetic, Policy, Risk assessment, Stakeholder engagementL. C. Rodrigues, Revista Jurídica (FURB), 22. 2019.
This research aims to study the way in which the environmental risks of Gene Drive biotechnology challenge forms of effective social participation, inserted in the management of biotechnological risks, whose responsibility lies with the organs ...
Genetic pest management technologies to control invasive rodents
Tags: Biodiversity/Conservation, CRISPR, Culex, Gene drive, Gene drive synthetic, Genetic biocontrol, Invasive species, Pest management, Rodents, Sex distorter, Transmission distortionD. Kanavy and D. Threadgill, Island invasives: scaling up to meet the challenge, 2019.
Many strategies exist to manage invasive pests on islands, ranging from poison to trapping, with varying degrees of success. Genetic technologies are increasingly being applied to insect pests, but so far, not to vertebrates. We are implementing a genetic strategy to eradicate ...
Trialling gene drives to control invasive species: what, where and how?
Tags: Biodiversity/Conservation, CRISPR, Culex, Gene drive, Gene drive synthetic, Genetic biocontrol, Invasive species, Pest management, RodentsT. Harvey-Samuel, K. J. Campbell, M. Edgington and L. Alphey, Island invasives: scaling up to meet the challenge, 2019.
The control of invasive species would be enhanced through the addition of novel, more effective and sustainable pest management methods. One control option yet to be trialled in the field is to deploy transgene-based ‘Gene Drives’: technologies which force the inheritance of ...
Towards a genetic approach to invasive rodent eradications: assessing reproductive competitiveness between wild and laboratory mice
Tags: Biodiversity/Conservation, CRISPR, Gene drive, Gene drive synthetic, Genetic biocontrol, Invasive species, Pest management, RodentsM. Serr, N. Heard and J. Godwin, Island invasives: scaling up to meet the challenge, 2019.
House mice are significant invasive pests, particularly on islands without native mammalian predators. As part of a multi-institutional project aimed at suppressing invasive mouse populations on islands, we aim to create heavily male-biased sex ratios with the goal of causing the ...
A potential new tool for the toolbox: assessing gene drives for eradicating invasive rodent populations
Tags: Biodiversity/Conservation, CRISPR, Gene drive synthetic, Gene editing, Genetic biocontrol, Invasive species, Pest management, Risk assessment, Rodents, Stakeholder engagementK. J. Campbell, J. R. Saah, P. R. Brown, J. Godwin, F. Gould, G. R. Howald, A. Piaggio, P. Thomas, D. M. Tompkins, D. Threadgill, J. Delborne, D. Kanavy, T. Kuiken, H. Packard, M. Serr and A. Shiels, Island invasives: scaling up to meet the challenge, 2019.
Invasive rodents have significant negative impacts on island biodiversity. All but the smallest of rodent eradications currently rely on island-wide rodenticide applications. Although signifi cant advances have been made in mitigating unintended impacts, rodent eradication on ...
Meiotic drive shapes rates of karyotype evolution in mammals
Tags: Evolution, Genetic engineering, Other mammals, Transmission distortionBlackmon, H., J. Justison, I. Mayrose and E. E. Goldberg, Evolution, 73:511-523. 2019.
Chromosome number is perhaps the most basic characteristic of a genome, yet generalizations that can explain the evolution of this trait across large clades have remained elusive. Using karyotype data from over 1000 mammals, we developed and applied a phylogenetic model of ...
Modulating CRISPR gene drive activity through nucleocytoplasmic localization of Cas9 in S. cerevisiae
Tags: CRISPR, Gene drive synthetic, Yeast and FungiM. E. Goeckel, E. M. Basgall, I. C. Lewis, S. C. Goetting, Y. Yan, M. Halloran and G. C. Finnigan, Fungal Biology Biotechnology, 6:2. 2019.
In this study, we use artificial gene drives in budding yeast to explore mechanisms to modulate nuclease activity of Cas9 through its nucleocytoplasmic localization. We examine non-native nuclear localization sequences (both NLS and NES) on Cas9 fusion proteins in vivo through ...
A natural, conditional gene drive in plants
Tags: AgricultureConner, AJJ, J.M.E., bioRxiv, 519884:1-10. 2019.
A new class of gene drive in plant populations with herbicide resistance is described; a conditional gene drive that operates following herbicide application. Screening progeny from controlled crosses of Brassica napus heterozygous for a dominant allele conferring chlorsulfuron ...
An overview of OECD activities related to modern techniques of biotechnology and genome editing
Tags: Gene drive synthetic, Policy, Risk and safetyKearns, P, Transgenic Research, 28:41-44. 2019.
Since commercial use of genetically-engineered (genetically- modified) plants started in 1996, many agricultural products have been developed to improve crop traits. The foods and feeds derived from these commodities have drastically increased worldwide. However, answering health ...
Genome-wide transcriptome profiling reveals genes associated with meiotic drive system of Aedes aegypti
Tags: Other arthropods, Sex distorter, Transmission distortionShin, DB, K. Susanta; Severson, W. David, Insects, 10:e25. 2019.
Aedes aegypti is an important mosquito vector of several arboviruses, including dengue, yellow fever, Zika, and Chikungunya, which cause significant human morbidity and mortality globally. In certain populations of this mosquito, a native meiotic drive system causes abnormal ...
Does the U.S. public support using gene drives in agriculture? And what do they want to know?
Tags: Ethics, Gene drive synthetic, PolicyJones, MSD, Jason A.; Elsensohn, Johanna; Mitchell, Paul D.; Brown, Zachary S., Science Advances, 5:eaau8462. 2019.
Gene drive development is progressing more rapidly than our understanding of public values toward these technologies. We analyze a statistically representative survey (n = 1018) of U.S. adult attitudes toward agricultural gene drives. When informed about potential risks, ...
On the road to a gene drive in mammals
Tags: Gene drive mechanisms, Gene drive synthetic, RodentsConklin, BR, Nature, 566:43-45. 2019.
A method for making a version of a gene more likely to be inherited than normal, generating what is called a gene drive, might be used to control insect populations. It has now been reported to work in mammals, too.
Transmission ratio distortion is frequent in Arabidopsis thaliana controlled crosses
Tags: Agriculture, Ecology, Evolution, Genetic incompatibilities, Genetics, Sex distorter, Transmission distortionSeymour, DKC, E.; Arioz, B. I.; Koenig, D.; Weigel, D., Heredity, 122:294-304. 2019.
The equal probability of transmission of alleles from either parent during sexual reproduction is a central tenet of genetics and evolutionary biology. Yet, there are many cases where this rule is violated. The preferential transmission of alleles or genotypes is termed ...
CRISPR gene drive efficiency and resistance rate is highly heritable with no common genetic loci of large effect
Tags: Biological control, CRISPR, Evolution, Fruit fly, Gene drive, Gene drive synthetic, Genetic engineering, Replicator/site directed nuclease, ResistanceChamper, JW, Z. X.; Luthra, A.; Reeves, R.; Chung, J.; Liu, C.; Lee, Y. L.; Liu, J. X.; Yang, E.; Messer, P. W.; Clark, A. G., Genetics, 212:333-341. 2019.
Gene drives could allow for control of vector-borne diseases by directly suppressing vector populations or spreading genetic payloads designed to reduce pathogen transmission. Clustered regularly interspaced short palindromic repeat (CRISPR) homing gene drives work by cleaving ...
Killing two bugs with one stone: a perspective for targeting multiple pest species by incorporating reproductive interference into sterile insect technique
Tags: Gene drive, Gene drive synthetic, Other arthropodsHonma, AK, N.; Noriyuki, S., Pest Management Science, 75:571-577. 2019.
The sterile insect technique is an environmentally friendly method to control and even eradicate agricultural and veterinary insect pests without using chemical pesticides in excess. However, the continuous production and release of sterile insects is economically costly and ...
MGDrivE: A modular simulation framework for the spread of gene drives through spatially-explicit mosquito populations
Tags: Aedes, Anopheles, Gene drive, Gene drive synthetic, Population genetics/dynamics, ResistanceSánchez C, HMW, Sean L.; Bennett, Jared B.; Marshall, John M., Methods in Ecology and Evolution, 10:1-24. 2019.
Malaria, dengue, Zika, and other mosquito-borne diseases continue to pose a major global health burden through much of the world, despite the widespread distribution of insecticide-based tools and antimalarial drugs. The advent of CRISPR/Cas9-based gene editing and its ...
Arthropod containment guidelines, version 3.2
Tags: Other arthropods, Risk and safetyAmerican Committee of Medical Entomology, American Society of Tropical Medicine and Hygiene Vector-Borne and Zoonotic Diseases, 19:3:152-173. 2019.
In 2003, just a few months after I became editor of Vector-; Borne and Zoonotic Diseases, we published the Arthropod; Containment Guidelines, likely our first of what would become; known as an Open Access publication. The concept to; produce the guidelines resulted from a ...
Molecular safeguarding of CRISPR gene drive experiments
Tags: Gene drive synthetic, Risk and safetyChamper, JC, Joan; Lee, Yoo Lim; Liu, Chen; Yang, Emily; Wen, Zhaoxin; Clark, Andrew G.; Messer, Philipp W., eLife, 8:e41439. 2019.
CRISPR-based homing gene drives have sparked both enthusiasm and deep concerns due to their potential for genetically altering entire species. This raises the question about our ability to prevent the unintended spread of such drives from the laboratory into a natural population. ...
Population management using gene drive: molecular design, models ofspread dynamics and assessment of ecological risks
Tags: Gene drive synthetic, Risk and safetyRode, NOE, A.; Bourguet, D.; Courtier-Orgogozo, V.; Debarre, F., Conservation Genetics, 20:671-690. 2019.
CRISPR gene drive has recently been proposed as a promising technology for population management, including in conservation genetics. The technique would consist in releasing genetically engineered individuals that are designed to rapidly propagate a desired mutation or transgene ...
Gene drives as a response to infection and resistance
Tags: Ethics, Gene drive synthetic, Malaria, Other arthropods, Risk and safetyHayirli, TCM, P.F., Infection and Drug Resistance, 12:229-234. 2019.
Vector-borne infectious diseases continue to be a major threat to public health. Although some prevention and treatment modalities exist for these diseases, resistance to such modalities, exacerbated by global climate change, remains a fundamental challenge. Developments in ...
Male competition and the evolution of mating and ire-history traits in experimental populations of Aedes aegypti
Tags: Ecology, Gene drive synthetic, MosquitoesQureshi, AA, A.; Hollis, B.; Ponlawat, A.; Cator, L. J., Proceedings of the Royal Society B-Biological Sciences, 286:20190591. 2019.
Aedes aegypti is an important disease vector and a major target of reproductive control efforts. We manipulated the opportunity for sexual selection in populations of Ae. aegypti by controlling the number of males competing for a single female. Populations exposed to higher ...
Variability in the durability of CRISPR-Cas immunity
Tags: Arbovirus, Evolution, Gene drive mechanisms, Gene drive syntheticChabas, HN, A.; Meaden, S.; Westra, E. R.; Tremblay, D. M.; Pradier, L.; Lion, S.; Moineau, S.; Gandon, S., Philosophical Transactions of the Royal Society B-Biological Sciences, 374:1-9. 2019.
The durability of host resistance is challenged by the ability of pathogens to escape the defence of their hosts. Understanding the variability in the durability of host resistance is of paramount importance for designing more effective control strategies against infectious ...
A Y-chromosome shredding gene drive for controlling pest vertebrate populations
Tags: Gene drive synthetic, Rodents, Vector control, X chromosomeProwse, TAAA, F.; Cassey, P.; Thomas, P.; Ross, J. V., eLife, 8:19. 2019.
Self-replicating gene drives that modify sex ratios or infer a fitness cost could be used to control populations of invasive alien species. The targeted deletion of Y sex chromosomes using CRISPR technology offers a new approach for sex bias that could be incorporated within ...
Gene drive gone wild: exploring deliberative possibilities by developing One Health ethics
Tags: Ethics, Gene drive synthetic, Policy, RegulationCapps, B, Law, Innovation and Technology, 11:231-256. 2019.
Gene editing may be used to engineer organisms that are better or worse adapted to survival. Coupled with gene drives ? molecular genetic strategies that perpetuate specific phenotypes in a target species ? it would now be possible to edit wild animal populations that impact on ...
Knowledge engagement in gene drive research for malaria control
Tags: Ethics, Gene drive syntheticHartley, ST, D.; Ledingham, K.; Coulibaly, M.; Diabate, A.; Dicko, B.; Diop, S.; Kayondo, J.; Namukwaya, A.; Nourou, B.; Toe, L. P., PLOS Neglected Tropical Diseases, 13:e0007233. 2019.
Scientists and funding bodies have made repeated calls for public engagement in gene drive. In 2016, the National Academies of Sciences, Engineering, and Medicine (NASEM) published its report, Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning ...
Predicting the spatial dynamics of Wolbachia infections in Aedes aegypti arbovirus vector populations in heterogeneous landscapes
Tags: Ecology, Evolution, Gene drive mechanisms, Other SymbiontsHancock, PAR, S. A.; Koenraadt, C. J. M.; Scott, T. W.; Hoffmann, A. A.; Godfray, H. C. J., Journal of Applied Ecology, 56:1674-1686. 2019.
A promising strategy for reducing the transmission of dengue and other arboviral human diseases by Aedes aegypti mosquito vector populations involves field introductions of the endosymbiotic bacteria Wolbachia. Wolbachia infections inhibit viral transmission by the mosquito, and ...
Safe CRISPR: Challenges and Possible Solutions
Tags: Gene drive synthetic, Policy, Risk and safetyPineda, ML, A.; Collins, J. P.; Kiani, S., Trends in Biotechnology, 37:389-401. 2019.
Applications of CRISPR in human health and in gene drives are at the forefront of biological research as tools. This technology will affect humankind and our environment, so as this technology pushes forward, the design and implementation of safety measures is imperative. Novel ...
The ethical landscape of gene drive research
Tags: Ethics, PolicyCallies, DE, Bioethics, 33:1091-1097. 2019.
Gene drive technology has immense potential. The ability to bypass the laws of Mendelian inheritance and almost ensure the transmission of specific genetic material to future generations creates boundless possibilities. But alongside these boundless possibilities are major social ...
Design, execution, and analysis of CRISPR-Cas9-based deletions and genetic interaction networks in the fungal pathogen Candida albicans
Tags: Gene drive mechanisms, Gene drive synthetic, Other SymbiontsHalder, VP, C. B. M.; Chavez, A.; Shapiro, R. S., Nature Protocols, 14:955-975. 2019.
The study of fungal pathogens is of immediate importance, yet progress is hindered by the technical challenges of genetic manipulation. For Candida species, their inability to maintain plasmids, unusual codon usage, and inefficient homologous recombination are among the obstacles ...
Population genetics of Anopheles funestus, the African malaria vector, Kenya
Tags: Ecology, Gene drive synthetic, MosquitoesOgola, EOO, J. O.; Mwangangi, J. M.; Masiga, D. K.; Tchouassi, D. P., Parasites & Vectors, 12:15. 2019.
Anopheles funestus is among the major malaria vectors in Kenya and sub-Saharan Africa and has been recently implicated in persistent malaria transmission. However, its ecology and genetic diversity remain poorly understood in Kenya.MethodsUsing 16 microsatellite loci, we examined ...
Spatial structure undermines parasite suppression by gene drive cargo
Tags: Ecology, Evolution, Gene drive synthetic, Genetic engineering, Selfish genetic elementsBull, JJR, Christopher H.; Gomulkiewicz, Richard; Krone, Stephen M., PeerJ, 7:e7921. 2019.
Gene drives may be used in two ways to curtail vectored diseases. Both involve engineering the drive to spread in the vector population. One approach uses the drive to directly depress vector numbers, possibly to extinction. The other approach leaves intact the vector population ...
CRISPR in sub-Saharan Africa: Applications and education
Tags: Gene drive synthetic, PolicyOgaugwu, CEA, S. O.; Adekoya, M. A., Trends in Biotechnology, 37:234-237. 2019.
Clustered regularly interspaced shortpalindromicrepeats (CRISPR) technology has enabled genetic engineering feats previously considered impracticable, offering great hopes for solutions to problems facing society. We consider it timely to highlight how CRISPR can benefit public ...
Efficient allelic-drive in Drosophila
Tags: Gene drive synthetic, Other arthropodsGuichard, AH, T.; Bobik, M.; Xu, X. R. S.; Klanseck, C.; Kushwah, R. B. S.; Berni, M.; Kaduskar, B.; Gantz, V. M.; Bier, E., Nature Communications, 10:1640. 2019.
Gene-drive systems developed in several organisms result in super-Mendelian inheritance of transgenic insertions. Here, we generalize this "active genetic" approach to preferentially transmit allelic variants (allelic-drive) resulting from only a single or a few nucleotide ...
Engineered resistance to Zika virus in transgenic Aedes aegypti expressing a polycistronic cluster of synthetic small RNAs
Tags: Aedes, Arbovirus, Gene drive, Gene drive synthetic, Population suppression, Resistance, Vector control, WolbachiaBuchman, AG, S.; Li, M.; Antoshechkin, I.; Li, H. H.; Wang, H. W.; Chen, C. H.; Klein, M. J.; Duchemin, J. B.; Paradkar, P. N.; Akbari, O. S., Proceedings of the National Academy of Sciences of the United States of America, 116:3656-3661. 2019.
Recent Zika virus (ZIKV) outbreaks have highlighted the necessity for development of novel vector control strategies to combat arboviral transmission, including genetic versions of the sterile insect technique, artificial infection with Wolbachia to reduce population size and/or ...
Cleave and Rescue, a novel selfish genetic element and general strategy for gene drive
Tags: Gene drive synthetic, Other arthropods, Toxin-antidoteOberhofer, GI, T.; Hay, B. A., Proceedings of the National Academy of Sciences of the United States of America, 116:6250-6259. 2019.
There is great interest in being able to spread beneficial traits throughout wild populations in ways that are self-sustaining. Here, we describe a chromosomal selfish genetic element, CleaveR [Cleave and Rescue (ClvR)], able to achieve this goal. ClvR comprises two linked ...
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9-mediated mutagenesis of the multiple edematous wings gene induces muscle weakness and flightlessness in Bactrocera dorsalis (Diptera: Tephritidae)
Tags: Gene drive synthetic, Other arthropodsZheng, WL, Q.; Sun, H.; Ali, M. W.; Zhang, H., Insect Molecular Biology, 28:222-234. 2019.
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) system is a versatile, efficient and heritable gene editing tool that can be useful for genome engineering. Bactrocera dorsalis (Hendel) is a major pest of agriculture that causes ...
CRISPR in Parasitology: Not Exactly Cut and Dried!
Tags: Chromosomal drive, Gene drive, Gene drive synthetic, Mosquitoes, Other SymbiontsBryant, JMB, S.; Glover, L.; Hutchinson, S.; Rachidi, N., Trends in Parasitology, 35:409-422. 2019.
CRISPR/Cas9 technology has been developing rapidly in the field of parasitology, allowing for the dissection of molecular processes with unprecedented efficiency. Optimization and implementation of a new technology like CRISPR, especially in nonmodel organisms, requires ...
Super-Mendelian inheritance mediated by CRISPR-Cas9 in the female mouse germline
Tags: Biodiversity/Conservation, CRISPR, Gene drive synthetic, Other mammals, Replicator/site directed nuclease, RodentsGrunwald, HAG, V. M.; Poplawski, G.; Xu, X. R. S.; Bier, E.; Cooper, K. L., Nature, 566:105-109. 2019.
A gene drive biases the transmission of one of the two copies of a gene such that it is inherited more frequently than by random segregation. Highly efficient gene drive systems have recently been developed in insects, which leverage the sequence-targeted DNA cleavage activity of ...
CRISPR-Cas9. The greatest advancement in genetic edition techniques requires an ethical reflection
Tags: CRISPR, Ethics, Gene drive synthetic, Gene editingGomez-Tatay, LA, J., Cuadernos De Bioetica, 30:171-185. 2019.
The adaptation of the CRISPR system as a genetic editing tool has led to a revolution in many fields of application, as this technique is considerably faster, easier to perform and more efficient than predecessor techniques. However, some of these applications raise objective ...
Efficient somatic and germline genome engineering of Bactrocera dorsalis by the CRISPR/Cas9 system
Tags: Gene drive synthetic, Other arthropodsZhao, STX, Z. Z.; Liu, Z. G.; Liu, Y. H.; Liu, X. R.; Chen, Z.; Li, J. H.; Yan, R. H., Pest Management Science, 75:1921-1932. 2019.
Bactrocera dorsalis (Hendel), a very destructive insect pest of many fruits and vegetables, is widespread in many Asian countries. To facilitate control of this pest, it is essential to investigate its genetics and gene function using targeted gene disruption. RESULTS Here, we ...
Modelling the potential of genetic control of malaria mosquitoes at national scale
Tags: Ecology, Gene drive synthetic, MosquitoesNorth, ARB, Austin; Godfray, H. Charles J., BMC Biology, 17:26. 2019.
The persistence of malaria in large parts of sub-Saharan Africa has motivated the development of novel tools to complement existing control programmes, including gene-drive technologies to modify mosquito vector populations. Here, we use a stochastic simulation model to explore ...
The EU regulatory framework on genetically modified organisms (GMOs)
Tags: Europe, Gene drive, Genetically modified organisms, Policy, Regulation, Risk and safety, Synthetic biologyBruetschy, C, Transgenic Research, 28:169-174. 2019.
The European Union (EU) legislation on genetically modified organisms (GMOs) aims to ensure a high level of protection for human, animal and environmental health and a well-functioning EU internal market. The framework regulates the release of GMOs into the environment and their ...
A genetic system for biasing the sex ratio in mice
Tags: Gene drive, Gene drive synthetic, Other mammals, Rodents, X chromosome, Y-chromosomeYosef, IEB, Liat; Globus, Rea; Shlomovitz, Inbar; Munitz, Ariel; Gerlic, Motti; Qimron, Udi, EMBO reports, 20:e48269. 2019.
Biasing the sex ratio of populations of different organisms, including plants, insects, crustacean, and fish, has been demonstrated by genetic and non-genetic approaches. However, biasing the sex ratio of mammalian populations has not been demonstrated genetically. Here, we ...
Daisy-chain gene drives for the alteration of local populations
Tags: Gene drive syntheticNoble, CM, J.; Olejarz, J.; Buchthal, J.; Chavez, A.; Smidler, A. L.; DeBenedictis, E. A.; Church, G. M.; Nowak, M. A.; Esvelt, K. M., Proceedings of the National Academy of Sciences of the United States of America, 116:8275-8282. 2019.
If they are able to spread in wild populations, CRISPR-based gene-drive elements would provide new ways to address ecological problems by altering the traits of wild organisms, but the potential for uncontrolled spread tremendously complicates ethical development and use. Here, ...
Precision control of CRISPR-Cas9 using small molecules and light
Tags: Gene drive synthetic, Risk and safetyGangopadhyay, SAC, K. J.; Manna, D.; Lim, D.; Maji, B.; Zhou, Q. X.; Choudhary, A., Biochemistry, 58:234-244. 2019.
The CRISPR (clustered regularly interspaced short palindromic repeat)-Cas system is an adaptive immune system of bacteria that has furnished several RNA-guided DNA endonucleases (e.g., Cas9) that are revolutionizing the field of genome engineering. Cas9 is being used to effect ...
Promises and perils of gene drives: Navigating the communication of complex, post-normal science
Tags: Ethics, Policy, Risk and safetyBrossard, DB, Pam; Gould, Fred; Wirz, Christopher D., Proceedings of the National Academy of Sciences of the United States of America, 116:7692-7697. 2019.
In November of 2017, an interdisciplinary panel discussed the complexities of gene drive applications as part of the third Sackler Colloquium on “The Science of Science Communication.” The panel brought together a social scientist, life scientist, and journalist to discuss ...
CRISPR ethics: Moral considerations for applications of a powerful tool
Tags: Ethics, Gene drive synthetic, Risk and safetyBrokowski, C. and Adli, M., Journal of Molecular Biology, 431:88-101. 2019.
With the emergence of CRISPR technology, targeted editing of a wide variety of genomes is no longer an abstract hypothetical, but occurs regularly. As application areas of CRISPR are exceeding beyond research and biomedical therapies, new and existing ethical concerns abound ...
CRISPR-Clear: A fieldable detection procedure for potential CRISPR-Cas9 gene drive based bioweapons.
Tags: Gene drive mechanisms, Gene drive synthetic, Risk and safetyNieuwenweg, ACvG, Martijn M.; Horsting, Angelina; Hegge, Jorrit W; Velders, Aldrik; Saggiomo, Vittorio, ChemRxiv, 2019:1-11. 2019.
Rapid progression in genetic modification research has made gene editing increasingly cheaper and easier to use. CRISPR-Cas9 for example, allows for the specific alteration of the genome of an organism with relative simplicity and low costs. This raised a worrying question; can ...
Gene drives as a new quality in GMO releases-a comparative technology characterization
Tags: Policy, Regulation, Risk and safetyFriess, JLvG, A.; Giese, B., Peerj, 7:e6793. 2019.
Compared to previous releases of genetically modified organisms (GMOs) which were primarily plants, gene drives represent a paradigm shift in the handling of GMOs: Current regulation of the release of GMOs assumes that for specific periods of time a certain amount of GMOs will be ...
Stakeholder attitudes towards the use of recombinant technology to manage the impact of an invasive species: Sea Lamprey in the North American Great Lakes
Tags: Biodiversity/Conservation, Ecology, Gene drive syntheticThresher, REJ, M.; Drake, D. A. R., Biological Invasions, 21:575-586. 2019.
Several factors, including: (1) on-going difficulties of cost-effectively managing invasive species; (2) recent successes in using recombinant genetics to suppress mosquito populations; and, (3) developments in gene-drive technology, have re-invigorated interest in using genetic ...
