Scholarly Literature
This is an aggregation of scholarly literature from peer-reviewed journals, bioRxiv , medRxiv and arXiv preprint servers focused on natural and engineered selfish genetic elements and genetic biocontrol. New citations are added as they appear. This content is intended for anyone interested in the scholarly literature on gene drive and genetic biocontrol.
Defects in nuclear transport enhance segregation distortion
Tags: Gene drive mechanisms, Other arthropods, Transmission distortionMcElroy, JMM, R. A.; McLean, J. R., Fly, 2:280-290. 2008.
The equal segregation of chromosomes into gametes is a central tenet of Mendelian genetics. It is this process that is responsible for generating predictable outcomes of crosses, as well as subjecting all chromosomes to the natural selective pressures that exert themselves on a ...
Transmission ratio distortion in Arabidopsis lyrata: effects of population divergence and the S-locus
Tags: Gene drive mechanismsLeppala, JB, J. S.; Schierup, M. H.; Savolainen, O., Heredity, 100:71-78. 2008.
We investigated transmission ratio distortion within an Icelandic population of Arabidopsis lyrata using 16 molecular markers unlinked to the S-locus. Transmission ratio distortion was found more often than expected by chance at the gametic level, but not at the genotypic or ...
The evolution of sex-independent transmission ratio distortion involving multiple allelic interactions at a single locus in rice
Tags: Ecology, Evolution, Gene drive mechanismsKoide, YI, M.; Sawamura, N.; Nishimoto, D.; Matsubara, K.; Onishi, K.; Kanazawa, A.; Sano, Y., Genetics, 180:409-420. 2008.
Transmission ratio distortion (TRD) is frequently observed in inter-and intraspecific hybrids of plants, leading to a violation of Mendelian inheritance. Sex-independent TRD (siTRD) was detected in a hybrid between Asian cultivated rice and its wild ancestor. Here we examined how ...
X chromosome drive
Tags: Evolution, X chromosomeJaenike, J, Current Biology, 18:R508-R511. 2008.
In the past 10 years, the world record for the men's 100 meter dash has declined from 9.79 to 9.74 seconds, the detection of such small differences being made possible by sophisticated electronic timing devices. If someone were to run the 100 meters in 9.73999 seconds in the 2008 ...
A Killer–Rescue system for self-limiting gene drive of anti-pathogen constructs
Tags: Gene drive mechanisms, Gene drive synthetic, Toxin-antidote, UnderdominanceGould, FH, Yunxin; Legros, Mathieu; Lloyd, Alun L., Proceedings of the Royal Society B: Biological Sciences, 275:2823-2829. 2008.
A number of genetic mechanisms have been suggested for driving anti-pathogen genes into natural populations. Each of these mechanisms requires complex genetic engineering, and most are theoretically expected to permanently spread throughout the target species' geographical range. ...
Broadening the application of evolutionarily based genetic pest management
Tags: Birds, Gene drive synthetic, Other arthropods, Other mammals, Transmission distortionGould, F, Evolution, 62:500-510. 2008.
Insect- and tick-vectored diseases such as malaria, dengue fever, and Lyme disease cause human suffering, and current approaches for prevention are not adequate. Invasive plants and animals such as Scotch broom, zebra mussels, and gypsy moths continue to cause environmental ...
Centromere-associated female meiotic drive entails male fitness costs in Monkeyflowers
Tags: Ecology, Transmission distortionFishman, LS, A., Science, 322:1559-1562. 2008.
Female meiotic drive, in which paired chromosomes compete for access to the egg, is a potentially powerful but rarely documented evolutionary force. In interspecific monkeyflower ( Mimulus) hybrids, a driving M. guttatus allele ( D) exhibits a 98: 2 transmission advantage via ...
Selective sweeps in a 2-locus model for sex-ratio meiotic drive in Drosophila simulans
Tags: Gene drive mechanisms, Other arthropods, Transmission distortionDerome, NB, E.; Ogereau, D.; Veuille, M.; Montchamp-Moreau, C., Molecular Biology and Evolution, 25:409-416. 2008.
A way to identify loci subject to positive selection is to detect the signature of selective sweeps in given chromosomal regions. It is revealed by the departure of DNA polymorphism patterns from the neutral equilibrium predicted by coalescent theory. We surveyed DNA sequence ...
The population genetics of using homing endonuclease genes in vector and pest management
Tags: Gene drive mechanisms, Gene drive synthetic, Replicator/site directed nuclease, Y-chromosomeDeredec, AB, A.; Godfray, H. C. J., Genetics, 179:2013-2026. 2008.
Homing endonuclease genes (HEGs) encode proteins that in the heterozygous state cause double- strand breaks in the homologous chromosome at the precise position opposite the HFG. If the double-strand break is repaired using the homologous chromosome, the HEG becomes homozygous, ...
Rapid evolution of yeast centromeres in the absence of drive
Tags: Evolution, Genetic engineering, Genomics, Transmission distortion, Yeast and FungiBensasson, DZ, M.; Burt, A.; Koufopanou, V., Genetics, 178:2161-2167. 2008.
To find the most rapidly evolving regions in the yeast genome we compared most of chromosome III from three closely related lineages of the wild yeast Saccharomyces paradoxits. Unexpectedly, the centromere appears to be the fastest-evolving part of the chromosome, evolving even ...
Guidance for contained field trials of vector mosquitoes engineered to contain a gene drive system: Recommendations of a scientific working group
Tags: Gene drive synthetic, Other arthropods, Risk and safetyBenedict, MDA, P.; Dobson, S.; Gottlieb, M.; Harrington, L.; Higgs, S.; James, A.; James, S.; Knols, B.; Lavery, J.; O'Neill, S.; Scott, T.; Takken, W.; Toure, Y.; Core Working Grp Guidance, Containe, Vector-Borne and Zoonotic Diseases, 8:127-166. 2008.
The following recommendations represent the response of a group of involved scientists to the need for guidance to aid researchers, government authorities, and community leaders as they consider the design and implementation of field trials to assess the safety and efficacy of ...
Targeting the X chromosome during spermatogenesis induces Y chromosome transmission ratio distortion and early dominant embryo lethality in Anopheles gambiae
Tags: Gene drive mechanisms, Gene drive synthetic, Mosquitoes, Other arthropods, Replicator/site directed nucleaseWindbichler, NP, P. A.; Crisanti, A., PLOS Genetics, 4:1-9. 2008.
We have exploited the high selectivity of the homing endonuclease I-PpoI for the X-linked Anopheles gambiae 28S ribosomal genes to selectively target X chromosome carrying spermatozoa. Our data demonstrated that in heterozygous males, the expression of I-PpoI in the testes ...
Meiotic drive and sex determination: molecular and cytological mechanisms of sex ratio adjustment in birds
Tags: Birds, Ecology, Evolution, Gene drive mechanisms, Transmission distortionRutkowska, JB, A. V., Philosophical Transactions of the Royal Society B-Biological Sciences, 363:1675-1686. 2008.
Differences in relative fitness of male and female offspring across ecological and social environments should favour the evolution of sex-determining mechanisms that enable adjustment of brood sex ratio to the context of breeding. Despite the expectation that genetic sex ...
Sexually antagonistic “Zygotic Drive” of the sex Chromosomes
Tags: Evolution, Gene drive mechanisms, Transmission distortionRice, WRG, S.; Friberg, U., PLOS Genetics, 4:e1000313. 2008.
Genomic conflict is perplexing because it causes the fitness of a species to decline rather than improve. Many diverse forms of genomic conflict have been identified, but this extant tally may be incomplete. Here, we show that the unusual characteristics of the sex chromosomes ...
Selfish genetic elements promote polyandry in a fly
Tags: Evolution, Gene drive mechanisms, Transmission distortionPrice, TARH, D. J.; Lewis, Z.; Hurst, G. D. D.; Wedell, N., Science, 322:1241-1243. 2008.
It is unknown why females mate with multiple males when mating is frequently costly and a single copulation often provides enough sperm to fertilize all a female's eggs. One possibility is that remating increases the fitness of offspring, because fertilization success is biased ...
Control of introduced species using Trojan sex chromosomes
Tags: Genetic biocontrol, Invasive species, Sex distorterS. Cotton and C. Wedekind, Trends in Ecology & Evolution, 22:441-443. 2007.
To control introduced exotic species that have predominantly genetic, but environmentally reversible, sex determination (e.g. many species of fish), Gutierrez and Teem recently modeled the use of carriers of Trojan Y chromosomes - individuals who are phenotypically sex reversed ...
Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos
Tags: Gene drive mechanisms, Gene drive synthetic, Mosquitoes, Other arthropods, Replicator/site directed nucleaseWindbichler, NP, P. A.; Catteruccia, F.; Ranson, H.; Burt, A.; Crisanti, A., Nucleic Acids Research, 35:5922-5933. 2007.
Homing endonuclease genes (HEGs) are selfish genetic elements that combine the capability to selectively disrupt specific gene sequences with the ability to rapidly spread from a few individuals to an entire population through homologous recombination repair events. Because of ...
Viability effects and not meoitic drive cause dramatic departures from Mendelian inheritance for malic enzyme in hybrids of Tigriopus californicus populations
Tags: Ecology, Gene drive mechanisms, Transmission distortionWillett, CSB, J. N., Journal of Evolutionary Biology, 20:1196-1205. 2007.
The genetic basis of post-zygotic reproductive isolation is beginning to be untangled in closely related species, but less is known about the genetics of reproductive isolation between divergent populations. Here, two genes encoding malic enzyme (ME) are isolated from the copepod ...
Small steps or giant leaps for male-killers? Phylogenetic constraints to male-killer host shifts
Tags: Evolution, Other arthropodsTinsley, MCM, M. E. N., BMC Evolutionary Biology, 7:e1000313. 2007.
Background: Arthropods are infected by a wide diversity of maternally transmitted microbes. Some of these manipulate host reproduction to facilitate population invasion and persistence. Such parasites transmit vertically on an ecological timescale, but rare horizontal ...
A sex-ratio meiotic drive system in Drosophila simulans. I: An autosomal suppressor
Tags: Gene drive mechanisms, Other arthropods, Transmission distortionTao, YM, J. P.; Araripe, L.; Ke, Y.; Hartl, D. L., PLOS Biology, 5:2560-2575. 2007.
Sex ratio distortion (sex-ratio for short) has been reported in numerous species such as Drosophila, where distortion can readily be detected in experimental crosses, but the molecular mechanisms remain elusive. Here we characterize an autosomal sex-ratio suppressor from D. ...
A sex-ratio meiotic drive system in Drosophila simulans. II: An X-linked distorter
Tags: Evolution, Gene drive mechanisms, Other arthropodsTao, YA, L.; Kingan, S. B.; Ke, Y.; Xiao, H.; Hartl, D. L., PLOS Biology, 5:2576-2588. 2007.
The evolution of heteromorphic sex chromosomes creates a genetic condition favoring the invasion of sex-ratio meiotic drive elements, resulting in the biased transmission of one sex chromosome over the other, in violation of Mendel's first law. The molecular mechanisms of ...
Neurospora spore killers Sk-2 and Sk-3 suppress meiotic silencing by unpaired DNA
Tags: Ecology, Gene drive mechanisms, Toxin-antidote, Transmission distortionRaju, NBM, R. L.; Shiu, P. T., Genetics, 176:43-52. 2007.
In Neurosphora, crassa., pairing of homologous DNA segments is monitored during meiotic prophase I. Any genes not paired with a homolog, as well as any paired homologs of that gene, are silenced during the sexual phase by a mechanism known as meiotic silencing by unpaired DNA ...
Meiotic drive by the Y-linked D gene in Aedes aegypti (L.) (Diptera : Culicidae) is associated with disruption of spermiogenesis, leading to premature senescence of spermatozoa
Tags: Gene drive mechanisms, Mosquitoes, Transmission distortion, Y-chromosomeOwusu-Daaku, KOB, R. D.; Wood, R. J., Arthropod Structure & Development, 36:233-243. 2007.
Y chromosome meiotic drive in the mosquito Aedes aegypti, due to the gene D (Distorter) in coupling with M (male determination) [the MD haplotype], is associated with spermiogenic disruption, leading to senescence, at a rate Proportionate to male excess. Spermiogenesis was ...
Identification and characterization of segregation distortion loci along chromosome 5B in tetraploid wheat
Tags: Gene drive mechanisms, Transmission distortionKumar, SG, B. S.; Faris, J. D., Molecular Genetics and Genomics, 278:187-196. 2007.
Segregation distortion genes are widespread in plants and animals and function by their effect on competition among gametes for preferential fertilization. In this study, we evaluated the segregation distortion of molecular markers in multiple reciprocal backcross populations ...
Introducing desirable transgenes into insect populations using Y-linked meiotic drive – A theoretical assessment
Tags: Other arthropods, Transmission distortion, Y-chromosomeHuang, YXM, K.; Lloyd, A. L.; Gould, F., Evolution, 61:717-726. 2007.
The use of genetic drive mechanisms to replace native mosquito genotypes with individuals bearing antipathogen transgenes is a potential strategy for repressing insect transmission of human diseases such as malaria and dengue. Antipathogen transgenes have been developed and ...
Introducing transgenes into insect populations using combined gene-drive strategies: Modeling and analysis
Tags: Other arthropods, Toxin-antidote, UnderdominanceHuang, YXM, K.; Lloyd, A. L.; Gould, F., Insect Biochemistry and Molecular Biology, 37:1054-1063. 2007.
Engineered underdominance (EU), meiotic drive (MD) and Wolbachia have been proposed as mechanisms for driving anti-pathogen transgenes into natural populations of insect vectors of human diseases. EU can drive transgenes to high and stable frequencies but requires the release of ...
Chromosome-wide linkage disequilibrium as a consequence of meiotic drive
Tags: Evolution, Gene drive mechanisms, Other arthropods, X chromosomeDyer, KAC, B.; Jaenike, J., Proceedings of the National Academy of Sciences of the United States of America, 104:1587-1592. 2007.
Adaptation by natural selection proceeds most efficiently when alleles compete solely on the basis of their effects on the survival and reproduction of their carriers. A major condition for this is equal Mendelian segregation, but meiotic drive can short-circuit this process. The ...
A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila
Tags: Anopheles, Mosquitoes, ResistanceChen, CHH, H. X.; Ward, C. M.; Su, J. T.; Schaeffer, L. V.; Guo, M.; Hay, B. A., Science, 316:597-600. 2007.
One proposed strategy for controlling the transmission of insect-borne pathogens uses a drive mechanism to ensure the rapid spread of transgenes conferring disease refractoriness throughout wild populations. Here, we report the creation of maternal-effect selfish genetic elements ...
First Anopheles arabiensis germline transformation: Toward the development of a transgenic genetic sexing strain
Tags: Anopheles, Genetically modified mosquitoes, Malaria, Sterile insect technique (SIT)H. C. Bossin, J. Thailayil, F. Catteruccia, J. P. Benton, A. Crisanti, M. Q. Benedict, B. G. Knols and A. S. Robinson, American Journal of Tropical Medicine and Hygiene, 75:66-66. 2006.
The ability to genetically engineer mosquitoes is likely to have major implications for the development and implementation of genetic control systems against mosquito disease vectors such as the Sterile Insect Technique (SIT). In particular, genetically transformed mosquito ...
The Sterile Insect Technique: can established technology beat malaria?
Tags: Africa, Anopheles, Mosquitoes, Sterile insect technique (SIT)M. E. H. Helinski, B. El-Sayed and B. G. J. Knols, Entomologische Berichten, 66:13-20. 2006.
The Sterile Insect Technique (SIT) is the mass production, sterilisation and subsequent release of sterile insects into a target population in an area-wide integrated approach. The released sterile males mate with wild females; they thus no longer produce offspring and therefore ...
Radiation-induced sterility for pupal and adult stages of the malaria mosquito Anopheles arabiensis
Tags: Africa, Anopheles, Genetic biocontrol, Sterile insect technique (SIT)M. E. H. Helinski, A. G. Parker and B. G. J. Knols, Malaria Journal, 5:10. 2006.
The optimal dose for male insects to be released in an SIT programme depends on their level of sterility and competitiveness. The use of semi-sterilizing doses to produce more competitive insects is discussed. The most convenient developmental stage for mosquito irradiation on a ...
Genetic strategies for controlling mosquito-borne diseases
Tags: Gene drive synthetic, Genetic biocontrol, Sterile insect technique (SIT), Transmission distortion, UnderdominanceF. Gould, K. Magori and Y. Huang, American Scientist, 94:238. 2006.
Malaria kills more than a million people each year, primarily children under the age of six. Dengue fever is less deadly, but an outbreak can debilitate millions of people and easily overwhelm doctors and hospitals in tropical cities
The hitchhiking effect of an autosomal meiotic drive gene
Tags: Evolution, Gene drive mechanisms, Transmission distortionChevin, LMH, F., Genetics, 173:1829-1832. 2006.
Transmission-ratio distortion is a departure from a 1:1 segregation of alleles in the gametes of a heterozygous individual. The so-called driving allele is strongly selected regardless of its effect on the fitness of the carrying individual. It may then have an important impact ...
Cage trials using an endogenous meiotic drive gene in the mosquito Aedes aegypti to promote population replacement
Tags: Ecology, Other arthropods, Y-chromosomeCha, SJM, A.; Chadee, D. D.; Severson, D. W., American Journal of Tropical Medicine and Hygiene, 74:62-68. 2006.
Control of arthropod-borne diseases based on population replacement with genetically modified noncompetent vectors has been proposed as a promising alternative to conventional control strategies. Due to likely fitness costs associated with vectors manipulated to carry ...
Isolation and characterization of the RanGAP gene in the mosquito Aedes aegypti
Tags: Other arthropodsCha, SJL, N.; Debruyn, B.; Severson, D. W., DNA Sequence, 17:223-230. 2006.
A duplicated 3'-truncated version of RanGAP was previously identified as Segregation distorter (Sd), the meiotic drive gene in Drosophila melanogaster. Here we report the cloning and characterization of the complete gene sequence for the RanGAP homolog from the mosquito Aedes ...
Population dynamics of an endogenous meiotic drive system in Aedes aegypti in Trinidad
Tags: Gene drive mechanisms, Other arthropods, Y-chromosomeCha, SJC, D. D.; Severson, D. W., American Journal of Tropical Medicine and Hygiene, 75:70-77. 2006.
An endogenous meiotic drive system was previously reported to be segregating in the yellow fever mosquito Aedes aegypti L. (Diptera: Culicidae) population in Trinidad. The meiotic driver (M-D) is tightly linked to the male determining locus and selectively targets sensitive ...
Fitness effects of X chromosome drive in the stalk-eyed fly, Cyrtodiopsis dalmanni
Tags: Ecology, Gene drive mechanisms, Other arthropods, Transmission distortion, X chromosomeWilkinson, GSJ, P. M.; Kelleher, E. S.; Muscedere, M. L.; Lorsong, A., Journal of Evolutionary Biology, 19:1851-1860. 2006.
Sex-ratio (SR) males produce predominantly female progeny because most Y chromosome sperm are rendered nonfunctional. The resulting transmission advantage of X-SR chromosomes should eventually cause population extinction unless segregation distortion is masked by suppressors or ...
Segregation distortion in Arabidopsis C24/Col-0 and Col-0/C24 recombinant inbred line populations is due to reduced fertility caused by epistatic interaction of two loci
Tags: Gene drive mechanisms, Transmission distortionTorjek, OW-W, H.; Meyer, R. C.; von Korff, M.; Kusterer, B.; Rautengarten, C.; Altmann, T., Theoretical and Applied Genetics, 113:1551-1561. 2006.
A new large set of reciprocal recombinant inbred lines (RILs) was created between the Arabidopsis accessions Col-0 and C24 for quantitative trait mapping approaches, consisting of 209 Col-0 x C24 and 214 C24 x Col-0 F-7 RI lines. Genotyping was performed using 110 evenly ...
Gene drive systems for insect disease vectors
Tags: Gene drive synthetic, Other arthropodsSinkins, SPG, F., Nature Reviews Genetics, 7:427-435. 2006.
The elegant mechanisms by which naturally occurring selfish genetic elements, such as transposable elements, meiotic drive genes, homing endonuclease genes and Wolbachia, spread at the expense of their hosts provide some of the most fascinating and remarkable subjects in ...
A model describing the effect of sex-reversed YY fish in an established wild population: The use of a Trojan Y chromosome to cause extinction of an introduced exotic species
Tags: Genetic biocontrol, Sex distorterJ. B. Gutierrez and J. L. Teem, Journal of Theoretical Biology, 241:333-341. 2006.
A novel means of inducing extinction of an exotic fish population is proposed using a genetic approach to shift the ratio of male to females within a population. In the proposed strategy, sex-reversed fish containing two Y chromosomes are introduced into a normal fish population. ...
Male biased sex ratio in the Mediterranean fruit fly Ceratitis capitata, an example of Y-chromosome meiotic drive
Tags: Gene drive mechanisms, Other arthropods, Transmission distortion, Y-chromosomeShahjahan, RMR, P. A.; Cook, L. M.; Wood, R. J., Heredity, 96:464-470. 2006.
A case of Y-chromosome meiotic drive is reported in the Mediterranean fruit fly Ceratitis capitata. It arose in an irradiated male and results in excess of males. Male excess is inherited strictly from father to son. A Y-linked factor MP (male producer) is proposed. Higher drive ...
The maize Ab 10 meiotic drive system maps to supernumerary sequences in a large complex haplotype
Tags: Evolution, Gene drive mechanisms, Transmission distortionMroczek, RJM, J. R.; Luce, A. C.; Hiatt, E. N.; Dawe, R. K., Genetics, 174:145-154. 2006.
The meiotic drive system on maize abnormal chromosome 10 (Ab10) is contained within a terminal domain of chromatin that extends the long arm of Ab10 to similar to 1.3 times the size of normal chromosome 10L. Ab10 type I (Ab10-I) does not recombine with normal chromosome 10 (N10) ...
Organization of the sex-ratio meiotic drive region in Drosophila simulans
Tags: Gene drive mechanisms, Other arthropodsMontchamp-Moreau, CO, D.; Chaminade, N.; Colard, A.; Aulard, S., Genetics, 174:1365-1371. 2006.
Sex-ratio meiotic drive is the preferential transmission of the X chromosome by XY males, which occurs in several Drosophila species and results in female-biased progeny. Although the trait has long been known to exist, its molecular basis remains completely unknown. Here we ...
Sex-ratio meiotic drive in Drosophila simulans: cellular mechanism, candidate genes and evolution
Tags: Evolution, Gene drive mechanisms, Other arthropods, X chromosomeMontchamp-Moreau, C, Biochemical Society Transactions, 34:562-565. 2006.
The sex-ratio trait, reported in a dozen Drosophila species, is a type of naturally occurring meiotic drive in which the driving elements are located on the X chromosome. Typically, as the result of a shortage of Y bearing spermatozoa, males carrying a sex-ratio X chromosome ...
Transmission ratio distortion in the human body louse, Pediculus humanus (Insecta : Phthiraptera)
Tags: Gene drive mechanisms, Other arthropods, Transmission distortionMcMeniman, CJB, S. C., Heredity, 96:63-68. 2006.
We studied inheritance at three microsatellite loci in eight F-1 and two F-2 families of the body (clothes) louse of humans, Pediculus humanus. The alleles of heterozygous female-parents were always inherited in a Mendelian fashion in these families. Alleles from heterozygous ...
An Anopheles transgenic sexing strain for vector control
Tags: Genetic biocontrol, Genetically modified mosquitoes, Sterile insect technique (SIT)F. Catteruccia, J. P. Benton and A. Crisanti, Nature Biotechnology, 23:1414-1417. 2005.
Here we report on the development of transgenic sexing lines for the mosquito Anopheles stephensi, the principal vector of human malaria in Asia. Male mosquitoes, expressing enhanced green fluorescent protein (EGFP) under the control of the beta 2-tubulin promoter, are identified ...
History of the Sterile Insect Technique
Tags: Gene drive synthetic, History, Sterile insect technique (SIT)Klassen, W. and C. F. Curtis, Sterile Insect Technique: Principles and Practice in Area-Wide Integrated Pest Managemen, 2005:3-36.. 2005.
During the 1930s and 1940s the idea of releasing insects of pest species to introduce sterility (sterile insect technique or SIT) into wild populations, and thus control them, was independently conceived in three extremely diverse intellectual environments. The key researchers ...
Maternal transmission ratio distortion at the mouse Om locus results from meiotic drive at the second meiotic division
Tags: Gene drive mechanisms, Rodents, Transmission distortionWu, GMH, L. P.; Han, Z. M.; Gao, S. R.; Latham, K. E.; de Villena, F. P. M.; Sapienza, C., Genetics, 170:327-334. 2005.
We have observed maternal transmission ratio distortion (TRD) in favor of DDK alleles at the Ovum mutant (Om) locus on mouse chromosome I I among the offspring of (C57BL/6 X DDK) F, females and C57BL/6 males. Although significant lethality occurs in this backcross (similar to ...
Population dynamics of transposable elements: Copy number regulation and species invasion requirements
Tags: Gene drive synthetic, Selfish genetic elementsStruchiner, CJK, M. G.; Ribeiro, J. M. C., Journal of Biological Systems, 13:455-475. 2005.
A deterministic population dynamics model of the spread of transposable elements (TE) in sexually reproducing populations is presented. The population is modeled by a three-parameter equation describing host reproductive capacity, population size and the strength of the density ...
Evidence of susceptibility and resistance to cryptic X-linked meiotic drive in natural populations of Drosophila melanogaster
Tags: Evolution, Gene drive mechanisms, Other arthropods, Transmission distortionReed, FAR, R. G.; Aquadro, C. F., Evolution, 59:1280-1291. 2005.
There is mounting evidence consistent with a general role of positive selection acting on the Drosophila melanogaster X-chromosome. However, this positive selection need not necessarily arise from forces that are adaptive to the organism. Nonadaptive meiotic drive may exist on ...
