Enhancement of Aedes aegypti susceptibility to dengue by Wolbachia is not supported

T. H. Ant, M.-V. Mancini, J. Martinez and S. P. Sinkins,  Nature Communications,  11:6111. 2020.

Releases of Aedes aegypti mosquitoes carrying Wolbachia to block the transmission of dengue virus (DENV) are currently being deployed as a novel dengue control strategy in a number of countries, with very encouraging results1,2. In their paper entitled “Variation in Wolbachia effects on Aedes mosquitoes as a determinant of invasiveness and vectorial capacity”, King et al.3 used DENV infection and transmission modelling to reinterpret experimental data from two previous studies4,5. The authors claimed that wMel Wolbachia increase the mean susceptibility of Ae. aegypti to DENV, contradicting various other studies6,7,8,9,10,11,12. Here, we raise concerns with the experimental approaches used to generate one of the primary datasets on which the modelling is based, and we discuss how these limitations could make some of the original conclusions misleading.

More related to this:

Variation in Wolbachia effects on Aedes mosquitoes as a determinant of invasiveness and vectorial capacity

Wolbachia as a possible means of driving genes into populations

Wolbachia and cytoplasmic incompatibility in mosquitoes

The mosquito strategy that could eliminate dengue