Keywords: dengue

New self-sexing Aedes aegypti strain eliminates barriers to scalable and sustainable vector control for governments and communities in dengue-prone environments

S. A. M. Spinner, Z. H. Barnes, A. M. Puinean, P. Gray, T. Dafa’alla, C. E. Phillips, C. Nascimento de Souza, T. F. Frazon, K. Ercit, A. Collado, N. Naish, E. Sulston, G. C. Ll. Phillips, K. K. Greene, M. Poletto, B. D. Sperry, S. A. Warner, N. R. Rose, G,  Frontiers in Bioengineering and Biotechnology,  10. 2022.
For more than 60 years, efforts to develop mating-based mosquito control technologies have largely failed to produce solutions that are both effective and scalable, keeping them out of reach of most governments and communities in disease-impacted regions globally. High pest ...
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Assessing single-locus CRISPR/Cas9-based gene drive variants in the mosquito Aedes aegypti via single generation crosses and modeling

W. Reid, A. E. Williams, I. Sanchez-Vargas, J. Lin, R. Juncu, K. E. Olson and A. W. E. Franz,  G3 Genes|Genomes|Genetics,  2022.
Critical to the design of a single-locus autonomous GD is that the selected genomic locus is amenable to both GD and appropriate expression of the antiviral effector. In our study, we used reverse engineering to target two intergenic genomic loci, which had previously shown to be ...
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Wolbachia Biology, Mechanisms and Applications 2022

David O'Brochta,  GeneConvene Global Collaborative,  2022.
Intracellular and extracellular symbiotic/commensal bacteria have enormous potential when manipulated and deployed appropriately to serve as agents of control of insects and the pathogens they transmit. Wolbachia, an intracellular bacteria, is a well studied system and one that ...
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Wolbachia wAlbB inhibit dengue and Zika infection in the mosquito Aedes aegypti with an Australian background

L. E. Hugo, G. Rašić, A. J. Maynard, L. Ambrose, C. Liddington, C. J. E. Thomas, N. S. Nath, M. Graham, C. Winterford, B. M. C. R. Wimalasiri-Yapa, Z. Xi, N. W. Beebe and G. J. Devine,  PLOS Neglected Tropical Diseases,  16:e0010786. 2022.
Biological control of mosquito vectors using the endosymbiotic bacteria Wolbachia is an emerging strategy for the management of human arboviral diseases. We recently described the development of a strain of Aedes aegypti infected with the Wolbachia strain wAlbB (referred to as ...
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Risk Assessment on the Release of Wolbachia-Infected Aedes aegypti in Yogyakarta, Indonesia

D. Buchori, A. Mawan, I. Nurhayati, A. Aryati, H. Kusnanto and U. K. Hadi,  Insects,  13. 2022.
Wolbachia-infected Aedes aegypti is the latest technology that was developed to eliminate dengue fever. The Ministry of Research and Technology of the Republic of Indonesia (Kemenristekdikti) established an expert group to identify future potential risks that may occur over a ...
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Combating Mosquito-Borne Diseases with CRISPR

N. Spahich,  The Scientist,  2022.
Female mosquitoes are some of the deadliest organisms in the world due to their ability to spread infectious diseases through a simple bite. Mosquito-borne diseases such as yellow fever, Zika, Dengue fever, and malaria kill millions of humans every year, and there are limited ...
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Fitness costs of Wolbachia shift in locally-adapted Aedes aegypti mosquitoes

P. A. Ross and A. A. Hoffmann,  Environmental Microbiology,  2022.
Aedes aegypti mosquito eggs can remain quiescent for many months before hatching, allowing populations to persist through unfavorable conditions. Aedes aegypti infected with the Wolbachia strain wMel have been released in tropical and subtropical regions for dengue control. wMel ...
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How We’re Reducing Disease With Genetically Modified Mosquitoes

V. Wise,  HealthMatch,  2022.
We all know mosquitoes as those annoying insects we swat away from our faces. They carry diseases, so we don’t want them anywhere near us. There are over 200 types of wild mosquitoes bugging us across America and the U.S. territories. Approximately 12 types can spread disease, ...
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Externalities modulate the effectiveness of the Wolbachia release programme

E. E. Ooi and A. Wilder-Smith,  The Lancet Infectious Diseases,  2022.
Despite the remarkable outcome in Yogyakarta, the wMel approach also has some challenges. In particular, the extent to which ecological, weather, and other external factors influence the dissemination and establishment of wMel in complex urban environments remains unclear. ...
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Estimating the effect of the wMel release programme on the incidence of dengue and chikungunya in Rio de Janeiro, Brazil: a spatiotemporal modelling study

G. Ribeiro dos Santos, B. Durovni, V. Saraceni, T. I. Souza Riback, S. B. Pinto, K. L. Anders, et al.,  The Lancet Infectious Diseases,  2022.
Summary Background Introgression of genetic material from species of the insect bacteria Wolbachia into populations of Aedes aegypti mosquitoes has been shown in randomised and non-randomised trials to reduce the incidence of dengue; however, evidence for the real-world ...
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The Involvement of Atlastin in Dengue Virus and Wolbachia Infection in Aedes aegypti and Its Regulation by aae-miR-989

M. Hussain, T. Bradshaw, M. Lee and S. Asgari,  Microbiology Spectrum,  2022.
Endoplasmic reticulum (ER)-shaping atlastin proteins (ATLs) have been demonstrated to play a functional role during flavivirus replication in mammalian cells. For dengue virus (DENV), atlastin is required in the formation of the replication organelles and RNA replication, virion ...
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Bill Gates’ Colombian Mosquito Factory Breeding 30 Million Bacteria-Infected Mosquitos Per Week

anonymous,  GREATGAMEINDIA,  2022.
Bill Gates’ Colombian ‘mosquito factory’ is breeding 30 million bacteria-infected mosquitos per week. The project’s objective appears to be to introduce Wolbachia into native mosquito populations by employing lab-bred mosquitoes, resulting in the infection of such ...
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Modified mosquito releases to fight dengue fever, chikungunya or yellow fever

Sewell, Tammy,  OICANADIAN,  2022.
To date, only one technique based on genetically modified mosquitoes has been developed at an operational level, it is the RIDL technique (release of insects carrying a dominant lethal gene, or release of insects carrying a dominant lethality gene). Male mosquitoes which, unlike ...
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An optimal control problem for dengue transmission model with Wolbachia and vaccination

J. Zhang, L. L. Liu, Y. Z. Li and Y. Wang,  Communications In Nonlinear Science and Numerical Simulation,  116. 2022.
The release of Wolbachia-infected mosquitoes into the wild mosquitoes population is an excellent biological control strategy which can be effective against mosquito-borne infections. In this work, we propose a dengue transmission model that incorporates releasing Wolbachia into ...
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World Mosquito Day: Can genetic modification techniques quash the menace?

CNBCTV18,  CNBC TV18,  2022.
Genetically modified (GM) mosquitoes are prepared in labs and are supposed to fight the Aedes aegypti mosquitoes which spread viruses including dengue, Zika, and chikungunya. Billions have apparently been successfully released in the US, Brazil, the Cayman Islands, Panama, and ...
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Outbreaks of arboviruses, biotechnological innovations and vector control: facing the unexpected

C. Boëte,  Innovative Strategies for Vector Control,  6:219-231. 2022.
Outbreaks of arboviruses have occurred in the last decades in many places around the world and a variety of responses have been taken in order to control them. Responses ranged from vaccination campaigns to the use of conventional vector control methods. Innovative approaches ...
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Changing mosquito genes, spreading bacteria: Science sees success vs dengue

C. E. Baclig,  INQUIRER.NET,  2022.
Wolbachia, according to WMP, are extremely common bacteria that occur naturally in 50 percent of insect species, including mosquitoes, fruit flies, moths, dragonflies, and butterflies. Aedes aegypti or dengue-carrying mosquitoes, however, do not normally carry Wolbachia. Studies ...
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Aedes aegypti and Ae. albopictus microbiome/virome: new strategies for controlling arboviral transmission?

M. Gómez, D. Martinez, M. Muñoz and J. D. Ramírez,  Parasites and Vectors,  15:287. 2022.
Aedes aegypti and Aedes albopictus are the main vectors of highly pathogenic viruses for humans, such as dengue (DENV), chikungunya (CHIKV), and Zika (ZIKV), which cause febrile, hemorrhagic, and neurological diseases and remain a major threat to global public health. The high ...
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Studies on the fitness characteristics of wMel- and wAlbB-introgressed Aedes aegypti (Pud) lines in comparison with wMel- and wAlbB-transinfected Aedes aegypti (Aus) and wild-type Aedes aegypti (Pud) lines

C. Sadanandane, K. Gunasekaran, D. Panneer, S. K. Subbarao, M. Rahi, B. Vijayakumar, V. Athithan, A. Sakthivel, S. Dinesh and P. Jambulingam,  Frontiers in Microbiology,  13:947857. 2022.
Wolbachia, an intracellular maternally transmitted endosymbiont, has been shown to interfere with the replication of dengue virus in Aedes aegypti mosquitoes. The Wolbachia-transinfected Ae. aegypti has been currently released in many countries to test its effectiveness in ...
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Intron-derived small RNAs for silencing viral RNAs in mosquito cells

P. Y. L. Tng, L. Z. Carabajal Paladino, M. A. E. Anderson, Z. N. Adelman, R. Fragkoudis, R. Noad and L. Alphey,  PLOS Neglected Tropical Diseases,  16:e0010548. 2022.
Aedes aegypti and Ae. albopictus are the main vectors of mosquito-borne viruses of medical and veterinary significance. Many of these viruses have RNA genomes. Exogenously provided, e.g. transgene encoded, small RNAs could be used to inhibit virus replication, breaking the ...
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Modifying mosquitoes to suppress disease transmission: Is the long wait over?

J. R. Powell,  Genetics,  2022.
For more than 50 years it has been a dream of medical entomologists and public health workers to control diseases like malaria and dengue fever by modifying, through genetics and other methods, the arthropods that transmit them to humans. A brief synopsis of the history of ...
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Modeling the impact of genetically modified male mosquitoes in the spatial population dynamics of Aedes aegypti

M. R. da Silva, P. H. G. Lugão, F. Prezoto and G. Chapiro,  Scientific Reports,  12:9112. 2022.
The mosquito Aedes aegypti is the primary vector of diseases such as dengue, Zika, chikungunya, and yellow fever. Improving control techniques requires a better understanding of the mosquito’s life cycle, including spatial population dynamics in endemic regions. One of the most ...
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Elimination of a closed population of the yellow fever mosquito, Aedes aegypti, through releases of self-limiting male mosquitoes

P. B. Patil, S. K. Dasgupta, K. Gorman, A. Pickl-Herk, M. Puinean, A. McKemey, B. Char, U. B. Zehr and S. R. Barwale,  PLOS Neglected Tropical Diseases,  16:e0010315. 2022.
Author summary Aedes aegypti L. species is the primary vector responsible for transmission of the dengue virus worldwide including chikungunya, yellow fever and Zika virus. The experiment presented in the manuscript represents a study undertaken to demonstrate suppression of the ...
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Simple, sensitive, and cost-effective detection of wAlbB Wolbachia in Aedes mosquitoes, using loop mediated isothermal amplification combined with the electrochemical biosensing method

P. Thayanukul, B. Lertanantawong, W. Sirawaraporn, S. Charasmongkolcharoen, T. Chaibun, R. Jittungdee and P. Kittayapong,  PLOS Neglected Tropical Diseases,  16:e0009600. 2022.
Author summary Mosquito-borne diseases such as dengue, chikungunya, zika, and yellow fever are transmitted to humans mainly by the bites of Aedes aegypti mosquitoes. Controlling the vectors of these diseases relies mostly on the use of insecticides. However, the efficiency has ...
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Mosquitoes Genetically Modified to Stop Disease Pass Early Test

L. Rapaport,  WebMD,  2022.
Genetically modified mosquitoes released in the U.S. appear to have passed an early test that suggests they might one day help reduce the population of insects that transmit infectious diseases. As part of the test, scientists released nearly 5 million genetically engineered ...
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Genetically Modified Mosquitoes May Protect The World From Disease

J. R. Learn,  DISCOVER,  2022.
Forget lions, hippos or venomous spiders. Aedes aegypti mosquitoes may be among the deadliest wildlife in the world. Their bite is relatively harmless in normal circumstances. But many of these mosquitoes carry diseases they transmit from the blood of one host to another, ...
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Transient Introgression of Wolbachia into Aedes aegypti Populations Does Not Elicit an Antibody Response to Wolbachia Surface Protein in Community Members

E. Lee, T. Hien Nguyen, T. Yen Nguyen, S. Nam Vu, N. Duong Tran, L. Trung Nghia, Q. Mai Vien, T. Dong Nguyen, R. Kriiger Loterio, I. Iturbe-Ormaetxe, H. A. Flores, S. L. O'Neill, D. Anh Dang, C. P. Simmons and J. E. Fraser,  Pathogens,  11. 2022.
Wolbachia is an endosymbiotic bacterium that can restrict the transmission of human pathogenic viruses by Aedes aegypti mosquitoes. Recent field trials have shown that dengue incidence is significantly reduced when Wolbachia is introgressed into the local Ae. aegypti population. ...
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International shipments of Wolbachia-infected mosquito eggs: towards the scaling-up of World Mosquito Program operations

J. A. Denton, D. A. Joubert, A. A. Goundar and J. R. L. Gilles,  Scientific and Technical Review,  41:91-99. 2022.
The Wolbachia insect control method, employed by the World Mosquito Program (WMP), relies on introgressing Wolbachia through target Aedes aegypti populations to reduce the incidence of dengue. Since 2010, the WMP has been producing Wolbachia-infected mosquitoes at numerous sites ...
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Role of CRISPR Technology in Gene Editing of Emerging and Re-emerging Vector Borne Disease

K. K. Mahto, P. Prasad, M. Kumar, H. Dubey and A. Ranjan,  Recent Advances in Pathogen Interactions, Immunity, and Vector Control Strategies,  2022.
Vector borne diseases are rampant across the world. Due to spread and estab-lishment of vector species in different geographical areas, vector adaptation and resistance towards many insecticides the only option left is vector control for vari-ous vector borne diseases. Recent ...
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Aedes aegypti abundance and insecticide resistance profiles in the applying Wolbachia to eliminate dengue trial

W. Tantowijoyo, S. K. Tanamas, I. Nurhayati, S. Setyawan, N. Budiwati, I. Fitriana, I. Ernesia, D. S. Wardana, E. Supriyati, E. Arguni, Y. Meitika, E. Prabowo, B. Andari, B. R. Green, L. Hodgson, E. Rancès, P. A. Ryan, S. L. O'Neill, K. L. Anders, M. R. A,  PLOS Neglected Tropical Diseases,  16:e0010284. 2022.
The Applying Wolbachia to Eliminate Dengue (AWED) trial was a parallel cluster randomised trial that demonstrated Wolbachia (wMel) introgression into Ae. aegypti populations reduced dengue incidence. In this predefined substudy, we compared between treatment arms, the relative ...
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A metapopulation approach to identify targets for Wolbachia-based dengue control

A. Reyna-Lara, D. Soriano-Paños, J. H. Arias-Castro, H. J. Martínez and J. Gómez-Gardeñes,  Chaos,  32:041105. 2022.
Over the last decade, the release of Wolbachia-infected Aedes aegypti into the natural habitat of this mosquito species has become the most sustainable and long-lasting technique to prevent and control vector-borne diseases, such as dengue, zika, or chikungunya. However, the ...
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Potential Adverse Effects of GE Mosquitoes Unknown

B. Giuffre,  The Epoch Times,  2022.
“Safe and sustainable.” That’s what Oxitec, a British biological pest control company, calls its genetically modified (GM) or genetically engineered (GE) mosquito pesticide product. The company claims its product is nontoxic to humans and animals and won’t harm beneficial ...
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Genetically Modified Mosquitoes May Be Released in California, Experts Express Concern

Z. Papadakis,  NEWSMAX,  2022.
Millions of genetically engineered mosquitos could soon be set loose in California in an effort to curb the disease-carrying Aedes aegypti mosquito population — but some experts are concerned that it could backfire. On March 7, Oxitec, a private company, obtained a permit from ...
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Genetic Stability and Fitness of Aedes aegypti Red-Eye Genetic Sexing Strains With Pakistani Genomic Background for Sterile Insect Technique Applications

M. Misbah-ul-Haq, D. O. Carvalho, L. D. de la Fuente, A. A. Augustinos and K. Bourtzis,  Frontiers in Bioengineering and Biotechnology,  10. 2022.
The mosquito species Aedes aegypti is the primary transmitter of viruses that cause endemic diseases like dengue in Pakistan. It is also a cause of other vector-borne diseases like yellow fever, Zika fever, and chikungunya, which significantly impact human health worldwide. In ...
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Special mosquitos to combat dengue fever in Binh Duong

L. Phuong,  VN Express,  2022.
Capsules containing mosquito eggs resistant to dengue fever viruses were released in southern Binh Duong's Thu Dau Mot Town on Thursday to help control the disease. The Wolbachia Project in southern Vietnam, conducted by the World Mosquito Program and collaborators, seeks to ...
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EVITA Dengue: a cluster-randomized controlled trial to EValuate the efficacy of Wolbachia-InfecTed Aedes aegypti mosquitoes in reducing the incidence of Arboviral infection in Brazil

M. H. Collins, G. E. Potter, M. D. T. Hitchings, E. Butler, M. Wiles, J. K. Kennedy, S. B. Pinto, A. B. M. Teixeira, A. Casanovas-Massana, N. G. Rouphael, G. A. Deye, C. P. Simmons, L. A. Moreira, M. L. Nogueira, D. A. T. Cummings, A. I. Ko, M. M. Teixeir,  Trials,  23:185. 2022.
BACKGROUND: Arboviruses transmitted by Aedes aegypti including dengue, Zika, and chikungunya are a major global health problem, with over 2.5 billion at risk for dengue alone. There are no licensed antivirals for these infections, and safe and effective vaccines are not yet ...
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Regulation of genetically engineered (GE) mosquitoes as a public health tool: a public health ethics analysis

Z. Meghani,  Globalization and Health,  18:21. 2022.
In recent years, genetically engineered (GE) mosquitoes have been proposed as a public health measure against the high incidence of mosquito-borne diseases among the poor in regions of the global South. While uncertainties as well as risks for humans and ecosystems are entailed ...
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Assessing Aedes aegypti candidate genes during viral infection and Wolbachia-mediated pathogen blocking

L. T. Sigle, M. Jones, M. Novelo, S. A. Ford, N. Urakova, K. Lymperopoulos, R. T. Sayre, Z. Xi, J. L. Rasgon and E. A. McGraw,  Insect Molecular Biology,  2022.
Abstract One approach to control dengue virus transmission is the symbiont Wolbachia, that limits viral infection in mosquitoes. Despite plans for its widespread use in Aedes aegypti, Wolbachia's mode of action remains poorly understood. Many studies suggest that the mechanism is ...
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A flavivirus-inducible gene expression system that modulates broad-spectrum antiviral activity against dengue and Zika viruses

S.-C. Weng, Y.-X. Zhou and S.-H. Shiao,  Insect Biochemistry and Molecular Biology,  142:103723. 2022.
Incidence of dengue virus (DENV) and Zika virus (ZIKV), two mosquito-borne flaviviruses, is increasing in large parts of the world. Vaccination and medication for these diseases are unsatisfactory. Here, we developed a novel antiviral approach, using a virus-inducible gene ...
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CRISPR Technology Can Eliminate Disease-Spreading Mosquitoes

S. Krishana,  Now,  2022.
Scientists have uncovered a new technique they call the “precision-guided sterile insect technique,” or pgSIT. While most CRISPR procedures affect organisms that spread diseases by passing a gene change down generations, this system is more limited. It targets male mosquito ...
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Lab-scale characterization and semi-field trials of Wolbachia Strain wAlbB in a Taiwan Wolbachia introgressed Ae. aegypti strain

W. L. Liu, H. Y. Yu, Y. X. Chen, B. Y. Chen, S. N. Leaw, C. H. Lin, M. P. Su, L. S. Tsai, Y. Chen, S. H. Shiao, Z. Y. Xi, A. C. C. Jang and C. H. Chen,  PLOS Neglected Tropical Diseases,  16:24. 2022.
Author summaryPrior to open field release, new genetic approaches that interfere with mosquito abilities and reduce mosquito population density require progressive evaluation both in the laboratory and contained field trials. Trials in contained outdoor systems are thus an ...
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Determinants of stakeholders’ attitudes and intentions toward supporting the use of Wolbachia-infected Aedes mosquitoes for dengue control

A. F. Arham, L. Amin, M. A. C. Mustapa, Z. Mahadi, M. Yaacob and M. Ibrahim,  BMC Public Health,  21:2314. 2021.
BACKGROUND: A recent approach in controlling dengue is by using the Wolbachia-infected Aedes mosquito (WiAM). The approach has been reported to be more effective than traditional methods, such as fogging. Therefore, it is imperative to assess the factors predicting its acceptance ...
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Aedes Control Using Sterile Insect Technique (SIT) in Malaysia

W. A. Nazni, G.-N. Teoh, S. I. Shaikh Norman Hakimi, M. A. Muhammad Arif, M. Tanusshni, M. A. Nuradila, A. Nurfarahin Hanini, I. A. Shazia, A.-M. Tan, H. Rabizah, M. D. Ahmad Zainuri, A. Hasnor Hadi, Y.-L. Cheong, A. Norazah, H. Maiga, R. S. Lees and L. H,  Genetically Modified and other Innovative Vector Control Technologies,  2021.
The continued occurrence of massive outbreaks of Aedes-borne viral diseases of dengue, chikungunya, Zika and yellow fever, in spite of intensive and extensive application of conventional control measures, necessitates application of new tools, such as sterile insect technique ...
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Engineering RNA Interference-Based Dengue Virus Resistance in the Mosquito Vector Aedes aegypti: The Current Status and Future Directions

S. D. Denipitiyage, Y. I. N. S. Gunawardene, Z. Federico and R. S. Dassanayake,  Genetically Modified and other Innovative Vector Control Technologies,  2021.
Dengue is an acute, febrile disease caused by the dengue viruses (DENV) comprising four serotypes and transmitted by the mosquito vector Ae. aegypti. DENV are single-stranded, positive-sense RNA viruses of the family Flaviviridae. Dengue is declared as a current significant ...
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Measuring Public Attitudes to Releases of Transgenic Mosquitoes for Disease Control, with Special Reference to Dengue and Malaria

L. A. De Las Llagas and M. S. T. Gunigundo,  Genetically Modified and other Innovative Vector Control Technologies,  2021.
Since the advent of DDT in public health and agriculture, science leaped forward with revolutionary technology such as gene drive or editing, thus making it possible to develop alternative approaches to address vector-borne diseases. However, their utilization and sustenance in ...
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Advances in Aedes Mosquito Vector Control Strategies Using CRISPR/Cas9

P. D. S. U. Wickramasinghe, G. N. Silva, Y. I. N. Silva Gunawardene and R. S. Dassanayake,  Genetically Modified and other Innovative Vector Control Technologies,  2021.
Advancements in genetic engineering have resulted in the development of mosquitoes with impaired vector competence, thereby limiting acquisition and transmission of pathogens. The main dengue (DENV) vector, Aedes aegypti, is an invasive species that have spread unwittingly across ...
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Safe Application of Genetically Modified Mosquito (GMM) to Combat Dengue and Chikungunya Depends on Socioeconomic Status and Social Acceptance in the Developing Countries: A Comprehensive Analysis

M. N. Islam,  Genetically Modified and other Innovative Vector Control Technologies,  2021.