Scholarly Literature
This is an aggregation of scholarly literature from peer-reviewed journals, bioRxiv , medRxiv and arXiv preprint servers focused on natural and engineered selfish genetic elements and genetic biocontrol. New citations are added as they appear. This content is intended for anyone interested in the scholarly literature on gene drive and genetic biocontrol.
Fighting malaria with genetically modified mosquitoes
Tags: Africa, Containment, Gene drive synthetic, Genetically modified mosquitoes, Malaria, Target malariaE. Nakkazi, BMJ, 370:m2172. 2020.
Could a bold project to genetically engineer mosquitoes curb the scourge of malaria in Africa? Finding out will require careful science—and public acceptance, writes Esther Nakkazi
Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi
Tags: Africa, Anopheles, CRISPR, Gene drive synthetic, Genetic biocontrol, Genetics, Malaria, Population modification/replacement, Replicator/site directed nuclease, Risk and safetyA. Adolfi, V. M. Gantz, N. Jasinskiene, H.-F. Lee, K. Hwang, E. A. Bulger, A. Ramaiah, J. B. Bennett, G. Terradas, J. J. Emerson, J. M. Marshall, E. Bier and A. A. James, bioRxiv, 2020.08.02.233056. 2020.
We developed the first recoded gene-drive rescue system for population modification in the malaria vector, Anopheles stephensi, that relieves the load in females caused by integration of the drive into the kynurenine hydroxylase gene by rescuing its function. Non-functional ...
Extensive Recombination Suppression and Epistatic Selection Causes Chromosome-Wide Differentiation of a Selfish Sex Chromosome in Drosophila pseudoobscura
Tags: Chromosomal drive, Fruit fly, Genetics, Sex distorterZ. L. Fuller, S. A. Koury, C. J. Leonard, R. E. Young, K. Ikegami, J. Westlake, S. Richards, S. W. Schaeffer and N. Phadnis, Genetics, 216:205. 2020.
Here, we conduct a multifaceted study of the multiply inverted Drosophila pseudoobscura SR chromosome to understand the evolutionary history, genetic architecture, and present-day dynamics that shape this enigmatic selfish chromosome.
A One-Sided Competition Mathematical Model for the Sterile Insect Technique
Tags: Modeling, Population suppression, Sterile insect technique (SIT)A. Ben Dhahbi, Y. Chargui, S. M. Boulaaras and S. Ben Khalifa, Complexity, 2020:12. 2020.
We study a simple mathematical model describing the dynamics of a wild-type pest insects population experiencing competition from sterile insects (one-sided competition).
Chemical controllable gene drive in Drosophila
Tags: Fruit fly, Gene drive synthetic, Replicator/site directed nucleaseD. Chae, J. Lee, N. Lee, K. Park, S. J. Moon and H. H. Kim, ACS Synthetic Biology, in press. 2020.
Here, we report a chemical-induced control of gene drive. We prepared a CRISPR-based gene drive system that can be removed by a site-specific recombinase, Rippase, the expression of which is induced by the chemical RU486 in fruit flies. Exposure of fruit flies to RU486 resulted ...
Nix alone is sufficient to convert female Aedes aegypti into fertile males and myo-sex is needed for male flight
Tags: Aedes, Fruit fly, Gene drive synthetic, Genetic biocontrol, Population suppression, Sterile insect technique (SIT), Y-chromosomeA. Aryan, M. A. E. Anderson, J. K. Biedler, Y. M. Qi, J. M. Overcash, A. N. Naumenko, M. V. Sharakhova, C. H. Mao, Z. N. Adelman and Z. J. Tu, Proceedings of the National Academy of Sciences of the United States of America, 117:17702-17709. 2020.
Here, we report the generation of multiple transgenic lines that express Nix under the control of its own promoter. Genetic and molecular analyses of these lines provided insights unattainable from previous transient experiments. We show that the Nix transgene alone, in the ...
The Biochemistry of Cytoplasmic Incompatibility Caused by Endosymbiotic Bacteria
Tags: Cytoplasmic incompatibility, Toxin-antidote, WolbachiaH. Chen, M. Zhang and M. Hochstrasser, Genes, 11. 2020.
Many species of arthropods carry maternally inherited bacterial endosymbionts that can influence host sexual reproduction to benefit the bacterium. The most well-known of such reproductive parasites is Wolbachia pipientis. Wolbachia are obligate intracellular ...
The potential for a CRISPR gene drive to eradicate or suppress globally invasive social wasps
Tags: Gene drive mechanisms, Gene drive synthetic, Other arthropodsP. J. Lester, M. Bulgarella, J. W. Baty, P. K. Dearden, J. Guhlin and J. M. Kean, Scientific Reports, 10:12398. 2020.
P. J. Lester, M. Bulgarella, J. W. Baty, P. K. Dearden, J. Guhlin and J. M. Kean (2020). Scientific Reports. doi: 10.1038/s41598-020-69259-6 Gene drives have potential for widespread and cost-efficient pest control, but are highly controversial. We examined a potential gene ...
Providing a policy framework for responsible gene drive research: an analysis of the existing governance landscape and priority areas for further research
Tags: Gene drive synthetic, Governance, Policy, RegulationD. Thizy, I. Coche and J. de Vries, Wellcome Open Research, 2020.
D. Thizy, I. Coche and J. de Vries (2020). Wellcome Open Research. doi: 10.12688/wellcomeopenres.16023.1 In this manuscript, we review the existing regulatory landscape around gene drive research and map areas of convergence and divergence, as well as gaps in relation to ...
Socrates Untenured: Ethics, Experts, and the Public in the Synthetic Age
Tags: Ethics, Gene drive synthetic, Gene editing, Genetically modified organisms, Synthetic biologyC. Preston, ISSUES in Science and Technology, 2020.
C. Preston (2020). Three tools have transformed biotechnology over the past decade and a half. Gene reading has made it possible to quickly sequence the genome of any living creature. Gene synthesis has made it possible to construct DNA sequences in the lab from constituent ...
Genome Editing 2020: Ethics and Human Rights in Germline Editing in Humans and Gene Drives in Mosquitoes
Tags: CRISPR, Ethics, Gene editing, Mosquitoes, Policy, Regulation, Risk and safetyG. J. Annas, American Journal of Law and Medicine, 46:143-165. 2020.
G. J. Annas (2020). American Journal of Law and Medicine. doi: 10.1177/0098858820933492. I begin with a discussion of so far disastrously unsuccessful attempts to regulate germline editing in humans, including a summary of the first application of germline genome editing in ...
On Nonlinear Pest/Vector Control via the Sterile Insect Technique: Impact of Residual Fertility
Tags: Aedes, Genetic biocontrol, Modeling, Pest management, Sterile insect technique (SIT), Vector controlM. S. Aronna and Y. Dumont, Bulletin of Mathematical Biology, 82:29. 2020.
We consider a minimalist model for the Sterile Insect Technique (SIT), assuming that residual fertility can occur in the sterile male population.
2-Locus Cleave and Rescue; selfish elements harness a recombination rate-dependent generational clock for self limiting gene drive
Tags: Gene drive synthetic, Resistance, Self limitingG. Oberhofer, T. Ivy and B. A. Hay, bioRxiv, 2020.
Self-limiting gene drive allows control over the spread and fate of linked traits. Cleave and Rescue (ClvR) elements create self-sustaining drive and comprise a DNA sequence-modifying enzyme (Cas9-gRNAs, Cleaver) that disrupts an essential gene, and a tightly linked, uncleavable ...
Maternal effect killing by a supergene controlling ant social organization
Tags: Genomics, Toxin-antidote, Transmission distortionA. Avril, J. Purcell, S. Béniguel and M. Chapuisat, Proceedings of the National Academy of Sciences, 2020.
Supergenes are clusters of linked loci producing complex alternative phenotypes. In a series of experiments, we demonstrate that a supergene controlling ant social organization distorts Mendel’s laws to enhance its transmission to adult offspring. One supergene haplotype is ...
Artificial Selection Finds New Hypotheses for the Mechanism of Wolbachia-Mediated Dengue Blocking in Mosquitoes
Tags: Aedes, Arbovirus, Genetic incompatibilities, Genetics, Resistance, WolbachiaS. A. Ford, I. Albert, S. L. Allen, S. F. Chenoweth, M. Jones, C. Koh, A. Sebastian, L. T. Sigle and E. A. McGraw, Frontiers in Microbiology, 11:1456. 2020.
We recently used experimental evolution to reveal that Wolbachia-mediated dengue blocking could be selected upon in the A. aegypti host and showed evidence that strong levels of blocking could be maintained by natural selection. In this study, we investigate the genetic variation ...
Small-Molecule Control of Super-Mendelian Inheritance in Gene Drives
Tags: CRISPR, Gene drive, Gene drive synthetic, Replicator/site directed nucleaseV. López Del Amo, B. S. Leger, K. J. Cox, S. Gill, A. L. Bishop, G. D. Scanlon, J. A. Walker, V. M. Gantz and A. Choudhary, Cell Reports, 31:107841. 2020.
Summary Synthetic CRISPR-based gene-drive systems have tremendous potential in public health and agriculture, such as for fighting vector-borne diseases or suppressing crop pest populations. These elements can rapidly spread in a population by breaching the inheritance limit of ...
Invasion and maintenance of spore killers in populations of ascomycete fungi
Tags: Modeling, Population genetics/dynamics, Selfish genetic elements, Transmission distortion, Yeast and FungiI. Martinossi-Allibert, C. Veller, S. L. Ament-Velásquez, A. A. Vogan, C. Rueffler and H. Johannesson, bioRxiv, 2020.04.06.026989. 2020.
We show how ploidy level, rate of selfing, and efficiency of spore killing affect the invasion probability of a driving allele and the conditions for its stable coexistence with the non-driving allele. Our model can be adapted to different fungal life-cycles, and is applied here ...
Role of gene drives in malaria elimination strategy: modeling impact and cost-effectiveness in the Democratic Republic of the Congo
Tags: Africa, Gene drive synthetic, Population suppression, X chromosomeN. Metchanun, C. Borgemeister, J. von Braun, M. Nikolov, P. Selvaraj and J. Gerardin, medRxiv, 2020.
The tremendous burden of malaria has led to renewed efforts on malaria elimination and the development of novel tools for application where existing tools fall short. Gene drive mosquitoes, where transgenes and their associated phenotypes are efficiently propagated to future ...
Can natural gene drives be part of future fungal pathogen control strategies in plants?
Tags: Transmission distortionD. M. Gardiner, A. Rusu, L. Barrett, G. C. Hunter and K. Kazan, New Phtologist, 2020.
Globally, fungal pathogens cause enormous crop losses and current control practices are not always effective, economical or environmentally sustainable. Tools enabling genetic management of wild pathogen populations could potentially solve many problems associated with plant ...
Translating gene drive science to promote linguistic diversity in community and stakeholder engagement
Tags: Gene drive synthetic, Genetic engineering, Stakeholder engagementC. Cheung, S. Gamez, R. Carballar-Lejarazú, V. Ferman, V. N. Vásquez, G. Terradas, J. Ishikawa, C. E. Schairer, E. Bier, J. M. Marshall, A. A. James, O. S. Akbari and C. S. Bloss, Global Public Health, 2020.
Information about genetic engineering (GE) for vector control in the United States is disseminated primarily in English, though non-English speakers are equally, and in some geographic regions even more affected by such technologies. Non-English-speaking publics should have equal ...
Development of zygotic and germline gene drives in mice
Tags: CRISPR, Gene drive synthetic, Invasive species, RodentsC. Pfitzner, J. N. Hughes, M. A. White, M. Scherer, S. G. Piltz and P. Q. Thomas, bioRxiv, 2020.
Here we investigated the efficiency of CRISPR/Cas9-based gene drives in Mus musculus by constructing "split drive" systems with Cas9 under the control of zygotic (CAG) or germline (Vasa) promoters.
Analysis of a Strong Suppressor of Segregation Distorter inDrosophila melanogaster
Tags: Fruit fly, Gene drive mechanisms, Population suppression, Transmission distortionR. G. Temin, Genetics, 215:1085-1105. 2020.
These studies highlight the polygenic nature of distortion and its dependence on a constellation of positive and negative modifiers, provide insight into the stability of Mendelian transmission in natural populations even when a drive system arises, and pave the way for molecular ...
Genetic breakdown of a Tet-off conditional lethality system for insect population control
Tags: Genetic biocontrol, Resistance, Sterile insect technique (SIT)Y. Zhao, M. F. Schetelig and A. M. Handler, Nature Communications, 11:3095. 2020.
Genetically modified conditional lethal strains have been created to improve the control of insect pest populations damaging to human health and agriculture. However, understanding the potential for the genetic breakdown of lethality systems by rare spontaneous mutations, or ...
Detecting the population dynamics of an autosomal sex ratio distorter transgene in malaria vector mosquitoes
Tags: Anopheles, Dengue, Gene drive synthetic, Genetically modified organisms, Malaria, Replicator/site directed nuclease, WolbachiaP. Pollegioni, A. R. North, T. Persampieri, A. Bucci, R. L. Minuz, D. A. Groneberg, T. Nolan, P. A. Papathanos, A. Crisanti and R. Muller, Journal of Applied Ecology, 11. 2020.
A sex-distorting autosomal transgene has been developed recently in G3 mosquitoes, a laboratory strain of the malaria vectorAnopheles gambiaes.l. Following the World Health Organization guidance framework for the testing of GM mosquitoes, we assessed the dynamics of this ...
Field performance of sterile male mosquitoes released from an uncrewed aerial vehicle
Tags: Aedes, Gene drive, Modeling, Sterile insect technique (SIT)J. Bouyer, N. J. Culbert, A. H. Dicko, M. G. Pacheco, J. Virginio, M. C. Pedrosa, L. Garziera, A. T. M. Pinto, A. Klaptocz, J. Germann, T. Wallner, G. Salvador-Herranz, R. A. Herrero, H. Yamada, F. Balestrino and M. J. B. Vreysen, Science Robotics, 5:10. 2020.
Genetic control methods of mosquito vectors of malaria, dengue, yellow fever, and Zika are becoming increasingly popular due to the limitations of other techniques such as the use of insecticides. The sterile insect technique is an effective genetic control method to manage ...
The need for new vector control approaches targeting outdoor biting anopheline malaria vector communities
Tags: Anopheles, Gene drive synthetic, MosquitoesS. Sougoufara, E. C. Ottih and F. Tripet, Parasites & Vectors, 13:15. 2020.
Since the implementation of Roll Back Malaria, the widespread use of insecticide-treated nets (ITNs) and indoor residual spraying (IRS) is thought to have played a major part in the decrease in mortality and morbidity achieved in malaria-endemic regions. In the past decade, ...
Gene Drive: Can this be the Future of Agricultural Pest Management?
Tags: Agriculture, Gene drive synthetic, Genetic biocontrol, PolicyP. Mondal, U. Mohapatra and M. Ganguly, International Journal of Current Microbiology and Applied Sciences, 9. 2020.
A world free of hunger may be possible when the agricultural production exceeds the global demand for the food. In the era of increasing population, the need for increased food production can be attainable by managing the destructive pests of the agricultural and horticultural ...
Conservation implications of disease control
Tags: Biodiversity/Conservation, Ecology, Gene drive synthetic, Risk and safetyJ. C. Buck, S. B. Weinstein, G. Titcomb and H. S. Young, Frontiers in Ecology and the Environment, 6. 2020.
Infectious diseases have indelibly altered human history and, in doing so, have shaped the ecology and conservation of the natural world. Attempts to control diseases often result in adverse environmental impacts, including habitat degradation and unintended outcomes such as ...
Meiotic drive
Tags: Toxin-antidote, Transmission distortionA. N. Srinivasa and S. E. Zanders, Current Biology, 30:R627-R629. 2020.
What is meiotic drive? Diploid organisms, like you, have two copies of each autosomal chromosome, one from each parent. Sometimes organisms are heterozygous at a given region, meaning they carry different copies (or alleles) of the DNA sequence on the two homologous chromosomes. ...
Motivations and expectations driving community participation in entomological research projects: Target Malaria as a case study in Bana, Western Burkina Faso
Tags: Africa, Gene drive synthetic, Stakeholder engagementN. Barry, P. Toé, L. Pare Toe, J. Lezaun, M. Drabo, R. K. Dabiré and A. Diabate, Malaria Journal, 19:199. 2020.
Most field entomology research projects require active participation by local community members. Since 2012, Target Malaria, a not-for-profit research consortium, has been working with residents in the village of Bana, in Western Burkina Faso, in various studies involving ...
Gene drives: benefits, risks, and possible applications
Tags: Ethics, Gene drive synthetic, Policy, Regulation, Risk and safetyA. Deplazes-Zemp, U. Grossniklaus, F. Lefort, P. Müller, J. Romeis, A. Rüegsegger, N. Schoenenberger and E. Spehn, Swiss Academies Factsheets, 15. 2020.
Gene drives are genetic elements that skew the pattern of inheritance of a given characteristic in sexually reproducing organisms. They can be used to spread a characteristic that can alter or even reduce the numbers of individuals in wild populations of a certain species. As ...
CRISPR/Cas9 gene drive technology to control transmission of vector-borne parasitic infections
Tags: CRISPR, Gene drive, Malaria, Synthetic biology, Vector controlM. Nateghi Rostami, Parasite Immunology, preprint:e12762. 2020.
Gene drive is the process of copying of an endonuclease-containing cassette that leads to increased frequency of inheritance of the desired traits in a targeted population. CRISPR/Cas9 technology is advancing genetic manipulation of insects in the field of gene drive ...
Can CRISPR gene drive work in pest and beneficial haplodiploid species?
Tags: CRISPR, Gene drive, Gene drive synthetic, Genetic engineering, Pest managementJ. Li, O. Aidlin Harari, A.-L. Doss, L. L. Walling, P. W. Atkinson, S. Morin and B. E. Tabashnik, Evolutionary Applications, 2020.
Gene drives based on CRISPR/Cas9 have the potential to reduce the enormous harm inflicted by crop pests and insect vectors of human disease, as well as to bolster valued species. In contrast with extensive empirical and theoretical studies in diploid organisms, little is known ...
Islands as Laboratories: Indigenous Knowledge and Gene Drives in the Pacific
Tags: Ethics, Gene drive synthetic, Oceania, Stakeholder engagementR. I. Taitingfong, Human Biology, 91:179-188. 2020.
This article argues that the genetic engineering technology known as gene drive must be evaluated in the context of the historic and ongoing impacts of settler colonialism and military experimentation on indigenous lands and peoples. After defining gene drive and previewing some ...
A Protamine Knockdown Mimics the Function of Sd in Drosophila melanogaster
Tags: Chromosomal drive, Transmission distortionL. F. Gingell and J. R. McLean, G3-Genes Genomes Genetics, 10:2111-2115. 2020.
Segregation Distorter (SD) is an autosomal meiotic drive system found worldwide in natural populations of Drosophila melanogaster. This gene complex induces the preferential and nearly exclusive transmission of the SD chromosome in SD/SD+ males. This selfish propagation occurs ...
Engineered Gene Drives for Pest Management
Tags: Gene drive synthetic, Genetic biocontrolG. Miglani, Biotechnology for Plant Disease Diagnosis and Management, 2020.
Genes in sexually reproducing organisms normally have, on average, a 50% chance of being inherited, but some genes have a higher chance of being inherited. These genes can increase in relative frequency in a population even if they reduce the odds that each organism will ...
Bioengineering horizon scan 2020
Tags: Agriculture, Gene drive syntheticL. Kemp, L. Adam, C. R. Boehm, R. Breitling, R. Casagrande, M. Dando, A. Djikeng, N. G. Evans, R. Hammond, K. Hills, L. A. Holt, T. Kuiken, A. Markotić, P. Millett, J. A. Napier, C. Nelson, S. S. ÓhÉigeartaigh, A. Osbourn, M. J. Palmer, N. J. Patron, E. P, eLife, 9:e54489. 2020.
Horizon scanning is intended to identify the opportunities and threats associated with technological, regulatory and social change. In 2017 some of the present authors conducted a horizon scan for bioengineering (Wintle et al., 2017). Here we report the results of a new horizon ...
Simulation models from: Can CRISPER-mediated gene drive work in pest and beneficial haplodiploid species?
Tags: CRISPR, Gene drive synthetic, ModelingJ. Li and B. Tabashnik, Dryad, 2020.
Gene drives based on CRISPR/Cas9 have the potential to reduce the enormous harm inflicted by crop pests and insect vectors of human disease, as well as to bolster valued species. In contrast with extensive empirical and theoretical studies in diploid organisms, little is known ...
Genetic Biocontrol for Invasive Species
Tags: Gene drive synthetic, Genetic biocontrol, Invasive species, Sex distorterJ. L. Teem, L. Alphey, S. Descamps, M. P. Edgington, O. Edwards, N. Gemmell, T. Harvey-Samuel, R. L. Melnick, K. P. Oh, A. J. Piaggio, J. R. Saah, D. Schill, P. Thomas, T. Smith and A. Roberts, Frontiers in Bioengineering and Biotechnology, 8:452. 2020.
Invasive species are increasingly affecting agriculture, food, fisheries, and forestry resources throughout the world. As a result of global trade, invasive species are often introduced into new environments where they become established and cause harm to human health, ...
RNAi: Applications in Vertebrate Pest Management
Tags: Gene editing, Genetic biocontrol, Genetic engineeringK. E. Horak, Trends in Biotechnology, 38:1200-1202. 2020.
the development of novel control technologies must be focused on species specificity and low environmental impact. Sequence-specific gene silencing via RNAi holds promise for effective management of pest wildlife.
The Y Chromosome as a Battleground for Intragenomic Conflict
Tags: Evolution, Genetic engineering, Transmission distortion, Y-chromosomeD. Bachtrog, Trends in Genetics, 2020.
Recurrent sex chromosome drive can have profound ecological, evolutionary, and cellular impacts and account for unique features of sex chromosomes.
Gene Drives: Pursuing opportunities, minimizing risk
Tags: Gene drive synthetic, Policy, Regulation, Risk and safety, Risk assessmentK. L. Warmbrod, A. Kobokovich, R. West, G. Ray, M. Trotochaud and M. Montague, Center for Health Security, 2020.
This study analyzed the current state of gene drive technologies, the ways in which they might be deployed in the field, and the state of regulatory policy governing their development.
Le forçage génétique (gène drive) et ses applications
Tags: Agriculture, Biodiversity/Conservation, CRISPR, Gene drive syntheticV. Courtier-Orgogozo, Bulletin de l'Académie Vétérinaire de France, 172:94-98. 2020.
Gene drive is a new genetic engineering technology that has been developed over the past five years and that allows genetic modifications to spread rapidly in natural populations. Potential applications are numerous, for public health issues, agriculture and conservation biology. ...
Recessive Z-linked lethals and the retention of haplotype diversity in a captive butterfly population
Tags: Chromosomal drive, Evolution, Fruit fly, Genetics, Moths, Transmission distortionI. J. Saccheri, S. Whiteford, C. J. Yung and A. E. van't Hof, Heredity, 2020.
Sex chromosomes are predicted to harbour elevated levels of sexually antagonistic variation due to asymmetries in the heritability of recessive traits in the homogametic versus heterogametic sex.
Modeling confinement and reversibility of threshold-dependent gene drive systems in spatially-explicit Aedes aegypti populations
Tags: Containment, Gene drive synthetic, Mosquitoes, UnderdominanceH. M. Sánchez C, J. B. Bennett, S. L. Wu, G. Rašić, O. S. Akbari and J. M. Marshall, BMC Biology, 18:50. 2020.
Here, we model hypothetical releases of two recently engineered threshold-dependent gene drive systems—reciprocal chromosomal translocations and a form of toxin-antidote-based underdominance known as UDMEL—to explore their ability to be confined and remediated.
A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae
Tags: Anopheles, CRISPR, Gene drive synthetic, Malaria, Replicator/site directed nucleaseA. Simoni, A. M. Hammond, A. K. Beaghton, R. Galizi, C. Taxiarchi, K. Kyrou, D. Meacci, M. Gribble, G. Morselli, A. Burt, T. Nolan and A. Crisanti, Nature Biotechnology, 2020.
We report a male-biased sex-distorter gene drive (SDGD) in the human malaria vector Anopheles gambiae.
Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacement
Tags: Anopheles, CRISPR, Gene drive synthetic, Genetic biocontrol, Malaria, Population modification/replacement, Replicator/site directed nucleaseA. Hoermann, S. Tapanelli, P. Capriotti, E. K. G. Masters, T. Habtewold, G. K. Christophides and N. Windbichler, bioRxiv, 2020.
Here we explore how minimal genetic modifications of endogenous mosquito genes can convert them directly into non-autonomous gene drives without disrupting their expression.
Gene drive dynamics in natural populations: The importance of density-dependence, space and sex
Tags: Gene drive syntheticS. Dhole, A. L. Lloyd and F. Gould, arXiv, arXiv:2005.01838. 2020.
Here we review how different forms of density-dependence, spatial heterogeneity and mating behaviors can impact the spread of self-sustaining gene drives. We highlight specific aspects of gene drive dynamics and the target populations that need further research.
Beyond limits – the pitfalls of global gene drives for environmental risk assessment in the European Union
Tags: Europe, Gene drive synthetic, Genetically modified organisms, Regulation, Risk and safety, Risk assessmentM. Dolezel, C. Lüthi and H. Gaugitsch, BioRisk, 15:1-29. 2020.
We evaluate the novel features of GDOs and outline the resulting challenges for the environmental risk assessment.
The development of complex and controversial innovations. Genetically modified mosquitoes for malaria eradication
Tags: Gene drive, Gene drive synthetic, Genetically modified mosquitoes, Malaria, Policy, Risk and safety, Target malariaV. Cisnetto and J. Barlow, Research Policy, 49:103917. 2020.
e use a longitudinal process approach and qualitative system dynamics modelling to study the development of genetically modified (GM) mosquitoes for malaria eradication in an African country.
