Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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Evidence for B chromosome drive suppression in the grasshopper Eyprepocnemis plorans

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Herrera, JAL, M. D.; Cabrero, J.; Shaw, M. W.; Camacho, J. P. M.,  Heredity,  76:633-639. 1996.
The grasshopper Eyprepocnemis plorans is polymorphic for both a B chromosome and a heterochromatic segment of chromatin on the smallest autosome. Females transmit these to their offspring more frequently after copulating with a male from a population without Bs than after ...

Segregation distortion of the CTG repeats at the myotonic dystrophy locus

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Chakraborty, RS, D. N.; Deka, R.; Yu, L. M.; Shriver, M. D.; Ferrell, R. E.,  American Journal of Human Genetics,  59:109-118. 1996.
Myotonic dystrophy (DM), an autosomal dominant neuromuscular disease, is caused by a CTG-repeat expansion, with affected individuals having greater than or equal to 50 repeats of this trinucleotide, at the DMPK locus of human chromosome 19q13.3. Severely affected individuals die ...

The inheritance of B chromosomes in Allium schoenoprasum L

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Bougourd, SMP, A. B.,  Chromosome Research,  4:151-158. 1996.
The inheritance of B chromosomes has been investigated in Allium schoenoprasum from the River Wye, Powys; controlled crosses between plants of known B chromosome constitution were carried out, and the numbers of Bs present in the progenies scored. There was considerable ...

Low frequency of mouse t haplotypes in wild populations is not explained by modifiers of meiotic drive

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Ardlie, KGS, L. M.,  Genetics,  144:1787-1797. 1996.
t haplotypes are naturally occurring forms of mouse chromosome 17 that show non-Mendelian transmission from heterozygous +/t males. In laboratory studies, transmission ratios of greater than or equal to 0.90 or higher are typically observed. With transmission ratios of this ...

Gene transfer into the Medfly, Ceratitis capitata, using a Drosophila hydei transposable element.

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T. G. Loukeris, I. Livadaras, B. Arca, S. Zabalou and C. Savakis,  Science,  270:2002-2005. 1995.
Exogenous functional DNA was introduced into the germline chromosomes of the Mediterranean fruit fly (medfly) Ceratitis capitata with a germline transformation system based on the transposable element Minos from Drosophila hydei. Transformants were identified as phenotypic ...

Meiotic drive in female mice: An essay

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Ruvinsky, A,  Mammalian Genome,  6:315-320. 1995.
Since the rediscovery of Mendel's laws, geneticists have accumulated various examples in which equal meiotic segregation in heterozygotes is violated. However, only a few natural meiotic drive systems have been characterized in detail and the majority of these are sex chromosome ...

Sex-ratio distortion in Drosophila simulans – cooccurrence of a meiotic drive and a suppressor of drive

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Mercot, HA, A.; Jacques, M.; Montchampmoreau, C.,  Journal of Evolutionary Biology,  8:283-300. 1995.
A sex-ratio distortion factor was found at high frequency in D. simulans strains from Seychelles and New Caledonia. This factor is poorly or not expressed within those strains which are resistant to it. Its presence was detected by crossing females from New Caledonia or the ...

Tctex2 – a sperm tail surface protein mapping to the t-complex

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Huw, LYG, A. S.; Willison, K.; Artzt, K.,  Developmental Biology,  170:183-194. 1995.
Transmission ratio distortion (TRD) in mouse t-haplotypes remains the most significant example of meiotic drive in vertebrates. While the underlying mechanism that fuels it is still mysterious, TRD is clearly a complex multigene phenomenon. The characterization of Tctex2 ...

Meiotic drive an Myotonic Dystrophy – Reply

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Carey, NJ, K.; Nokelainen, P.; Peltonen, L.; Savontaus, M. L.; Juvonen, V.; Anvret, M.; Grandell, U.; Chotai, K.; Robertson, E.; Middletonprice, H.; Malcolm, S.,  Nature Genetics,  10:133-133. 1995.
Myotonic dystrophy (DM) is a trinucleotide disorder and in sub-clinical individuals there is considerable variation in the length of the CTG repeat. Two groups have recently analysed the patterns of segregation of different sized alleles at this locus and both report an excess of ...

Ascoycete spore killers: Chromosomal elements that distort genetic ratios among the products of meiosis

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Raju, NB,  Mycologia,  86:461-473. 1994.
Spore killers (Sk), studied most extensively in Neurospora, are also known in Podospora, Gibberella and Cochliobolus. Spore killers are no doubt present in natural populations of other fungi. Criteria are outlined here for recognizing their presence and distinguishing them from ...

Characterization of 2 Segregation Distorter revertants: Evidence that the tandem duplication is necessary for SD activity in Drosophila melanogaster

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Palopoli, MFD, P.; Wu, C. I.,  Genetics,  136:209-215. 1994.
Segregation Distorter (SD) is a naturally occurring system of meiotic drive in Drosophila melanogaster. Males heterozygous for an SD second chromosome and a normal homolog (SD+) transmit predominantly SD-bearing sperm. To accomplish this, the Segregation distorter (Sd) locus ...

Functional identification of the Segregation Distorter locus of Drosophila melanogaster by germline transformation

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McLean, JRM, C. J.; Powers, P. A.; Ganetzky, B.,  Genetics,  137:201-209. 1994.
Segregation Distorter (SD) is a meiotic drive system in D. melanogaster that results in the failure of SD/SD+ males to transmit SD+ homologs owing to the induced dysfunction of spermatids carrying the normal chromosome. Segregation distorter (Sd), the gene primarily responsible ...

Selfish DNA as method of pest control

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Hastings, IM,  Philosophical Transactions of the Royal Society B-Biological Sciences,  344:313-324. 1994.
The inheritance of most genes is tightly controlled, governed by the rules of mendelian inheritance if nuclear or uniparental inheritance if cytoplasmic. A few notable genes and cytoplasmic genomes have escaped this regulation. Such genes may spread by increasing their own rate ...

Meiotic drive at the myotonic dystrophy locus

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Gennarelli, MD, B.; Baiget, M.; Martorell, L.; Novelli, G.,  Journal of Medical Genetics,  31:980-980. 1994.
The mutation underlying myotonic dystrophy (DM, MIM* 160900) is the expansion of a CTG trinucleotide repeat sequence at the 3' untranslated region of a protein kinase gene (MT-PK).' The kinetics of this process is influenced by the sex of the transmitting parent and size of the ...

Y-linked suppressors of the sex-ratio trait in Drosophila mediopunctata

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Decarvalho, ABK, L. B.,  Heredity,  73:573-579. 1994.
X-linked meiotic drive causing female-biased progenies is known to occur in nine Drosophila species and is called 'sex-ratio'. In D. mediopunctata this trait is associated with the X:21 chromosome inversion and has variable expression. We describe here a powerful Y-linked ...

The evolution of lethals in the t-haplotype system of the mouse

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Charlesworth, B,  Proceedings of the Royal Society B-Biological Sciences,  258:101-107. 1994.
The evolution of lethal haplotypes in the t-haplotype segregation distortion system of Mus is examined by mathematical and computer models. The models assume that there is reproductive compensation for the loss of lethal embryos, such that the net reproductive success of a female ...

Hypothetical sisterkiller

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Butcher, DLD, H. W.,  Nature,  369:26-26. 1994.
It was premature of Hurst in his News and Views article I to accept Haig's claim2 that a hypothetical meiotic drive element, SisterKiller, can lead to evolution from one-step to multi-step meiosis. The basis of Haig's claim is that a SisterKiller allele that causes a gamete to ...

Bewildering Bs – An impression of the 1st B-chromosome conference

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Beukeboom, LW,  Heredity,  73:328-336. 1994.
Ever since their first discovery B chromosomes have attracted attention. Why are they so appealing? The standard chromosomes of an organism are A chromosomes; B chromosomes are extra to this normal complement. In the B chromosome 'bible' (Jones & Rees, 1982) Bs are defined as ...

Eradication of the screwworm from Libya using the sterile insect technique

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M. Vargas-Terán, B. S. Hursey and E. P. Cunningham,  Parasitology Today,  10:119-122. 1994.
The introduction in 1988 of the New World screwworrn into Libya presented a serious threat to the livestock and wildlife sectors of the African continent Mediterranean and the region. In this article, MoisPs Vargas-Terin, Brian 8. Hursey and Edward P. Cunningham describe the ...

The Segregation Distorter (SD) complex and the accumulation of deleterious genes in laboratory strains of Drosophila melanogaster

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Dominguez, AS, E.; Albornoz, J.; Gutierrez, A.,  Theoretical and Applied Genetics,  87:479-486. 1993.
Segregation Distorter (SD) associated with the second chromosome of D. melanogaster is found in nature at equilibrium frequencies lower than 5%. We report extremely high frequencies of SD (30-50%) in two selected strains, established in 1976, and show it to be responsible for the ...

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