
Keywords: Genetic engineering
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Gene Drive: Past, Present and Future Roads to Vertebrate BiocontrolG. R. McFarlane, C. B. A. Whitelaw and S. G. Lillico, Applied Biosciences, 2:52-70. 2023.![]() Scientists have long sought a technology to humanely control populations of damaging invasive pests in a species-specific manner. Gene drive technology could see this become a reality. This review charts the twists and turns on the road to developing gene drives in vertebrates. ... Keywords: Cas 9, CRISPR, gene editing, Genetic engineering |
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Empowering Indigenous Knowledge in Deliberations on Gene Editing in the WildR. Taitingfong and A. Ullah, Hastings Center Report, 51 Suppl 2:S74-s84. 2021.![]() Proposals to release genetically engineered organisms in the wild raise complex ethical issues related to their safe and equitable implementation. While there is broad agreement that community and public engagement is vital to decision-making in this context, more discussion is ... Keywords: Cas 9, CRISPR, gene editing, Genetic engineering |
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Interdisciplinary development of a standardized introduction to gene drives for lay audiencesC. E. Schairer, C. Triplett, A. Buchman, O. S. Akbari and C. S. Bloss, BMC Medical Research Methodology, 20:15. 2020.![]() While there is wide consensus that the public should be consulted about emerging technology early in development, it is difficult to elicit public opinion about innovations unfamiliar to lay audiences. We sought public input on a program of research on genetic engineering to ... Keywords: Cas 9, CRISPR, gene editing, Genetic engineering |
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Design and analysis of CRISPR-based underdominance toxin-antidote gene drivesJ. Champer, S. E. Champer, I. K. Kim, A. G. Clark and P. W. Messer, Evolutionary Applications, 18. 2020.![]() We model drives which target essential genes that are either haplosufficient or haplolethal, using nuclease promoters with expression restricted to the germline, promoters that additionally result in cleavage activity in the early embryo from maternal deposition, and promoters ... Keywords: Cas 9, CRISPR, gene editing, Genetic engineering |
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Suppressing evolution in genetically engineered systems through repeated supplementationN. C. Layman, B. M. Tuschhoff, A. J. Basinski, C. H. Remien, J. J. Bull and S. L. Nuismer, Evolutionary Applications, 12. 2020.![]() Genetically engineered organisms are prone to evolve in response to the engineering. This evolution is often undesirable and can negatively affect the purpose of the engineering. Methods that maintain the stability of engineered genomes are therefore critical to the successful ... Keywords: Cas 9, CRISPR, gene editing, Genetic engineering |
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Translating gene drive science to promote linguistic diversity in community and stakeholder engagementC. Cheung, S. Gamez, R. Carballar-Lejarazú, V. Ferman, V. N. Vásquez, G. Terradas, J. Ishikawa, C. E. Schairer, E. Bier, J. M. Marshall, A. A. James, O. S. Akbari and C. S. Bloss, Global Public Health, 2020.![]() Information about genetic engineering (GE) for vector control in the United States is disseminated primarily in English, though non-English speakers are equally, and in some geographic regions even more affected by such technologies. Non-English-speaking publics should have equal ... Keywords: Cas 9, CRISPR, gene editing, Genetic engineering |
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Can CRISPR gene drive work in pest and beneficial haplodiploid species?J. Li, O. Aidlin Harari, A.-L. Doss, L. L. Walling, P. W. Atkinson, S. Morin and B. E. Tabashnik, Evolutionary Applications, 2020.![]() Gene drives based on CRISPR/Cas9 have the potential to reduce the enormous harm inflicted by crop pests and insect vectors of human disease, as well as to bolster valued species. In contrast with extensive empirical and theoretical studies in diploid organisms, little is known ... Keywords: Cas 9, CRISPR, gene editing, Genetic engineering |
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Should the humans be allowed to genetically modify insects?Olivia Abbe, NYK Daily, 2020.![]() Genetic engineering, also called Genetic modification or Genetic manipulation, is the direct manipulation of an organism’s genes using biotechnology. It is a set of technologies used to change the genetic makeup of cells, including the transfer of genes within and across ... Keywords: Cas 9, CRISPR, gene editing, Genetic engineering |
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Population-level multiplexing: A promising strategy to manage the evolution of resistance against gene drives targeting a neutral locusM. P. Edgington, T. Harvey-Samuel and L. Alphey, Evolutionary Applications, 10. 2020.![]() CRISPR-based gene drives bias inheritance in their favour by inducing double-stranded breaks (DSBs) at wild-type homologous loci and using the drive transgene as a repair template-converting drive heterozygotes into homozygotes. Recent studies have shown that alternate ... Keywords: Cas 9, CRISPR, gene editing, Genetic engineering |
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What is genome editing?NHGRI, NHGRI, 2019.![]() Genome editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals. Editing DNA can lead to changes in physical traits, like eye color, and disease risk. Scientists use different technologies to do this. Keywords: Cas 9, CRISPR, gene editing, Genetic engineering |
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Spatial structure undermines parasite suppression by gene drive cargoBull, JJR, Christopher H.; Gomulkiewicz, Richard; Krone, Stephen M., PeerJ, 7:e7921. 2019.![]() Gene drives may be used in two ways to curtail vectored diseases. Both involve engineering the drive to spread in the vector population. One approach uses the drive to directly depress vector numbers, possibly to extinction. The other approach leaves intact the vector population ... Keywords: Cas 9, CRISPR, gene editing, Genetic engineering |
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Genetic frontiers for conservation: An assessment of synthetic biology and biodiversity conservationK. H. Redford, T. Brooks, M., B. W. Nicholas and J. S. A. Macfarlane, International Union for Conservation of Nature, 2019.![]() This assessment is the beginning of a process that will lead to the development of an IUCN policy to guide the Union’s Director General, Commissions, and Members. The draft policy will be discussed in many fora before it is brought to vote at the World Conservation Congress in ... Keywords: Cas 9, CRISPR, gene editing, Genetic engineering |
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THE NATIONAL BIOSAFETY TECHNICAL COMMISSION (CTNBio) NORMATIVE RESOLUTION No. 16, OF JANUARY 15, 2018CTNBio, National Biosafety Technical Commission of Brasil, 2018.![]() Sets forth the technical requirements for submitting an inquiry to the CTNBio concerning Precision Breeding Innovation Techniques. THE NATIONAL BIOSAFETY TECHNICAL COMMISSION (CTNBio), using its legal and regulatory powers and in observance of sections XV and XVI of article 14 of ... Keywords: Cas 9, CRISPR, gene editing, Genetic engineering |
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Driven to extinction? The ethics of eradicating mosquitoes with gene-drive technologiesPugh, J, Journal of Medical Ethics, 42:578-581. 2016.![]() Mosquito-borne diseases represent a significant global disease burden, and recent outbreaks of such diseases have led to calls to reduce mosquito populations. Furthermore, advances in gene-drive' technology have raised the prospect of eradicating certain species of mosquito via ... Keywords: Cas 9, CRISPR, gene editing, Genetic engineering |

Contact
David O’Brochta
Foundation for the
National Institutes of Health
geneconvenevi@fnih.org
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