Keywords: Sex distorter
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Autosomal suppression of sex-ratio meiotic drive influences the dynamics of X and Y chromosome coevolutionAnjali Gupta, Robert L Unckless, Journal of Heredity, 2024.
Sex-ratio meiotic drivers are selfish genes or gene complexes that bias the transmission of sex chromosomes resulting in skewed sex ratios. Existing theoretical models have suggested the maintenance of a four-chromosome equilibrium (with driving and standard X and suppressing and ... |
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Transformation of meiotic drive into hybrid sterility in DrosophilaJackson Bladen, Hyuck-Jin Nam, Nitin Phadnis, bioRxiv, 2024.
Hybrid male sterility is one of the fastest evolving intrinsic reproductive barriers between recently isolated populations. A leading explanation for the evolution of hybrid male sterility involves genomic conflicts with meiotic drivers in the male germline. There are, however, ... |
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Quantifying Fitness Costs in Transgenic Aedes aegypti MosquitoesWilliams, A. E., Sanchez-Vargas, I., Martin, L. E., Martin-Martin, I., Bennett, S., Olson, K. E., Calvo, E., The Journal of Visualized Experiments, 199. 2024.
The present protocol describes how to measure common life parameter data in Aedes aegypti mosquitoes, including fecundity, wing size, fertility, sex ratio, viability, development times, male contribution, and adult longevity. |
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The haplolethal gene wupA of Drosophila exhibits potential as a target for an X-poisoning gene driveLawler, Clancy D ,Parra Nuñez, Ana Karla ,Hernandes, Natalia ,Bhide, Soumitra ,Lohrey, Isabelle ,Baxter, Simon ,Robin, Charles, G3 Genes Genome Genetics, jkae025. 2024.
We examine this ‘X-poisoning’ strategy by targeting four of the 11 known X-linked haplolethal/haplosterile genes of Drosophila melanogaster with CRISPR/Cas9. We find that targeting the wupA gene during spermatogenesis skews the sex ratio so fewer than 14% of progeny are ... |
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The haplolethal gene wupA of Drosophila exhibits potential as a target for an X-poisoning gene driveClancy D. Lawler, Ana Karla Parra Nuñez, Natalia Hernandes, Soumitra Bhide, Isabelle Lohrey, Simon Baxter, Charles Robin, bioRxiv, 2024.
A synthetic gene drive that targets haplolethal genes on the X-chromosome can skew the sex ratio towards males. Like an ‘X-shredder’ it does not involve ‘homing’ and that has advantages including the reduction of gene drive resistance allele formation. We examine this ... |
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Male-killing virus leads to more female mothsAnonymous, Nature, 2023.
Keisuke Nagamine at Minami Kyushu University in Miyazaki, Japan, and his colleagues have identified another virus that kills male embryos of the tobacco caterpillar, Spodoptera litura. Female moths infected with the virus produced an equal number of male and female embryos, but ... |
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Male-killing virus in a noctuid moth Spodoptera lituraK. Nagamine, Y. Kanno, K. Sahara, T. Fujimoto, A. Yoshido, Y. Ishikawa, M. Terao, D. Kageyama and Y. Shintani, Proceedings of the National Academy of Sciences, 120:e2312124120. 2023.
A female-biased sex ratio is considered advantageous for the cytoplasmic elements that inhabit sexually reproducing organisms. There are numerous examples of bacterial symbionts in the arthropod cytoplasm that bias the host sex ratio toward females through various means, ... |
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Gene drive and genetic sex conversion in the global agricultural pest Ceratitis capitataA. Meccariello, S. Hou, S. Davydova, J. Fawcett, A. Siddall, P. Leftwich, T. , F. Krsticevic, P. A. Papathanos and N. Windbichler, bioRxiv, 2023.08.16.553191. 2023.
Homing-based gene drives are novel interventions promising the area-wide, species-specific genetic control of harmful insect populations. Here we characterise a first set of gene drives in a tephritid agricultural pest species, the Mediterranean fruit fly Ceratitis capitata ... |
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Female meiotic drive in plants: mechanisms and dynamicsF. Finseth, Current Opinion in Genetics and Development, 82:102101. 2023.
Female meiosis is fundamentally asymmetric, creating an arena for genetic elements to compete for inclusion in the egg to maximize their transmission. Centromeres, as mediators of chromosomal segregation, are prime candidates to evolve via ‘female meiotic drive’. According to ... |
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Assessing the suitability of YY males and ZZ females as an invasive species population control method across life historiesR. A. Erickson, H. M. Thompson, S. A. Kageyama, G. M. Andriacchi, A. R. Cupp, R. Patiño and J. J. Amberg, Biological Invasions, 25:3737-3751. 2023.
Natural resource managers use tools to control invasive species. In theory, stocking YY males or ZZ females would allow managers to skew sex ratios until populations collapse. In combination with other suppression methods, such as removal, this approach could be incorporated into ... |
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Ability of a selfish B chromosome to evade genome elimination in the jewel wasp, Nasonia vitripennisH. Lee, P. Seo, S. Teklay, E. Yuguchi, E. D. Benetta, J. H. Werren and P. M. Ferree, Heredity, 2023.
B chromosomes are non-essential, extra chromosomes that can exhibit transmission-enhancing behaviors, including meiotic drive, mitotic drive, and induction of genome elimination, in plants and animals. A fundamental but poorly understood question is what characteristics allow B ... |
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Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in DrosophilaC. Weizhe, G. Jialiang, L. Yiran and C. Jackson, bioRxiv, 2023.07.17.549342. 2023.
Gene drive alleles, which bias their own inheritance and increase in frequency, show great promise for blocking disease transmission or directly suppressing pest populations. The most common engineered drive system is the CRISPR homing drive, which converts wild-type alleles to ... |
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N. Wybouw, E. Van Reempts, J. Zarka, F. Zélé and D. Bonte, Heredity, 2023.
Maternally transmitted symbionts such as Wolbachia can alter sex allocation in haplodiploid arthropods. By biasing population sex ratios towards females, these changes in sex allocation may facilitate the spread of symbionts. In contrast to symbiont-induced cytoplasmic ... |
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The evolutionary history of Drosophila simulans Y chromosomes reveals molecular signatures of resistance to sex ratio meiotic driveC. Courret, D. Ogereau, C. Gilbert, A. M. Larracuente and C. Montchamp-Moreau, Mol Biol Evol, 2023.
The recent evolutionary history of the Y chromosome in Drosophila simulans, a worldwide species of Afrotropical origin, is closely linked to that of X-linked meiotic drivers (Paris system). The spread of the Paris drivers in natural populations has elicited the selection of drive ... |
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Meiotic drive of noncentromeric loci in mammalian meiosis II eggsD. M. Silva and T. Akera, Curr Opin Genet Dev, 81:102082. 2023.
The germline produces haploid gametes through a specialized cell division called meiosis. In general, homologous chromosomes from each parent segregate randomly to the daughter cells during meiosis, providing parental alleles with an equal chance of transmission. Meiotic drivers ... |
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Impacts of sex ratio meiotic drive on genome structure and function in a stalk-eyed flyJ. A. Reinhardt, R. H. Baker, A. V. Zimin, C. Ladias, K. A. Paczolt, J. H. Werren, C. Y. Hayashi and G. S. Wilkinson, Genome Biology Evolution, 2023.
Stalk-eyed flies in the genus Teleopsis carry selfish genetic elements that induce sex ratio meiotic drive (SR) and impact the fitness of male and female carriers. Here, we assemble and describe a chromosome-level genome assembly of the stalk-eyed fly, Teleopsis dalmanni, to ... |
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A male-killing gene encoded by a symbiotic virus of DrosophilaD. Kageyama, T. Harumoto, K. Nagamine, A. Fujiwara, T. N. Sugimoto, A. Jouraku, M. Tamura, T. K. Katoh and M. Watada, Nature Communications, 14:1357. 2023.
In most eukaryotes, biparentally inherited nuclear genomes and maternally inherited cytoplasmic genomes have different evolutionary interests. Strongly female-biased sex ratios that are repeatedly observed in various arthropods often result from the male-specific lethality ... |
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Heterogeneous distribution of sex ratio distorters in natural populations of the isopod Armadillidium vulgareS. Durand, B. Lheraud, I. Giraud, N. Bech, F. Grandjean, T. Rigaud, J. Peccoud and R. Cordaux, Biology Letters, 19:20220457. 2023.
In the isopod Armadillidium vulgare, many females produce progenies with female-biased sex ratios, owing to two feminizing sex ratio distorters (SRD): Wolbachia endosymbionts and the f element. We investigated the distribution and population dynamics of these SRD and ... |
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A natural gene drive could steer invasive rodents on islands to extinctionB. Brookshire, ScienceNews, 2022.
In the battle against the invasive house mouse on islands, scientists are using the rodent’s own genes against it. With the right tweaks, introducing a few hundred genetically altered mice could drive an island’s invasive mouse population to extinction in about 25 years, ... |
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Deregulation of Y-linked protamine-like genes in sex chromosome-biased spermatid demiseJ. I. Park, G. W. Bell and Y. M. Yamashita, bioRxiv, 2022.
Meiotic drive is a phenomenon wherein a genetic element achieves a higher rate of transmission than dictated by Mendelian segregation (1-3). One proposed mechanism for meiotic drivers to achieve biased transmission is by sabotaging essential processes of gametogenesis (e.g. ... |
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Meiotic drive adaptive testes enlargement during early development in the stalk-eyed flyS. L. Bradshaw, L. Meade, J. Tarlton-Weatherall and A. Pomiankowski, Biology Letters, 18:20220352. 2022.
The sex ratio (SR) X-linked meiotic drive system in stalk-eyed flies destroys Y-bearing sperm. Unlike other SR systems, drive males do not suffer fertility loss. They have greatly enlarged testes which compensate for gamete killing. We predicted that enlarged testes arise from ... |
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Introgression of a synthetic sex ratio distortion transgene into different genetic backgrounds of Anopheles coluzziiP. Pollegioni, T. Persampieri, R. L. Minuz, A. Bucci, A. Trusso, S. Di Martino, C. Leo, M. Bruttini, M. Ciolfi, A. M. Waldvogel, F. Tripet, A. Simoni, A. Crisanti and R. Müller, Insect Molecular Biology, 2022.
The development of genetically modified mosquitoes (GMM) and their subsequent field release offers innovative approaches for vector control of malaria. A non-gene drive self-limiting male-bias Ag(PMB)1 strain has been developed in a 47-year-old laboratory G3 strain of Anopheles ... |
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Mitotic exchange in female germline stem cells is the major source of Sex Ratio chromosome recombination in Drosophila pseudoobscuraS. Koury, G3 Genes|Genomes|Genetics, 2022.
Sex Ratio chromosomes in Drosophila pseudoobscura are selfish X chromosome variants associated with three non-overlapping inversions. In the male germline, Sex Ratio chromosomes distort segregation of X and Y chromosomes (99:1), thereby skewing progeny sex ratio. In the female ... |
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Distribution of sex ratio distorters in natural populations of the isopod Armadillidium vulgare2022. |
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Hoisted with his own petard: How sex-ratio meiotic drive in Drosophila affinis creates resistance alleles that limit its spreadW. J. Ma, E. M. Knoles, K. B. Patch, M. M. Shoaib and R. L. Unckless, J Evol Biol, 2022.
Meiotic drivers are selfish genetic elements that tinker with gametogenesis to bias their own transmission into the next generation of offspring. Such tinkering can have significant consequences on gametogenesis and end up hampering the spread of the driver. In Drosophila ... |
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Meiotic drive in house mice: mechanisms, consequences, and insights for human biologyU. P. Arora and B. L. Dumont, Chromosome Research, 2022.
Meiotic drive occurs when one allele at a heterozygous site cheats its way into a disproportionate share of functional gametes, violating Mendel's law of equal segregation. This genetic conflict typically imposes a fitness cost to individuals, often by disrupting the process of ... |
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Partial masculinization of Aedes aegypti females by conditional expression of NixB. B. Kojin, E. Jakes, J. K. Biedler, Z. Tu and Z. N. Adelman, PLOS Neglected Tropical Diseases, 16:e0010598. 2022.
Here, we report on the conditional expression of Nixin transgenic A. aegypti under the control of the tetracycline-dependent (Tet-off) system, with the goal of establishing repressible sex distortion. A masculinization phenotype was observed in three of the seven transgenic lines ... |
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Gene drive designs for efficient and localisable population suppression using Y-linked editorsR. Geci, K. Willis and A. Burt, bioRxiv, 2022.06.29.498122. 2022.
The sterile insect technique (SIT) has been successful in controlling some pest species but is not practicable for many others due to the large numbers of individuals that need to be reared and released. Previous computer modelling has demonstrated that the release of males ... |
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Hoisted with his own petard: how sex-ratio meiotic drive in <em>Drosophila affinis</em> creates resistance alleles that limit its spreadW.-J. Ma, E. M. Knoles, K. B. Patch, M. M. Shoaib and R. L. Unckless, bioRxiv, 2022.02.14.480432. 2022.
Meiotic drivers are selfish genetic elements that tinker with gametogenesis to bias their own transmission into the next generation of offspring. Such tinkering can have significant consequences on gametogenesis and end up hampering the spread of the driver. In Drosophila ... |
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Natural and Engineered Sex Ratio Distortion in InsectsA. Compton and Z. Tu, Frontiers in Ecology and Evolution, 10. 2022.
Insects have evolved highly diverse genetic sex-determination mechanisms and a relatively balanced male to female sex ratio is generally expected. However, selection may shift the optimal sex ratio while meiotic drive and endosymbiont manipulation can result in sex ratio ... |
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Generation of Gene Drive Mice for Invasive Pest Population SuppressionM. D. Bunting, C. Pfitzner, L. Gierus, M. White, S. Piltz and P. Q. Thomas, Applications of Genome Modulation and Editing, 2022.
Gene drives are genetic elements that are transmitted to greater than 50% of offspring and have potential for population modification or suppression. While gene drives are known to occur naturally, the recent emergence of CRISPR-Cas9 genome-editing technology has enabled ... |
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Male-killing-associated bacteriophage WO identified from comparisons of Wolbachia endosymbionts of Homona magnanimaH. Arai, H. Anbutsu, Y. Nishikawa, M. Kogawa, K. Ishii, M. Hosokawa, S.-R. Lin, M. Ueda, M. Nakai, Y. Kunimi, T. Harumoto, D. Kageyama, H. Takeyama and M. N. Inoue, bioRxiv, 2022.
The origin and mechanism of male-killing, an advantageous strategy employed by maternally transmitted symbionts such as Wolbachia, remain unclear. We compared genomes of four Wolbachia strains derived from Homona magnanima, a male-killing strain wHm-t (1.5 Mb), and three ... |
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Mitotic exchange in female germline stem cells is the major source of Sex Ratio chromosome recombination in Drosophila pseudoobscuraS. Koury, bioRxiv, 2022.06.07.495109. 2022.
Sex Ratio chromosomes in Drosophila pseudoobscura are selfish X chromosome variants associated with three non-overlapping inversions. In the male germline, Sex Ratio chromosomes distort segregation of X and Y chromosomes (99:1), thereby skewing progeny sex ratio. In the female ... |
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Combined Trojan Y Chromosome Strategy and Sterile Insect Technique to Eliminate Mosquitoes: Modelling and AnalysisJ. Lyu, M. Gu, S. Wang and K. Cheng, Mathematical Problems in Engineering, 2022:2373350. 2022.
Sterile insect technique has been successfully applied in the control of agricultural pests; however, it has a limited ability to control mosquitoes. A promising alternative approach is the Trojan Y Chromosome strategy, which works by manipulating the sex ratio of a population ... |
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Aquatic invasive species specialists’ perceptions on the importance of genetic tools and concepts to inform managementT. A. Bernos, K. M. Jeffries and N. E. Mandrak, Biological Invasions, 24:1863-1879. 2022.
Perceptions related to the importance of genetic research influence the mobilization of genetic tools and concepts to inform conservation actions. Research characteristics, stakeholders’ perspectives, knowledge, and social linkages with geneticists influence the outcome of ... |
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The fate of a suppressed X-linked meiotic driver: experimental evolution in Drosophila simulansH. Bastide, D. Ogereau, C. Montchamp-Moreau and P. R. Gérard, Chromosome Research, 2022.
Sex-ratio (SR) meiotic drivers are X-linked selfish genetic elements that promote their own transmission by preventing the production of Y-bearing sperm, which usually lowers male fertility. The spread of SR drivers in populations is expected to trigger the evolution of unlinked ... |
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The evolutionary significance of meiotic driveJ. B. Searle and F. P.-M. de Villena, Heredity, 2022.
In this essay, we will focus on‘true meiotic drive’ where the distorted transmission does arise within meiosis itself (Zanders and Unckless2019),specifically in females. Here, the non-transmission of one of the products of meiotic division is inherent in the gametogenic ... |
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Trojan trout: could turning an invasive fish into a ‘super-male’ save a native species?J. Miller, The Guardian, 2022.
Brook trout may greatly outnumber the Rio Grande cutthroat here, but nearly every brookie the team captures is male. That’s because many are a lab-produced variety known as “Trojan” brook trout. They are unique in that they carry not one, but two copies of the Y chromosome ... |
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Propagation of seminal toxins through binary expression gene drives could suppress populationsJ. Hurtado, S. Revale and L. M. Matzkin, Scientific Reports, 12:6332. 2022.
Gene drives can be highly effective in controlling a target population by disrupting a female fertility gene. To spread across a population, these drives require that disrupted alleles be largely recessive so as not to impose too high of a fitness penalty. We argue that this ... |
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Hoisted with his own petard: how sex-ratio meiotic drive in Drosophila affnis creates resistance alleles that limit its spreadW.-J. Ma, K. B. Patch, E. M. Knoles, M. M. Shoaib and R. L. Unckless, bioRxiv, 2022.02.14.480432. 2022.
Meiotic drivers are selfish genetic elements that tinker with gameto-genesis to bias their own transmission into the next generation of off-spring. Such tinkering can have significant consequences on gameto-genesis and end up hampering the spread of the driver. In Drosophila ... |
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Endosymbionts moderate constrained sex allocation in a haplodiploid thrips species in a temperature-sensitive wayA. Katlav, D. T. Nguyen, J. L. Morrow, R. N. Spooner-Hart and M. Riegler, Heredity, 9. 2022.
Maternally inherited bacterial endosymbionts that affect host fitness are common in nature. Some endosymbionts colonise host populations by reproductive manipulations (such as cytoplasmic incompatibility; CI) that increase the reproductive fitness of infected over uninfected ... |
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Characterization of the first Wolbachia from the genus Scaptodrosophila, a male-killer from the rainforest species S. claytoniK. M. Richardson, M. Schiffer, P. A. Ross, J. A. Thia and A. A. Hoffmann, Insect Science, 2022.
Abstract The Scaptodrosophila genus represents a large group of drosophilids with a worldwide distribution and a predominance of species in Australia, but there is little information on the presence and impacts of Wolbachia endosymbionts in this group. Here we describe the first ... |
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Scientists Used CRISPR Gene Editing to Choose the Sex of Mouse PupsS. Fan, Singuarity Hub, 2021.
“Do you want a boy or a girl?” can be an awkward question.But in certain circles, it’s a question that’s asked every day. Take agriculture. In a perfect world, most cows would only birth females. Chicks would grow up to be all hens. “Sexing” a farm animal when ... |
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Exploiting a Y chromosome-linked Cas9 for sex selection and gene driveS. Gamez, D. Chaverra-Rodriguez, A. Buchman, N. P. Kandul, S. C. Mendez-Sanchez, J. B. Bennett, C. H. Sánchez, T. Yang, I. Antoshechkin, J. E. Duque, P. A. Papathanos, J. M. Marshall and O. S. Akbari, Nature Communications, 7202. 2021.
CRISPR-based genetic engineering tools aimed to bias sex ratios, or drive effector genes into animal populations, often integrate the transgenes into autosomal chromosomes. However, in species with heterogametic sex chromsomes (e.g. XY, ZW), sex linkage of endonucleases could be ... |
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Gene editing used to create all-male or all-female litters of miceJ. Goodyer, Science Focus, 2021.
As males are unable to produce milk or lay eggs, the ability to breed cows and hens that produce all-female litters is likely to be high on most poultry and dairy farmers’ wish lists. Now, scientists at the Francis Crick Institute and the University of Kent have come a step ... |
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Gene editing used to create all-male or all-female mice littersA. Reis, European Scientist, 2021.
Researchers from the Francis Crick Institute and the University of Kent used gene-editing technologies to create male-only and female-only mice litters, according to a study published in Nature Communications (1). The authors also suggested ways in which this method could be used ... |
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The Potential for a Released Autosomal X-Shredder Becoming a Driving-Y Chromosome and Invasively Suppressing Wild Populations of Malaria MosquitoesY. Alcalay, S. Fuchs, R. Galizi, F. Bernardini, R. E. Haghighat-Khah, D. B. Rusch, J. R. Adrion, M. W. Hahn, P. Tortosa, R. Rotenberry and P. A. Papathanos, Frontiers in Bioengineering and Biotechnology, 9. 2021.
Sex-ratio distorters based on X-chromosome shredding are more efficient than sterile male releases for population suppression. X-shredding is a form of sex distortion that skews spermatogenesis of XY males towards the preferential transmission of Y-bearing gametes, resulting in a ... |
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Gene-editing used to create single sex mice littersThe Francis Crick Institute, Phys Org, 2021.
Scientists at the Francis Crick Institute, in collaboration with University of Kent, have used gene editing technology to create female-only and male-only mice litters with 100% efficiency. This proof of principle study, published in Nature Communications today, demonstrates how ... |
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Single-sex mice litters were created with 100% efficiency using gene editing.R. Silman, Brinkwire, 2021.
The Francis Crick Institute, in partnership with the University of Kent, has employed gene editing technology to construct 100% efficient female-only and male-only mouse litters. This proof-of-concept study, which was published today (Friday, December 3rd, 2021) in Nature ... |
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Lab animals: Gene-editing technology is used to create female-only and male-only mice litterstodayuknews, Today UK News, 2021.
Single-sex litters of mice — comprising only either female or male pups — have been produced by means of so-called CRISPR-Cas9 gene editing technology. The technique, developed by experts at the Francis Crick Institute and the University of Kent, works by inactivating embryos ... |
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Gene editing produces all-male or all-female litters of miceE. Pennisi, Science, 2021.
In some farmers’ ideal world, cows would birth only females, sows would bear no boars, and chicks would all grow up to be hens. Such sex ratios would stop them from killing millions of male animals, which don’t produce eggs or milk. Now, scientists are a step closer to this ... |
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CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypesC. Douglas, V. Maciulyte, J. Zohren, D. M. Snell, S. K. Mahadevaiah, O. A. Ojarikre, P. J. I. Ellis and J. M. A. Turner, Nature Communications, 12:6926. 2021.
Animals are essential genetic tools in scientific research and global resources in agriculture. In both arenas, a single sex is often required in surplus. The ethical and financial burden of producing and culling animals of the undesired sex is considerable. Using the mouse as a ... |
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Propagation of seminal toxins through binary expression gene drives can suppress polyandrous populationsJ. Hurtado, S. Revale and L. M. Matzkin, bioRxiv, 2021.11.23.469777. 2021.
Gene drives can be highly effective in controlling a target population by disrupting a female fertility gene. To spread across a population, these drives require that disrupted alleles be largely recessive so as not to impose too high of a fitness penalty. We argue that this ... |
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Satellite DNA-mediated diversification of a sex-ratio meiotic drive gene family in DrosophilaC. A. Muirhead and D. C. Presgraves, Nature Ecology & Evolution, 2021.
Sex chromosomes are susceptible to the evolution of selfish meiotic drive elements that bias transmission and distort progeny sex ratios. Conflict between such sex-ratio drivers and the rest of the genome can trigger evolutionary arms races resulting in genetically suppressed ... |
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Patterns and mechanisms of sex ratio distortion in the Collaborative Cross mouse mapping populationB. A. Haines, F. Barradale and B. L. Dumont, Genetics, 219:iyab136. 2021.
In species with single-locus, chromosome-based mechanisms of sex determination, the laws of segregation predict an equal ratio of females to males at birth. Here, we show that departures from this Mendelian expectation are commonplace in the 8-way recombinant inbred Collaborative ... |
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Patterns and Mechanisms of Sex Ratio Distortion in the Collaborative Cross Mouse Mapping PopulationB. A. Haines, F. Barradale and B. L. Dumont, bioRxiv, 2021.
In species with single-locus chromosome-based mechanisms of sex determination, the laws of segregation predict an equal ratio of females to males at birth. Here, we show that departures from this Mendelian expectation are commonplace in the 8-way recombinant inbred Collaborative ... |
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Meiotic drive does not cause condition-dependent reduction of the sexual ornament in stalk-eyed fliesS. R. Finnegan, M. Mondani, K. Fowler and A. Pomiankowski, Journal of Evolutionary Biology, 11. 2021.
Meiotic drive systems are associated with low-frequency chromosomal inversions. These are expected to accumulate deleterious mutations due to reduced recombination and low effective population size. We test this prediction using the 'sex-ratio' (SR) meiotic drive system of the ... |
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Converting female mosquitoes to non-biting males with implications for mosquito controlM. V. Candy, Vet Candy, 2020.
Virginia Tech researchers have proven that a single gene can convert female Aedes aegypti mosquitoes into fertile male mosquitoes and identified a gene needed for male mosquito flight. Male mosquitoes do not bite and are unable to transmit pathogens to humans. Female mosquitoes, ... |
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Polyandry blocks gene drive in a wild house mouse populationA. Manser, B. Konig and A. K. Lindholm, Nature Communications, 11:8. 2020.
Here, we study the impact of polyandry on a well-known gene drive, called t haplotype, in an intensively monitored population of wild house mice. First, we show that house mice are highly polyandrous: 47% of 682 litters were sired by more than one male. Second, we find that ... |
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X-linked meiotic drive can boost population size and persistenceC. Mackintosh, A. Pomiankowski and M. F. Scott, Genetics, 217:11. 2020.
Here, we find general conditions for the spread and fixation of X-linked alleles. Our conditions show that the spread of X-linked alleles depends on sex-specific selection and transmission rather than the time spent in each sex. Applying this logic to meiotic drive, we show that ... |
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Cellular mechanisms regulating synthetic sex ratio distortion in the Anopheles gambiae germlineR. E. Haghighat-Khah, A. Sharma, M. R. Wunderlich, G. Morselli, L. A. Marston, C. Bamikole, A. Hall, N. Kranjc, C. Taxiarchi, I. Sharakhov and R. Galizi, Pathogens and Global Health, 114:370-378. 2020.
Meiotic cleavage of rDNA repeats, located in the sex chromosomes of A. gambiae SD males, affects the competitiveness of mature sperm to fertilize the female oocyte. |
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Selfish genetic elements and male fertilityR. L. Verspoor, T. A. R. Price and N. Wedell, Philosophical Transactions of the Royal Society B-Biological Sciences, 375:7. 2020.
Selfish genetic elements (SGEs) are diverse and near ubiquitous in Eukaryotes and can be potent drivers of evolution. Here, we discuss SGEs that specifically act on sperm to gain a transmission advantage to the next generation. The diverse SGEs that affect sperm often impose ... |
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Assessing the acoustic behaviour of Anopheles gambiae (s.l.) dsxF mutants: implications for vector controlM. P. Su, M. Georgiades, J. Bagi, K. Kyrou, A. Crisanti and J. T. Albert, Parasites and Vectors, 13:507. 2020.
We analysed sound emissions and acoustic preference in a doublesex mutant previously used to collapse Anopheles gambiae (s.l.) cages. |
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Resistance to natural and synthetic gene drive systemsT. A. R. Price, N. Windbichler, R. L. Unckless, A. Sutter, J.-N. Runge, P. A. Ross, A. Pomiankowski, N. L. Nuckolls, C. Montchamp-Moreau, N. Mideo, O. Y. Martin, A. Manser, M. Legros, A. M. Larracuente, L. Holman, J. Godwin, N. Gemmell, C. Courret, A. Buc, Journal of Evolutionary Biology, 2020.
This review summarizes our current knowledge of drive resistance in both natural and synthetic gene drives. We explore how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases ... |
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Generating single-sex litters: development of CRISPR-Cas9 genetic tools to produce all-male offspringC. Douglas, V. Maciulyte, J. Zohren, D. M. Snell, O. A. Ojarikre, P. J. Ellis and J. M. A. Turner, bioRxiv, 2020.09.07.285536. 2020.
Using the mouse as a model, we developed a synthetic, two-part bicomponent strategy for generating all-male litters. |
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Mixed knobs in corn cobsP. Lamelza and M. A. Lampson, Genes and Development, 34:1110-1112. 2020.
In this issue of Genes & Development, Swentowsky and colleagues (pp. 1239-1251) show that two types of knobs, those composed of 180-bp and TR1 sequences, recruit their own novel and divergent kinesin-14 family members to form neocentromeres. |
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Distinct kinesin motors drive two types of maize neocentromeresK. W. Swentowsky, J. I. Gent, E. G. Lowry, V. Schubert, X. Ran, K. F. Tseng, A. E. Harkess, W. H. Qiu and R. K. Dawe, Genes and Development, 34:1239-1251. 2020.
Here we describe a second kinesin-14 gene, TR-1 kinesin (Trkin), that is required to mobilize neocentromeres made up of the minor tandem repeat TR-1. |
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Towards Responsive Eco-technology: The Development of a Male Sex-biased MouseW. Kamau, Massachusetts Institute of Technology, 2020.
CRISPR-Cas systems have catalyzed the emergence of several synthetic population management strategies, like gene drives, for controlling pests and disease vectors. As these technologies garner greater visibility in both general and regulatory audiences, questions have arisen ... |
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Meet Cosmo, the gene-edited Crispr calfS. D. McClain, Capital Press, 2020.
Cosmo was the grand finale of a series of experiments to create a line of genome-edited cattle tailored for the beef industry. He was designed to produce 75% male offspring. |
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Extensive Recombination Suppression and Epistatic Selection Causes Chromosome-Wide Differentiation of a Selfish Sex Chromosome in Drosophila pseudoobscuraZ. L. Fuller, S. A. Koury, C. J. Leonard, R. E. Young, K. Ikegami, J. Westlake, S. Richards, S. W. Schaeffer and N. Phadnis, Genetics, 216:205. 2020.
Here, we conduct a multifaceted study of the multiply inverted Drosophila pseudoobscura SR chromosome to understand the evolutionary history, genetic architecture, and present-day dynamics that shape this enigmatic selfish chromosome. |
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The future of beef might be a sausage festN. Johnson, grist, 2020.
N. Johnson. (2020) grist. A media report on the creation of a cow with a sex ratio altering genetic change expected to lead to 3/4 of the cow's offspring being males. This type of sex ratio distortion results in gene drive and is also being considered to help control populations ... |
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Meet Cosmo the Frankenbull: Scientists genetically engineer a bull calf so that 75 per cent of its offspring will be maleJ. Pinkstone, Daily Mail, 2020.
J. Pinkstone (2020). Daily Mail. A media report on the creation of a cow with a sex ratio altering genetic change expected to lead to 3/4 of the cow's offspring being males. This type of sex ratio distortion results in gene drive and is also being considered to help control ... |
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A Crispr calf is born. It’s definitely a boyM. Molteni, WIRED, 2020.
M. Molteni (2020). Wired. UC Davis scientists spent years editing a sex-determining gene into bovine embryos. In April, Cosmo arrived—and his DNA reveals how far the field has to go. This type of sex ratio distortion results in gene drive and is also being considered to help ... |
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Meet the first genetically modified bull. Why did scientists change itJ. Kessler, Free News, 2020.
J. Kessler (2020). Free News. UC Davis scientists have successfully introduced a bovine embryo, or the bovine SRY gene, which is responsible for the development of the male. This is the first demonstration of targeted gene insertion for large DNA sequences through embryo-mediated ... |
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Scientists use CRISPR technology to insert sex-determining geneA. Quinton, Phys Org, 2020.
A. Quinton (2020). Phys Org. Scientists at the University of California, Davis, have successfully produced a bull calf, named Cosmo, who was genome-edited as an embryo so that he'll produce more male offspring. The research was presented in a poster on July 23 at the American ... |
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Tackling Dengue fever by turning female mosquitoes into malesT. Sandle, DIGTAL JOURNAL, 2020.
T. Sandle (2020). DIGTAL JOURNAL Genetic engineering appears to be the key for delivering mosquito control, according to new research. Scientists have successfully converted female mosquitoes into non-biting males. |
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Genetic Biocontrol for Invasive SpeciesJ. L. Teem, L. Alphey, S. Descamps, M. P. Edgington, O. Edwards, N. Gemmell, T. Harvey-Samuel, R. L. Melnick, K. P. Oh, A. J. Piaggio, J. R. Saah, D. Schill, P. Thomas, T. Smith and A. Roberts, Frontiers in Bioengineering and Biotechnology, 8:452. 2020.
Invasive species are increasingly affecting agriculture, food, fisheries, and forestry resources throughout the world. As a result of global trade, invasive species are often introduced into new environments where they become established and cause harm to human health, ... |
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Hope rises as scientists eliminate malaria mosquitoesA. Adeyemi, New Telegraph, 2020.
A team of researchers led by Imperial College London have spread a genetic modification that distorted the sex ratio through a population of caged Anopheles gambiae mosquitoes using ‘gene drive’ technology. According to the results of their study published yesterday in ... |
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Malaria mosquitoes eliminated in lab by creating all-male offspringsAishwarya, Inshorts, 2020.
Imperial College London-led team used 'gene drive' technology to spread genetic modification that distorted sex ratio through caged breed of malaria mosquitoes. This caused mosquitoes to produce more male offspring, eventually leading to no female birth. The study suggested such ... |
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Researchers use “gene drive” technology to eliminate malaria mosquitoes in lab experimentsJ. Ives, News Medical Life Sciences, 2020.
A team led by Imperial College London spread a genetic modification that distorts the sex ratio through a population of caged Anopheles gambiae mosquitoes using 'gene drive' technology. |
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Genetically-manipulated male mosquitoes could eliminate femalesB. Coxworth, New Atlas, 2020.
Several years ago, we heard how scientists were looking at eradicating malaria-carrying mosquitoes by making the females infertile. Now they're going a step further, by eliminating the females altogether. |
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Researchers discover way to eliminate malaria carrying mosquitoesS. Digon, International Business Times, 2020.
Researchers from the Imperial College London have come up with a genetic modification that will pave the way for the elimination of malaria mosquitoes. Scientists say that the alteration distorts the sex ratio of caged Anopheles gambiae mosquitoes using what they call a ‘gene ... |
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The malaria mosquito is eliminated in the lab by creating a population of all malesNewsDesk, Instant, 2020.
A team led by Imperial College London disseminates genetic modification that distorts the sex ratio through the Anopheles gambiae mosquito population that is locked up using ‘gene drive’ technology. |
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Malaria mosquitoes eliminated in lab by creating all male populationsH. Dunning, Imperial College London, 2020.
A team led by Imperial College London spread a genetic modification that distorts the sex ratio through a population of caged Anopheles gambiae mosquitoes using ‘gene drive’ technology. |
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Gene editing could fight malaria by causing only male mosquitos to be bornL. Dormehl, Digital Trends, 2020.
What’s the theoretically easiest way to ensure that a population of mosquitos is not able to sustain itself through breeding? Make sure that there aren’t enough females, of course. That’s the exploratory approach being pioneered by researchers at the U.K.’s Imperial ... |
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Simulating effects of fitness and dispersal on the use of Trojan sex chromosomes for the management of invasive speciesC. C. Day, E. L. Landguth, R. K. Simmons, W. P. Baker, A. R. Whiteley, P. M. Lukacs and A. Bearlin, Journal of Applied Ecology, 2020.
The use of Trojan Y chromosomes (TYC) for controlling invasive species involves manipulating the sex chromosomes of captive-raised individuals. Following release, the offspring of these individuals consist of only one sex, thereby skewing the sex ratio of the invasive population ... |
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Autosomal suppression and fitness costs of an old driving X chromosome in Drosophila testaceaG. Keais, S. Lu and S. Perlman, Journal of Evolutionary Biology, 2020.
Driving X chromosomes (XDs) are meiotic drivers that bias their own transmission through males by killing Y-bearing gametes. These chromosomes can in theory spread rapidly in populations and cause extinction, but many are found as balanced polymorphisms or as ?cryptic? XDs shut ... |
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Optimal control and analysis of a modified trojan Y-Chromosome strategyM. A. Beauregard, R. D. Parshad, S. Boon, H. Conaway, T. Griffin and J. J. Lyu, Ecological Modelling, 416. 2020.
The Trojan Y Chromosome (TYC) strategy is a promising eradication method that attempts to manipulate the female to male ratio to promote the reduction of the population of an invasive species. The manipulation stems from an introduction of sex-reversed males, called supermales, ... |
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Standard deviations: The biological bases of transmission ratio distortionL. Fishman and M. McIntosh, Annual Review of Genetics, 53:347-372. 2019.
The rule of Mendelian inheritance is remarkably robust, but deviations from the equal transmission of alternative alleles at a locus [a.k.a. transmission ratio distortion (TRD)] are also commonly observed in genetic mapping populations. Such TRD reveals locus-specific selection ... |
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The association between mitochondrial genetic variation and reduced colony fitness in an invasive waspJ. Dobelmann, A. Alexander, J. W. Baty, N. J. Gemmell, M. A. M. Gruber, O. Quinn, T. Wenseleers and P. J. Lester, Molecular Ecology, 28:3324-3338. 2019.
Despite the mitochondrion's long-recognized role in energy production, mitochondrial DNA (mtDNA) variation commonly found in natural populations was assumed to be effectively neutral. However, variation in mtDNA has now been increasingly linked to phenotypic variation in life ... |
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Exploring Stakeholder Perspectives on the Development of a Gene Drive Mouse for Biodiversity Protection on Islands: Workshop ReportM. Farooque, S. K. Barnhill-Dilling, J. Shapiro and J. Delborne, North Carolina State University, 2019.
The “Exploring Stakeholder Perspectives on the Development of a Gene Drive Mouse for Biodiversity Protection” workshop was held on the North Carolina State University campus in Raleigh, NC on March 7-8, 2019, aiming to convene a diverse group of stakeholders, scientists, ... |
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Genetic pest management technologies to control invasive rodentsD. Kanavy and D. Threadgill, Island invasives: scaling up to meet the challenge, 2019.
Many strategies exist to manage invasive pests on islands, ranging from poison to trapping, with varying degrees of success. Genetic technologies are increasingly being applied to insect pests, but so far, not to vertebrates. We are implementing a genetic strategy to eradicate ... |
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Genome-wide transcriptome profiling reveals genes associated with meiotic drive system of Aedes aegyptiShin, DB, K. Susanta; Severson, W. David, Insects, 10:e25. 2019.
Aedes aegypti is an important mosquito vector of several arboviruses, including dengue, yellow fever, Zika, and Chikungunya, which cause significant human morbidity and mortality globally. In certain populations of this mosquito, a native meiotic drive system causes abnormal ... |
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Transmission ratio distortion is frequent in Arabidopsis thaliana controlled crossesSeymour, DKC, E.; Arioz, B. I.; Koenig, D.; Weigel, D., Heredity, 122:294-304. 2019.
The equal probability of transmission of alleles from either parent during sexual reproduction is a central tenet of genetics and evolutionary biology. Yet, there are many cases where this rule is violated. The preferential transmission of alleles or genotypes is termed ... |
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Population Consequences of Releasing Sex-Reversed Fish: Applications and ConcernsC. Wederkind, Sex Control in Aquaculture, Chp 8:179-188. 2018.
Sex differentiation is generally more labile in gonochoristic fish than it is, for example, in birds and mammals. Environmentally induced sex reversal is, therefore, often possible, and creates genotype‐phenotype mismatches that can be useful in population management. ... |
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Sex Control in Aquaculture: Concept to PracticeH.P. Wang and Z.G. Shen, Sex Control in Aquaculture, 2018.
Understanding sex determining (SD) mechanisms and related concepts in a wide range of fish species is critical for sex control and large‐scale monosex production in aquaculture, in which monosex culture is superior to mixed‐sex culture. Establishment of phenotypic sex is ... |
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Invasion Success and Management Strategies for Social Vespula WaspsP. J. Lester and J. R. Beggs, Annual Review of Entomology, 64:51-71. 2018.
Three species of Vespula have become invasive in Australia, Hawai'i, New Zealand, and North and South America and continue to spread. Economically, their main negative effect is associated with pollination and the apicultural industry. Climate change is likely to exacerbate ... |
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A spatially discrete, integral projection model and its application to invasive carpR. A. Erickson, E. A. Eager, P. M. Kocovsky, D. C. Glover, J. L. Kallis and K. R. Long, Ecological Modelling, 387:163-171. 2018.
Natural resource managers and ecologists often desire an understanding of spatial dynamics such as migration, dispersion, and meta-population dynamics. Network-node models can capture these salient features. Additionally, the state-variable used with many species may be ... |
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Pest demography critically determines the viability of synthetic gene drives for population controlK. E. Wilkins, T. A. A. Prowse, P. Cassey, P. Q. Thomas and J. V. Ross, Mathematical Biosciences, 305:160-169. 2018.
Synthetic gene drives offer a novel solution for the control of invasive alien species. CRISPR-based gene drives can positively bias their own inheritance, and comprise a DNA sequence that is replicated by homologous recombination. Since gene drives can be positioned to silence ... |
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Sex determination in Neotropical fish: Implications ranging from aquaculture technology to ecological assessmentJ. I. Fernandino and R. S. Hattori, General and Comparative Endocrinology, 273:172-183. 2018.
The high biodiversity of fish in the Neotropical region contrasts with scarce or biased studies on the mechanisms involved in the sex determination in members of this fauna. In this review, we attempted to compile the information available on determination, differentiation, and ... |
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Rapid comeback of males: evolution of male-killer suppression in a green lacewing populationHayashi, MN, M.; Kageyama, D., Proceedings of the Royal Society B-Biological Sciences, 285:6. 2018.
Evolutionary theory predicts that the spread of cytoplasmic sex ratio distorters leads to the evolution of host nuclear suppressors, although there are extremely few empirical observations of this phenomenon. Here, we demonstrate that a nuclear suppressor of a cytoplasmic male ... |
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Selfish genetic elementsAgren, JAC, A. G., PLOS Genetics, 14:20. 2018.
Selfish genetic elements (historically also referred to as selfish genes, ultra-selfish genes, selfish DNA, parasitic DNA, genomic outlaws) are genetic segments that can enhance their own transmission at the expense of other genes in the genome, even if this has no or a negative ... |
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Production of YY Supermale and XY Physiological Female Common Carp for Potential Eradication of this Invasive SpeciesM. Y. Jiang, X. X. Wu, K. X. Chen, H. R. Luo, W. Yu, S. T. Jia, Y. M. Li, Y. F. Wang, P. H. Yang, Z. Y. Zhu and W. Hu, Journal of the World Aquaculture Society, 49:315-327. 2018.
The common carp, Cyprinus carpio, is the third most cultivated freshwater species worldwide, but is also considered an invasive species. The Trojan Y chromosome strategy is one of the most promising methods to eradicate this invasive species. However, obtaining fertile YY ... |
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Trojan Females and Judas Goats: Evolutionary Traps as Tools in Wildlife ManagementB. A. Robertson, R. S. Ostfeld and F. Keesing, Bioscience, 67:982-993. 2017.
Here, we bring together science from the pest-control, eco-evolutionary, and conservation communities to outline how evolutionary traps can be repurposed to eliminate or control pest species. We highlight case studies and devise strategies for the selection of appropriate cues to ... |
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The optimal implementation of the Trojan Y chromosome eradication strategy of invasive speciesM. R. Kelly and X. Y. Wang, Journal of Biological Systems, 25:399-418. 2017.
Invasive aquatic species continue to be a persistent problem around the world. The Trojan Y Chromosome (TYC) eradication strategy has recently been developed to help fight the problem in aquatic systems by targeting only the invasive species, sparing native marine stock. It ... |
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Mitonuclear interactions, mtDNA-mediated thermal plasticity, and implications for the Trojan Female Technique for pest controlJ. N. Wolff, D. M. Tompkins, N. J. Gemmell and D. K. Dowling, Scientific Reports, 6. 2016.
Here we test whether the male-sterilizing effects previously associated with the mt: Cyt-b mutation are consistent across three thermal and three nuclear genomic contexts. The effects of this mutation were indeed moderated by the nuclear background and thermal environment, but ... |
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Cheating evolution: engineering gene drives to manipulate the fate of wild populationsChamper, JB, A.; Akbari, O. S., Nature Reviews Genetics, 17:146-159. 2016.
Engineered gene drives - the process of stimulating the biased inheritance of specific genes - have the potential to enable the spread of desirable genes throughout wild populations or to suppress harmful species, and may be particularly useful for the control of vector-borne ... |
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Meiotic drive changes sperm precedence patterns in house mice: potential for male alternative mating tactics?Sutter, AL, A. K., BMC Evolutionary Biology, 16:15. 2016.
Background: With female multiple mating (polyandry), male-male competition extends to after copulation (sperm competition). Males respond to this selective pressure through physiological, morphological and behavioural adaptations. Sperm competitiveness is commonly decreased in ... |
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Production of a YY Male Brook Trout Broodstock for Potential Eradication of Undesired Brook Trout PopulationsD. J. Schill, J. A. Heindel, M. R. Campbell, K. A. Meyer and E. Mamer, North American Journal of Aquaculture, 78:72-83. 2015.
Brook Trout Salvelinus fontinalis introduced outside of their native range often negatively impact native aquatic fauna or provide marginal fisheries and are frequently targeted for manual or piscicide removal in lakes and streams. Unfortunately, complete eradication of exotic ... |
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Stochastic models for the Trojan Y-Chromosome eradication strategy of an invasive speciesX. Y. Wang, J. R. Walton and R. D. Parshad, Journal of Biological Dynamics, 10:179-199. 2015.
The Trojan Y-Chromosome (TYC) strategy, an autocidal genetic bio-control method, has been proposed to eliminate invasive alien species. In this work, we develop a Markov jump process model for this strategy, and we verify that there is a positive probability for wild-type females ... |
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The Trojan Female Technique for pest control: a candidate mitochondrial mutation confers low male fertility across diverse nuclear backgrounds in Drosophila melanogasterD. K. Dowling, D. M. Tompkins and N. J. Gemmell, Evolutionary Applications, 8:8710880. 2015.
The Trojan Female Technique (TFT) was recently proposed as a prospective approach to biological pest control. However, applicability of the TFT relies on mitochondrial mutations whose male-sterilizing effects are general across nuclear genomic contexts. We test this assumption, ... |
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Ecological and evolutionary applications for environmental sex reversal of fishA. McNair, P. M. Lokman, G. P. Closs and S. Nakagawa, Quarterly Review of Biology, 90:23-44. 2015.
Environmental sex reversal (ESR), which results in a mismatch between genotypic and phenotypic sex, is well documented in numerous fish species and may be induced by chemical exposure. Historically, research involving piscine ESR has been carried out with a view to improving ... |
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Sperm traits of masculinized fish relative to wild-type males: a systematic review and meta-analysesA. M. Senior, S. L. Johnson and S. Nakagawa, Fish and Fisheries, 17:143-164. 2014.
Environmental sex reversal (ESR), whereby environmental effects (e.g. exogenous chemicals) override genetic sex determination, is a commonly used technique in aquaculture and physiology research. We performed a systematic review and meta-analyses of the literature that compares ... |
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The Trojan female technique: a novel, effective and humane approach for pest population controlN. J. Gemmell, A. Jalilzadeh, R. K. Didham, T. Soboleva and D. M. Tompkins, Proceedings of the Royal Society B: Biological Sciences, 280:20132549. 2013.
We use mathematical models to test a new twist on the SMT, using maternally inherited mitochondrial (mtDNA) mutations that affect male, but not female reproductive fitness. ‘Trojan females’ carrying suchmutations, and their female descendants, produce ... |
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Global existence and asymptotic behavior of a model for biological control of invasive species via supermale introductionR. D. Parshad, S. Kouachi and J. B. Gutierrez, Communications in Mathematical Sciences, 11:971-992. 2013.
The purpose of this manuscript is to propose a model for the biological control of invasive species, via introduction of phenotypically modified organisms into a target population. We are inspired by the earlier Trojan Y Chromosome model [J.B. Gutierrez, J.L. Teem, J. Theo. Bio., ... |
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Demographic effects on the use of genetic options for the control of mosquitofish, Gambusia holbrookiR. E. Thresher, M. Canning and N. J. Bax, Ecological Applications, 23:801-814. 2013.
This study tests the sensitivity of genetically based pest control options based on sex ratio distortion to intra-and intersexual aggressive interactions that affect male and female survival and fitness. Data on these interactions and their impacts were gathered for the ... |
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Analysis of the Trojan Y-Chromosome eradication strategy for an invasive speciesX. Y. Wang, J. R. Walton, R. D. Parshad, K. Storey and M. Boggess, Journal of Mathematical Biology, 68:1731-1756. 2013.
The Trojan Y-Chromosome (TYC) strategy, an autocidal genetic biocontrol method, has been proposed to eliminate invasive alien species. In this work, we analyze the dynamical system model of the TYC strategy, with the aim of studying the viability of the TYC eradication and ... |
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Combining the Trojan Y chromosome and daughterless carp eradication strategiesJ. L. Teem and J. B. Gutierrez, Biological Invasions, 16:1231-1240. 2013.
The Trojan Y chromosome (TYC) strategy and the daughterless carp (DC) strategy represent two autocidal genetic biocontrol methods for eliminating invasive fish by changing the sex ratio of the population. Each strategy is designed to reduce the number of females in a target ... |
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A comparison of the Trojan Y Chromosome and daughterless carp eradication strategiesJ. L. Teem, J. B. Gutierrez and R. D. Parshad, 16, 16:1217-1230. 2013.
Two autocidal genetic biocontrol methods have been proposed as a means to eliminate invasive fish by changing the sex ratio of the population: the Trojan Y Chromosome (TYC) strategy and the Daughterless Carp (DC) strategy. Both strategies were modeled using ordinary differential ... |
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Genetic control of invasive fish: technological options and its role in integrated pest managementR. E. Thresher, K. Hayes, N. J. Bax, J. Teem, T. J. Benfey and F. Gould, Biological Invasions, 16:1201-1216. 2013.
Genetic options for the control of invasive fishes were recently reviewed and synthesized at a 2010 international symposium, held in Minneapolis/St. Paul, MN, USA. The only option currently available "off-the-shelf'' is triploidy, which can be used to produce sterile males for a ... |
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A Theoretical Strategy for Eradication of Asian Carps Using a Trojan Y Chromosome to Shift the Sex Ratio of the PopulationJ.L. teem and J.B. Gutierrez, Invasive Asian Carps in North America, 74:227-238. 2011.
The directed extinction of an exotic fish population is proposed using a genetic approach to drastically reduce the ratio of females to males within the population. In the proposed strategy, sex-reversed female fish containing two Y chromosomes (Fyy) are introduced into a normal ... |
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On the Well Posedness and Refined Estimates for the Global Attractor of the TYC ModelR. D. Parshad and J. B. Gutierrez, Boundary Value Problems, 2010.
The Trojan Y Chromosome strategy (TYC) is a theoretical method for eradication of invasive species. It requires constant introduction of artificial individuals into a target population, causing a shift in the sex ratio that ultimately leads to local extinction. In this work we ... |
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On the global attractor of the Trojan Y chromosome model.R. D. Parshad and J. B. Gutierrez, Communications on Pure and Applied Analysis, 10:339-359. 2010.
We consider the Trojan Y Chromosome (TYC) model for eradication of invasive species in population dynamics. We present global estimates for the TYC system in a spatial domain. In this work we prove the existence of a global attractor for the system. We derive uniform estimates to ... |
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Control of introduced species using Trojan sex chromosomesS. Cotton and C. Wedekind, Trends in Ecology & Evolution, 22:441-443. 2007.
To control introduced exotic species that have predominantly genetic, but environmentally reversible, sex determination (e.g. many species of fish), Gutierrez and Teem recently modeled the use of carriers of Trojan Y chromosomes - individuals who are phenotypically sex reversed ... |
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A model describing the effect of sex-reversed YY fish in an established wild population: The use of a Trojan Y chromosome to cause extinction of an introduced exotic speciesJ. B. Gutierrez and J. L. Teem, Journal of Theoretical Biology, 241:333-341. 2006.
A novel means of inducing extinction of an exotic fish population is proposed using a genetic approach to shift the ratio of male to females within a population. In the proposed strategy, sex-reversed fish containing two Y chromosomes are introduced into a normal fish population. ... |
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B chromosomes and genome size in flowering plantsTrivers, RB, A.; Palestis, B. G., Genome, 47:1-8. 2004.
B chromosomes are extra chromosomes found in some, but not all, individuals within a species, often maintained by giving themselves an advantage in transmission, i.e. they drive. Here we show that the presence of B chromosomes correlates to and varies strongly and positively with ... |
