Keywords: Stakeholder engagement
Russia’s Latest Target in Africa: U.S.-Funded Anti-Malaria Programs
Tags: Africa, Ethics, Risk and safety, Stakeholder engagement, Target malariaElian Peltier, The New York Times, 2024.
The scientists sifting through thousands of genetically modified mosquito larvae in a laboratory in Burkina Faso were trying to stop the spread of malaria, one of the biggest killers on the African continent. But in the pro-Russian propaganda telling of their work, the ...
Practical Application of a Relationship-Based Model to Engagement for Gene-Drive Vector Control Programs
Tags: Africa, Gene drive, Modeling, Stakeholder engagement, Vector controlAna Kormos, Lodney Nazaré, Adionilde Aguiar dos Santos, and Gregory C. Lanzaro, The American Journal of Tropical Medicine and Hygiene, 111:341-360. 2024.
Engagement is an important component in the advancement of gene-drive vector control research programs as developers look to transition the technology from the laboratory to the field. As research advances and engagement surrounding this novel technology is put into practice, ...
Professor Abdoulaye Diabaté’s frank conversation with Bill Gates
Tags: Africa, Gene drive, Stakeholder engagement, Target malariaAfrican Media Agency, 2024.
On October 2, 2024, Professor Abdoulaye Diabaté, a prominent figure in malaria research and Head of Medical Entomology at Burkina Faso’s Research Institute in Health Sciences, gained international attention by appearing in the Netflix documentary series "What’s Next? The ...
Gene Drive and Symbiont Technologies for Control of Mosquito-Borne Diseases
Tags: Gene drive, Malaria, Stakeholder engagement, WolbachiaGuan-Hong Wang, Ary Hoffmann, and Jackson Champer, Annual Reviews, 70. 2024.
Mosquito-borne diseases, such as dengue and malaria, pose a significant burden to global health. Current control strategies with insecticides are only moderately effective. Scalable solutions are needed to reduce the transmission risk of these diseases. Symbionts and genome ...
Gene Editing in the Wild: Shaping Decisions through Broad Public Deliberation
Tags: Stakeholder engagementHastings Center, Hastings Center Report, 51(S2). 2024.
A series of articles about the design of public engagement around modifying nonhuman organisms in the shared environment.
Operationalizing stakeholder engagement for gene drive research in malaria elimination in Africa – translating guidance into practice
Tags: Africa, Regulation, Stakeholder engagementPare Toe L, Dicko B, Linga R, Barry N, et al., Malar J, 21:225. 2024.
Gene drive mosquitoes are increasingly considered a potential transformational tool for vector control of malaria mosquitoes. As part of efforts to promote responsible research in this field, a number of guidance documents have been published by the World Health Organization, ...
Communicating the uncertainties associated with genetic biocontrol approaches: insights from communicators, science journalists and scientists in Africa
Tags: Africa, Genetic biocontrol, Stakeholder engagementTonui, W. K., Ogoyi, D., Thuo, C., Tareh, C., et al., Journal of Science Communication, 23. 2024.
Genetic biocontrol approaches, such as gene drive technology is rapidly gaining interest from scientists and public health professionals due to their potential to overcome many challenges of current malaria control tools and strategies. This is particularly the case in Africa ...
How expensive it is to be poor Prof. Abdoulaye Diabaté inspires global action against malaria at TED2024
Tags: Africa, Stakeholder engagement, Target malariaRealnews Magazine, 2024.
In a stirring address at TED2024, Prof. Abdoulaye Diabaté, Head of Medical Entomology and Parasitology at the Research Institute in Health Sciences in Bobo-Dioulasso, Burkina Faso, and Principal Investigator of Target Malaria Burkina Faso, shared his journey with malaria and his ...
Talking About Gene Drive in Uganda: The Need for Science Communication to Underpin Engagement
Tags: Africa, Gene drive, Mosquitoes, Stakeholder engagementHartley, S., Stelmach, A., Opesen, C., Openjuru, G. L., and Neema, S., Science Communication, 2024.
Uganda may host the world’s first field trials of gene drive mosquitoes for malaria control. Global North discourses pre-suppose African publics have access to information about gene drive and are ready to make decisions about its governance. We explore assumptions about the ...
African researchers committed to ending malaria
Tags: Africa, Malaria, Stakeholder engagementAfrican Media Agency, 2024.
The need to encourage more young African girls to pursue careers in science cannot be overemphasized.
Scientism, trust, value alignment, views of nature, and U.S. public opinion about gene drive mosquitos
Tags: Gene drive, Stakeholder engagementEvans, J. H., & Schairer, C. E., Public Understanding of Science, 2024.
Gene drive could be a powerful tool for addressing problems of conservation, agriculture, and human health caused by insect and animal pests but is likely to be controversial as it involves the release of genetically modified organisms. This study examined the social determinants ...
Stakeholder engagement in the development of genetically modified mosquitoes for malaria control in West Africa: lessons learned from 10 years of Target Malaria’s work in Mali
Tags: Stakeholder engagement, Vector controlBakara Dicko, Souleymane Kodio, Hatouma Samoura, Fatoumata Traoré, Naima Sykes, Mouhamed Drabo, Delphine Thizy, Isabelle Coche, Benjamin Robinson, Kadiatou Sanogo, Bilkissou Yagouré, Samba Diop, Mamadou B. Coulibaly, Frontiers in Bioengineering and Biotechnology, 11. 2024.
From 2012 to 2023, the Malaria Research and Training Center (MRTC), based out of the University of Sciences, Techniques and Technologies of Bamako (USTTB), was part of the Target Malaria research consortium working towards developing novel gene drive-based tools for controlling ...
General science-technology orientation, specific benefit–risk assessment frame, and public acceptance of gene drive biotechnology
Tags: Gene drive, Gene drive synthetic, Governance, Risk and safety, Risk assessment, Stakeholder engagementX. Liu, C. L. Goldsmith, K. E. Kang, A. Vedlitz, Z. N. Adelman, L. W. Buchman, E. Heitman and R. F. Medina, Risk Analysis, 2023.
Abstract With limited understanding of most new biotechnologies, how do citizens form their opinion and what factors influence their attitudes about these innovations? In this study, we use gene drive biotechnology in agricultural pest management as an example and theoretically ...
Off Target: Gene Drives and the Balance of Life
Tags: Gene drive, Gene drive synthetic, Risk assessment, Stakeholder engagementSave Our Seeds, 2023.
This is a compilation of conversations with experts about gene drive technologies and the science/social questions it raises.
The attitudes of young adults towards mammalian predator control and Predator Free 2050 in Aotearoa New Zealand
Tags: Ethics, Gene drive, Gene drive synthetic, Invasive species, Oceania, Stakeholder engagementL. Dickie and F. Medvecky, Australasian Journal of Environmental Management, 2023.
Predator Free 2050 (PF2050) is an ambitious goal that aims to remove three types of invasive mammals from New Zealand by 2050. It will require a significant amount of funding, research, and support. Young adults will have an important role to play for this programme to be ...
Gene Drives
Tags: Ethics, Gene drive, Gene drive synthetic, Policy, Stakeholder engagementD. M. Berube, Pandemics and Resilience, 2023.
A “gene drive” is a version of gene editing—a newer, more precise way to change a DNA (or RNA) sequence; in this case, combining a guide RNA with an enzyme that can make a gene drive takes this to another level, making sure that a new or altered genetic sequence has a ...
The boundary problem: Defining and delineating the community in field trials with gene drive organisms
Tags: Ethics, Gene drive, Gene editing, Malaria, Mosquitoes, Population modification/replacement, Stakeholder engagementN. de Graeff, I. Pirson, R. van der Graaf, A. L. Bredenoord and K. R. Jongsma, Bioethics, 2023.
Despite widespread and worldwide efforts to eradicate vector-borne diseases such as malaria, these diseases continue to have an enormous negative impact on public health. For this reason, scientists are working on novel control strategies, such as gene drive technologies (GDTs). ...
Gene Drives as Interventions into Nature: the Coproduction of Ontology and Morality in the Gene Drive Debate
Tags: Ethics, Gene drive, Gene drive synthetic, Policy, Stakeholder engagementK. Boersma, B. Bovenkerk and D. Ludwig, NanoEthics, 17:4. 2023.
Gene drives are potentially ontologically and morally disruptive technologies. The potential to shape evolutionary processes and to eradicate (e.g. malaria-transmitting or invasive) populations raises ontological questions about evolution, nature, and wilderness. The ...
Engagement on risk assessment for gene drive mosquitoes by EFSA and Target Malaria
Tags: Europe, Gene drive, Gene drive synthetic, Policy, Risk and safety, Risk assessment, Stakeholder engagement, Target malariaS. Hartley, A. Kokotovich, Y. Devos and J. Mumford, Environmental Science and Policy, 142:183-193. 2023.
As engineered gene drive technologies continue to advance, many actors are actively considering how environmental risk assessments (RAs) for gene drive organisms should be conducted, and how stakeholder engagement opportunities should be provided. There is, however, a lack of ...
Moving beyond narrow definitions of gene drive: Diverse perspectives and frames enable substantive dialogue among science and humanities teachers in the United States and United Kingdom
Tags: Gene drive, Policy, Stakeholder engagementS. Hartley, A. Stelmach, J. A. Delborne and S. K. Barnhill-Dilling, Public Understanding of Science, 2023.
Gene drive is an emerging biotechnology with applications in global health, conservation and agriculture. Scientists are preparing for field trials, triggering debate about when and how to release gene-drive organisms. These decisions depend on public understandings of gene ...
Trust in science and scientists: Effects of social attitudes and motivations on views regarding climate change, vaccines and gene drive technology
Tags: Ethics, Gene drive, Oceania, Stakeholder engagementH. G. W. Dixson, A. F. Komugabe-Dixson, F. Medvecky, J. Balanovic, H. Thygesen and E. A. MacDonald, Journal of Trust Research, 2023.
Trust in science and scientists (TSS) is an increasingly important topic with respect to how science is applied within society. However, its role regarding specific issues may vary depending upon other psychosocial factors. In this study, we investigated how trust interacts with ...
Exploring the value of a global gene drive project registry
Tags: Gene drive, Gene drive synthetic, Governance, Policy, Risk and safety, Stakeholder engagementR. I. Taitingfong, C. Triplett, V. N. Vásquez, R. M. Rajagopalan, R. Raban, A. Roberts, G. Terradas, B. Baumgartner, C. Emerson, F. Gould, F. Okumu, C. E. Schairer, H. C. Bossin, L. Buchman, K. J. Campbell, A. Clark, J. Delborne, K. Esvelt, J. Fisher, R., Nature Biotechnology, 2022.
Recent calls to establish a global project registry before releasing any gene-drive-modified organisms (GDOs) have suggested a registry could be valuable to coordinate research, collect data to monitor and evaluate potential ecological impacts, and facilitate transparent ...
Influence of public hesitancy and receptivity on reactive behaviours towards releases of male Wolbachia-Aedes mosquitoes for dengue control
Tags: Aedes, Policy, Stakeholder engagement, WolbachiaM. O. Lwin, Z. Ong, C. Panchapakesan, A. Sheldenkar, L. T. Soh, I. Chen, X. Li, W. Niah, K. Vasquez, S. Sim and L.-C. Ng, PLOS Neglected Tropical Diseases, 16:e0010910. 2022.
Singapore, a highly urbanized Asian tropical country that experiences periodic dengue outbreaks, is piloting field releases of male Wolbachia-carrying Aedes aegyptimosquitoes with the aim of suppressing urban populations of the primary dengue vector Aedes aegypti. This study ...
Why we need to talk about ‘gene-drive’ grey squirrels
Tags: Biodiversity/Conservation, Gene drive, Genetic biocontrol, Invasive species, Population suppression, Stakeholder engagementL. Clarke, DevonLive, 2022.
Would the best way of controlling the UK’s rampant grey squirrel population be to spread genetic changes throughout the species? A new research film, to be shown next month at Exeter Phoenix, sees scientists, conservation and wildlife experts debate the use of emergent ...
Ethics of gene drive mosquitoes for malaria elimination
Tags: Ethics, Policy, Stakeholder engagement, Synthetic biologyA. J. Roberts, McMaster University, 2022.
This thesis is concerned with presenting analyses regarding key ethical issues regarding and arising from the development and potential use of gene drive modified mosquitoes for the purpose of malaria elimination. Each of the chapters constituting this thesis offers a rigorously ...
Hurdles in responsive community engagement for the development of environmental biotechnologies
Tags: Ethics, Gene drive, Gene drive synthetic, Policy, Stakeholder engagement, Synthetic biologyA. M. Normandin, L. M. Fitzgerald, J. Yip and S. W. Evans, Synthetic Biology, 7:ysac022. 2022.
Recent calls for engaging communities in biotechnology development do not draw enough attention to the hurdles that must be overcome for engagement strategies to effectively feed back into research design and conduct. These hurdles call into question many standard ways of ...
Operationalizing stakeholder engagement for gene drive research in malaria elimination in Africa-translating guidance into practice
Tags: Gene drive, Gene drive synthetic, Malaria, Stakeholder engagement, Vector controlL. Pare Toe, B. Dicko, R. Linga, N. Barry, M. Drabo, N. Sykes and D. Thizy, Malaria Journal, 21:225. 2022.
Gene drive mosquitoes are increasingly considered a potential transformational tool for vector control of malaria mosquitoes. As part of efforts to promote responsible research in this field, a number of guidance documents have been published by the World Health Organization, ...
Public perspectives towards using gene drive for invasive species management in Australia
Tags: Biodiversity/Conservation, Gene drive synthetic, Genetic biocontrol, Oceania, Other mammals, Policy, Population suppression, Stakeholder engagementA. Mankad, E. V. Hobman and L. Carter, CSIRO, 2022.
Many pest animal species live and reproduce in high numbers across Australia. This includes animal species, such as cane toads, feral cats, foxes, rodents, wild pigs, wild rabbits. These species significantly damage Australia’s agricultural industries, natural landscapes, and ...
Public deliberation and the regulation of gene drive in the USA
Tags: Gene drive synthetic, Policy, Regulation, Risk and safety, Stakeholder engagementW. F. West, L. W. Buchman and R. F. Medina, Science and Public Policy, scac032. 2022.
Gene drive is a new form of biotechnology designed to bias the inheritance of selected traits in animal or plant species that reproduce sexually and have relatively short reproductive cycles. Unlike traditional breeding techniques and other forms of biotechnology, gene drive is ...
Gene Drive Research Forum: Stakeholder engagement panel discussions
Tags: Stakeholder engagementGeneConvene Global Collaborative, 2022. [YouTube Playlist]
Who decides whether to use gene drives against malaria-carrying mosquitoes?
Tags: Gene drive synthetic, Malaria, Policy, Risk and safety, Stakeholder engagement, Target malariaT. H. Saey, ScienceNews, 2022.
The gene drive interferes with the insects’ ability to reproduce. It wiped out captive populations of mosquitoes in eight to 12 generations (SN: 10/27/18, p. 6) in a small lab study. In 2021, the technology worked in the large cages in Terni, Italy, too. Within as little as ...
Exploring value change
Tags: Ethics, Gene drive synthetic, Policy, Stakeholder engagementT. E. de Wildt and V. J. Schweizer, Prometheus, 38. 2022.
This article aims to explore the use of cross-impact balances (CIB) to identify scenarios of value change. The possibility of value change has received little attention in the literature on value-sensitive design (VSD). Examples of value change include the emergence of new values ...
Recommendations for environmental risk assessment of gene drive applications for malaria vector control
Tags: Gene drive synthetic, Malaria, Modeling, Population suppression, Risk and safety, Stakeholder engagement, Vector controlJ. B. Connolly, J. D. Mumford, D. C. M. Glandorf, S. Hartley, O. T. Lewis, S. W. Evans, G. Turner, C. Beech, N. Sykes, M. B. Coulibaly, J. Romeis, J. L. Teem, W. Tonui, B. Lovett, A. Mankad, A. Mnzava, S. Fuchs, T. D. Hackett, W. G. Landis, J. M. Marshall, Malar J, 21:152. 2022.
Building on an exercise that identified potential harms from simulated investigational releases of a population suppression gene drive for malaria vector control, a series of online workshops identified nine recommendations to advance future environmental risk assessment of gene ...
A multi-disciplinary approach for a building common understanding of genetic engineering for malaria control in Burkina Faso
Tags: Gene drive synthetic, Stakeholder engagement, Target malariaL. Pare Toe, N. Barry, A. D. Ky, S. Kekele, W. I. Meda, K. Bayala, et al., Humanities and Social Sciences Communications, 9. 2022.
Genetic engineering is a complex topic, even for scientists working in other areas, and even more so for those who lack a formal scientific training. To help gene specialists and affected communities talk with one another, international guidance documents have been published that ...
Governing Gene Drive Technologies: A Qualitative Interview Study
Tags: Ethics, Gene drive synthetic, Governance, Policy, Stakeholder engagementN. de Graeff, K. R. Jongsma, J. E. Lunshof and A. L. Bredenoord, AJOB Empirical Bioethics, 13:107-124. 2022.
Gene drive technologies (GDTs) bias the inheritance of a genetic element within a population of non-human organisms, promoting its progressive spread across this population. If successful, GDTs may be used to counter intractable problems such as vector-borne diseases. A key issue ...
UC Davis — Malaria Gene Drive Feasibility Analysis
Tags: Africa, Gene drive synthetic, Policy, Population modification/replacement, Risk and safety, Stakeholder engagementGood Ventures, Good Ventures, 2022.
Open Philanthropy recommended a grant of $10,248,967 over three years to UC Davis to support subsequent stages of a feasibility analysis of a potential test of gene drives for malaria control on the adjoining West African islands of São Tomé and Príncipe. The work, led by Dr. ...
Prescribing engagement in environmental risk assessment for gene drive technology
Tags: Gene drive synthetic, Governance, Risk assessment, Stakeholder engagementS. Hartley, A. Kokotovich and C. McCalman, Regulation and Governance, 2022.
Abstract Gene drive technology is a nascent biotechnology with the potential to purposefully alter or eliminate a species. There have been broad calls for engagement to inform gene drive governance. Over the past seven years, the gene drive community has been developing risk ...
Opening up, closing down, or leaving ajar? How applications are used in engaging with publics about gene drive
Tags: Gene drive synthetic, Policy, Stakeholder engagementA. W. Russell, A. Stelmach, S. Hartley, L. Carter and S. Raman, Journal of Responsible Innovation, 2022.
Public engagement and responsible innovation are strongly emphasised in gene drive research, together with the goal of addressing societal challenges, notably, malaria and environmental conservation. We aim to explore whether public engagement is used to ‘open up' or ‘close ...
The power of gene editing
Tags: Gene drive synthetic, Gene editing, Policy, Regulation, Risk and safety, Stakeholder engagementThe Economist, The Economist, 2022.
Technologies such as genetic modification and ‘CRISPR’ will cure hereditary diseases, produce disease-resistant crops and enable the breeding of malaria-free mosquitos. But advances bring ethical and practical dilemmas. Genetically modified food is banned in the EU, and ...
California Residents’ Perceptions of Gene Drive Systems to Control Mosquito-Borne Disease
Tags: Gene drive synthetic, North America, Stakeholder engagementC. E. Schairer, C. Triplett, O. S. Akbari and C. S. Bloss, Frontiers in Bioengineering and Biotechnology, 10. 2022.
Scientists developing gene drive mosquitoes for vector control must understand how residents of affected areas regard both the problem of mosquito-borne disease and the potential solutions offered by gene drive. This study represents an experiment in public engagement at an early ...
Articulating ethical principles guiding Target Malaria’s engagement strategy
Tags: Ethics, Gene drive synthetic, Stakeholder engagement, Target malariaA. J. Roberts and D. Thizy, Malaria Journal, 21:35. 2022.
Progress in gene drive research has engendered a lively discussion about community engagement and the ethical standards the work hinges on. While there is broad agreement regarding ethical principles and established best practices for conducting clinical public health research, ...
Conditions for Investment in Genetic Biocontrol of Pest Vertebrates in Australia
Tags: Genetic biocontrol, Governance, Oceania, Risk and safety, Stakeholder engagementL. Carter, A. Mankad, S. Campbell, W. Ruscoe, K. P. Oh, P. R. Brown, M. Byrne, M. Tizard and T. Strive, Frontiers in Agronomy, 3. 2022.
Managing pest vertebrate species in Australia is a significant challenge for government, industry, research sectors and land-managers. Innovative tools such as genetic biocontrol offers decision-makers a potentially effective means of reducing the impact of pest species ...
Gene Drives in the U.K., U.S., and Australian Press (2015–2019): How a New Focus on Responsibility Is Shaping Science Communication
Tags: Ethics, Gene drive synthetic, Policy, Stakeholder engagementA. Stelmach, B. Nerlich and S. Hartley, Science Communication, 10755470211072245. 2022.
Gene drive is a controversial biotechnology for pest control. Despite a commitment from gene drive researchers to responsibility and the key role of the media in debates about science and technology, little research has been conducted on media reporting of gene drive. We employ ...
Ethical Considerations for Gene Drive: Challenges of Balancing Inclusion, Power and Perspectives
Tags: Ethics, Gene drive synthetic, Policy, Stakeholder engagementA. Kormos, G. C. Lanzaro, E. Bier, V. Santos, L. Nazare, J. Pinto, A. A. dos Santos and A. James, Frontiers in Bioengineering and Biotechnology, 2022.
Progress in gene-drive research has stimulated discussion and debate on ethical issues including community engagement and consent, policy and governance, and decision-making involved in development and deployment. Many organizations, academic institutions, foundations, and ...
Gene drives and metaphors
Tags: Gene drive synthetic, Stakeholder engagementB. Nerlich, Making Science Public, 2022.
I have been writing about developments in the biosciences for twenty years. In that time, I have covered a wide variety of topics, such as cloning, genomics, the human genome project, the microbiome project, faecal microbial transplants, synthetic biology, epigenetics, genome ...
Gene drive communication: exploring experts’ lived experience of metaphor use
Tags: Gene drive synthetic, Stakeholder engagementB. Nerlich and A. Stelmach, New Genetics and Society, 2022.
Metaphors have been crucial in making genetics and genomics public, fromthe code and the book of life to genetic scissors and gene surgery. A newfield is emerging called“gene drive”–a range of controversial technologiesthat can potentially be used for the eradication or ...
Stakeholder engagement to inform the risk assessment and governance of gene drive technology to manage spotted-wing drosophila
Tags: Fruit fly, Gene drive synthetic, Genetic biocontrol, Governance, Invasive species, Risk assessment, Stakeholder engagementA. E. Kokotovich, S. K. Barnhill-Dilling, J. E. Elsensohn, R. Li, J. A. Delborne and H. Burrack, Journal of Environmental Management, 307:114480. 2022.
Emerging biotechnologies, such as gene drive technology, are increasingly being proposed to manage a variety of pests and invasive species. As one method of genetic biocontrol, gene drive technology is currently being developed to manage the invasive agricultural pest ...
Information Sharing in Senegal on the Gene Drive Technology as a potential Complementary Tool for Malaria Vector Control
Tags: Africa, Gene drive synthetic, Mosquitoes, Policy, Regulation, Risk assessment, Stakeholder engagementAUDA-NEPAD, AUDA-NEPAD, 2022.
AUDA-NEPAD in partnership with the National Biosafety Authority (Autorité Nationale de Biosécurité (ANB) in Senegal organized an Information sharing meeting on the gene drive technology as a complementary tool for malaria vector control, from 22-23 December 2021, in Somone, ...
Stakeholder Views on Engagement, Trust, Performance, and Risk Considerations About Use of Gene Drive Technology in Agricultural Pest Management
Tags: Agriculture, Gene drive synthetic, Policy, Regulation, Risk and safety, Stakeholder engagementC. L. Goldsmith, K. E. Kang, E. Heitman, Z. N. Adelman, L. W. Buchman, D. Kerns, X. Liu, R. F. Medina and A. Vedlitz, Health Security, 2021.
Gene drive is an experimental technique that may make it possible to alter the genetic traits of whole populations of a species through the genetic modification of a relatively small number of individuals. This technology is sufficiently new that literature on the understanding ...
Facilitating the Conversation: Gene Drive Classification
Tags: Gene drive synthetic, Policy, Regulation, Risk and safety, Stakeholder engagementJ. Overcash and A. Golnar, Health Security, 2021.
Gene drives are an emerging technology with tremendous potential to impact public health, agriculture, and conservation. While gene drives can be described simply as selfish genetic elements (natural or engineered) that are inherited at non-Mendelian rates, upon closer ...
Determinants of stakeholders’ attitudes and intentions toward supporting the use of Wolbachia-infected Aedes mosquitoes for dengue control
Tags: Aedes, Dengue, Incompatible insect technique, Stakeholder engagement, WolbachiaA. F. Arham, L. Amin, M. A. C. Mustapa, Z. Mahadi, M. Yaacob and M. Ibrahim, BMC Public Health, 21:2314. 2021.
BACKGROUND: A recent approach in controlling dengue is by using the Wolbachia-infected Aedes mosquito (WiAM). The approach has been reported to be more effective than traditional methods, such as fogging. Therefore, it is imperative to assess the factors predicting its acceptance ...
Integrated Management of Malaria Vectors in Africa
Tags: Genetic biocontrol, Malaria, Mosquitoes, Policy, Regulation, Risk assessment, Stakeholder engagementR. Mbabazi, K. Maredia, B. B. El-Sayed, A. K. Babumba, M. Savadogo and O. Akinbo, Genetically Modified and other Innovative Vector Control Technologies, 2021.
Malaria disease is a major public health burden in Africa. The control of malaria vectors is a critical component for prevention, management, and eradication of malaria disease. This chapter presents information on the current status of malaria vector control in Africa with ...
Measuring Public Attitudes to Releases of Transgenic Mosquitoes for Disease Control, with Special Reference to Dengue and Malaria
Tags: Dengue, Genetic biocontrol, Genetically modified mosquitoes, Malaria, Policy, Regulation, Risk and safety, Risk assessment, Stakeholder engagementL. A. De Las Llagas and M. S. T. Gunigundo, Genetically Modified and other Innovative Vector Control Technologies, 2021.
Since the advent of DDT in public health and agriculture, science leaped forward with revolutionary technology such as gene drive or editing, thus making it possible to develop alternative approaches to address vector-borne diseases. However, their utilization and sustenance in ...
Arthropods of Medical Importance: Need for Genetic and Other Innovative Vector Control Technologies, with Emphasis on Eco-biosocial and Environmental Considerations.
Tags: Gene drive synthetic, Genetic biocontrol, Incompatible insect technique, Mosquitoes, Policy, Risk and safety, Stakeholder engagement, Sterile insect technique (SIT), WolbachiaB. K. Tyagi, Genetically Modified and other Innovative Vector Control Technologies, 2021.
Among the world’s known vector groups, viz. arthropods, snails and rodents, the most important vectors originate from arthropods, the jointed legs. Arthropods are doubtlessly regarded as the most dominant creatures on the Earth due largely to their remarkable structural and ...
Genetically Modified and other Innovative Vector Control Technologies
Tags: Gene drive synthetic, Genetic biocontrol, Incompatible insect technique, Mosquitoes, Policy, Risk and safety, Stakeholder engagement, Sterile insect technique (SIT), WolbachiaB. K. Tyagi, SpringerLink, 2021.
This book comprehensively covers the latest development in developing and deploying the genetically modified vectors, particularly Anopheles and Aedes mosquitoes responsible for transmitting malaria parasites and dengue viruses, the most deadly and/or debilitating among all the ...
Safe Application of Genetically Modified Mosquito (GMM) to Combat Dengue and Chikungunya Depends on Socioeconomic Status and Social Acceptance in the Developing Countries: A Comprehensive Analysis
Tags: Dengue, Genetic biocontrol, Genetically modified mosquitoes, Malaria, Policy, Regulation, Risk and safety, Risk assessment, Stakeholder engagementM. N. Islam, Genetically Modified and other Innovative Vector Control Technologies, 2021.
The emerging and re-emerging vector-borne diseases are a serious public health problem throughout the world. It has been observed that more than 100 countries and approximately half of the world’s population are at risk on vector-borne diseases (VBDs). The global burden of the ...
Malaria vector control tools in emergency settings: What do experts think? Results from a DELPHI survey
Tags: Genetically modified mosquitoes, Malaria, Policy, Stakeholder engagementC. Boete, S. Burza, E. Lasry, S. Moriana and W. Robertson, Conflict and Health, 15:11. 2021.
Background The use and implementation of novel tools for malaria control such as long lasting impregnated bednets (LLINs) and Indoor Residual Spraying (IRS) over the last decade has contributed to a substantial reduction in malaria burden globally. However numerous challenges ...
Gene Editing in the Wild: Shaping Decisions through Broad Public Deliberation
Tags: Ethics, Gene drive synthetic, Gene editing, Stakeholder engagementM. K. Gusmano, G. E. Kaebnick, K. J. Maschke, C. P. Neuhaus and B. C. Wills, The Hastings Center Report, 51. 2021.
The essays in this special report grew out of a project funded by the National Science Foundation (with NSF award number 1827935). Gregory E. Kaebnick and Michael K. Gusmano were co-principal investigators on the project, and Karen J. Maschke and Carolyn P. Neuhaus were ...
Deficits of Public Deliberation in U.S. Oversight for Gene Edited Organisms
Tags: Ethics, Gene editing, Regulation, Stakeholder engagementJ. Kuzma, Hastings Center Report, 51 Suppl 2:S25-s33. 2021.
Environmental releases of gene edited (GEdOs) and gene drive organisms (GDOs) will likely occur under conditions of high uncertainty and in complex socioecological systems. Therefore, public deliberation is especially important to account for diverse interpretations of safety, ...
Public Deliberation about Gene Editing in the Wild
Tags: Ethics, Gene drive, Gene editing, Stakeholder engagementM. K. Gusmano, G. E. Kaebnick, K. J. Maschke, C. P. Neuhaus and B. C. Wills, Hastings Center Report, 51 Suppl 2:S2-s10. 2021.
Genetic editing technologies have long been used to modify domesticated nonhuman animals and plants. Recently, attention and funding have also been directed toward projects for modifying nonhuman organisms in the shared environment-that is, in the "wild." Interest in gene editing ...
Empowering Indigenous Knowledge in Deliberations on Gene Editing in the Wild
Tags: Ethics, Gene drive, Genetic engineering, Stakeholder engagementR. Taitingfong and A. Ullah, Hastings Center Report, 51 Suppl 2:S74-s84. 2021.
Proposals to release genetically engineered organisms in the wild raise complex ethical issues related to their safe and equitable implementation. While there is broad agreement that community and public engagement is vital to decision-making in this context, more discussion is ...
The Decision Phases Framework for Public Engagement: Engaging Stakeholders about Gene Editing in the Wild
Tags: Ethics, Gene drive synthetic, Gene editing, Stakeholder engagementS. K. Barnhill-Dilling, A. Kokotovich and J. A. Delborne, Hastings Center Report, 51 Suppl 2:S48-s61. 2021.
Some experts and advocates propose environmental biotechnologies such as genetic engineering, gene drive systems, and synthetic biology as potential solutions to accelerating rates of species loss. While these tools may offer hope for a seemingly intractable problem, they also ...
Public Perceptions Regarding Genomic Technologies Applied to Breeding Farm Animals: A Qualitative Study
Tags: Agriculture, Gene editing, Genetic biocontrol, Stakeholder engagementF. Z. Naab, D. Coles, E. Goddard and L. J. Frewer, BioTech, 10. 2021.
The societal acceptability of different applications of genomic technologies to animal production systems will determine whether their innovation trajectories will reach the commercialisation stage. Importantly, technological implementation and commercialisation trajectories, ...
New molecular genetic techniques: regulatory and societal considerations
Tags: Gene drive synthetic, Genetic biocontrol, Incompatible insect technique, Policy, Regulation, Risk and safety, Risk assessment, Stakeholder engagement, Sterile insect technique (SIT)Nielsen, K. M., AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application, 2021.
A rapidly expanding toolbox of techniques available for genome editing provides the basis for a new continuum in types of modifications that can be introduced into a genome and blur the bimodal GMO vs. non-GMO (genetically modified organism) divide. Site-directed nucleases (SDN) ...
Genome editing and its applications for insect pest control: Curse or blessing?
Tags: CRISPR, Gene drive synthetic, Gene editing, Genetic biocontrol, Genetically modified mosquitoes, Policy, Regulation, Risk and safety, Stakeholder engagementHacker, I. , and Schetelig, M. F, AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application, 2021.
Gene and genome editing are described as cutting-edge research tools with the potential to tackle urgent global challenges in the management of agricultural pests and human disease vectors such as mosquitoes. The field is defined by the chances and challenges to interlink the ...
Barriers and facilitators of area-wide management including sterile insect technique application: The example of Queensland fruit fly
Tags: Genetic biocontrol, Incompatible insect technique, Policy, Stakeholder engagement, Sterile insect technique (SIT)Mankad, A., Loechel, B., and Measham, P. F., AREA-WIDE INTEGRATED PEST MANAGEMENT: Development and Field Application, 2021.
The area-wide management (AWM) of highly mobile insect pests such as tephritid fruit flies requires an integrated understanding of technical, social and institutional processes that drive a coordinated approach within a defined area. Furthermore, the success of an AWM programme ...
Podcast: Malaria Gene Drive
Tags: Ethics, Gene drive synthetic, Malaria, Policy, Stakeholder engagementS. Hartley, S. Neema and C. Opesen, University of Exeter Business School, 2021.
Professor Sarah Hartley and her two colleagues in Uganda, Stella Neema and Chris Opesen discuss gene drive research for malaria control. Funded by British Academy and Wellcome trust, their work is to understand the social science challenges around the development of this kind of ...
A Household-Based Survey to Understand Factors Influencing Awareness, Attitudes and Knowledge towards Wolbachia-Aedes Technology
Tags: Dengue, Genetic biocontrol, Policy, Stakeholder engagement, WolbachiaL. T. Soh, Z. Ong, K. Vasquez, I. Chen, X. Li, W. Niah, C. Panchapakesan, A. Sheldenkar, S. Sim, L. C. Ng and M. O. Lwin, International Journal of Environmental Research and Public Health, 18. 2021.
In 2016, Singapore introduced the release of male Wolbachia-Aedes mosquitoes to complement vector control efforts and suppress Aedes aegypti mosquitoes in selected study sites. With ongoing expansion of Project Wolbachia-Singapore to cover larger areas, a household-based survey ...
Gene drive and RNAi technologies: a bio-cultural review of next-generation tools for pest wasp management in New Zealand
Tags: Gene drive synthetic, Genetic engineering, Oceania, Policy, Population suppression, Regulation, Stakeholder engagementS. Palmer, P. K. Dearden, O. R. Mercier, A. King-Hunt and P. J. Lester, Journal of the Royal Society of New Zealand, 1-18. 2021.
There is a global need for novel, next-generation technologies and techniques to manage pest species. We review work on potential step-changing technologies for large landscape (>1000 hectares) pest management of social Vespula wasps. We also review M?ori perspectives on these ...
Small-scale release of non-gene drive mosquitoes in Burkina Faso: from engagement implementation to assessment, a learning journey
Tags: Africa, Ethics, Gene drive synthetic, Genetically modified mosquitoes, Malaria, Policy, Stakeholder engagement, Target malariaL. Pare Toe, N. Barry, A. D. Ky, S. Kekele, W. Meda, K. Bayala, M. Drabo, D. Thizy and A. Diabate, Malaria Journal, 20:395. 2021.
This study provides a review of engagement activities relevant to field trials on non-gene drive genetically-modified mosquitoes as well as an assessment framework-using both qualitative and quantitative studies as well as an audit procedure. The latter was implemented to ...
Oxitec and MosquitoMate in the United States: lessons for the future of gene drive mosquito control
Tags: Genetic biocontrol, Genetically modified mosquitoes, History, Oxitec, Policy, Regulation, Stakeholder engagementC. E. Schairer, J. Najera, A. A. James, O. S. Akbari and C. S. Bloss, Pathogens and Global Health, 2021.
ABSTRACTIn response to growing concerns regarding mosquito-borne diseases, scientists are developing novel systems of vector control. Early examples include Oxitec?s OX513A genetically-engineered mosquito and MosquitoMate?s Wolbachia-infected mosquito, and systems using ...
Risk management recommendations for environmental releases of gene drive modified insects
Tags: Field trials, Gene drive synthetic, Modeling, Policy, Risk assessment, Stakeholder engagementY. Devos, J. D. Mumford, M. B. Bonsall, D. C. M. Glandorf and H. D. Quemada, Biotechnology Advances, 2021.
The ability to engineer gene drives (genetic elements that bias their own inheritance) has sparked enthusiasm and concerns. Engineered gene drives could potentially be used to address long-standing challenges in the control of insect disease vectors, agricultural pests and ...
How do local communities participate in gene drive research?
Tags: Gene drive, Governance, Stakeholder engagement, VideoOutreach Network for Gene Drive Research, 2021.
How do local communities participate in gene drive research?
Experimenting with co-development: a qualitative study of gene drive research for malaria control in Mali
Tags: Ethics, Gene drive synthetic, Policy, Risk and safety, Stakeholder engagementS. Hartley, K. Ledingham, R. Owen, S. Leonelli, S. Diarra and S. Diop, Social Science and Medicine, 2021.
Our findings suggest co-development is opening up previously expert-dominated spaces as researchers attempt to take responsibility for the societal implications of their work. However, its main function is as a project management tool to enable and instrumentally support ...
The ethical scientist in a time of uncertainty
Tags: Ethics, Gene drive synthetic, Malaria, Policy, Population suppression, Stakeholder engagement, Target malariaL. Zoloth, Cell, 184:1430-1439. 2021.
Using the example of gene drives for malaria control to explore the problem of deep uncertainty in biomedical research, I argue that profound uncertainty is an essential feature. Applying the language and presumptions of the discipline of philosophical ethics, I describe three ...
Ugandan stakeholder hopes and concerns about gene drive mosquitoes for malaria control: new directions for gene drive risk governance
Tags: Africa, Ethics, Gene drive synthetic, Stakeholder engagementS. Hartley, R. D. J. Smith, A. Kokotovich, C. Opesen, T. Habtewold, K. Ledingham, B. Raymond and C. B. Rwabukwali, Malaria Journal, 20:149. 2021.
The African Union’s High-Level Panel on Emerging Technologies identified gene drive mosquitoes as a priority technology for malaria elimination. The first field trials are expected in 5–10 years in Uganda, Mali or Burkina Faso. In preparation, regional and international ...
Experts’ moral views on gene drive technologies: a qualitative interview study
Tags: Ethics, Gene drive synthetic, Policy, Stakeholder engagementN. de Graeff, K. R. Jongsma and A. L. Bredenoord, BMC Medical Ethics, 22:25. 2021.
Gene drive technologies (GDTs) promote the rapid spread of a particular genetic element within a population of non-human organisms. Potential applications of GDTs include the control of insect vectors, invasive species and agricultural pests. Whether, and if so, under what ...
Hybrid mosquitoes? Evidence from rural Tanzania on how local communities conceptualize and respond to modified mosquitoes as a tool for malaria control
Tags: Africa, Ethics, Genetic biocontrol, Genetically modified mosquitoes, Stakeholder engagementM. F. Finda, F. O. Okumu, E. Minja, R. Njalambaha, W. Mponzi, B. B. Tarimo, P. Chaki, J. Lezaun, A. H. Kelly and N. Christofides, Malaria Journal, 20:134. 2021.
Different forms of mosquito modifications are being considered as potential high-impact and low-cost tools for future malaria control in Africa. Although still under evaluation, the eventual success of these technologies will require high-level public acceptance. Understanding ...
Knowledge, Attitude, and Practices Survey in Greece before the Implementation of Sterile Insect Technique against Aedes albopictus
Tags: Aedes, Mosquitoes, Stakeholder engagement, Sterile insect technique (SIT)A. Stefopoulou, S. L. LaDeau, N. Syrigou, G. Balatsos, V. Karras, I. Lytra, E. Boukouvala, D. P. Papachristos, P. G. Milonas, A. Kapranas, P. Vahamidis and A. Michaelakis, Insects, 12. 2021.
A KAP tool was used to shed light on the knowledge, practices, and attitudes of local community members in order to better prepare and motivate participation in household mosquito control and to assess current understanding of SIT. Each household also received specific ...
Demographic and psychographic drivers of public acceptance of novel invasive pest control technologies
Tags: Gene drive synthetic, Genetic biocontrol, Invasive species, Policy, Stakeholder engagementF. Eppink, P. J. Walsh and E. MacDonald, Ecology and Society, 26. 2021.
Invasive mammals are a primary threat to New Zealand's endemic species. In remote areas, aerial delivery of poison is the preferred method of pest management, although it faces some public backlash. Novel pest control technologies are currently being investigated as alternatives ...
Sterile Insect Technique (SIT) against Aedes Species Mosquitoes: A Roadmap and Good Practice Framework for Designing, Implementing and Evaluating Pilot Field Trials
Tags: Aedes, Field trials, Mosquitoes, Stakeholder engagement, Sterile insect technique (SIT), Vector controlC. F. Oliva, M. Q. Benedict, C. M. Collins, T. Baldet, R. Bellini, H. Bossin, J. Bouyer, V. Corbel, L. Facchinelli, F. Fouque, M. Geier, A. Michaelakis, D. Roiz, F. Simard, C. Tur and L.-C. Gouagna, Insects, 12. 2021.
We offer here a pragmatic and accessible ‘roadmap’ for the pre-pilot and pilot phases to guide any interested party. This will support stakeholders, non-specialist scientists, implementers, and decision-makers. Applying these concepts will ensure, given adequate resources, a ...
Plain language summary: How do we have a public conversation about new technologies for conservation? The possibilities and pitfalls of scientific language
Tags: Biodiversity/Conservation, Gene drive synthetic, Oceania, Stakeholder engagement, Synthetic biologyAnnonymous, Relational Thinking, 2021.
Having caused a catastrophic decline of animal species, people now look to new technologies to reverse the damage. Gene drive is a potential tool that could increase the proportion of male offspring in rat populations and eventually reduce their overall numbers. Some suggest this ...
Scientifically framed gene drive communication perceived as credible but riskier
Tags: CRISPR, Gene drive synthetic, Invasive species, Policy, Risk and safety, Stakeholder engagement, Synthetic biologyE. A. MacDonald, E. D. Edwards, J. Balanovic and F. Medvecky, People and Nature, 2021.
Framing is a communication technique in which certain beliefs or values are emphasized that resonate with the target audience. Framing may increase how much people objectively think about new information and update their opinions; framing may mitigate emo
Public attitudes towards synthetic biology
Tags: Gene drive synthetic, Genetic biocontrol, Oceania, Policy, Stakeholder engagement, Synthetic biologyCSIRO, Synthetic Biology Future Science Platform, 2021.
A national survey has been conducted by CSIRO’s Synthetic Biology Future Science Platform as an important first step in measuring public attitudes towards synthetic biology. The survey draws on the views of more than 8,000 Australians, and researchers are examining the data to ...
How to engage communities on a large scale? Lessons from World Mosquito Program in Rio de Janeiro, Brazil [version 2; peer review: 1 approved, 2 approved with reservations]
Tags: Arbovirus, Cytoplasmic incompatibility, Dengue, Ethics, Genetic biocontrol, Policy, Stakeholder engagement, WolbachiaG. B. Costa, R. Smithyman, S. L. O'Neill and L. A. Moreira, Gates Open Research, 2021.
Here we discuss and analyse the framework for community engagement implemented by the WMP in Brazil, during the large-scale deployment of the method in the municipalities of Niterói and Rio de Janeiro, Brazil. Our experience indicates that the community engagement work for ...
Les Européens très critiques vis-à-vis du forçage génétique
Tags: Gene drive synthetic, Policy, Regulation, Risk and safety, Stakeholder engagementL. Duboua-Lorsch, EURACTIV, 2021.
Cette technique, qui vise à éradiquer ou modifier certaines espèces dites nuisibles, sera au cœur des négociations cette année, alors que se profile la COP15 sur la biodiversité. maginez un monde débarrassé d’insectes porteurs de maladies, de parasites agricoles, ...
Proceedings of an expert workshop on community agreement for gene drive research in Africa – Co-organised by KEMRI, PAMCA and Target Malaria [version 1; peer review: awaiting peer review]
Tags: Gene drive synthetic, Genetically modified mosquitoes, Genetically modified organisms, Malaria, Stakeholder engagement, Target malariaD. Thizy, L. Pare Toe, C. Mbogo, D. Matoke-Muhia, V. P. Alibu, S. K. Barnhill-Dilling, T. Chantler, G. Chongwe, J. Delborne, L. Kapiriri, E. Nassonko Kavuma, S. Koloi-Keaikitse, A. Kormos, K. Littler, D. Lwetoijera, R. Vargas de Moraes, N. Mumba, L. Muten, Gates Open Research, 2021.
Target Malaria, the Kenya Medical Research Institute and the Pan African Mosquito Control Association co-organised a workshop with researchers and practitioners on this topic to question the model proposed by Target Malaria in its research so far that involved the release of ...
GENE DRIVE ACCEPTANCE SURVEY
Tags: Gene drive synthetic, Policy, Regulation, Risk and safety, Stakeholder engagementYouGov, Pollinis, 2021.
This representative survey was conducted by the international market research institute YouGov and polled 8.826 citizens from 8 EU countries in December 2020. It was commissioned by WeMove Europe, Save Our Seeds (Germany), Skiftet (Sweden), France Nature Environnement (FNE) ...
Playing God and tampering with nature: popular labels for real concerns in synthetic biology
Tags: Biodiversity/Conservation, Ethics, Gene drive, Genetic biocontrol, Policy, Risk and safety, Risk assessment, Stakeholder engagement, Synthetic biologyL. Carter, A. Mankad, E. V. Hobman and N. B. Porter, Transgenic Research, 2021.
We present the findings from a large Australian study (N = 4593) which suggests ‘playing God’ objections and their variants can be multilayered and, at times, accompanied by meaningful information about risk perceptions. We use qualitative analysis of ope
The Promises and Realities of Integration in Synthetic Biology: A View From Social Science
Tags: Gene drive synthetic, Genetic biocontrol, Invasive species, Policy, Stakeholder engagement, Synthetic biologyL. Carter and A. Mankad, Frontiers in Bioengineering and Biotechnology, 8. 2021.
We take stock of thepromises and realities of science integration by sharing our experiences of embarking onthis very challenge in Australia. We conclude by offering suggestions for bringing aboutthe enabling conditions for improved integration across the natural and social ...
Co‐developing a common glossary with stakeholders for engagement on new genetic approaches for malaria control in a local African setting
Tags: Ethics, Gene drive synthetic, Genetic biocontrol, Stakeholder engagement, Target malariaE. Chemonges Wanyama, B. Dicko, L. Pare Toe, M. B. Coulibaly, N. Barry, K. Bayala Traore, A. Diabate, M. Drabo, J. K. Kayondo, S. Kekele, S. Kodio, A. D. Ky, R. R. Linga, E. Magala, W. I. Meda, S. Mukwaya, A. Namukwaya, B. Robinson, H. Samoura, K. Sanogo, Malaria Journal, 20:53. 2021.
Scientific terminologies are mainly lacking in local languages, yet when research activities involve international partnership, the question of technical jargon and its translation is crucial for effective and meaningful communication with stakeholders. Target Malaria, a ...
Exploring Gene Drive Technologies in Agriculture, Biodiversity and Human Disease
Tags: Biodiversity/Conservation, Ethics, Gene drive synthetic, Mosquitoes, Policy, Population modification/replacement, Population suppression, Regulation, Risk and safety, Stakeholder engagementThe GBIRd Partnership and The GeneConvene Global Collaborative, Gene Drive Research Forum, 2021.
The GBIRd Partnership and The GeneConvene Global Collaborative recently collaborated through The Gene Drive Research Forum, to create and produce an engaging conversation between Drs. Fred Gould and Charles Godfray about gene drive technologies – the potential benefits and ...
Next-generation tools to control biting midge populations and reduce pathogen transmission
Tags: Agriculture, Cytoplasmic incompatibility, Gene drive synthetic, Genetic biocontrol, Other mammals, Policy, Population modification/replacement, Population suppression, Regulation, Stakeholder engagement, WolbachiaP. Shults, L. W. Cohnstaedt, Z. N. Adelman and C. Brelsfoard, Parasites and Vectors, 14:31. 2021.
Biting midges of the genus Culicoides transmit disease-causing agents resulting in a significant economic impact on livestock industries in many parts of the world. Localized control efforts, such as removal of larval habitat or pesticide application, can be logistically ...
Conservation pest control with new technologies: public perceptions
Tags: Biodiversity/Conservation, Gene drive synthetic, Genetic biocontrol, Oceania, Policy, Regulation, Risk assessment, Stakeholder engagementE. A. MacDonald, M. B. Neff, E. Edwards, F. Medvecky and J. Balanovic, Journal of the Royal Society of New Zealand, 2021.
We conducted eleven focus groups in New Zealand to explore three questions about novel technologies (gene drive and two others for comparison of pest control tools): (1) what are the risks/benefits? (2) how do they compare to current methods? and (3) who should be represented on ...
Application of the Relationship-Based Model to Engagement for Field Trials of Genetically Engineered Malaria Vectors
Tags: Ethics, Field trials, Gene drive synthetic, Malaria, Policy, Stakeholder engagementA. Kormos, G. C. Lanzaro, E. Bier, G. Dimopoulos, J. M. Marshall, J. Pinto, A. Aguiar dos Santos, A. Bacar, H. Sousa Pontes Sacramento Rompão and A. A. James, The American Journal of Tropical Medicine and Hygiene, 2020.
Although guidelines and recommendations for engagement for gene drives have recently been described, we argue here that communities and stakeholders should lead the planning, development, and implementation phases of engagement. The RBM provides a new approach to the development ...
Scientists paved the way for field trials of gene-driven organisms
Tags: Field trials, Gene drive synthetic, Policy, Regulation, Risk and safety, Risk assessment, Stakeholder engagementK. Winslet, FLORIDA News Times, 2020.
The recent rise of gene drive research, accelerated by CRISPR-Cas9 gene editing technology, has brought about a wave of transformation throughout science.Developed with selected traits that have been genetically engineered to spread throughout the population, Gene Drive ...
Scientists Set a Path for Field Trials of Gene Drive Organisms
Tags: Ethics, Field trials, Gene drive synthetic, Policy, Regulation, Risk and safety, Stakeholder engagementM. Aguilera, UC San Diego News Center, 2020.
The modern rise of gene drive research, accelerated by CRISPR-Cas9 gene editing technology, has led to transformational waves rippling across science. Gene drive organisms (GDOs), developed with select traits that are genetically engineered to spread through a population, have ...
Interdisciplinary development of a standardized introduction to gene drives for lay audiences
Tags: Field trials, Gene drive synthetic, Genetic engineering, Policy, Stakeholder engagement, Vector controlC. E. Schairer, C. Triplett, A. Buchman, O. S. Akbari and C. S. Bloss, BMC Medical Research Methodology, 20:15. 2020.
While there is wide consensus that the public should be consulted about emerging technology early in development, it is difficult to elicit public opinion about innovations unfamiliar to lay audiences. We sought public input on a program of research on genetic engineering to ...
Engineered Gene Drives: Ecological, Environmental, and Societal Concerns
Tags: Ethics, Gene drive synthetic, Governance, Policy, Regulation, Risk and safety, Stakeholder engagementJ. Kuzma, GMOs: Implications for Biodiversity Conservation and Ecological Processes, 2020.
This chapter overviews the types, purposes, and potential impacts of gene drive organisms (GDOs) and discusses challenges with foreseeing and assessing these impacts prior to their environmental release. It concludes with a few examples of risk analysis methods and governance ...
Transformation and slippage in co-production ambitions for global technology development: The case of gene drive
Tags: Ethics, Gene drive synthetic, Governance, Policy, Stakeholder engagementK. Ledingham and S. Hartley, Environmental Science & Policy, 116:78-85. 2020.
Co-production is an increasingly popular framework for knowledge generation, evaluation and decision making. Despite its potential to open up decisions and practices to the input of others, co-production regularly falls short of its transformative ambitions. Through documentary ...
FNIH Panel on Gene Drive Regulation Emphasizes Need for Local Community Engagement
Tags: Gene drive synthetic, Policy, Regulation, Risk and safety, Stakeholder engagementC. Rizk, GenomeWeb, 2020.
Genetically modified organisms are another topic of deep debate, with some activists agitating for and getting governments to implement deep restrictions on modified crops. More recently, GMO crops have started to regain public favor, particularly in countries where boosting the ...
ARRIGE 2020 Meeting | The promise of CRISPR and gene drive systems to end malaria in Africa
Tags: Africa, Gene drive synthetic, Population modification/replacement, Population suppression, Stakeholder engagement, Target malaria, Video, WebinarE. Gomez-Diaz, ARRIGE org, 2020.
Presentation by Elena Gómez Díaz (IPBLN-CSIC, Granada, Spain) at the ARRIGE 2020 meeting on "The promise of CRISPR and gene drive systems to end malaria in Africa". Discussion is included at the end of the Ruud de Maagd presentation.https://youtu.be/te3MJ8EZoes
Outcome of a public consultation on the draft adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post-market environmental monitoring of genetically modified insects containing engineered gene drives
Tags: Europe, Gene drive synthetic, Policy, Regulation, Risk and safety, Stakeholder engagementEuropean Food Safety Authority, Y. Devos, M. B. Bonsall, F. Nogué, K. Paraskevopoulos, E. A. Wimmer and L. G. Firbank, EFSA Supporting Publications, 17:1939E. 2020.
The European Food Safety Authority (EFSA) carried out an online public consultation to receive input from interested parties/persons on the draftscientific opinion on the adequacy and sufficiencyevaluation of existing guidelines for the molecular characterisation (MC), ...
Brave New Planet: Reshaping Nature Through Gene Drives
Tags: Gene drive synthetic, Governance, Mosquitoes, Policy, Population modification/replacement, Regulation, Risk and safety, Stakeholder engagement, Target malariaE. Lander, Brave New Planet, 2020.
A new technology, called gene drives, has the power to spread any genetic instructions you wish across an entire animal or plant species in the wild. It might let us restore ecosystems ravaged by invasive species, or help species adapt to climate change. And, it might save ...
Advances in genetic engineering test democracy’s capacity for good decision-making
Tags: Gene drive, Genetic biocontrol, Policy, Regulation, Risk and safety, Stakeholder engagementN. Kofler and R. Taitingfong, Boston Globe, 2020.
New advances in genetic engineering and their application for environmental conservation and public health are further testing our democracy’s capacity for good decision-making. With minimal public input, the Environmental Protection Agency recently approved the release of ...
GeneConvene Global Collaborative Webinar | Research and Innovation for biodiversity: what role for gene drive research?
Tags: Biodiversity/Conservation, Gene drive, Gene drive synthetic, Policy, Regulation, Risk and safety, Stakeholder engagement, WebinarEP Intergroup CCBSD, European Bureau of Conservation and Development, 2020.
This webinar will provide an overview of how gene drive works and the problems it seeks to solve, introduce the most advanced research projects on gene drive in the sector of public health and conservation and present the work that international and European bodies such as WHO, ...
Educating the Public on Genetically Modified Mosquitoes
Tags: Genetically modified mosquitoes, North America, Oxitec, Stakeholder engagement, Sterile insect technique (SIT)Buckner, Eva A., UF - IFAS, 2020.
In May 2020, the U.S. Environmental Protection Agency (EPA) approved Oxitec’s Experimental Use Permit to carry out pilot projects in the Florida Keys. Oxitec is a biotechnology company founded in 2002 out of Oxford University in the United Kingdom. They will be collaborating ...
GeneConvene Global Collaborative Webinar Series | Engineered Gene Drives: Policy and Regulatory Considerations Webinar Series October-December 2020
Tags: Gene drive synthetic, Governance, Policy, Regulation, Risk and safety, Risk assessment, Stakeholder engagement, WebinarHector Quemada and David O'Brochta, GeneConvene Global Collaborative, 2020. [YouTube Playlist]
In this series of webinars the regulatory and policy challenges of moving new innovative genetic biocontrol products such as gene drive technologies to the field will be featured. Each seminar will be ~60 minutes in length followed by questions and answers.
Heinrich-Böll-Stiftung | Gene Drives – Mit gentechnischer Ausrottung Menschen und Natur schützen?
Tags: Gene drive synthetic, Genetic biocontrol, Policy, Regulation, Stakeholder engagement, WebinarHeinrich-Böll-Stiftung, Heinrich-Böll-Stiftung, 2020.
Am Beispiel von Gene Drives zur Malariabekämpfung soll in diesem Online-Seminar aufgezeigt werden, wie die Technologie funktioniert, wer sie entwickelt, finanziert und ihre Anwendung vorantreibt, welche Risiken sie birgt, wie in betroffenen Ländern darüber diskutiert und warum ...
GeneConvene Global Collaborative Webinar Series | Gene Drive Policy and Regulatory Considerations 2020
Tags: Gene drive synthetic, Governance, Policy, Risk and safety, Risk assessment, Stakeholder engagement, Video, WebinarHector Quemada and David O'Brochta, GeneConvene Global Collaborative, 2020. [YouTube Playlist]
This is series of webinars the regulatory and policy challenges of moving new innovative genetic biocontrol products such as gene drive technologies to the field will be featured.
ESA Position Statement on the Importance of Continued Innovation in Gene Drive Technology
Tags: Gene drive synthetic, Policy, Regulation, Risk and safety, Risk assessment, Stakeholder engagementEntomological Society of America, Annals of the Entomological Society of America, 2020.
The risks and benefits of GDTs should be considered with the risks and benefits of continuing current pest control interventions, which may be comparatively less effective or pose exposure risks to human health and the environment.
GeneConvene Global Collaborative Webinar Series | Gene Drive Policy and Regulatory Consideration
Tags: Gene drive synthetic, Governance, Policy, Regulation, Risk and safety, Risk assessment, Stakeholder engagement, Video, WebinarHector Quemada and David O'Brochta, GeneConvene Global Collaborative, 2020. [YouTube Playlist]
This is series of webinars the regulatory and policy challenges of moving new innovative genetic biocontrol products such as gene drive technologies to the field will be featured.
Do Africans Want Genetically Modified Mosquitoes?
Tags: Africa, Gene drive synthetic, Genetic biocontrol, Policy, Regulation, Stakeholder engagementU. Effiong, The Pursuit, 2020.
The recent publication by fellow Nigerian scientists—Patricia Okorie and colleagues—originally drew my attention to the issue of GMMs.
Global citizen deliberation on genome editing
Tags: Gene drive synthetic, Gene editing, Governance, Policy, Regulation, Stakeholder engagementJ. S. Dryzek, D. Nicol, S. Niemeyer, S. Pemberton, N. Curato, A. Bächtiger, P. Batterham, B. Bedsted, S. Burall, M. Burgess, G. Burgio, Y. Castelfranchi, H. Chneiweiss, G. Church, M. Crossley, J. de Vries, M. Farooque, M. Hammond, B. He, R. Mendonça, J., Science, 369:1435. 2020.
Here we show how, as the global governance vacuum is filled, deliberation by a global citizens' assembly should play a role, for legitimate and effective governance.
Responsible innovation in biotechnology: Stakeholder attitudes and implications for research policy
Tags: Genetically modified organisms, Governance, Policy, Regulation, Risk and safety, Stakeholder engagementP. Roberts, J. Herkert and J. Kuzma, Elementa, 2020.
Using a mixed methods approach, we analyzed the attitudes of different biotechnology stakeholders, particularly those working in areas related to genetically modified organisms (GMOs) in agriculture and the environment, towards the principles and practices of RI. Homogenous focus ...
Do Africans need genetically modified mosquitoes?
Tags: Gene drive synthetic, Genetically modified organisms, Malaria, Oxitec, Stakeholder engagement, Sterile insect technique (SIT)genetically modified, mosquito, oxitec, autocidal, SIT, perspective, malaria, gene drive synthetic, engagement,, Mail and Guardian, 2020.
The following is an updated version of an article I wrote for the University of Michigan Risk Science Centre a while ago:
Global Governing Bodies: A Pathway for Gene Drive Governance for Vector Mosquito Control
Tags: Gene drive synthetic, Governance, Policy, Regulation, Risk and safety, Stakeholder engagementA. Kelsey, D. Stillinger, T. B. Pham, J. Murphy, S. Firth and R. Carballar-Lejarazú, American Journal of Tropical Medicine and Hygiene, 2020.
We examined the current institutions and governing bodies among various continents that could have an impact on gene drive governance or the potential to adapt to its future use. Possible governance strategies also are proposed that seek to bridge gaps and promote an ethically ...
Exploring gene drive’s role in fight against malaria
Tags: Gene drive synthetic, Genetic biocontrol, Malaria, Policy, Regulation, Risk and safety, Stakeholder engagementJ. Conrow, Genetic Literacy Project, 2020.
J. Conrow (2020) Genetic Literacy Project. An international initiative has formed to ensure that gene drive technology gets a chance to prove its mettle in the quest to control malaria.
Biotechnologies in pest wasp control: taking the sting out of pest management for Māori businesses?
Tags: Gene drive synthetic, Genetic biocontrol, Oceania, Other arthropods, Policy, Regulation, Risk and safety, Stakeholder engagementS. Palmer and O. R. Mercier, New Genetics and Society, 2020.
A Maori-centered mixed-method study gauged the perceptions of eight Maori businesses about the potential use of five specific new biotechnological controls in pest management.
Après les OGM, la nouvelle technique du forçage génétique inquiète écologistes et scientifiques
Tags: Africa, Agriculture, Gene drive synthetic, Malaria, Policy, Risk and safety, Stakeholder engagementH. Leussier, Reporterre, 2020.
Les organismes issus du forçage génétique peuvent transmettre, sans autre intervention humaine, des gènes modifiés à tous leurs descendants. Cette technique permettrait d’éradiquer des espèces nuisibles, comme certains moustiques vecteurs de la malaria. Mais des ...
Release of genetically modified mosquitoes in the Florida Keys put on hold
Tags: Genetic biocontrol, North America, Oxitec, Regulation, Risk and safety, Stakeholder engagement, Sterile insect technique (SIT)D. Goodhue, Miami Herald, 2020.
Opponents of a plan to release millions of genetically modified mosquitoes in the Florida Keys landed a temporary win on Tuesday.
Genome Editing in Food and Farming: Risks and unexpected consequences
Tags: Gene drive synthetic, Gene editing, Policy, Regulation, Risk and safety, Stakeholder engagementJ. Cotter and D. Perls, Canadian Biotechnology Action Network, 2020.
J. Cotter and D. Perls (2020). Canadian Biotechnology Action Network. In this report, we provide an overview of genome editing techniques being explored in agriculture, and the range of potential unexpected effects that can arise from them. The report draws on recent scientific ...
Translating gene drive science to promote linguistic diversity in community and stakeholder engagement
Tags: Gene drive synthetic, Genetic engineering, Stakeholder engagementC. Cheung, S. Gamez, R. Carballar-Lejarazú, V. Ferman, V. N. Vásquez, G. Terradas, J. Ishikawa, C. E. Schairer, E. Bier, J. M. Marshall, A. A. James, O. S. Akbari and C. S. Bloss, Global Public Health, 2020.
Information about genetic engineering (GE) for vector control in the United States is disseminated primarily in English, though non-English speakers are equally, and in some geographic regions even more affected by such technologies. Non-English-speaking publics should have equal ...
ENSSER | Gene Drive Webinar Series
Tags: Ethics, Gene drive synthetic, Policy, Population modification/replacement, Population suppression, Regulation, Risk and safety, Stakeholder engagement, WebinarEuropean Network of Scientists for Social and Environmental Responsibility, 2020. [YouTube Playlist]
This series of 5 Webinars by some of the authors of the interdisciplinary Gene Drive Report (2019) and were organised by four organisations of independent scientists: the European Network of Scientists for Social and Environmental Responsibility (ENSSER), Critical Scientists ...
Jonathan Latham on Gene Drives and the Gates Foundation
Tags: Gene drive synthetic, Risk assessment, Stakeholder engagementJames Corbett, The Corbett Report, 2020.
Jonathan Latham of Independent Science News joins us to discuss his 2017 article, “Gates Foundation Hired PR Firm to Manipulate UN Over Gene Drives.” We talk about gene drives, the dangers inherent in this technology, how the UN is involved, and why the Gates Foundation and ...
Motivations and expectations driving community participation in entomological research projects: Target Malaria as a case study in Bana, Western Burkina Faso
Tags: Africa, Gene drive synthetic, Stakeholder engagementN. Barry, P. Toé, L. Pare Toe, J. Lezaun, M. Drabo, R. K. Dabiré and A. Diabate, Malaria Journal, 19:199. 2020.
Most field entomology research projects require active participation by local community members. Since 2012, Target Malaria, a not-for-profit research consortium, has been working with residents in the village of Bana, in Western Burkina Faso, in various studies involving ...
Islands as Laboratories: Indigenous Knowledge and Gene Drives in the Pacific
Tags: Ethics, Gene drive synthetic, Oceania, Stakeholder engagementR. I. Taitingfong, Human Biology, 91:179-188. 2020.
This article argues that the genetic engineering technology known as gene drive must be evaluated in the context of the historic and ongoing impacts of settler colonialism and military experimentation on indigenous lands and peoples. After defining gene drive and previewing some ...
Position Paper on Integrated Vector Management: Strengthening AU Members’ Regulatory Capacities for Responsible Research Towards Elimination of Malaria in Africa
Tags: Africa, Ethics, Gene drive synthetic, Malaria, Policy, Regulation, Stakeholder engagement, Vector controlAfrican Union Development Agency - NEPAD, AUDA-NEPAD, 2020.
Africa continues to bear a heavy brunt of the malaria which is a disease transmitted by the female Anopheles mosquito. Thousands of lives, mostly of young children, are lost every year; which undermines efforts deployed at various levels for increased life expectancy and improved ...
Public opinion on gene editing
Tags: Gene drive synthetic, Stakeholder engagementP. Thomas, The Ecologist, 2020.
What does the public think of genetic engineering in food and farming? Is there more acceptance, or less, these days? Have the issues changed over time, or is it just more of the same? How well informed do you believe you are? Beyond GM like you to participate in our survey to ...
Opinions of key stakeholders on alternative interventions for malaria control and elimination in Tanzania
Tags: Gene drive synthetic, Malaria, Mosquitoes, Stakeholder engagement, Vector controlM. F. Finda, N. Christofides, J. Lezaun, B. Tarimo, P. Chaki, A. H. Kelly, N. Kapologwe, P. Kazyoba, B. Emidi and F. O. Okumu, Malaria Journal, 19:164. 2020.
Malaria control in Tanzania currently relies primarily on long-lasting insecticidal nets and indoor residual spraying, alongside effective case management and behaviour change communication. This study explored opinions of key stakeholders on the national progress towards malaria ...
Public Opinion Towards Gene Drive as a Pest Control Approach for Biodiversity Conservation and the Association of Underlying Worldviews
Tags: CRISPR, Ecology, Gene drive synthetic, Invasive species, Oceania, Stakeholder engagement, Synthetic biologyE. A. MacDonald, J. Balanovic, E. D. Edwards, W. Abrahamse, B. Frame, A. Greenaway, R. Kannemeyer, N. Kirk, F. Medvecky, T. L. Milfont, J. C. Russell and D. M. Tompkins, Environmental Communication-a Journal of Nature and Culture, 15:1-16. 2020.
Synthetic gene drive approaches are nascent technologies with potential applicability for pest control for conservation purposes. Responsible science mandates that society be engaged in a dialogue over new technology, particularly where there exist global ramifications as with ...
Public Opinion Towards Gene Drive as a Pest Control Approach for Biodiversity Conservation and the Association of Underlying Worldviews
Tags: Gene drive synthetic, Genetic biocontrol, Oceania, Policy, Stakeholder engagementE. A. MacDonald, J. Balanovic, E. D. Edwards, W. Abrahamse, B. Frame, A. Greenaway, R. Kannemeyer, N. Kirk, F. Medvecky, T. L. Milfont, J. C. Russell and D. M. Tompkins, Environmental Communication, 14:904-918. 2020.
Synthetic gene drive approaches are nascent technologies with potential applicability for pest control for conservation purposes. Responsible science mandates that society be engaged in a dialogue over new technology, particularly where there exist global ramifications as with ...
Metaphor, Trust and Support for Non-native Species Control
Tags: Biodiversity/Conservation, Gene drive, Invasive species, Pest management, Policy, Stakeholder engagement, Synthetic biologyP. A. Kohl, S. J. Collins and M. Eichholz, Environmental Communication, 14:672-685. 2020.
This experimental study used a representative sample of U.S. residents (N = 1,042) to test whether the use of the term "invasive" increases support for non-native species control efforts. The term invasive had a small influence on support for two out of three non-native species ...
A typology of community and stakeholder engagement based on documented examples in the field of novel vector control
Tags: Ethics, Gene drive synthetic, Genetic biocontrol, Policy, Risk and safety, Stakeholder engagementC. E. Schairer, R. Taitingfong, O. S. Akbari and C. S. Bloss, PLoS Neglected Tropical Diseases, 13:e0007863. 2019.
Background Despite broad consensus on the importance of community and stakeholder engagement (CSE) for guiding the development, regulation, field testing, and deployment of emerging vector control technologies (such as genetically engineered insects), the types of activities ...
Community Engagement Prior to a Small-Scale Pilot of the Sterile Insect Technique in Kwazulu-Natal, South Africa 2018
Tags: Africa, Anopheles, Stakeholder engagement, Sterile insect technique (SIT)P. N. Manana, J. Zikhali, D. Dlamini, S. Gumede, N. Mabaso, T. Mpungose and G. Munhenga, Journal of Public Health and Disease Prevention, 2. 2019.
Approximately 165 000 listeners were engaged during two 30 minute radio interviews at a local radio station. Two hundred and fifty farm workers, several outpatients from primary health care facilities and 1400 secondary school pupils were given education on malaria transmission ...
Peri-Urban Community Attitudes towards Codling Moth Trapping and Suppression Using the Sterile Insect Technique in New Zealand
Tags: Genetic biocontrol, Moths, Policy, Risk assessment, Stakeholder engagementG. Paterson, G. L. W. Perry, J. T. S. Walker and D. M. Suckling, Insects, 10. 2019.
New, more socially-acceptable technologies are being developed to suppress horticultural pests, because suppression is technically difficult with current technologies, especially in urban areas. One technique involves the release of sterile insects to prevent offspring in the ...
Two unresolved issues in community engagement for field trials of genetically modified mosquitoes
Tags: Ethics, Field trials, Genetically modified mosquitoes, Genetically modified organisms, Stakeholder engagementD. B. Resnik, Pathogens and Global Health, 113:238-245. 2019.
There is an emerging consensus among scientists, ethicists, and public health officials that substantive and effective engagement with communities and the wider public is required prior to releasing genetically modified mosquitoes into the environment.
Autonomy of Nations and Indigenous Peoples and the Environmental Release of Genetically Engineered Animals with Gene Drives
Tags: Gene drive synthetic, Policy, Regulation, Risk and safety, Stakeholder engagementZ. Meghani, Global Policy, 10:554-568. 2019.
This article contends that the environmental release of genetically engineered (GE) animals with heritable traits that are patented will present a challenge to the efforts of nations and indigenous peoples to engage in self-determination. The environmental release of such animals ...
Gene Drives in Africa: Civil Society Speaks Out
Tags: Africa, Gene drive synthetic, Policy, Regulation, Stakeholder engagement, Target malariaAfrican Centre for Biodiversity, 2019.
On Monday 1st July 2019, Target Malaria announced the release of genetically modified (GM) sterile male mosquitoes in Bana, a village in Burkina Faso – the first GM insect to be released in Africa. This is Phase I – by Phase III, Target Malaria aims to release gene drive ...
Biological control of pests and a social model of animal welfare
Tags: Gene drive synthetic, Genetic biocontrol, Invasive species, Policy, Stakeholder engagement, Synthetic biologyA. Mankad, U. Kennedy and L. Carter, Journal of Environmental Management, 247:313-322. 2019.
We consider the role of perceived humaneness or, more accurately, animal welfare as it relates to managing invasive species from a scientific and social perspective. In order to highlight and articulate particular nuances and standards across different pest control contexts, we ...
RISCOS BIOTECNOLÓGICOS AMBIENTAIS E PARTICIPAÇÃO SOCIAL: POR UMA GESTÃO DEMOCRÁTICA DA BIOTECNOLOGIA GENE DRIVE NA ATUAÇÃO DA CTNBIO
Tags: Gene drive synthetic, Policy, Risk assessment, Stakeholder engagementL. C. Rodrigues, Revista Jurídica (FURB), 22. 2019.
This research aims to study the way in which the environmental risks of Gene Drive biotechnology challenge forms of effective social participation, inserted in the management of biotechnological risks, whose responsibility lies with the organs ...
A potential new tool for the toolbox: assessing gene drives for eradicating invasive rodent populations
Tags: Biodiversity/Conservation, CRISPR, Gene drive synthetic, Gene editing, Genetic biocontrol, Invasive species, Pest management, Risk assessment, Rodents, Stakeholder engagementK. J. Campbell, J. R. Saah, P. R. Brown, J. Godwin, F. Gould, G. R. Howald, A. Piaggio, P. Thomas, D. M. Tompkins, D. Threadgill, J. Delborne, D. Kanavy, T. Kuiken, H. Packard, M. Serr and A. Shiels, Island invasives: scaling up to meet the challenge, 2019.
Invasive rodents have significant negative impacts on island biodiversity. All but the smallest of rodent eradications currently rely on island-wide rodenticide applications. Although signifi cant advances have been made in mitigating unintended impacts, rodent eradication on ...
Public engagement pathways for emerging GM insect technologies
Tags: Ethics, Gene drive synthetic, Regulation, Risk and safety, Stakeholder engagementBurgess, M. M., J. D. Mumford and J. V. Lavery, BMC Proceedings, 12(Suppl 8):12. 2018. [YouTube Playlist]
Policy and management related to the release of organisms generated by emerging biotechnologies for pest management should be informed through public engagement. Regulatory decisions can be conceptually distinguished into the development of frameworks, the assessment of the ...
The ethical implications of population suppression and the irreversibility of gene drives
Tags: Ethics, Gene drive synthetic, Genetically modified organisms, Policy, Population suppression, Risk and safety, Stakeholder engagementJ. Kim, International Journal of Life Sciences Research, 2018.
This paper aims to examine the current situation by presenting important ethical arguments that include Chardin’s principle of irreversibility and Weiss’ beliefs on intergenerational equity, ideals upheld by the United Nations
Gene drives and the management of agricultural pests
Tags: Agriculture, Gene drive synthetic, Risk and safety, Risk assessment, Stakeholder engagementR. F. Medina, Journal of Responsible Innovation, 5:S255-S262. 2018.
Like all pest control strategies, gene drives are not hazard-free. Ecological risk assessment of gene drives designed to control agricultural pests should be conducted before their deployment. The present commentary provides some thoughts on some of the issues one should consider ...
Summary
Tags: Agriculture, Biodiversity/Conservation, Gene drive synthetic, Policy, Risk and safety, Risk assessment, Stakeholder engagementCommittee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible, Journal of Responsible Innovation, 5:S243-S254. 2018.
Scientists have studied gene drives for more than 50 years. The development of a powerful genome editing tool in 2012, CRISPR/Cas9,1 led to recent breakthroughs in gene drive research that built on that half century’s worth of knowledge, and stimulated new discussion of the ...
Anomaly handling and the politics of gene drives
Tags: Gene drive synthetic, Governance, Policy, Regulation, Stakeholder engagementS. W. Evans and M. J. Palmer, Journal of Responsible Innovation, 5:S223-S242. 2018.
Decisions about the development and use of gene drives are framing broader debates about the need for fundamental changes to biotechnology regulatory systems. We summarize this debate and describe how gene drives are being constructed as potential anomalies within the regulatory ...
Identifying and detecting potentially adverse ecological outcomes associated with the release of gene-drive modified organisms
Tags: Ecology, Gene drive synthetic, Risk assessment, Stakeholder engagementK. R. Hayes, G. R. Hosack, G. V. Dana, S. D. Foster, J. H. Ford, R. Thresher, A. Ickowicz, D. Peel, M. Tizard, P. De Barro, T. Strive and J. M. Dambacher, Journal of Responsible Innovation, 5:S139-S158. 2018.
In this paper, we outline methods to identify hazards and detect potentially adverse ecological outcomes at the individual (genotype, phenotype), population, community and ecosystem level, when progressing Gene Drive Modified Organisms through a phased test and release pathway. ...
Harnessing gene drive
Tags: Gene drive synthetic, Governance, Policy, Regulation, Stakeholder engagementJ. Min, A. L. Smidler, D. Najjar and K. M. Esvelt, Journal of Responsible Innovation, 5. 2018.
Determining whether, when, and how to develop gene drive interventions responsibly will be a defining challenge of our time. Here we describe capabilities, safeguards, applications, and opportunities relevant to gene drive technologies.
A roadmap for gene drives: using institutional analysis and development to frame research needs and governance in a systems context
Tags: Gene drive synthetic, Governance, Policy, Regulation, Stakeholder engagementJ. Kuzma, F. Gould, Z. Brown, J. Collins, J. Delborne, E. Frow, K. Esvelt, D. Guston, C. Leitschuh, K. Oye and S. Stauffer, Journal of Responsible Innovation, 5:S13-S39. 2018.
This paper reports on a workshop held in February 2016 to explore the complex intersection of political, economic, ethical, and ecological risk issues associated with gene drives. Workshop participants were encouraged to use systems thinking and mapping to describe the ...
Mapping research and governance needs for gene drives
Tags: Gene drive synthetic, Governance, Policy, Regulation, Stakeholder engagementJ. Delborne, J. Kuzma, F. Gould, E. Frow, C. Leitschuh and J. Sudweeks, Journal of Responsible Innovation, 5:S4-S12. 2018.
This special issue represents both deep and broad thinking about gene drives. The papers were first drafted nearly two years ago, and since then have been reviewed and revised to flesh out key arguments and take account of ongoing developments in the field. This field has moved ...
Gene drives and the expanding horizon of governance
Tags: Gene drive synthetic, Governance, Policy, Regulation, Stakeholder engagementE. Fisher, Journal of Responsible Innovation, 5:S1-S3. 2018.
Like other areas of emerging science and technology that trigger prolonged public debate over their transformative prospects, gene drives simultaneously generate prospects for new knowledge, hoped-for benefits, and formidable concerns. Their ability to bias inheritance of and in ...
Identifying and detecting potentially adverse ecological outcomes associated with the release of gene-drive modified organisms
Tags: Agriculture, CRISPR, Ecology, Field trials, Gene drive, Gene drive synthetic, Malaria, Mosquitoes, Risk and safety, Risk assessment, Stakeholder engagement, Transmission distortionHayes, KRH, G. R.; Dana, G. V.; Foster, S. D.; Ford, J. H.; Thresher, R.; Ickowicz, A.; Peel, D.; Tizard, M.; De Barro, P.; Strive, T.; Dambacher, J. M., Journal of Responsible Innovation, 5:S139-S158. 2018.
Synthetic gene drives could provide new solutions to a range of old problems such as controlling vector-borne diseases, agricultural pests and invasive species. In this paper, we outline methods to identify hazards and detect potentially adverse ecological outcomes at the ...
Community engagement and field trials of genetically modified insects and animals
Tags: Ethics, Gene drive synthetic, Stakeholder engagementNeuhaus, C. P., Hastings Center Report, 48:25-36. 2018.
New techniques for the genetic modification of organisms are creating new strategies for addressing persistent public health challenges. For example, the company Oxitec has conducted field trials internationally?and has attempted to conduct field trials in the United States?of a ...
Informed consent in field trials of gene-drive mosquitoes
Tags: Field trials, Gene drive synthetic, Policy, Regulation, Risk and safety, Stakeholder engagementP. A. Kolopack and J. V. Lavery, Gates Open Research, 2017.
We argue that informed consent from individual research participants in gene drive trials may be required: (1) when blood and other forms of clinical data are collected from them, as will likely be the case in some studies involving epidemiological endpoints, such as the ...
The potential for the use of gene drives for pest control in New Zealand: a perspective
Tags: Gene drive synthetic, Genetic biocontrol, Invasive species, Oceania, Pest management, Policy, Regulation, Risk and safety, Stakeholder engagementP. K. Dearden, N. J. Gemmell, O. R. Mercier, P. J. Lester, M. J. Scott, R. D. Newcomb, T. R. Buckley, J. M. E. Jacobs, S. G. Goldson and D. R. Penman, Journal of the Royal Society of New Zealand, 48:225-244. 2017.
Here we describe the current state of gene drive technologies and present a series of examples to examine the potential benefits and problems arising from gene drive approaches for pest control in New Zealand.
Using CRISPR-based gene drive for agriculture pest control
Tags: Agriculture, Gene drive synthetic, Policy, Regulation, Risk and safety, Stakeholder engagementV. Courtier-Orgogozo, B. Morizot and C. Boëte, EMBO Reports, 18:1481. 2017.
The authors respond to comments to their publication 10.15252/embr.201744205
Perceptions and recommendations by scientists for a potential release of genetically modified mosquitoes in Nigeria
Tags: Africa, Policy, Stakeholder engagementP. N. Okorie, J. M. Marshall, O. M. Akpa and O. G. Ademowo, Malaria Journal, 13:154. 2014.
The use of genetically modified mosquitoes (GMMs) for the control of malaria and other mosquito-borne diseases has been proposed in malaria-endemic countries, such as Nigeria, which has the largest burden in Africa. Scientists are major stakeholders whose opinions and perceptions ...