Keywords: Vector control
Exploring The Dynamics of Gene Drive Mosquitoes Within Wild Populations Using an Agent-Based Simulation
Tags: Africa, Gene drive, Malaria, Modeling, Vector controlS. Wickramasooriya, I. Mahmood, et al., IEEE Xplore, 2024.
Gene drive technology is emerging as a potentially powerful tool in combating vector-borne diseases – notably malaria. This study introduces an agent-based model (ABM) focused on the deployment of genetically engineered mosquitoes with gene drive (GEM) in Príncipe Island, ...
Variable effects of transient Wolbachia infections on alphaviruses in Aedes aegypti
Tags: Aedes, Mosquitoes, Vector control, WolbachiaBrittany L. Dodson, Sujit Pujhari, et al., PLoS Neglected Tropical Diseases, 2024.
Wolbachia pipientis (= Wolbachia) has promise as a tool to suppress virus transmission by Aedes aegypti mosquitoes. However, Wolbachia can have variable effects on mosquito-borne viruses. This variation remains poorly characterized, yet the multimodal effects of Wolbachia on ...
TWiV 1161: Baby you can drive my gene
Tags: Gene drive, Vector control, VideoMicrobeTV, YouTube, 2024.
TWiV reviews continuing expansion of poliovirus type 2, removal of influenza B/Yamagata from the vaccine, Nobel Prize for miRNAs, protective immune response with a adenovirus-associated virus vector expressing a computationally designed hemagglutinin, and viral gene drive during ...
Wolbachia-based emerging strategies for control of vector-transmitted disease
Tags: Arbovirus, Ecology, Genetically modified organisms, Risk and safety, Vector control, WolbachiaDiego Montenegro, Gerardo Cortés-Cortés, María Guadalupe Balbuena-Alonso, et al., Acta Tropica, 260. 2024.
Dengue fever is a mosquito-transmitted disease of great public health importance. Dengue lacks adequate vaccine protection and insecticide-based methods of mosquito control are proving increasingly ineffective. Here we review the emerging use of mosquitoes transinfected with the ...
Practical Application of a Relationship-Based Model to Engagement for Gene-Drive Vector Control Programs
Tags: Africa, Gene drive, Modeling, Stakeholder engagement, Vector controlAna Kormos, Lodney Nazaré, Adionilde Aguiar dos Santos, and Gregory C. Lanzaro, The American Journal of Tropical Medicine and Hygiene, 111:341-360. 2024.
Engagement is an important component in the advancement of gene-drive vector control research programs as developers look to transition the technology from the laboratory to the field. As research advances and engagement surrounding this novel technology is put into practice, ...
Exploring new tools to fight vector-borne diseases: research and governance implications
Tags: Europe, Governance, Policy, Target malaria, Vector controlAlekos Simoni, Outreach Network for Gene Drive Research, 2024.
I recently had the honor and pleasure of attending an event co-organized by the Outreach Network for Gene Drive Research at the European Parliament in Brussels, and delivering a presentation on our work at Target Malaria to develop new genetic tools to reduce malaria ...
Evaluation of Wolbachia infection in Aedes aegypti suggests low prevalence and highly heterogeneous distribution in Medellín, Colombia
Tags: Aedes, Arbovirus, Dengue, Population modification/replacement, South/Central America, Vector control, Wolbachiarley Calle-Tobón, Raúl Rojo-Ospina, et al., Acta Tropica, 260. 2024.
Dengue virus, transmitted mainly by Aedes aegypti mosquitoes, is a significant public health challenge in tropical and subtropical countries, with an incidence that is growing at an alarming rate. The release of Wolbachia-carrying mosquitoes has been suggested as a strategy to ...
Wolbachia infection in Aedes aegypti does not affect its vectorial capacity for Dirofilaria immitis
Tags: Aedes, Vector control, WolbachiaShirozu, T., Regilme, M.A.F., Ote, M. et al., Scientific Reports, 14. 2024.
Mosquito-borne diseases such as dengue and filariasis are a growing public health concern in endemic countries. Biological approaches, such as the trans-infection of Wolbachia pipientis in mosquitoes, are an alternative vector control strategy, especially for arthropod-borne ...
Current status of the sterile insect technique for the suppression of mosquito populations on a global scale
Tags: Aedes, Arbovirus, Sterile insect technique (SIT), Vector controlBouyer, J., Infectious Diseases of Poverty, 13. 2024.
The World Health Organization (WHO) has emphasized the urgent need for alternative strategies to chemical insecticides for controlling mosquito populations, particularly the invasive Aedes species, which are known vectors of arboviruses. Among these alternative approaches, the ...
Applications of Mathematical Programming to Genetic Biocontrol
Tags: Modeling, Vector controlVáleri N. Vásquez, John M. Marshall, SIAM Journal on Applied Mathematics, 84. 2024.
We review existing approaches to optimizing the deployment of genetic biocontrol technologies—tools used to prevent vector-borne diseases such as malaria and dengue—and formulate a mathematical program that enables the incorporation of crucial ecological and logistical ...
Mark–Release–Recapture Trial with Aedes albopictus (Diptera, Culicidae) Irradiated Males: Population Parameters and Climatic Factors
Tags: Aedes, Arbovirus, Sterile insect technique (SIT), Vector controlAmaro FIF, Soares P, Velo E, et al, Insects, 15. 2024.
Aedes albopictus mosquitoes spread arboviruses like dengue, Zika, or chikungunya. The Sterile Insect Technique (SIT) can be used as a prevention and control tool against Ae. albopictus populations. Mark–release–recapture (MRR) trials are fundamental to estimate the size of ...
Genetically Modified Wolbachia mosquitoes help reduce virus transmission
Tags: Dengue, Mosquitoes, Vector control, WolbachiaPrecision Vaccinations, 2024.
Every year on World Mosquito Day, diseases spread by mosquitoes, which account for over 17% of all infectious diseases and lead to more than 700,000 deaths annually, are highlighted. Parasites, bacteria, or viruses can cause these diseases, including chikungunya, malaria, dengue, ...
A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae
Tags: Anopheles, Malaria, Synthetic biology, Vector controlIgnacio Tolosana, Katie Willis, Austin Burt, Matthew Gribble, Tony Nolan, Andrea Crisanti, Federica Bernardini, bioRxiv, 2024.
Genetic control – the deliberate introduction of genetic traits to control a pest or vector population – offers a powerful tool to augment conventional mosquito control tools that have been successful in reducing malaria burden but that are compromised by a range of ...
How could genetic approaches be integrated in the malaria toolkit?
Tags: Africa, Malaria, Mosquitoes, Vector controlDamaris Matoke-Muhia, Outreach Network for Gene Drive Research, 2024.
The Outreach Network for Gene Drive Research organized a symposium on the margins of the Multilateral Initiative on Malaria (MIM Society)’s 8th Pan-African Malaria Conference held last week in Kigali, Rwanda. The event explored how novel genetic approaches could be integrated ...
To fend off aggressive female mosquitoes, L.A. is releasing thousands of sterile males
Tags: Mosquitoes, Sterile insect technique (SIT), Vector controlEvan Bush, NBC News, 2024.
In Los Angeles, those who wage war on mosquitoes are adding a weapon to their arsenal: more mosquitoes. The Greater Los Angeles County Vector Control District on Thursday launched a pilot program to release tens of thousands of irradiated, lab-raised mosquitoes into the local ...
Monitoring Aedes populations for arboviruses, Wolbachia, insecticide resistance and its mechanisms in various agroecosystems in Benin
Tags: Aedes, Gene editing, Resistance, Vector control, WolbachiaS. Ateutchia-Ngouanet, F. Nanfack-Minkeu, K. Mavridis, S. Wanji, M. Demanou, J. Vontas, R. Djouaka, Acta Tropica, 253. 2024.
The susceptibility of arbovirus vectors to insecticides and the microbiome of Aedes species are understudied in Benin.
Acceptability of emergent Aedes aegypti vector control methods in Ponce, Puerto Rico: A qualitative assessment
Tags: Aedes, Genetically modified mosquitoes, Vector control, WolbachiaPérez-Guerra CL, Rosado-Santiago C, Ramos SA, Marrero-Santos KM, González-Zeno G, Partridge SK, et al., PLoS Global Public Health, 2024.
Aedes aegypti control has been fraught with challenges in Puerto Rico. The government has implemented commonly used vector control methods, but arboviral epidemics still occur. It is necessary to explore new Ae. aegypti control methods. This study aimed to understand the ...
Aedes aegypti Controls Ae. aegypti: SIT and IIT—An Overview
Tags: Aedes, Mosquitoes, Vector control, WolbachiaRobert L. Aldridge; Seth Gibson; Kenneth J. Linthicum, Journal of the American Mosquito Control Association, 20:32-49. 2024.
The sterile insect technique (SIT) and the incompatible insect technique (IIT) are emerging and potentially revolutionary tools for controlling Aedes aegypti (L.), a prominent worldwide mosquito vector threat to humans that is notoriously difficult to reduce or eliminate in ...
Stakeholder engagement in the development of genetically modified mosquitoes for malaria control in West Africa: lessons learned from 10 years of Target Malaria’s work in Mali
Tags: Stakeholder engagement, Vector controlBakara Dicko, Souleymane Kodio, Hatouma Samoura, Fatoumata Traoré, Naima Sykes, Mouhamed Drabo, Delphine Thizy, Isabelle Coche, Benjamin Robinson, Kadiatou Sanogo, Bilkissou Yagouré, Samba Diop, Mamadou B. Coulibaly, Frontiers in Bioengineering and Biotechnology, 11. 2024.
From 2012 to 2023, the Malaria Research and Training Center (MRTC), based out of the University of Sciences, Techniques and Technologies of Bamako (USTTB), was part of the Target Malaria research consortium working towards developing novel gene drive-based tools for controlling ...
Germline transformation of the West Nile Virus and avian malaria vector Culex quinquefasciatus Say using the piggyBac transposon system
Tags: Malaria, Vector controlKatherine Nevard, Rajdeep Kaur, Tim Harvey-Samuel, bioRxiv, 2023.
Culex quinquefasciatus Say is a mosquito which acts as a vector for numerous diseases including West Nile Virus, lymphatic filariasis and avian malaria, over a broad geographical range. As the effectiveness of insecticidal mosquito control methods declines, the need has grown to ...
Advances and challenges in synthetic biology for mosquito control
Tags: Gene editing, Genetic biocontrol, Mosquitoes, Synthetic biology, Vector controlShih-Che Weng, Reem A. Masri, Omar S. Akbari, Trends in Parasitology, 2023.
Mosquito-borne illnesses represent a significant global health peril, resulting in approximately one million fatalities annually. West Nile, dengue, Zika, and malaria are continuously expanding their global reach, driven by factors that escalate mosquito populations and pathogen ...
Utility of surveillance data for planning for dengue elimination in Yogyakarta, Indonesia: a scenario-tree modelling approach
Tags: Aedes, Dengue, Field trials, Vector controlMelanie Bannister-Tyrrell, Alison Hillman, Citra Indrian, Riris Andono Ahmad, Adi Utarini, Cameron P Simmons, Katherine L Anders, Evan Sergeant, BMJ Global Health, 8. 2023.
Field trials and modelling studies suggest that elimination of dengue transmission may be possible through widespread release of Aedes aegypti mosquitoes infected with the insect bacterium Wolbachia pipientis (wMel strain), in conjunction with routine dengue control activities. ...
Targeting Sex Determination to Suppress Mosquito Populations
Tags: Aedes, Dengue, Genetic biocontrol, Mosquitoes, Population suppression, Sterile insect technique (SIT), Vector controlL. Ming, P. K. Nikolay, S. Ruichen, Y. Ting, D. B. Elena, J. B. Daniel, A. Igor, M. S. C. Hector, Z. Yinpeng, A. D. Nicolas, M. L. YuMin, P. S. Matthew, M. Craig, M. M. John and S. A. Omar, bioRxiv, 2023.04.18.537404. 2023.
Each year, hundreds of millions of people are infected with arboviruses such as dengue, yellow fever, chikungunya, and Zika, which are all primarily spread by the notorious mosquito Aedes aegypti. Traditional control measures have proven insufficient, necessitating innovations. ...
Life-history traits of a fluorescent Anopheles arabiensis genetic sexing strain introgressed into South African genomic background
Tags: Anopheles, Genetically modified mosquitoes, Malaria, Mosquitoes, Sterile insect technique (SIT), Vector controlN. L. Ntoyi, T. Mashatola, J. Bouyer, C. Kraupa, H. Maiga, W. Mamai, N. S. Bimbile-Somda, T. Wallner, D. O. Carvalho, G. Munhenga and H. Yamada, Malaria Journal, 21:12. 2022.
Background South Africa has set a mandate to eliminate local malaria transmission by 2023. In pursuit of this objective a Sterile Insect Technique programme targeting the main vector Anopheles arabiensis is currently under development. Significant progress has been made towards ...
Operationalizing stakeholder engagement for gene drive research in malaria elimination in Africa-translating guidance into practice
Tags: Gene drive, Gene drive synthetic, Malaria, Stakeholder engagement, Vector controlL. Pare Toe, B. Dicko, R. Linga, N. Barry, M. Drabo, N. Sykes and D. Thizy, Malaria Journal, 21:225. 2022.
Gene drive mosquitoes are increasingly considered a potential transformational tool for vector control of malaria mosquitoes. As part of efforts to promote responsible research in this field, a number of guidance documents have been published by the World Health Organization, ...
Recommendations for environmental risk assessment of gene drive applications for malaria vector control
Tags: Gene drive synthetic, Malaria, Modeling, Population suppression, Risk and safety, Stakeholder engagement, Vector controlJ. B. Connolly, J. D. Mumford, D. C. M. Glandorf, S. Hartley, O. T. Lewis, S. W. Evans, G. Turner, C. Beech, N. Sykes, M. B. Coulibaly, J. Romeis, J. L. Teem, W. Tonui, B. Lovett, A. Mankad, A. Mnzava, S. Fuchs, T. D. Hackett, W. G. Landis, J. M. Marshall, Malar J, 21:152. 2022.
Building on an exercise that identified potential harms from simulated investigational releases of a population suppression gene drive for malaria vector control, a series of online workshops identified nine recommendations to advance future environmental risk assessment of gene ...
Role of CRISPR Technology in Gene Editing of Emerging and Re-emerging Vector Borne Disease
Tags: Dengue, Gene drive synthetic, Genetic biocontrol, Malaria, Vector controlK. K. Mahto, P. Prasad, M. Kumar, H. Dubey and A. Ranjan, Recent Advances in Pathogen Interactions, Immunity, and Vector Control Strategies, 2022.
Vector borne diseases are rampant across the world. Due to spread and estab-lishment of vector species in different geographical areas, vector adaptation and resistance towards many insecticides the only option left is vector control for vari-ous vector borne diseases. Recent ...
New frontiers in vector control
Tags: Anopheles, Gene drive synthetic, Malaria, Vector controlWHO, World Health Organization, 2022.
Ever since Sir Ronald Ross discovered malaria parasites in an Anopheles mosquito in 1897, controlling insect vectors has played an increasingly important role in reducing the burden of the disease. For decades after World War II, indoor residual spraying (IRS) with insecticides ...
Genetic Stability and Fitness of Aedes aegypti Red-Eye Genetic Sexing Strains With Pakistani Genomic Background for Sterile Insect Technique Applications
Tags: Aedes, Arbovirus, Dengue, Sterile insect technique (SIT), Vector controlM. Misbah-ul-Haq, D. O. Carvalho, L. D. de la Fuente, A. A. Augustinos and K. Bourtzis, Frontiers in Bioengineering and Biotechnology, 10. 2022.
The mosquito species Aedes aegypti is the primary transmitter of viruses that cause endemic diseases like dengue in Pakistan. It is also a cause of other vector-borne diseases like yellow fever, Zika fever, and chikungunya, which significantly impact human health worldwide. In ...
Sterile Insect Technique in an Integrated Vector Management Program against Tiger Mosquito Aedes albopictus in the Valencia Region (Spain): Operating Procedures and Quality Control Parameters
Tags: Aedes, Dengue, Mosquito husbandry, Sterile insect technique (SIT), Vector controlC. Tur, D. Almenar, S. Benlloch-Navarro, R. Argilés-Herrero, M. Zacarés, V. Dalmau and I. Pla, Insects, 12. 2021.
The Agriculture Department of the Valencian Region is promoting an ongoing pilot project to evaluate the efficacy of an integrated vector management program (IVM) based on the use of the SIT as the main method of control. The laboratory studies for evaluating the entomological ...
Thirteenth meeting of the WHO Vector Control Advisory Group
Tags: Genetic biocontrol, Vector controlVector Control Advisory Group, WHO, 2021.
VCAG experts met virtually with product developers, innovators and researchers from 7 to 10 December 2020 for the 13th VCAG meeting. This report details the proceedings and outcomes of the meeting, including advice provided to the following applicants: bait stations; lethal house ...
Sterile Insect Technique (SIT) against Aedes Species Mosquitoes: A Roadmap and Good Practice Framework for Designing, Implementing and Evaluating Pilot Field Trials
Tags: Aedes, Field trials, Mosquitoes, Stakeholder engagement, Sterile insect technique (SIT), Vector controlC. F. Oliva, M. Q. Benedict, C. M. Collins, T. Baldet, R. Bellini, H. Bossin, J. Bouyer, V. Corbel, L. Facchinelli, F. Fouque, M. Geier, A. Michaelakis, D. Roiz, F. Simard, C. Tur and L.-C. Gouagna, Insects, 12. 2021.
We offer here a pragmatic and accessible ‘roadmap’ for the pre-pilot and pilot phases to guide any interested party. This will support stakeholders, non-specialist scientists, implementers, and decision-makers. Applying these concepts will ensure, given adequate resources, a ...
The Antiviral Small-Interfering RNA Pathway Induces Zika Virus Resistance in Transgenic Aedes aegypti
Tags: Aedes, Arbovirus, CRISPR, Gene drive, Gene editing, Genetic engineering, Vector controlA. E. Williams, I. Sanchez-Vargas, W. R. Reid, J. Y. Lin, A. W. E. Franz and K. E. Olson, Viruses, 12:18. 2020.
We used CRISPR/Cas9 to re-target a previously characterized locus (Chr2:321382225) and engineered mosquitoes expressing an inverted repeat (IR) dsRNA against the NS3/4A region of the ZIKV genome. Small RNA analysis revealed that the IR effector triggered the mosquito's siRNA ...
Interdisciplinary development of a standardized introduction to gene drives for lay audiences
Tags: Field trials, Gene drive synthetic, Genetic engineering, Policy, Stakeholder engagement, Vector controlC. E. Schairer, C. Triplett, A. Buchman, O. S. Akbari and C. S. Bloss, BMC Medical Research Methodology, 20:15. 2020.
While there is wide consensus that the public should be consulted about emerging technology early in development, it is difficult to elicit public opinion about innovations unfamiliar to lay audiences. We sought public input on a program of research on genetic engineering to ...
Burkina Faso Stakeholders consultations on Gene Drive Technology for integrated vector management towards malaria elimination
Tags: Africa, Policy, Regulation, Risk and safety, Vector controlAUDA-NEPAD, AUDA-NEPAD, 2020.
Under its flagship Integrated Vector Management (IVM) Programme, African Union Development Agency (AUDA-NEPAD) in partnership with the National biosafety agency (ANB) of Burkina Faso organized an information sharing workshop on the applications of "Gene Drive" technology and ...
Ethics and vector-borne diseases
Tags: Ethics, Gene drive synthetic, Genetic biocontrol, Genetically modified mosquitoes, Malaria, Policy, Regulation, Vector controlGeneva: World Health Organization, WHO Guidance, 2020.
The guidance was developed by an international group of experts in vector control, infectious disease ethics, maternal and child health, ecology and climate change, research and vaccine development, and public health communication. It examines a broad range of ethical ...
On Nonlinear Pest/Vector Control via the Sterile Insect Technique: Impact of Residual Fertility
Tags: Aedes, Genetic biocontrol, Modeling, Pest management, Sterile insect technique (SIT), Vector controlM. S. Aronna and Y. Dumont, Bulletin of Mathematical Biology, 82:29. 2020.
We consider a minimalist model for the Sterile Insect Technique (SIT), assuming that residual fertility can occur in the sterile male population.
CRISPR/Cas9 gene drive technology to control transmission of vector-borne parasitic infections
Tags: CRISPR, Gene drive, Malaria, Synthetic biology, Vector controlM. Nateghi Rostami, Parasite Immunology, preprint:e12762. 2020.
Gene drive is the process of copying of an endonuclease-containing cassette that leads to increased frequency of inheritance of the desired traits in a targeted population. CRISPR/Cas9 technology is advancing genetic manipulation of insects in the field of gene drive ...
Position Paper on Integrated Vector Management: Strengthening AU Members’ Regulatory Capacities for Responsible Research Towards Elimination of Malaria in Africa
Tags: Africa, Ethics, Gene drive synthetic, Malaria, Policy, Regulation, Stakeholder engagement, Vector controlAfrican Union Development Agency - NEPAD, AUDA-NEPAD, 2020.
Africa continues to bear a heavy brunt of the malaria which is a disease transmitted by the female Anopheles mosquito. Thousands of lives, mostly of young children, are lost every year; which undermines efforts deployed at various levels for increased life expectancy and improved ...
Mosquito-Borne Diseases Emergence/Resurgence and How to Effectively Control It Biologically
Tags: Aedes, Anopheles, Pest management, Resistance, Vector control, WolbachiaH. Dahmana and O. Mediannikov, Pathogens, 9:26. 2020.
Deadly pathogens and parasites are transmitted by vectors and the mosquito is considered the most threatening vector in public health, transmitting these pathogens to humans and animals. We are currently witnessing the emergence/resurgence in new regions/populations of the most ...
Opinions of key stakeholders on alternative interventions for malaria control and elimination in Tanzania
Tags: Gene drive synthetic, Malaria, Mosquitoes, Stakeholder engagement, Vector controlM. F. Finda, N. Christofides, J. Lezaun, B. Tarimo, P. Chaki, A. H. Kelly, N. Kapologwe, P. Kazyoba, B. Emidi and F. O. Okumu, Malaria Journal, 19:164. 2020.
Malaria control in Tanzania currently relies primarily on long-lasting insecticidal nets and indoor residual spraying, alongside effective case management and behaviour change communication. This study explored opinions of key stakeholders on the national progress towards malaria ...
Winning the tug-of-war between effector gene design and pathogen evolution in vector population replacement strategies
Tags: Evolution, Gene drive, Gene drive synthetic, Vector controlMarshall, J. M., R. R. Raban, N. P. Kandul, J. R. Edula, T. M. León and O. S. Akbari, Frontiers in Genetics, 10:1072. 2019.
While efforts to control malaria with available tools have stagnated, and arbovirus outbreaks persist around the globe, the advent of clustered regularly interspaced short palindromic repeat (CRISPR)-based gene editing has provided exciting new opportunities for genetics-based ...
A Y-chromosome shredding gene drive for controlling pest vertebrate populations
Tags: Gene drive synthetic, Rodents, Vector control, X chromosomeProwse, TAAA, F.; Cassey, P.; Thomas, P.; Ross, J. V., eLife, 8:19. 2019.
Self-replicating gene drives that modify sex ratios or infer a fitness cost could be used to control populations of invasive alien species. The targeted deletion of Y sex chromosomes using CRISPR technology offers a new approach for sex bias that could be incorporated within ...
Engineered resistance to Zika virus in transgenic Aedes aegypti expressing a polycistronic cluster of synthetic small RNAs
Tags: Aedes, Arbovirus, Gene drive, Gene drive synthetic, Population suppression, Resistance, Vector control, WolbachiaBuchman, AG, S.; Li, M.; Antoshechkin, I.; Li, H. H.; Wang, H. W.; Chen, C. H.; Klein, M. J.; Duchemin, J. B.; Paradkar, P. N.; Akbari, O. S., Proceedings of the National Academy of Sciences of the United States of America, 116:3656-3661. 2019.
Recent Zika virus (ZIKV) outbreaks have highlighted the necessity for development of novel vector control strategies to combat arboviral transmission, including genetic versions of the sterile insect technique, artificial infection with Wolbachia to reduce population size and/or ...
Transgenic Mosquitoes – Fact or Fiction?
Tags: Gene drive synthetic, Genetically modified mosquitoes, Risk and safety, Vector controlWilke, A. B. B., J. C. Beier and G. Benelli, Trends in Parasitology, 34:456-465. 2018.
echnologies for controlling mosquito vectors based on genetic manipulation and the release of genetically modified mosquitoes (GMMs) are gaining ground. However, concrete epidemiological evidence of their effectiveness, sustainability, and impact on the environment and nontarget ...
Engineered Reciprocal Chromosome Translocations Drive High Threshold, Reversible Population Replacement in Drosophila
Tags: Dengue, Gene drive, Gene drive mechanisms, Gene drive synthetic, Malaria, Other arthropods, Selfish genetic elements, Underdominance, Vector controlBuchman, ABI, Tobin; Marshall, John M.; Akbari, Omar S.; Hay, Bruce A., ACS Synthetic Biology, 7:1359-1370. 2018.
Replacement of wild insect populations with transgene-bearing individuals unable to transmit disease or survive under specific environmental conditions using gene drive provides a self-perpetuating method of disease prevention. Mechanisms that require the gene drive element and ...
Area-wide Integrated Pest Management
Tags: Genetic biocontrol, Risk assessment, Sterile insect technique (SIT), Vector controlFood and Agriculture Organization of the United Nations (FAO), International Atomic Energy Agency, 2017.
Throughout history, people have had to fight insect pests to reduce diseases, minimize food losses, protect agricultural trade or simply to avoid the nuisance of stinging, biting and buzzing bugs. Insect pest control is usually implemented locally in individual fields or ...
Gene drives do not always increase in frequency: from genetic models to risk assessment
Tags: CRISPR, Evolution, Gene drive, Gene drive mechanisms, Replicator/site directed nuclease, Risk and safety, Transmission distortion, Vector controlde Jong, TJ, Journal Fur Verbraucherschutz Und Lebensmittelsicherheit-Journal of Consumer Protection and Food Safety, 12:299-307. 2017.
Homing genes encode endonucleases that make a double stranded break in the DNA, destroying a target site on the homologous chromosome. When the cell repairs the break the homing allele is copied, converting a heterozygote into a homozygote. This results in gene drive (GD), an ...
Requirements for effective malaria control with homing endonuclease genes
Tags: Aedes, Anopheles, Biological control, Fruit fly, Other arthropods, Replicator/site directed nuclease, Vector controlDeredec, AG, H. C. J.; Burt, A., Proceedings of the National Academy of Sciences of the United States of America, 108:e874-e880. 2011.
Malaria continues to impose a substantial burden on human health. We have previously proposed that biological approaches to control the mosquito vector of disease could be developed using homing endonuclease genes (HEGs), a class of selfish or parasitic gene that exists naturally ...
Site-specific selfish genes as tools for the control and genetic engineering of natural populations
Tags: Evolution, Fruit fly, Gene drive synthetic, Genetic engineering, Replicator/site directed nuclease, Vector controlBurt, A, Proceedings of the Royal Society B-Biological Sciences, 270:921-928. 2003.
Site-specific selfish genes exploit host functions to copy themselves into a defined target DNA sequence, and include homing endonuclease genes, group II introns and some LINE-like transposable elements. If such genes can be engineered to target new host sequences, then they can ...
Stable transformation of the yellow fever mosquito, Aedes aegypti, with the Hermes element from the housefly
Tags: Anopheles, Fruit fly, Gene editing, Selfish genetic elements, Vector controlN. Jasinskiene, C. J. Coates, M. Q. Benedict, A. J. Cornel, C. S. Rafferty, A. A. James and F. H. Collins, Proceedings of the National Academy of Sciences of the United States of America, 95:3743-3747. 1998.
The mosquito Aedes aegypti is the world's most important vector of yellow fever and dengue viruses, Work is currently in progress to control the transmission of these viruses by genetically altering the capacity of wild Ae, aegypti populations to support virus replication. The ...
