
Keywords: history
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Mendel’s laws of heredity on his 200th birthday: What have we learned by considering exceptions?J. B. Wolf, A. C. Ferguson-Smith and A. Lorenz, Heredity, 129:1-3. 2022.![]() Violations of Mendel’s laws can generically be referred to as ‘non-Mendelian inheritance’. However, from that broad perspective, nearly all inheritance systems would show non-Mendelian inheritance (at least to some degree). To hold exactly, Mendel’s laws impose strict ... Keywords: elements, gene drive evolution, gene drive genetics, gene drive natural, group-i introns, history, homing endonucleases, plants, protein, recombination, ribosomal-rna gene, saccharomyces-cerevisiae, sensu-stricto complex, sequences, site |
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The fight against malariaF. Ammache, Year 2049, 2022.![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Malaria is a disease we’ve been dealing with for thousands of years. Traces of the malaria parasite have been found in the remains of Egyptian mummies. Hippocrates described the fevers caused by malaria in Ancient Greece. The mosquito-filled Pontine Marshes protected Ancient ... Keywords: elements, gene drive evolution, gene drive genetics, gene drive natural, group-i introns, history, homing endonucleases, plants, protein, recombination, ribosomal-rna gene, saccharomyces-cerevisiae, sensu-stricto complex, sequences, site |
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New weapons to fight malaria transmission: A historical viewW. Huang, S.-J. Cha and M. Jacobs-Lorena, Entomological Research, 2022.![]() ![]() ![]() ![]() ![]() ![]() ![]() The stagnation of our fight against malaria in recent years, mainly due to the development of mosquito insecticide resistance, argues for the urgent development of new weapons. The dramatic evolution of molecular tools in the last few decades led to a better understanding of ... Keywords: elements, gene drive evolution, gene drive genetics, gene drive natural, group-i introns, history, homing endonucleases, plants, protein, recombination, ribosomal-rna gene, saccharomyces-cerevisiae, sensu-stricto complex, sequences, site |
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Genetic Control in Historical Perspective: The Legacy of India’s Genetic Control of Mosquitoes UnitR. Wilbanks, Hastings Center Report, 51:S11-S18. 2021.![]() ![]() ![]() ![]() ![]() ![]() ![]() Abstract In the early 1970s, a World Health Organization-initiated and United States-funded project released lab-reared mosquitoes outside New Delhi in the first large-scale field trials of the genetic control of mosquitoes. Despite partnering with the Indian Council of Medical ... Keywords: elements, gene drive evolution, gene drive genetics, gene drive natural, group-i introns, history, homing endonucleases, plants, protein, recombination, ribosomal-rna gene, saccharomyces-cerevisiae, sensu-stricto complex, sequences, site |
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New mosquito control tools are criticalL. Braack, Open Access Government, 2021.![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Globally, we are making slow headway in the fight against malaria, but there has been progress, nonetheless. Since 2000, 39 countries and territories have managed to rid themselves of malaria; the most recent is China. Existing tools can achieve local elimination, but the battle ... Keywords: elements, gene drive evolution, gene drive genetics, gene drive natural, group-i introns, history, homing endonucleases, plants, protein, recombination, ribosomal-rna gene, saccharomyces-cerevisiae, sensu-stricto complex, sequences, site |
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Oxitec and MosquitoMate in the United States: lessons for the future of gene drive mosquito controlC. E. Schairer, J. Najera, A. A. James, O. S. Akbari and C. S. Bloss, Pathogens and Global Health, 2021.![]() ![]() ![]() ![]() ![]() ![]() ![]() ABSTRACTIn response to growing concerns regarding mosquito-borne diseases, scientists are developing novel systems of vector control. Early examples include Oxitec?s OX513A genetically-engineered mosquito and MosquitoMate?s Wolbachia-infected mosquito, and systems using ... Keywords: elements, gene drive evolution, gene drive genetics, gene drive natural, group-i introns, history, homing endonucleases, plants, protein, recombination, ribosomal-rna gene, saccharomyces-cerevisiae, sensu-stricto complex, sequences, site |
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His Passion Was ContagiousD. C. McCool, Notre Dame Magazine, 2021.![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Craig was an entomologist and vector biologist whose interest in mosquitoes and the diseases they transmit to people was as contagious as the pathogens themselves. Hesburgh could not have chosen a more driven faculty member. In his 38 years at Notre Dame, before he died in 1995 ... Keywords: elements, gene drive evolution, gene drive genetics, gene drive natural, group-i introns, history, homing endonucleases, plants, protein, recombination, ribosomal-rna gene, saccharomyces-cerevisiae, sensu-stricto complex, sequences, site |
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Teach Me in 10 – Gene Drive Research with Dr. Jennifer BaltzegarJ. Baltzegar, Technology Networks, 2020.![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Dr Baltzegar teaches us about how the maturation of genetic engineering approaches has advanced gene drives, the two different strategies for gene drives and some of the key questions surrounding the application of gene drives in society. Keywords: elements, gene drive evolution, gene drive genetics, gene drive natural, group-i introns, history, homing endonucleases, plants, protein, recombination, ribosomal-rna gene, saccharomyces-cerevisiae, sensu-stricto complex, sequences, site |
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America’s Never-Ending Battle Against Flesh-Eating WormsS. Zhang, The Atlantic, 2020.![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() The United States Department of Agriculture undertook what would ultimately become an immense, multidecade effort to wipe out the screwworms, first in the U.S. and then in Mexico and Central America—all the way down to the narrow strip of land that is the Isthmus of Panama. The ... Keywords: elements, gene drive evolution, gene drive genetics, gene drive natural, group-i introns, history, homing endonucleases, plants, protein, recombination, ribosomal-rna gene, saccharomyces-cerevisiae, sensu-stricto complex, sequences, site |
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Recurrent invasion and extinction of a selfish geneGoddard, MRB, A., Proceedings of the National Academy of Sciences of the United States of America, 96:13880-13885. 1999.![]() ![]() ![]() ![]() ![]() ![]() ![]() Homing endonuclease genes show super-Mendelian inheritance, which allows them to spread in populations even when they are of no benefit to the host organism. To test the idea that regular horizontal transmission is necessary for the long-term persistence of these genes, we ... Keywords: elements, gene drive evolution, gene drive genetics, gene drive natural, group-i introns, history, homing endonucleases, plants, protein, recombination, ribosomal-rna gene, saccharomyces-cerevisiae, sensu-stricto complex, sequences, site |
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Population replacement in Culex fatigens by means of cytoplasmic incompatibility. Laboratory experiments with non-overlapping generationsC. F. Curtis and T. Adak, Bulletin of the World Health Organization, 51:249-255. 1974.![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Bidirectional cytoplasmic incompatibility in the Culex pipiens complex appears to provide a mechanism for the replacement of a wild population by a strain refractory to filaria or a strain made partly sterile by a translocation. As a preliminary test of the feasibility of the ... Keywords: elements, gene drive evolution, gene drive genetics, gene drive natural, group-i introns, history, homing endonucleases, plants, protein, recombination, ribosomal-rna gene, saccharomyces-cerevisiae, sensu-stricto complex, sequences, site |
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Genetic control of insect populations: I. Cage studies of chromosome replacement by compound autosomes in Drosophila melanogasteM. Fitz-Earle, D. G. Holm and D. T. Suzuki, Genetics, 74:461-475. 1973.![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() A genetic method for insect control was evaluated using the test organism, Drosophila melanogaster. The technique involved the displacement under a system of continuous reproduction, of standard strains by those carrying compound autosomes. The eradication of the replacements ... Keywords: elements, gene drive evolution, gene drive genetics, gene drive natural, group-i introns, history, homing endonucleases, plants, protein, recombination, ribosomal-rna gene, saccharomyces-cerevisiae, sensu-stricto complex, sequences, site |
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Chromosome rearrangements for the control of insect pestsG. G. Foster, M. J. Whitten, T. Prout and R. Gill, Science, 176:875-880. 1972.![]() ![]() ![]() ![]() ![]() ![]() ![]() Over several years some biologists have been interested in the possibilities of employing genetic techniques in the control of insect pests. One idea has been to introduce in the natural population genotypes which could subsequently facilitate control, or which might render the ... Keywords: elements, gene drive evolution, gene drive genetics, gene drive natural, group-i introns, history, homing endonucleases, plants, protein, recombination, ribosomal-rna gene, saccharomyces-cerevisiae, sensu-stricto complex, sequences, site |


Contact
David O’Brochta
Foundation for the
National Institutes of Health
geneconvenevi@fnih.org
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