Scholarly Literature

This is a database of scholarly literature that concentrates currently on natural and engineered selfish genetic elements (gene drives).  The latest are shown here.
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B chromosome and its non-Mendelian inheritance in Atractylodes lancea

Hara K, Kikuchi S, Inoue M, Tsusaka T, Sakurai M, Tanabe H, et al.,  PLoS One,  2024.
Supernumerary B chromosomes contribute to intraspecific karyotypic variation. B chromosomes have been detected in more than 2000 organisms; they possess unique and diverse features, including non-Mendelian inheritance. Here, we report one or more B chromosomes in the ...

Viral gene drive spread during herpes simplex virus 1 infection in mice

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Walter, M., Haick, A.K., Riley, R. et al.,  Nature Communications,  15. 2024.
Gene drives are genetic modifications designed to propagate efficiently through a population. Most applications rely on homologous recombination during sexual reproduction in diploid organisms such as insects, but we recently developed a gene drive in herpesviruses that relies on ...

Overcoming drug-resistant tumors with selection gene drives

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Hui Wang, Mingqi Xie,  Cell Genomics,  4. 2024.
Drug resistance is a major hurdle prohibiting effective treatment of many diseases, including cancer. Using model-guided designs, Leighow et al.1 engineered a dual-switch selection gene drive system custom designed to combat drug-resistant tumors. By demonstrating remarkable ...

Applications of Mathematical Programming to Genetic Biocontrol

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Váleri N. Vásquez, John M. Marshall,  SIAM Journal on Applied Mathematics,  84. 2024.
We review existing approaches to optimizing the deployment of genetic biocontrol technologies—tools used to prevent vector-borne diseases such as malaria and dengue—and formulate a mathematical program that enables the incorporation of crucial ecological and logistical ...

Mark–Release–Recapture Trial with Aedes albopictus (Diptera, Culicidae) Irradiated Males: Population Parameters and Climatic Factors

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Amaro FIF, Soares P, Velo E, et al,  Insects,  15. 2024.
Aedes albopictus mosquitoes spread arboviruses like dengue, Zika, or chikungunya. The Sterile Insect Technique (SIT) can be used as a prevention and control tool against Ae. albopictus populations. Mark–release–recapture (MRR) trials are fundamental to estimate the size of ...

Effectiveness of Wolbachia-mediated sterility coupled with sterile insect technique to suppress adult Aedes aegypti populations in Singapore: a synthetic control study

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Bansal, Somya, et al.,  The Lancet Planetary Health,  8:617-628. 2024.
In this synthetic control study, we conducted a large-scale, field trial of IIT-SIT targeting Aedes aegypti among high-rise public housing estates in Singapore, an equatorial city state. Routinely collected data from a large, nationwide surveillance system of 57 990 unique ...

Deployment of tethered gene drive for confined suppression in continuous space requires avoiding drive wave interference

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Ruobing Feng, Jackson Champer,  Molecular Ecology,  33. 2024.
Gene drives have great potential for suppression of pest populations and removal of exotic invasive species. CRISPR homing suppression drive is a powerful but unconfined drive, posing risks of uncontrolled spread. Thus, developing methods for confining a gene drive is of great ...

A model-informed target product profile for population modification gene drives for malaria control

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Agastya Mondal, Héctor M. Sánchez C., John M. Marshall,  medRxiv,  2024.
As reductions in malaria transmission in sub-Saharan Africa stagnate, gene drive-modified mosquitoes represent one of the most promising novel tools for continued disease control. In order to advance from the laboratory to the field, gene drives will be assessed against target ...

Autosomal suppression of sex-ratio meiotic drive influences the dynamics of X and Y chromosome coevolution

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Anjali Gupta, Robert L Unckless,  Journal of Heredity,  2024.
Sex-ratio meiotic drivers are selfish genes or gene complexes that bias the transmission of sex chromosomes resulting in skewed sex ratios. Existing theoretical models have suggested the maintenance of a four-chromosome equilibrium (with driving and standard X and suppressing and ...

Bunyamwera Virus Infection of Wolbachia-Carrying Aedes aegypti Mosquitoes Reduces Wolbachia Density

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Lefteri, D.A.; Rainey, S.M.; Murdochy, S.M.; Sinkins, S.P.,  Viruses,  16. 2024.
Wolbachia symbionts introduced into Aedes mosquitoes provide a highly effective dengue virus transmission control strategy, increasingly utilised in many countries in an attempt to reduce disease burden. Whilst highly effective against dengue and other positive-sense RNA viruses, ...

Functional and evolutionary constraints of wtf killer meiotic drivers

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Ananya Nidamangala Srinivasa, Samuel Campbell, Shriram Venkatesan, Nicole L Nuckolls, Jeffrey J Lange, Randal Halfmann, Sarah E Zanders,  bioRxiv,  2024.
Killer meiotic drivers are selfish DNA loci that sabotage the gametes that do not inherit them from a driver+/driver- heterozygote. These drivers often employ toxic proteins that target essential cellular functions to cause the destruction of driver- gametes. Identifying the ...

Optimizing and synchronizing Aedes aegypti colony for Sterile Insect Technique application: Egg hatching, larval development, and adult emergence rate

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Jennifer Thieme Castellon, Solomon Kibret Birhanie, Ale Macias, Rubi Casas, Jacob Hans, Michelle Q. Brown,  Acta Tropica,  259. 2024.
Mosquito Sterile Insect Technique (SIT) programs can be developed in smaller agencies through synchronization of the colony development to take advantage of the natural male early emergence. This paper examined key aspects of Ae. aegypti colony synchronization work, including egg ...

Population dynamics in spatial suppression gene drive models and the effect of resistance, density dependence, and life history

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Xinyue Zhang, Weitang Sun, Isabel K. Kim, Philipp W. Messer, Jackson Champer,  bioRxiv,  2024.
Due to their super-Mendelian inheritance, gene drive systems have the potential to provide revolutionary solutions to critical public health and environmental problems. For suppression drives, however, spatial structure can cause “chasing” population dynamics that may ...

Generating and testing the efficacy of reagents for CRISPR/Cas9 homology directed repair-based manipulations in Tribolium

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Hannah C Markley, Kennedy J Helms, Megan Maar, Gabriel E Zentner, Michael J Wade, Andrew C Zelhof,  Journal of Insect Science,  24. 2024.
CRISPR/Cas9 manipulations are possible in many insects and ever expanding. Nonetheless, success in one species and techniques developed for it are not necessarily applicable to other species. As such, the development and expansion of CRISPR-based (clustered regularly interspaced ...

Non-Mendelian transmission of X chromosomes: mechanisms and impact on sex ratios and population dynamics in different breeding systems

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Sally Adams; Andre Pires-daSilva,  Biochemical Society Transactions,  2024.
The non-Mendelian transmission of sex chromosomes during gametogenesis carries significant implications, influencing sex ratios and shaping evolutionary dynamics. Here we focus on known mechanisms that drive non-Mendelian inheritance of X chromosomes during spermatogenesis and ...

A comprehensive review of Wolbachia-mediated mechanisms to control dengue virus transmission in Aedes aegypti through innate immune pathways

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Iqra Mushtaq, Muhammad Sajjad Sarwar, Iqra Munzoor,  Viral Immunology,  15. 2024.
The Dengue virus (DENV), primarily spread by Aedes aegypti and also by Aedes albopictus in some regions, poses significant global health risks. Alternative techniques are urgently needed because the current control mechanisms are insufficient to reduce the transmission of DENV. ...

An egg-sabotaging mechanism drives non-Mendelian transmission in mice

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Frances E. Clark, Naomi L. Greenberg, Duilio M.Z.A. Silva, et al,  Current Biology,  2024.
Selfish genetic elements drive in meiosis to distort their transmission ratio and increase their representation in gametes, violating Mendel’s law of segregation. The two established paradigms for meiotic drive, gamete killing and biased segregation, are fundamentally ...

Gene drives: an alternative approach to malaria control?

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Naidoo, K., Oliver, S.V.,  Gene Therapy,  2024.
Genetic modification for the control of mosquitoes is frequently touted as a solution for a variety of vector-borne diseases. There has been some success using non-insecticidal methods like sterile or incompatible insect techniques to control arbovirus diseases. However, control ...

Developing genetic tools to control the Oriental fruit fly: Potential approaches and target genes

Nouhoun Traoré, Roberto Galizi, Mahamadi Kientega, Hamidou Maïga, et al,  Journal of Applied Entomology,  2024.
The Oriental fruit fly, Bactrocera dorsalis, is a pest of significant economic interest that damages horticulture and causes major economic losses worldwide. The main control measures are based on insecticides, which are being increasingly restricted due to the development of ...

Selfing Promotes Spread and Introgression of Segregation Distorters in Hermaphroditic Plants

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Hongru Wang, Léo Planche, Vladimir Shchur, Rasmus Nielsen,  Molecular Biology and Evolution,  41. 2024.
Segregation distorters (SDs) are genetic elements that distort the Mendelian segregation ratio to favor their own transmission and are able to spread even when they incur fitness costs on organisms carrying them. Depending on the biology of the host organisms and the genetic ...

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