Keywords: population modification
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Wolbachia: Biological Control Strategy Against Arboviral DiseasesI. Mohanty, A. Rath and R. K. Hazra, Genetically Modified and other Innovative Vector Control Technologies, 2021.
Arboviral diseases like dengue, chikungunya, and Zika are among the major causes of mortality and morbidity in human population. The limited control methods together with lack of antiviral therapies and effective vaccines have paved way for new approaches. One such approach to ... |
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Wolbachia Endosymbiont and Mosquito Vectors, with Emphasis on Lymphatic Filariasis EliminationI. P. Sunish, Genetically Modified and other Innovative Vector Control Technologies, 2021.
Wolbachia are maternally inherited intracellular bacteria, known to alter early development and mitotic processes in their hosts. They are frequently observed as a reproductive parasite, capable of inducing feminization, parthenogenesis, male killing, or cytoplasmic ... |
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Genomic insertion locus and Cas9 expression in the germline affect CRISPR/Cas9-based gene drive performance in the yellow fever mosquito Aedes aegyptiW. R. Reid, J. Lin, A. E. Williams, R. Juncu, K. E. Olson and A. W. E. Franz, bioRxiv, 2021.12.08.471839. 2021.
The yellow fever mosquito Aedes aegypti is a major vector of arthropod-borne viruses, including dengue, chikungunya, and Zika. A novel approach to mitigate arboviral infections is to generate mosquitoes refractory to infection by overexpressing antiviral effector molecules. Such ... |
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Gene drive that results in addiction to a temperature-sensitive version of an essential gene triggers population collapse in DrosophilaG. Oberhofer, T. Ivy and B. A. Hay, Proceedings of the National Academy of Sciences, 118:e2107413118. 2021.
One strategy for population suppression seeks to use gene drive to spread genes that confer conditional lethality or sterility, providing a way of combining population modification with suppression. Stimuli of potential interest could be introduced by humans, such as an otherwise ... |
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High-resolution in situ analysis of Cas9 germline transcript distributions in gene-drive Anopheles mosquitoesG. Terradas, A. Hermann, A. A. James, W. McGinnis and E. Bier, G3-Genes Genomes Genetics, 2021.
Gene drives are programmable genetic elements that can spread beneficial traits into wild populations to aid in vector-borne pathogen control. Two different drives have been developed for population modification of mosquito vectors. The Reckh drive (vasa-Cas9) in Anopheles ... |
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High Temperature Cycles Result in Maternal Transmission and Dengue Infection Differences Between Wolbachia Strains in Aedes aegyptiM. V. Mancini, T. H. Ant, C. S. Herd, J. Martinez, S. M. Murdochy, D. D. Gingell, E. Mararo, P. C. D. Johnson and S. P. Sinkins, mBio, e0025021. 2021.
Environmental factors play a crucial role in the population dynamics of arthropod endosymbionts, and therefore in the deployment of Wolbachia symbionts for the control of dengue arboviruses. The potential of Wolbachia to invade, persist, and block virus transmission depends in ... |
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Population replacement gene drive characteristics for malaria elimination in a range of seasonal transmission settings: a modeling studyS. Leung, N. Windbichler, E. Wenger, C. Bever and P. Selvaraj, bioRxiv, 2021.11.01.466856. 2021.
Genetically engineering mosquitoes is a promising new vector control strategy to reinvigorate the fight against malaria in Sub-Saharan Africa. Using an agent-based model of malaria transmission with vector genetics, we examine the impacts of releasing population-replacement gene ... |
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Modeling the efficacy of CRISPR gene drive for schistosomiasis controlR. E. Grewelle, J. Perez-Saez, J. Tycko, E. K. O. Namigai, C. G. Rickards and G. A. De Leo, bioRxiv, 2021.10.29.466423. 2021.
CRISPR gene drives could revolutionize the control of infectious diseases by accelerating the spread of engineered traits that limit parasite transmission in wild populations. While much effort has been spent developing gene drives in mosquitoes, gene drive technology in molluscs ... |
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A decade of stability for wMel Wolbachia in natural Aedes aegypti populationsP. A. Ross, K. L. Robinson, Q. Yang, A. G. Callahan, T. L. Schmidt, J. K. Axford, M. P. Coquilleau, K. M. Staunton, M. Townsend, S. A. Ritchie, M.-J. Lau, X. Gu and A. A. Hoffmann, bioRxiv, 2021.10.27.466190. 2021.
Mosquitoes carrying Wolbachia endosymbionts are being released in many countries for arbovirus control. The wMel strain of Wolbachia blocks Aedes-borne virus transmission and can spread throughout mosquito populations by inducing cytoplasmic incompatibility. Aedes aegypti ... |
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Novel Symbiotic Genome-Scale Model Reveals Wolbachia’s Arboviral Pathogen Blocking Mechanism in Aedes aegyptiN. E. Jiménez, Z. P. Gerdtzen, Á. Olivera-Nappa, J. C. Salgado and C. Conca, mBio, e0156321. 2021.Arboviral diseases such as Zika and Dengue have been on the rise mainly due to climate change, and the development of new treatments and strategies to limit their spreading is needed. The use of Wolbachia as an approach for disease control has motivated new research related to ... |
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Spatial modelling for population replacement of mosquito vectors at continental scaleN. J. Beeton, A. Wilkins, A. Ickowicz, K. R. Hayes and G. R. Hosack, bioRxiv, 2021.10.06.463299. 2021.
We explore transmission of the gene drive between the subspecies, different hybridisation mechanisms, the effects of both local dispersal and potential wind-aided migration to the spread, and the development of resistance to the gene drive. We find that given best current ... |
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Wolbachia-Conferred Antiviral Protection Is Determined by Developmental TemperatureE. Chrostek, N. Martins, M. S. Marialva and L. Teixeira, mBio, e0292320. 2021.
Overall, we show that Wolbachia-conferred antiviral protection is temperature dependent, being present or absent depending on the environmental conditions. This interaction likely impacts Wolbachia-host interactions in nature and, as a result, frequencies of host and symbionts in ... |
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Assessment of fitness and vector competence of a New Caledonia wMel Aedes aegypti strain before field-releaseN. Pocquet, O. O’Connor, H. A. Flores, J. Tutagata, M. Pol, D. J. Hooker, C. Inizan, S. Russet, J. M. Duyvestyn, E. C. Pacidônio, D. Girault, D. da Silva Gonçalves, M. Minier, F. Touzain, E. Chalus, K. Lucien, F. Cheilan, T. Derycke, S. Laumond, C. P. Sim, PLOS Neglected Tropical Diseases, 15:e0009752. 2021.
Dengue represents a risk for almost half of the world’s population, especially throughout the tropics. In New Caledonia, dengue outbreaks have become more frequent in the past decade along with the recent circulation of chikungunya and Zika viruses. The opportunity to use the ... |
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Mosquito transgenesis for malaria controlS. Dong, Y. Dong, M. L. Simões and G. Dimopoulos, Trends in Parasitology, 2021.
Malaria is one of the deadliest diseases. Because of the ineffectiveness of current malaria-control methods, several novel mosquito vector-based control strategies have been proposed to supplement existing control strategies. Mosquito transgenesis and gene drive have emerged as ... |
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Identifying Sites for Testing Modified Mosquitoes as a Strategy to Eradicate MalariaA. Fell, UC Davis News, 2021.
In a newly published article in the journal Evolutionary Applications Professor Greg Lanzaro and his team at the Vector Genetics Laboratory, UC Davis School of Veterinary Medicine, set forth a framework for the selection of field sites in Africa best suited for testing ... |
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Gene drives gaining speedE. Bier, Nature Reviews Genetics, 2021.
Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian (>50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are highly efficient in laboratory settings, offering the potential to reduce the prevalence of vector-borne ... |
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Selection of sites for field trials of genetically engineered mosquitoes with gene driveG. C. Lanzaro, M. Campos, M. Crepeau, A. Cornel, A. Estrada, H. Gripkey, Z. Haddad, A. Kormos and S. Palomares, Evolutionary Applications, 15. 2021.
Novel malaria control strategies using genetically engineered mosquitoes (GEMs) are on the horizon. Population modification is one approach wherein mosquitoes are engineered with genes rendering them refractory to the malaria parasite, Plasmodium falciparum, coupled with a ... |
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Combating mosquito-borne diseases using genetic control technologiesG.-H. Wang, S. Gamez, R. R. Raban, J. M. Marshall, L. Alphey, M. Li, J. L. Rasgon and O. S. Akbari, Nature Communications, 12:4388. 2021.
Mosquito-borne diseases, such as dengue and malaria, pose significant global health burdens. Unfortunately, current control methods based on insecticides and environmental maintenance have fallen short of eliminating the disease burden. Scalable, deployable, genetic-based ... |
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Targeting Conserved Sequences Circumvents the Evolution of Resistance in a Viral Gene Drive against Human CytomegalovirusM. Walter, R. Perrone, E. Verdin and F. Goodrum, Journal of Virology, 95:e00802-21. 2021.
Gene drives are genetic systems designed to efficiently spread a modification through a population. They have been designed almost exclusively in eukaryotic species, especially in insects. We recently developed a CRISPR-based gene drive system in herpesviruses that relies on ... |
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Using gene drives to control malariaA. Fell, Daily News, 2021.
A group of UC scientists led by Greg Lanzaro, professor of pathology, microbiology and immunology in the UC Davis School of Veterinary Medicine, recently completed an analysis of a strategy aimed at eliminating malaria from Africa using genetically engineered mosquitoes. ... |
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Population modification strategies for malaria vector control are uniquely resilient to observed levels of gene drive resistance allelesG. C. Lanzaro, H. M. Sánchez C, T. C. Collier, J. M. Marshall and A. A. James, BioEssays, 2021.
Cas9/guide RNA (gRNA)-based gene drive systems are expected to play a transformative role in malaria elimination efforts., whether through population modification, in which the drive system contains parasite-refractory genes, or population suppression, in which the drive system ... |
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Stable high-density and maternally inherited Wolbachia infections in Anopheles moucheti and Anopheles demeilloni mosquitoesT. Walker, S. Quek, C. L. Jeffries, J. Bandibabone, V. Dhokiya, R. Bamou, M. Kristan, L. A. Messenger, A. Gidley, E. A. Hornett, E. R. Anderson, C. Cansado-Utrilla, S. Hegde, C. Bantuzeko, J. C. Stevenson, N. F. Lobo, S. C. Wagstaff, C. A. Nkondjio, S. R., Current Biology, 31:2310. 2021.
Wolbachia, a widespread bacterium that can reduce pathogen transmission in mosquitoes, has recently been reported to be present in Anopheles (An.) species. In wild populations of the An. gambiae complex, the primary vectors of Plasmodium malaria in Sub-Saharan Africa, Wolbachia ... |
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Using Wolbachia to Eliminate Dengue: Will the Virus Fight Back?M. Edenborough Kathryn, A. Flores Heather, P. Simmons Cameron, E. Fraser Johanna and C. Pierson Ted, Journal of Virology, 95:e02203-20. 2021.
Recent fieldtrials havedemonstratedthatdengue incidence can besubstantially reduced by introgressing strains of the endosymbiotic bacterium Wolbachia into Aedes aegypti mosquito populations. This strategy relies on Wolbachia reducing the susceptibility of Ae. aegypti to ... |
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Vector control: Discovery of Wolbachia in malaria vectorsP. A. Ross and A. A. Hoffmann, Current Biology, 31:R738-R740. 2021.
Wolbachia bacteria are being widely released for suppression of dengue transmitted by Aedes mosquitoes. Walker, Quek, Jeffries and colleagues present robust evidence for natural Wolbachia infections in malaria-vectoring Anopheles mosquitoes, paving the way for new ... |
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The origin of island populations of the African malaria mosquito, Anopheles coluzziiM. Campos, M. Hanemaaijer, H. Gripkey, T. C. Collier, Y. S. Lee, A. J. Cornel, J. Pinto, D. Ayala, H. Rompao and G. C. Lanzaro, Communications Biology, 4:9. 2021.
Anopheles coluzzii is a major malaria vector throughout its distribution in west-central Africa. Here we present a whole-genome study of 142 specimens from nine countries in continental Africa and three islands in the Gulf of Guinea. This sample set covers a large part of this ... |
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Selection of Sites for Field Trials of Genetically Engineered Mosquitoes with Gene DriveG. C. Lanzaro, M. Campos, M. Crepeau, A. Cornel, A. Estrada, H. Gripkey, Z. Haddad, A. Kormos, S. Palomares and W. Sharpee, bioRxiv, 2021.04.28.441877. 2021.
Novel malaria control strategies using genetically engineered mosquitoes (GEMs) are on the horizon. Population modification is one approach wherein mosquitoes are engineered with genes rendering them refractory to the malaria parasite coupled with a low-threshold, Cas9-based gene ... |
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CRISPR may help curb malaria by altering a mosquito’s gut genes, new study suggestsCornell Alliance for Science, Genetic Literacy Project, 2021.
Altering a mosquito’s gut genes to make them spread antimalarial genes to the next generation of their species shows promise as an approach to curb malaria, suggests a preliminary study published in eLife. The study is the latest in a series of steps toward using CRISPR-Cas9 ... |
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Eliminating malaria via a simple genetic modificationS. Gunn, Front Line Genomics, 2021.
Despite decades worth of research and efforts, data from 2015 onwards suggests that there has been no significant progress in reducing global malaria cases. Every year, around 400,00 people die from malaria, with over 90% of cases being within sub-Saharan Africa. The rise of ... |
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This Malaria Preventing Mosquito Is Not A GMO But Is A Science Boost For Nature – Will Activists Want To Block It?H. Campbell, science 2.0, 2021.
Mosquitoes like Aedes aegypti don't have any value ecologically. If Thanos snapped them out of existence tomorrow there is nothing they do that won't immediately be taken up by 3,000 other mosquito species, not to mention 25,000 bee species when it comes to pollination. The ... |
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Breeding Malaria Out: Scientists Engineer Mosquitos to Spread Antimalaria GenesL. Papadopoulos, INTERSTING ENGINEERING, 2021.
According to the Centers for Disease Control and Prevention (CDC), malaria is a "serious and sometimes fatal disease caused by a parasite that commonly infects a certain type of mosquito which feeds on humans." There are four types of malaria parasites: Plasmodium falciparum, P. ... |
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Curbing Malaria’s Spread by Genetic EngineeringAnonymous, Genetic Engineering & Biotechnology News, 2021.
There is an urgent need to find new ways to combat the growing mosquito resistance to pesticides and malaria parasite resistance to antimalarial drugs. Gene drives are being tested as a new approach. In a new study, researchers from the Imperial College London reported that their ... |
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New genetic modification could cut malaria spreadStaff Writers, MALAYSIA NOW, 2021.
Altering a mosquito’s gut genes to make them spread antimalarial genes to the next generation of their species shows promise as an approach to curb malaria, suggests a preliminary study published in eLife on Tuesday. The study is the latest in a series of steps being taken ... |
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Researchers Using Mutant Mosquitoes To End Malaria, Which Kills 4 Lakh Per YearM. Mohanti, India Times, 2021.
Every year, more than 22 crore people get infected with malaria and more than 4 lakh die because of it. In fact, in 2019, nearly half of the world's population was at risk of malaria. According to WHO, infants or children aged under 5 years are the most vulnerable group, ... |
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Evidence for natural hybridization and novel Wolbachia strain superinfections in the Anopheles gambiae complex from GuineaC. L. Jeffries, C. Cansado-Utrilla, A. H. Beavogui, C. Stica, E. K. Lama, M. Kristan, S. R. Irish and T. Walker, Royal Society Open Science, 8:18. 2021.
Wolbachia, a widespread bacterium which can influence mosquito-borne pathogen transmission, has recently been detected within Anopheles (An.) species that are malaria vectors in Sub-Saharan Africa. Although studies have reported Wolbachia strains in the An. gambiae complex, ... |
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Genetically modified mosquitoes for better healthD. Devis, COSMOS, 2021.
One method of preventing these mosquito-born diseases is to use insecticides to kill the mozzies and remove them, but sometimes this only works as a short term solution, or has unintended devasting effects on the ecosystem. Another method for decreasing the number of ... |
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Quantifying the risk of vector-borne disease transmission attributable to genetically modified vectorsG. R. Hosack, A. Ickowicz and K. R. Hayes, Royal Society Open Science, 8:201525. 2021.
The relative risk of disease transmission caused by the potential release of transgenic vectors, such as through sterile insect technique or gene drive systems, is assessed with comparison with wild-type vectors. The probabilistic risk framework is demonstrated with an assessment ... |
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Exploring Gene Drive Technologies in Agriculture, Biodiversity and Human DiseaseThe GBIRd Partnership and The GeneConvene Global Collaborative, Gene Drive Research Forum, 2021.
The GBIRd Partnership and The GeneConvene Global Collaborative recently collaborated through The Gene Drive Research Forum, to create and produce an engaging conversation between Drs. Fred Gould and Charles Godfray about gene drive technologies – the potential benefits and ... |
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CRISPR and the splice to survive: New gene-editing technology could be used to save species from extinction—or to eliminate them.E. Kolbert, New Yorker, 2021.
About a year ago, not long before the pandemic began, I paid a visit to the center, which is an hour southwest of Melbourne. The draw was an experiment on a species of giant toad known familiarly as the cane toad. The toad was introduced to Australia as an agent of pest control, ... |
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Next-generation tools to control biting midge populations and reduce pathogen transmissionP. Shults, L. W. Cohnstaedt, Z. N. Adelman and C. Brelsfoard, Parasites and Vectors, 14:31. 2021.
Biting midges of the genus Culicoides transmit disease-causing agents resulting in a significant economic impact on livestock industries in many parts of the world. Localized control efforts, such as removal of larval habitat or pesticide application, can be logistically ... |
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Mosquito Sexual Selection and Reproductive Control ProgramsL. J. Cator, C. A. S. Wyer and L. C. Harrington, Trends in Parasitology, 37:330-339. 2021.
The field of mosquito mating biology has experienced a considerable expansion in the past decade. Recent work has generated many key insights about specific aspects of mating behavior and physiology. Here, we synthesize these findings and classify swarming mosquito systems as ... |
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Control of malaria-transmitting mosquitoes using gene drivesT. Nolan, Philosophical Transactions of the Royal Society B: Biological Sciences, 376:20190803. 2020.
In this article, I will discuss the relative merits of this type of gene drive, as well as barriers to its technical development and to its deployment in the field as malaria control. This article is part of the theme issue ‘Novel control strategies for mosquito-borne ... |
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Mosquito population modification: the drive to malaria eradicationA. A. James, BugBitten BMC, 2020.
We have had considerable success in the past demonstrating that we can use modern molecular biological and insect transgenesis tools to make genes that prevent mosquitoes from passing on parasites (see 1 and 2). We have focused most recently on laboratory experiments to find ways ... |
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The promise of CRISPR and gene drive systems to end malaria in AfricaE. Gomez-Diaz, ARRIGE ORG, 2020.
Presentation by Elena Gómez Díaz (IPBLN-CSIC, Granada, Spain) at the ARRIGE 2020 meeting on "The promise of CRISPR and gene drive systems to end malaria in Africa". Discussion is included at the end of the Ruud de Maagd presentation.https://youtu.be/te3MJ8EZoes |
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Brave New Planet: Reshaping Nature Through Gene DrivesE. Lander, Brave New Planet, 2020.
A new technology, called gene drives, has the power to spread any genetic instructions you wish across an entire animal or plant species in the wild. It might let us restore ecosystems ravaged by invasive species, or help species adapt to climate change. And, it might save ... |
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Gene drive blocks malaria transmission in mosquitoeslabonline, labonline, 2020.
Employing a strategy known as ‘population modification’, which involves using a CRISPR-Cas9 gene drive system to introduce genes preventing parasite transmission into mosquito chromosomes, University of California (UC) researchers have made a major advance in the use of ... |
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Gene Drives: A Controversial Tool to Fight MalariaH. Albert, LABIOTECH.eu, 2020.
The possibility of creating gene drives was introduced into the scientific community in 2003 by Austin Burt, a professor at Imperial College London. Burt was studying ‘selfish genes’ that can copy themselves into a specific target DNA sequence. He suggested that these genes, ... |
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A gene-drive rescue system for the modification of malaria mosquito populationsA. Adolfi, Nature Research Bioengineering Community, 2020.
Mosquito populations can now be reliably modified using 1) antimalarial molecules that block parasite development and 2) a CRISPR-based gene drive system that mediates their rapid spreading across the vector population. |
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UC researchers pioneer more effective method of blocking malaria transmission in mosquitoesUCI, UCI News, 2020.
University of California, Irvine postdoctoral researcher Adriana Adolfi, in collaboration with colleagues at UCI, UC Berkeley and UC San Diego, followed up on the group’s pioneering effort to develop CRISPR-based gene drive systems for making mosquito vectors resistant to ... |
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Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensiA. Adolfi, V. M. Gantz, N. Jasinskiene, H.-F. Lee, K. Hwang, G. Terradas, E. A. Bulger, A. Ramaiah, J. B. Bennett, J. J. Emerson, J. M. Marshall, E. Bier and A. A. James, Nature Communications, 11:5553. 2020.
Here, we develop a recoded gene-drive rescue system for population modification of the malaria vector, Anopheles stephensi, that relieves the load in females caused by integration of the drive into the kynurenine hydroxylase gene by rescuing its function. Non-functional resistant ... |
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Engineered Gene Drives: State of Research Webinar Series by The GeneConvene Global Collaborative September-October 2020David O'Brochta and Hector Quemada, GeneConvene Global Collaborative, 2020.
A series of technical webinars on engineered gene drive technology research and development given by leading researchers in the field. |
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Viral gene drive in herpesvirusesM. Walter and E. Verdin, Nature Communications, 11:4884. 2020.
Here, we report on a gene drive system that allows the spread of an engineered trait in populations of DNA viruses and, in particular, herpesviruses. |
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Risks of releasing gene drives mosquitoes – a possible future scenarioTestbiotech, Testbiotech, 2020.
Genetically engineering the genome of an organism with gene drive means that it will be replicated in every following generation. This allows the altered gene to spread rapidly throughout natural populations, which may be decimated or even eradicated. The video contains both ... |
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A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage populationJ. Champer, E. Yang, E. Lee, J. Liu, A. G. Clark and P. W. Messer, Proceedings of the National Academy of Sciences, 202004373. 2020.
Here, we present a CRISPR homing drive that was able to successfully spread to all individuals in a laboratory cage study in Drosophila melanogaster without any apparent evolution of resistance. |
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GeneConvene Global Collaborative Webinar SeriesDavid O'Brochta and Hector Quemada, GeneConvene Global Collaborative, 2020.
This is a series of public scientific and technical seminars by researchers actively involved in the research and development of engineered gene drive and related systems. Presentations will be aimed at other researchers and scientists, highlighting the latest investigations in ... |
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Anthony James / Mosquito ModificationBig Picture Science, SETI Institute, 2020.
Anthony James, vector biologist at the University of California, Irvine, describeshow we might genetically modify mosquitoes to make them unable to pass malaria on to humans. |
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Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiaeR. Carballar-Lejarazú, C. Ogaugwu, T. Tushar, A. Kelsey, T. B. Pham, J. Murphy, H. Schmidt, Y. Lee, G. C. Lanzaro and A. A. James, Proceedings of the National Academy of Sciences, 202010214. 2020.
We show here that the Cas9/guide RNA-based gene-drive components of a genetically-engineered malaria mosquito vector, Anopheles gambiae, achieve key target product profile requirements for efficacy and performance. |
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Engineered Reproductively Isolated Species Drive Reversible Population ReplacementA. Buchman, I. Shriner, T. Yang, J. Liu, I. Antoshechkin, J. M. Marshall, M. W. Perry and O. S. Akbari, bioRxiv, 2020.08.09.242982. 2020.
Engineered reproductive species barriers are useful for impeding gene flow and driving desirable genes into wild populations in a reversible threshold-dependent manner. We engineer multiple reproductively isolated SPECIES and demonstrate their threshold-dependent gene drive ... |
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Gene Drive Webinars -ENSSER, CSS, VDW and SCEuropean Network of Scientists for Social and Environmental Responsibility, , 2020.
This series of 5 Webinars by some of the authors of the interdisciplinary Gene Drive Report (2019) and were organised by four organisations of independent scientists: the European Network of Scientists for Social and Environmental Responsibility (ENSSER), Critical Scientists ... |
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Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacementA. Hoermann, S. Tapanelli, P. Capriotti, E. K. G. Masters, T. Habtewold, G. K. Christophides and N. Windbichler, bioRxiv, 2020.
Here we explore how minimal genetic modifications of endogenous mosquito genes can convert them directly into non-autonomous gene drives without disrupting their expression. |
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Gene editing and the war against malariaE. Bier and E. Sobber, American Scientist, 102:162. 2020.
Malaria is a devastating disease transmitted from person to person by mosquitoes. It kills more than 400,000 people per year, more than half of those deaths being children 5 years old or younger. CRISPR (clustered regularly interspaced short palindromic repeats) is a new ... |
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Biomphalaria glabrata Granulin Increases Resistance to Schistosoma mansoni Infection in Several Biomphalaria Species and Induces the Production of Reactive Oxygen Species by HaemocytesJ. R. Hambrook, A. A. Gharamah, E. A. Pila, S. Hussein and P. C. Hanington, Genes, 11:12. 2019.
In this study, we demonstrate that in vivo addition of Biomphalaria glabrata pro-granulin (BgGRN) can reduce Schistosoma mansoni infection success in numerous Biomphalaria sp. when challenged with different S. mansoni strains. We also demonstrate that cleavage of BgGRN into ... |
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Malaysia Wolbachia trials: Battling dengue and other mosquito-borne viruses, 2019. |
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Possible replacement of malaria mosquitoesS. Avery Jones, Transactions of The Royal Society of Tropical Medicine and Hygiene, 51:469-470. 1957.
Sir,--The purpose of this letter is to draw the attention of research workers in control of mosquito colonies to the possible value of investigating the factors governing the infection of mosquitoes with parasites of human malaria. If a strain of a vector species could be ... |
