Perspectives

Opinions on and about gene drive technologies and their uses.

Just Say No to Agricultural Gene Drives

Bassey-Orovwuje, M.,  Project Syndicate,  2018.
By forcing laboratory-made genes on an entire population or species, cutting-edge gene-drive technologies have the power to transform entire ecosystems in one fell swoop. But where leading industrial agriculture firms see dollar signs, farmers in the regions where gene drives ...
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Gene drive organisms: Warning of risks due to uncontrolled releases

Bender, S.T., C.,  Testbiotech,  2018.

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Gene drive organisms: Warning of risks due to uncontrolled releases

Then, C,  Testbiotech,  2018.
The German Ministry for the Environment has in response to an open letter sent by several civil society organisations issued a statement very critical of genetically engineered organisms carrying a so-called gene drive. The ministry announced that it will take action on an ...
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Forcing the Farm

etc group,  etc group,  2018.
This report is being issued as an alert to governments, civil society organisations and grassroots movements. It points to how gene drives, while promoted as a tool for medicine and conservation, will find their real use in food and farming by agribusiness. It calls for a pause ...
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Letter: Gene Drive and Trust in Science

Boëte, C.,  Gene Watch,  2018.
Committee of Responsible Genetics
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Considerations for the governance of gene drive organisms

Rudenko, L.P., Megan J.; Oye, Kenneth,  Pathogens and Global Health,  2018.
Governance is a broader and more flexible concept than statute-driven regulations as it incorporates components outside the latter?s remit. Considerations of governance are critical in the development of emerging biotechnologies such as gene drive organisms. These have been ...
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Editing nature: Local roots of global governance

Kofler, N.C., James P.; Kuzma, Jennifer; Marris, Emma; Esvelt, Kevin; Nelson, Michael Paul; Newhouse, Andrew; Rothschild, Lynn J.; Vigliotti, Vivian S.; Semenov, Misha; Jacobsen, Rowan; Dahlman, James E.; Prince, Shannon; Caccone, Adalgisa; Brown, Timothy,  Science,  2018.

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Transgenic Mosquitoes – Fact or Fiction?

Wilke, A. B. B., J. C. Beier and G. Benelli,  Trends in Parasitology,  34:456-465. 2018.
echnologies for controlling mosquito vectors based on genetic manipulation and the release of genetically modified mosquitoes (GMMs) are gaining ground. However, concrete epidemiological evidence of their effectiveness, sustainability, and impact on the environment and nontarget ...
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Conservation demands safe gene drive

K. M. Esvelt and N. J. Gemmell,  PLOS Biology,  15:e2003850. 2017.
Here, we explore the risk of accidental spread posed by self-propagating gene drive technologies, highlight new gene drive designs that might achieve better outcomes, and explain why we need open and international discussions concerning a technology that could have global ...
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Using CRISPR-based gene drive for agriculture pest control

V. Courtier-Orgogozo, B. Morizot and C. Boëte,  EMBO Reports,  18:1481. 2017.
The authors respond to comments to their publication 10.15252/embr.201744205
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Agricultural pest control with CRISPR-based gene drive: time for public debate

V. Courtier-Orgogozo, B. Morizot and C. Boëte,  EMBO Reports,  18:878-880. 2017.
Gene drive technology to control disease vectors or pests has great potential for addressing humanitarian and public health problems. Its application for pest control in agriculture, however, raises important environmental, social and ethical issues.
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National Academies hit the brakes on gene drive-modified organisms

Abbasi, J.,  JAMA-Journal of the American Medical Association,  316:482-483. 2016.
Despite their potential for fighting Zika, malaria, and other public health scourges, organisms that have been engineered to quickly spread genetic modifications through a population—and possibly an entire species—are not ready for release into the wild, a committee of ...
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Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values

U. S. National Academies of Sciences, Engineering, and Medicine,  The National Academies Press,  2016.
Scientists have studied gene drives for more than 50 years. The development of a powerful genome editing tool in 2012, CRISPR/Cas9,1 led to recent breakthroughs in gene drive research that built on that half century’s worth of knowledge, and stimulated new discussion of the ...
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Opinion: Is CRISPR-based gene drive a biocontrol silver bullet or global conservation threat?

Webber, BLR, S.; Edwards, O. R.,  Proceedings of the National Academy of Sciences of the United States of America,  112:10565-10567. 2015.
Scientists have recognized the potential for applying gene drive technologies to the control of invasive species for several years, yet debate about the application of gene drive has been primarily restricted to mosquitoes. Recent developments in clustered regularly interspaced ...
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Safeguarding gene drive experiments in the laboratory

Akbari, OSB, H. J.; Bier, E.; Bullock, S. L.; Burt, A.; Church, G. M.; Cook, K. R.; Duchek, P.; Edwards, O. R.; Esvelt, K. M.; Gantz, V. M.; Golic, K. G.; Gratz, S. J.; Harrison, M. M.; Hayes, K. R.; James, A. A.; Kaufman, T. C.; Knoblich, J.; Malik, H. S.; Matthews, K. A.; O'Connor-Giles, K. M.; Parks, A. L.; Perrimon, N.; Port, F.; Russell, S.; Ueda, R.; Wildonger, J.,  Science,  349:927-929. 2015.
Gene drive systems promote the spread of genetic elements through populations by assuring they are inherited more often than Mendelian segregation would predict (see the figure). Natural examples of gene drive from Drosophila include sex-ratio meiotic drive, segregation ...
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Concerning RNA-guided gene drives for the alteration of wild populations

Esvelt, KMS, Andrea L.; Catteruccia, Flaminia; Church, George M.,  eLife,  3:e03401. 2014.
Gene drives may be capable of addressing ecological problems by altering entire; populations of wild organisms, but their use has remained largely theoretical due to technical; constraints. Here we consider the potential for RNA-guided gene drives based on the CRISPR; nuclease ...
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