Keywords: governance

iGEM and Gene Drives: A Case Study for Governance

P. Millett, T. Alexanian, M. J. Palmer, S. W. Evans, T. Kuiken and K. Oye,  Health Security,  2022.
Gene drives have already challenged governance systems. In this case study, we explore the International Genetically Engineered Machine (iGEM) competition's experiences in gene drive-related research and lessons in developing, revising, and implementing a governance system. ...
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Procedurally Robust Risk Assessment Framework for Novel Genetically Engineered Organisms and Gene Drives

Kuzma, J.,  Regulation and Governance,  15:1144-1165. 2021.
In this article, a new framework for improving risk assessments of novel genetically engineered organisms (GEOs) is developed and applied. The Procedurally Robust Risk Assessment Framework (PRRAF) provides a set of principles and criteria for assessing and enhancing risk ...
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Weltnaturschutzunion sucht Position

Anonymous,  Informationsdienst Gentechnik,  2021.
Die Weltnaturschutzunion IUCN will in den nächsten drei Jahren eine breite interne Diskussion führen, ob Gentechnik und Gene Drives im Naturschutz eingesetzt werden sollen. Mit diesem Beschluss ist der Versuch gentechnikfreundlicher Organisationen, mit Artenschutz-Argumenten ...
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Calling the latest gene technologies ‘natural’ is a semantic distraction — they must still be regulated

J. A. Heinemann, D. J. Paull, S. Walker and B. Kurenbach,  The Conversation,  2021.
Legislators around the world are being asked to reconsider how to regulate the latest developments in gene technology, genome editing and gene silencing. Both the European Court of Justice and the New Zealand High Court have ruled that genome editing techniques should remain ...
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New report demands moratorium on gene drives

GM Watch,  GM Watch,  2021.
To help the public understand what's at stake, the Germany-based NGO Save Our Seeds (SOS) has published a report, "Gene Drives: The New Dimension of Genetic Engineering", which can be downloaded as a pdf document. The report provides a scientifically founded overview of how ...
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Gene Drive Organisms: A new dimension of genetic engineering

V. Henn and M. Imken,  Save Our Seeds,  2021.
Enabled by new genetic engineering techniques such as CRISPR/Cas9, so-called gene drives have been developed in recent years that enable humans to spread new genes throughout the genome of wild animal populations. Gene drives force the inheritance of newly introduced genes to be ...
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The viral era

B. Giese,  EMBO reports,  22:e53229. 2021.
New biotechnologies such as gene drives and engineered viruses herald a viral era that would give humans exceptional power over any organism at the level of the genotype. In synthetic biology, orthogonality—in the sense of lack of interference—between different systems or ...
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The international governance of gene drive organisms

F. Rabitz,  Environmental Politics,  2021.
Gene Drive Organisms (GDOs) are a proposed biotechnological intervention that might generate significant benefits for the conservation and sustainable use of biological diversity while also raising critical biosafety issues. Despite their inevitable transboundary effects, their ...
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Earth system interventions as technologies of the Anthropocene

J. L. Reynolds,  Environmental Innovation and Societal Transitions,  40:132-146. 2021.
Earth system interventions (ESIs)—intentional large-scale interventions in Earth systems—are not entirely new. However, in response to threats to sustainability, particularly from climate change and biodiversity loss, some scientists and others are researching, developing, ...
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The legal regulation of gene drive technologies

C. Elves,  Univeristy of Oxford,  2021.
Gene drive technologies purport to provide a panacea and yet in doing so present unprecedented risks that threaten to change, potentially irreversibly, the way in which we live in the world. Gene drive technologies raise questions about what ends societies ought to seek for their ...
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Selection of Sites for Field Trials of Genetically Engineered Mosquitoes with Gene Drive

G. C. Lanzaro, M. Campos, M. Crepeau, A. Cornel, A. Estrada, H. Gripkey, Z. Haddad, A. Kormos, S. Palomares and W. Sharpee,  bioRxiv,  2021.04.28.441877. 2021.
Novel malaria control strategies using genetically engineered mosquitoes (GEMs) are on the horizon. Population modification is one approach wherein mosquitoes are engineered with genes rendering them refractory to the malaria parasite coupled with a low-threshold, Cas9-based gene ...
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How do local communities participate in gene drive research?

Outreach Network for Gene Drive Research,  Outreach Network for Gene Drive Research,  2021.

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US Gene Drive Governance: A Special Feature in Health Security

L. Warmbrod, A. Kobokovich, R. West, G. K. Gronvall and M. Montague,  Health Security,  19:131-132. 2021.
The novel potential of gene drives and related genetic pest control measures highlights a gap in the oversight of products using such technologies in the United States. The US Coordinated Framework for Regulation of Biotechnology, as applied by US Environmental Protection Agency, ...
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Ethics of Genome Editing

European Group on Ethics,  European Group on Ethics in Science and New Technologies,  2021.
This Opinion addresses the profound ethical questions raised and revived by them. It analyses various domains of application, from human health to animal experimentation, from livestock breeding to crop variety and to gene drives. With its wide view across areas, it identifies ...
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Differentiated impacts of human interventions on nature: Scaling the conversation on regulation of gene technologies

J. A. Heinemann, D. J. Paull, S. Walker and B. Kurenbach,  Elementa: Science of the Anthropocene,  9. 2021.
Biotechnology describes a range of human activities in medicine, agriculture, and environmental management. One biotechnology in particular, gene technology, continues to evolve both in capacity and potential to benefit and harm society. The purpose of this article is to offer a ...
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Evaluating Gene Drive Approaches for Public Benefit

M. R. Santos,  GMOs: Implications for Biodiversity Conservation and Ecological Processes,  2020.
Gene drive approaches—those which bias inheritance of a genetic element in a population of sexually reproducing organisms—have the potential to provide important public benefits. The spread of selected genetic elements in wild populations of organisms may help address certain ...
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Engineered Gene Drives: Ecological, Environmental, and Societal Concerns

J. Kuzma,  GMOs: Implications for Biodiversity Conservation and Ecological Processes,  2020.
This chapter overviews the types, purposes, and potential impacts of gene drive organisms (GDOs) and discusses challenges with foreseeing and assessing these impacts prior to their environmental release. It concludes with a few examples of risk analysis methods and governance ...
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Transformation and slippage in co-production ambitions for global technology development: The case of gene drive

K. Ledingham and S. Hartley,  Environmental Science & Policy,  116:78-85. 2020.
Co-production is an increasingly popular framework for knowledge generation, evaluation and decision making. Despite its potential to open up decisions and practices to the input of others, co-production regularly falls short of its transformative ambitions. Through documentary ...
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Engineering biological diversity: the international governance of synthetic biology, gene drives, and de-extinction for conservation

J. L. Reynolds,  Current Opinion in Environmental Sustainability,  49:1-6. 2020.
In the face of insufficient progress in conserving and restoring biodiversity, the in situ use of advanced genetic modification, gene drives, and other biotechnologies for conservation purposes are being considered, researched, and developed. This paper introduces the methods, ...
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Brave New Planet: Reshaping Nature Through Gene Drives

E. Lander,  Brave New Planet,  2020.
A new technology, called gene drives, has the power to spread any genetic instructions you wish across an entire animal or plant species in the wild. It might let us restore ecosystems ravaged by invasive species, or help species adapt to climate change. And, it might save ...
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Engineered Gene Drives: Policy and Regulatory Considerations Webinar Series by The GeneConvene Global Collaborative October-December 2020

Hector Quemada and David O'Brochta,  GeneConvene Global Collaborative,  2020.
In this series of webinars the regulatory and policy challenges of moving new innovative genetic biocontrol products such as gene drive technologies to the field will be featured. Each seminar will be ~60 minutes in length followed by questions and answers.
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Engineered Gene Drives: Regulatory and Policy Considerations Webinar Series by The GeneConvene Global Collaborative October-December 2020

Hector Quemada and David O'Brochta,  GeneConvene Global Collaborative,  2020.
This is series of webinars the regulatory and policy challenges of moving new innovative genetic biocontrol products such as gene drive technologies to the field will be featured.
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GeneConvene Global Collaborative Webinar Series Oct-Dec 2020

Hector Quemada and David O'Brochta,  GeneConvene Global Collaborative,  2020.
This is series of webinars the regulatory and policy challenges of moving new innovative genetic biocontrol products such as gene drive technologies to the field will be featured.
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Global citizen deliberation on genome editing

J. S. Dryzek, D. Nicol, S. Niemeyer, S. Pemberton, N. Curato, A. Bächtiger, P. Batterham, B. Bedsted, S. Burall, M. Burgess, G. Burgio, Y. Castelfranchi, H. Chneiweiss, G. Church, M. Crossley, J. de Vries, M. Farooque, M. Hammond, B. He, R. Mendonça, J.,  Science,  369:1435. 2020.
Here we show how, as the global governance vacuum is filled, deliberation by a global citizens' assembly should play a role, for legitimate and effective governance.
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Responsible innovation in biotechnology: Stakeholder attitudes and implications for research policy

P. Roberts, J. Herkert and J. Kuzma,  Elementa,  2020.
Using a mixed methods approach, we analyzed the attitudes of different biotechnology stakeholders, particularly those working in areas related to genetically modified organisms (GMOs) in agriculture and the environment, towards the principles and practices of RI. Homogenous focus ...
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Global Governing Bodies: A Pathway for Gene Drive Governance for Vector Mosquito Control

A. Kelsey, D. Stillinger, T. B. Pham, J. Murphy, S. Firth and R. Carballar-Lejarazú,  American Journal of Tropical Medicine and Hygiene,  2020.
We examined the current institutions and governing bodies among various continents that could have an impact on gene drive governance or the potential to adapt to its future use. Possible governance strategies also are proposed that seek to bridge gaps and promote an ethically ...
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Providing a policy framework for responsible gene drive research: an analysis of the existing governance landscape and priority areas for further research

D. Thizy, I. Coche and J. de Vries,  Wellcome Open Research,  2020.
D. Thizy, I. Coche and J. de Vries (2020). Wellcome Open Research. doi: 10.12688/wellcomeopenres.16023.1 In this manuscript, we review the existing regulatory landscape around gene drive research and map areas of convergence and divergence, as well as gaps in relation to ...
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Who is afraid of genetically modified mosquitoes?

G. Odogwu,  The PUNCH,  2020.
Genetically Modified Organisms have raised concerns in our clime, the same way they have in other countries of the world – where a clear line is drawn between the pro and the anti-GMO citizens. Nonetheless, this modern biotechnological technique is still at its infancy here. As ...
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Mosquito district workshop focuses on Keys trials

S. Matthis,  KEYSWEEKLY,  2020.
Now that the Oxitec “Friendly Mosquito” trials have been approved by the federal and state governments, it’s up to the Florida Keys Mosquito Control District to decide if, when and where to embrace the technology said to decrease the chances of mosquito-borne diseases such ...
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Genetically modified mosquitoes to be released in Florida and Texas

O. Ron,  The Jerusalem Post,  2020.
A plan to release 750 million genetically modified mosquitoes in Florida and Texas has been approved, The Guardian reported. According to the plan, the Aedes aegypti mosquitoes will be released into the wild, as they contain a special protein that would kill female offspring, ...
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Before genetically modified mosquitoes are released, we need a better EPA

N. Kofler and J. Kuzma,  The Boston Globe,  2020.
While the attention of the American public has rightfully been focused on the COVID-19 pandemic, its associated racial disparities, and broader issues of structural racism, the US government made a serious public health decision — one that could affect our health and our ...
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Are Genetically Modified Mosquitoes Coming To Florida?

M. Taylor,  Y100,  2020.
I'm not even going to lie, mosquitoes should be classified under domestic terrorism. The flying, biting bugs you can barely see wreak havoc on my life every single summer. I'm not sure if I'm allergic to them, but whenever I'm bit by them, that area of my skin swells up. It's the ...
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The Florida Keys are one step closer to getting genetically modified mosquitoes

D. Goodhue,  Miami Herald,  2020.
An international biotech company is one step closer to being able to release genetically modified mosquitoes in the Florida Keys. The Florida Department of Agriculture and Consumer Services this week granted Oxitec an experimental use permit to release potentially millions of ...
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Synthetic Biology: Research Needs for Assessing Environmental Impacts

C. M. Warner, S. R. Carter, R. F. Lance, F. H. Crocker, H. N. Meeks, B. L. Adams, M. L. Magnuson, T. Rycroft, K. Pokrzywinski and E. J. Perkins,  Synthetic Biology 2020: Frontiers in Risk Analysis and Governance,  2019.
Synthetic biology and its applications have the potential to greatly improve economic development, public health, environmental stewardship, technological advancement, and many other areas. In May 2017, sixty individuals gathered in Lexington, Massachusetts for a workshop ...
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Sustainability as a framework for considering gene drive mice for invasive rodent eradication

Barnhill-Dilling, SKS, M.; Blondel, D. V.; Godwin, J.,  Sustainability,  11:1334. 2019.
Gene drives represent a dynamic and controversial set of technologies with applications that range from mosquito control to the conservation of biological diversity on islands. Currently, gene drives are being developed in mice that may one day serve as an important tool for ...
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Anomaly handling and the politics of gene drives

S. W. Evans and M. J. Palmer,  Journal of Responsible Innovation,  5:S223-S242. 2018.
Decisions about the development and use of gene drives are framing broader debates about the need for fundamental changes to biotechnology regulatory systems. We summarize this debate and describe how gene drives are being constructed as potential anomalies within the regulatory ...
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Harnessing gene drive

J. Min, A. L. Smidler, D. Najjar and K. M. Esvelt,  Journal of Responsible Innovation,  5. 2018.
Determining whether, when, and how to develop gene drive interventions responsibly will be a defining challenge of our time. Here we describe capabilities, safeguards, applications, and opportunities relevant to gene drive technologies.
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A roadmap for gene drives: using institutional analysis and development to frame research needs and governance in a systems context

J. Kuzma, F. Gould, Z. Brown, J. Collins, J. Delborne, E. Frow, K. Esvelt, D. Guston, C. Leitschuh, K. Oye and S. Stauffer,  Journal of Responsible Innovation,  5:S13-S39. 2018.
This paper reports on a workshop held in February 2016 to explore the complex intersection of political, economic, ethical, and ecological risk issues associated with gene drives. Workshop participants were encouraged to use systems thinking and mapping to describe the ...
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Mapping research and governance needs for gene drives

J. Delborne, J. Kuzma, F. Gould, E. Frow, C. Leitschuh and J. Sudweeks,  Journal of Responsible Innovation,  5:S4-S12. 2018.
This special issue represents both deep and broad thinking about gene drives. The papers were first drafted nearly two years ago, and since then have been reviewed and revised to flesh out key arguments and take account of ongoing developments in the field. This field has moved ...
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Gene drives and the expanding horizon of governance

E. Fisher,  Journal of Responsible Innovation,  5:S1-S3. 2018.
Like other areas of emerging science and technology that trigger prolonged public debate over their transformative prospects, gene drives simultaneously generate prospects for new knowledge, hoped-for benefits, and formidable concerns. Their ability to bias inheritance of and in ...
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