An economic evaluation of Wolbachia deployments for dengue control in Vietnam

H. C. Turner, D. L. Quyen, R. Dias, P. T. Huong, C. P. Simmons and K. L. Anders,  PLOS Neglected Tropical Diseases,  17:e0011356. 2023.
INTRODUCTION: Dengue is a major public health challenge and a growing problem due to climate change. The release of Aedes aegypti mosquitoes infected with the intracellular bacterium Wolbachia is a novel form of vector control against dengue. However, there remains a need to ...
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The optimal strategy of incompatible insect technique (IIT) using Wolbachia and the application to malaria control

T. Matsufuji and S. Seirin-Lee,  Journal of Theoretical Biology,  569:111519. 2023.
For decades, techniques to control vector population with low environmental impact have been widely explored in both field and theoretical studies. The incompatible insect technique (IIT) using Wolbachia, based on cytoplasmic incompatibility, is a technique that ...
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Leveraging eco-evolutionary models for gene drive risk assessment

M. A. Combs, A. J. Golnar, J. M. Overcash, A. L. Lloyd, K. R. Hayes, D. A. O’Brochta and K. M. Pepin,  Trends in Genetics,  2023.
As development of gene drive systems accelerates and diversifies, predicting outcomes for target populations and the potential for human and environmental risks requires accounting for numerous eco-evolutionary processes.Gene drive dynamic models quantify the influence of ...
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Adversarial interspecies relationships facilitate population suppression by gene drive in spatially explicit models

Y. Liu, W. Teo, H. Yang and J. Champer,  Ecology Letters,  2023.
Abstract Suppression gene drives bias their inheritance to spread through a population, potentially eliminating it when they reach high frequency. CRISPR homing suppression drives have already seen success in the laboratory, but several models predict that success may be elusive ...
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The boundary problem: Defining and delineating the community in field trials with gene drive organisms

N. de Graeff, I. Pirson, R. van der Graaf, A. L. Bredenoord and K. R. Jongsma,  Bioethics,  2023.
Despite widespread and worldwide efforts to eradicate vector-borne diseases such as malaria, these diseases continue to have an enormous negative impact on public health. For this reason, scientists are working on novel control strategies, such as gene drive technologies (GDTs). ...
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Targeting Sex Determination to Suppress Mosquito Populations

L. Ming, P. K. Nikolay, S. Ruichen, Y. Ting, D. B. Elena, J. B. Daniel, A. Igor, M. S. C. Hector, Z. Yinpeng, A. D. Nicolas, M. L. YuMin, P. S. Matthew, M. Craig, M. M. John and S. A. Omar,  bioRxiv,  2023.04.18.537404. 2023.
Each year, hundreds of millions of people are infected with arboviruses such as dengue, yellow fever, chikungunya, and Zika, which are all primarily spread by the notorious mosquito Aedes aegypti. Traditional control measures have proven insufficient, necessitating innovations. ...
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First transgenic mosquito made in Africa by Transmission Zero

H. Dunning,  Imperial College London,  2023.
Transmission Zero, a global scientific programme led by scientists at Imperial College London and the Ifakara Health Institute (IHI) of Tanzania, in partnership with the Tanzanian National Institute of Medical Research (NIMR), announces the generation of the first transgenic ...
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A gene drive is a gene drive: the debate over lumping or splitting definitions

S. L. James, D. A. O'Brochta, F. Randazzo and O. Akbari,  Nature Communications,  2023.
Gene drive technologies are being considered as a new approach to address a variety of currently intractable global problems, including to prevent disease transmission, reduce crop loss, and preserve biodiversity1. There are some outside the genetics research community who argue ...
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Synthetic gene drives as an anthropogenic evolutionary force

A. D. Cutter,  Trends in Genetics,  2023.
Genetic drive represents a fundamental evolutionary force that can exact profound change to the genetic composition of populations by biasing allele transmission. Herein I propose that the use of synthetic homing gene drives, the human-mediated analog of endogenous genetic ...
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Regulatory and policy considerations for the implementation of gene drive-modified mosquitoes to prevent malaria transmission

S. L. James, B. Dass and H. Quemada,  Transgenic Research,  2023.
Gene drive-modified mosquitoes (GDMMs) are being developed as possible new tools to prevent transmission of malaria and other mosquito-borne diseases. To date no GDMMs have yet undergone field testing. This early stage is an opportune time for developers, supporters, and possible ...
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A male-killing gene encoded by a symbiotic virus of Drosophila

D. Kageyama, T. Harumoto, K. Nagamine, A. Fujiwara, T. N. Sugimoto, A. Jouraku, M. Tamura, T. K. Katoh and M. Watada,  Nature Communications,  14:1357. 2023.
In most eukaryotes, biparentally inherited nuclear genomes and maternally inherited cytoplasmic genomes have different evolutionary interests. Strongly female-biased sex ratios that are repeatedly observed in various arthropods often result from the male-specific lethality ...
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Alleviating the burden of malaria with gene drive technologies? A biocentric analysis of the moral permissibility of modifying malaria mosquitoes

N. de Graeff, K. R. Jongsma and A. L. Bredenoord,  Journal of Medical Ethics,  2023.
Gene drive technologies (GDTs) have been proposed as a potential new way to alleviate the burden of malaria, yet have also raised ethical questions. A central ethical question regarding GDTs relates to whether it is morally permissible to intentionally modify or eradicate ...
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Next-generation CRISPR gene-drive systems using Cas12a nuclease

S. Sanz Juste, E. M. Okamoto, X. Feng and V. L. Del Amo,  bioRxiv,  2023.02.20.529271. 2023.
One method for reducing the impact of vector-borne diseases is through the use of CRISPR-based gene drives, which manipulate insect populations due to their ability to rapidly propagate desired genetic traits into a target population. However, all current gene drives employ a ...
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From the Lab to the Field: Long-Distance Transport of Sterile Aedes Mosquitoes

H. Maïga, M. T. Bakhoum, W. Mamai, G. Diouf, N. S. Bimbilé Somda, T. Wallner, C. Martina, S. S. Kotla, O. B. Masso, H. Yamada, B. B. D. Sow, A. G. Fall and J. Bouyer,  Insects,  14. 2023.
Pilot programs of the sterile insect technique (SIT) against Aedes aegypti may rely on importing significant and consistent numbers of high-quality sterile males from a distant mass rearing factory. As such, long-distance mass transport of sterile males may contribute to meet ...
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Review of gene drive modelling and implications for risk assessment of gene drive organisms

J. L. Frieß, C. R. Lalyer, B. Giese, S. Simon and M. Otto,  Ecological Modelling,  478:110285. 2023.
Synthetic gene drive (GD) systems constitute a form of novel invasive environmental biotechnology with far-reaching consequences beyond those of other known genetically modified organisms (GMOs). During the last 10 years, the development of GD systems has been closely linked to ...
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The suppressive potential of a gene drive in populations of invasive social wasps is currently limited

A. B. Meiborg, N. R. Faber, B. A. Taylor, B. A. Harpur and G. Gorjanc,  Scientific Reports,  13:1640. 2023.
Social insects are very successful invasive species, and the continued increase of global trade and transportation has exacerbated this problem. The yellow-legged hornet, Vespa velutina nigrithorax (henceforth Asian hornet), is drastically expanding its range in Western Europe. ...
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Assessing potential hybridization between a hypothetical gene drive-modified Drosophila suzukii and nontarget Drosophila species

S. Wolf, J. Collatz, J. Enkerli, F. Widmer and J. Romeis,  Risk Analysis,  2023.
Genetically engineered gene drives (geGD) are potentially powerful tools for suppressing or even eradicating populations of pest insects. Before living geGD insects can be released into the environment, they must pass an environmental risk assessment to ensure that their release ...
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Bypassing Mendel’s First Law: Transmission Ratio Distortion in Mammals

G. Friocourt, A. Perrin, P. A. Saunders, E. Nikalayevich, C. Voisset, C. Coutton, G. Martinez and F. Morel,  International Journal Molecular Sciences,  24. 2023.
Mendel's law of segregation states that the two alleles at a diploid locus should be transmitted equally to the progeny. A genetic segregation distortion, also referred to as transmission ratio distortion (TRD), is a statistically significant deviation from this rule. TRD has ...
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Environmental, Socio-economic, and Health Impact Assessment (ESHIA) for Gene Drive Organisms

isaaa Inc. and Outreach Network for Gene Drive Research,  ISAAA,  2023.
Understanding the possible positive and negative impacts that gene drive organisms could have on the environment and people is essential before these technologies are considered for release, whether for research purposes or for use. Different impacts are assessed through ...
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Gene editing and agrifood systems

FAO,  FAO,  2022.
Gene-editing technologies represent a promising new tool for plant and animal breeding in low- and middle-income countries. They enhance precision and efficiency over current breeding methods and could lead to rapid development of improved plant varieties and animal breeds. ...
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