Gene Drive Technology in the News
Imperial College London hosts West African journalists for science media programme
35528Nana Appiah Acquaye, Tech Review Africa, 2026-03-28 08:17:45.
Imperial College London has hosted a delegation of journalists from Ghana and Nigeria under the UK-Ghana Science, Technology and Innovation (ST&I) Media Capacity Programme. The initiative, supported by the Foreign, Commonwealth and Development Office, the British High Commission Accra, and UK in Nigeria, aims to strengthen science communication and reporting capacity among African media professionals. During their visit to Imperial’s South Kensington campus, the journalists engaged with researchers working on advanced innovations including digital diagnostics, gene drive technology to combat malaria through Transmission Zero, and sustainable energy solutions under the DIGIBAT project. At the White City campus, the delegation met innovators in sustainable plastic development at Polymateria and explored emerging trends in agritech, areas expected to shape future science reporting. The group also interacted with Ofosua Adi-Dako of the University of Ghana, currently serving as a Global Faculty Fellow at Imperial’s I-X initiative, where she is advancing pharmacology research using artificial intelligence. The programme included workshops on science journalism and engagement with researchers, concluding with a media briefing by Imperial College President Hugh Brady. Organisers say the engagement is expected to strengthen collaboration between researchers and media practitioners, enhancing the quality and impact of science communication in West Africa.
As mosquitoes go year-round in L.A., a promising fix hits a snag
35516Lila Seidman, Los Angeles Times, 2026-03-23 09:06:38.
Residents were supposed to get a respite from the ankle-nipping mosquitoes that fueled a recent surge in dengue fever in Los Angeles County. Typically, the invasive mosquitoes — called Aedes aegypti — essentially disappear from winter until early May in the region. Instead, complaints to local agencies tasked with controlling the pests spiked recently. “We have not seen them go away altogether like they have in previous years,” said Susanne Kluh, general manager for the Greater Los Angeles County Vector Control District. Their unusual presence adds to the urgency of work going on in a 40-foot shipping container tucked away in Pacoima. It's about to transform into a bustling nursery for tens of thousands of mosquitoes. This May, the district is set for the third year in a row to release legions of sterilized male mosquitoes — which don't bite — into parts of Sunland-Tujunga. The last two years were promising, with the female population in two treated neighborhoods plunging by an average of more than 80%. Yet business owners have signaled they're not willing to pay to expand it. That's thrown uncertainty into officials' goal of eventually bringing the approach to their whole service area, spanning 36 cities and unincorporated communities. “Unfortunately, that's going to be a rather expensive endeavor,” said Steve Vetrone, an assistant general manager for the district. “I can tell you right now that's not something that we can do with our current operating budget.”
Ifakara’s Transmission Zero team convenes stakeholders to review project progress
35524Ifakara Health Institute, 2026-03-19 09:32:34.
The Transmission Zero Program’s team at the Ifakara Health Institute hosted key stakeholders from government and research institutions in Dar es Salaam on March 17-18, to review progress and strengthen collaboration on the Transmission Zero project, an international research programme working to develop innovative genetic tools to stop malaria transmission. The project is African-led by Scientists from Ifakara Health Institute in collaboration with Imperial College London in the United Kingdom, National Institute for Medical Research in Tanzania and Swiss Tropical and Public Health Institute in Switzerland. This collaborative model is paramount in ensuring sustainable capacity strengthening through infrastructure development, and knowledge and technology outputs. The meeting brought together members of the National Biosafety Committee (NBC) and ministerial authorities, and representatives from the International Union for Conservation of Nature (IUCN) to discuss program progress, challenges and considerations for introducing the program at scale.
Prairie grower groups fund research projects targeting canola diseases
35513Ian MacKay, Oyen Echo, 2026-03-17 08:56:22.
Three projects intended to deal with the canola disease verticillium stripe stand out among 11 research programs that a prairie growers consortium is funding this year. Leaders of the canola agronomic research program have chosen projects that they feel are “key to advancing canola productivity and mitigating production threats,” a statement said. The organization includes SaskOilseeds and similar Manitoba and Alberta grower groups, which together are spending over $2.4 million. Results Driven Agriculture Research in Alberta is supplying over $1 million and the Western Grains Research Foundation will chip in $495,000 to bring the total planned expenditure to over $4 million. “The genetic improvement and disease risks facing canola production need to be researched to find solutions,” said Laura Reiter of Radisson, who chairs the Western Grains Research Foundation. “As capacity among public research institutions decreases, grower-led investment isn't just an option anymore, it’s critical to the longevity of our industry,” said Cheryl Westman of Vermilion, who chairs Alberta Canola’s research program. A University of Calgary scientist heads a project titled “Discovering the verticillium longisporum genetic determinants of virulence,” a University of Manitoba scientist aims to test “biocontrol-based strategies” to deal with verticillium stripe in canola and another researcher from that university will use “genetic and molecular approaches” to increase canola’s resistance to verticillium stripe.
African scientists lead in Malaria research
35518Florian Jamax, Daily News, 2026-03-16 09:10:40.
For decades, African scientists have contributed essential data to global scientific research. Increasingly, however, they are no longer just contributors. Across the continent, researchers are assuming leadership roles, designing studies, building advanced laboratories and shaping research priorities that address Africa’s most urgent health challenges. This shift marks a significant transformation in the global scientific landscape. African institutions are developing the expertise and infrastructure required to lead high-impact studies from within the continent. Rather than relying solely on external partnerships, local scientists are defining research questions and creating solutions aligned with regional public health priorities. A major scientific breakthrough published in the journal Nature in late 2025 illustrates this transition. Beyond its immediate research findings, the study symbolised the growing capacity of African science to lead complex research addressing diseases that disproportionately affect the continent.
Selfish sperm hijack Overdrive gene to kill healthy rivals
35511Lisa Potter, Phys.org, 2026-03-12 15:14:08.
A new University of Utah-led study has discovered the mechanism behind a decades-old evolutionary mystery—how "selfish chromosomes" cheat the rules of genetic inheritance. The researchers found that rogue chromosomes hijack the Overdrive (Ovd) gene to destroy rival sperm. The study is the first to identify that the Ovd gene acts as a quality control checkpoint during sperm development. Normally, Ovd detects and eliminates abnormal sperm cells. But selfish chromosomes exploit the system to kill competitors, boosting their chances of passing into the next generation. The findings, published in Nature Communications, reveal the biology behind segregation distortion, a phenomenon in which genes sway inheritance in their favor to beat the standard 50/50 odds predicted by Mendelian genetics. The team observed the scheme in two Drosophila species, each carrying completely different selfish chromosomes, which suggests that multiple genetic systems may evolve independently to exploit the same Ovd pathway.
Feral rabbit numbers are booming, so do myxomatosis and calicivirus still work, and what’s next for biocontrol?
35522Belinda Smith, ABC News, 2026-03-12 09:20:38.
If you've noticed more feral rabbits around than usual, you're right. Much of Australia is experiencing a bunny boom, driven by consecutive years of good breeding conditions. But with an estimated 200 million feral European rabbits (Oryctolagus cuniculus) currently hopping around the continent, you might also have wondered if the viruses that kept their numbers down in the past — myxoma virus and a calicivirus that causes rabbit haemorrhagic disease — still work. Heidi Kleinert, national feral rabbit management coordinator at the Centre for Invasive Species Solutions, says ideally Australia needs to develop and release a new biocontrol every 10 to 15 years to keep rabbit numbers as low as possible. "It takes time to find another effective virus that we know is targeted specifically to rabbits, and we know is proven and tested and has approval from government organisations," Ms Kleinert says. "Across Australia, we're seeing more rabbits in peri-urban and urban areas. That's why we need that continuous pipeline of biological control, because in these areas we can't use bait and toxins close to domestic housing and domestic pets." So how do myxoma and rabbit haemorrhagic disease viruses work, and what goes into finding the next bunny biocontrol weapon?
Equatorial Guinea’s high-tech push to end malaria by 2030
35501Ronald Musoke, The Independent, 2026-03-10 09:39:41.
In the humid equatorial belt of Central Africa; where dense forests, heavy rains and winding rivers create ideal breeding grounds for mosquitoes, malaria has long been a stubborn public health adversary. For Equatorial Guinea, the disease has shaped health outcomes, economic prospects and daily life for decades. Now the small oil-rich nation is attempting something few countries in malaria-endemic regions have managed: complete elimination. Speaking during a virtual press briefing held on Feb. 26, hosted by the Addis Ababa-based Africa Centres for Disease Control and Prevention, Equatorial Guinea’s Minister of Health, Social Welfare and Health Infrastructure, Mitoha Ondo’o Ayekaba, laid out an ambitious national strategy known as Vision 2030. The goal is simple but formidable—eradicate malaria across the country within the next five years. The plan builds on two decades of progress on Bioko Island and introduces a new phase of intervention combining vaccines, advanced surveillance, cutting-edge vector control and emerging technologies such as genetically modified mosquitoes. “This is a historic transition from advanced malaria control to full national elimination,” Ayekaba said. But the path from control to eradication will test the limits of science, policy and community engagement.
Liverpool School of Tropical Medicine joins the Target Malaria Consortium
35499Dr. Tony Nolan, Target Malaria: News, 2026-03-10 09:34:21.
Target Malaria has so far been working on the three widespread vectors of the Anopheles gambiae species complex: An. coluzzii, An. gambiae, and An. arabiensis. As members of a species complex, these three species are morphologically indistinguishable. Together, they are among the most important malaria vectors in sub-Saharan Africa. Although they are distinct species, they can occasionally inter-breed. In addition, Anopheles funestus is a widespread vector across sub-Saharan Africa. It is more distantly related to the gambiae species complex and is not capable of hybridising with those species. An. funestus has distinct ecological characteristics and is a highly efficient vector of malaria – its species name, funestus, means “deadly”. In some areas, it is the dominant contributor to malaria transmission. Modelling indicates that achieving the full public health impact of gene drive will require trageting of An. funestus, as malaria transmission in many regions is shared between multiple vector species. Anopheles funestus is particularly challenging to colonise and maintain in the laboratory. Our team at the Liverpool School of Tropical Medicine was among the first to demonstrate stable genetic modification of An. funestus, establishing the technical foundation required to explore gene drive approaches in this species. Through joining Target Malaria, we will extend gene drive research beyond the gambiae complex and support the development of multi-species gene drive strategies for malaria control.
Is a ‘selfish gene’ making a Utah family have twice as many boys as girls?
35478Ewen Callaway, Nature, 2026-02-27 18:24:37.
By sifting through an anonymized genealogy database, researchers have discovered a Utah family that has been having twice as many boys as girls for seven generations. It is the first clear evidence that humans might have ‘selfish genes’ that distort the sex ratio of offspring from roughly 50:50, the researchers argue in a preprint posted on bioRxiv earlier this month. The findings have not been peer-reviewed. Such sex ‘distorters’ have been discovered — and studied in great depth — in laboratory animals such as mice and flies, in which their effects can be detected through selective breeding. “If you look, more often than not, you find them,” says Nitin Phadnis, an evolutionary geneticist at the University of Utah in Salt Lake City, who co-led the study. Theoretical predictions suggest that sex distorters probably do exist in people as well, and that they could produce excesses of biological boys or girls at birth. But humans’ long generation times and low birth rates as well as ethical issues have made such genes — and other ‘selfish’ genetic elements , meaning that they bias their own transmission to future generations whether or not they improve an individual’s biological fitness — difficult to spot.
“Millions have been released.” Hawaii’s beautiful birds are dying. But scientists have a controversial plan to save them
35457James Fair, BBC Wildlife Magazine, 2026-02-24 09:58:30.
About 6-7 million years ago, common rosefinches – which are today found across a vast expanse of northern Eurasia and are even occasional winter visitors to the British Isles – island-hopped their way from the Russian Far East across the Pacific Ocean and arrived in the newly formed, volcanic land masses of Hawaii. There, a single species evolved into an extended family of 56 Hawaiian honeycreepers, many of which only barely resemble their pioneering ancestor. Take, for example, the gorgeous scarlet honeycreeper or i’iwi, with its huge downward curving bill that is perfectly adapted for extracting nectar from endemic Hawaiian flowers. At first glance, it looks nothing like a finch. It’s an amazing story, but also a tragic one, because according to the US Fish & Wildlife Service, 39 of Hawaii’s honeycreepers are extinct, and 11 of the remaining 17 are threatened. One of the biggest factors in this natural history catastrophe is avian malaria. Neither the single-celled organism that causes malaria, nor the mosquito that transmits it, are native to Hawaii, so honeycreepers and other endemic birds have almost no immunity to it. All conservationists agree that something needs to be done – and quickly – if we are to save those that remain. Step forward scientists such as Tim Harvey-Samuel, an expert in arthropod genetics at the University of Keele. Harvey-Samuel and his team are seeing whether they can “modify the mosquito population in Hawaii such that it’s no longer able to transmit avian malaria.” The idea is to insert a gene into the mosquito (Culex quinquefasciatus) so that it doesn’t allow the Plasmodium protozoan that causes malaria to complete its life-cycle.
Space Coast releases X-rayed skeeters to take bite out of dengue
35410Jim Waymer, Florida Today, 2026-01-29 10:40:25.
The Space Coast has unleashed 'nuked' skeeters in a new biological bid to neuter dengue fever. Last year, Brevard saw its first locally caught cases of the tropical disease and wound up with the most in Florida. In response, the county decided to let loose thousands of X-rayed male mosquitoes to zap the insect's next generation. Turns out an adult skeeter can survive X-ray doses more than 10 times what would kill humans. Unlike humans, once mature, most mosquito cells stop dividing, so radiation rushing through has fewer chances to distort most of its DNA. But X-rays will tear up the insect's reproductive genes enough to render the male mosquito sterile. That's among the reasons mosquito-control officials assure this time-tested method is safe and environmentally friendly. They emphasize that it's not anything like the much-more controversial gene modification of mosquitoes used in recent years in the Florida Keys. "When we're releasing, there's no voodoo," said Joe Faella, Brevard's mosquito control director.
Wolbachia mosquito release cuts dengue cases 50–80 percent
35437Mohamad Al As, Zaf Seraj, New Straits Times, 2026-01-27 18:26:15.
The release of Wolbachia-infected Aedes mosquitoes has led to a 50 to 80 per cent drop in dengue cases in several outbreak areas in Selangor, the Dewan Rakyat was told. Health Minister Datuk Seri Dr Dzulkefly Ahmad said public health studies conducted during the early phase of the programme showed encouraging results. "During the early phase of implementation, the results of public health studies in six dengue outbreak localities in Selangor showed a reduction in dengue cases between 50 per cent and 80 per cent compared with control localities," he said in a written parliamentary reply last night. He was responding to Mohd Hasnizan Harun (PN-Hulu Selangor), who asked whether the ministry has conducted comprehensive environmental and public health impact studies related to the release of Wolbachia-infected mosquitoes. Hasnizan also asked about continuous monitoring mechanisms to ensure long-term safety. Dzulkefly said the early assessments also examined the interaction between Wolbachia-infected Aedes mosquitoes and the existing mosquito population in the environment.
Three Stunning Ways Biologists Aim to Edit Animal and Plant Genes to Fight Diseases and Extinction
35386Sandy Ong, Smithsonian Magazine, 2026-01-21 16:42:41.
In the summer of 1904, Herman Merkel, chief forester at the Bronx Zoo, in New York City, was making his usual rounds across the property when he noticed something strange growing on American chestnut trees: misshapen constellations of swollen, orange-brown cankers. Unbeknownst to Merkel, his observations were the first signs of what would later be referred to as “the greatest ecological disaster in North America since the Ice Age.” Further investigation revealed that the culprit was a fungus called Cryphonectria parasitica, or chestnut blight, which slips its spores through cracks in the bark and fatally severs a tree’s water and nutrient supply. The pathogen was a stowaway that had arrived on imported Japanese chestnut trees, which are resistant—but on American soil, it proved to be a swift and merciless killer. Barely a year later, the blight had claimed nearly all the zoo’s chestnuts—as well as those in the surrounding Bronx parks. By the 1950s, it had wiped out 99 percent of the species’ population across the Eastern United States, where more than four billion of the towering trees had once so blanketed the landscape that a squirrel was said to be able to travel from Maine to Georgia on chestnut branches alone. Since then, scientists have tried, with little success, to bring the trees back from the brink. Today, American chestnuts are considered functionally extinct. Full-sized trees are hard to come by; mainly roots and shoots remain. Scientists have bred hybrid American-Chinese chestnut trees, but planting fully native species is important for ecological restoration goals, says Andrew Newhouse, director of the American Chestnut Research and Restoration Project at the State University of New York (SUNY). Thanks to an emerging field, the iconic trees—and other imperiled species—could one day be restored. The discipline, called synthetic biology, relies on editing organisms’ DNA to introduce new genes or modify existing ones, essentially reprogramming life to fight disease, clean up the environment, increase food production and more. For chestnut trees, making changes to their genome could boost their resistance to the blight.
Color-coded mosquitoes safely enables male-only releases to combat Dengue and Zika
35369Joshua Shavit, The Brighter Side of News, 2026-01-16 11:13:48.
Across much of the world, a tiny striped insect shapes whether families stay healthy or get sick. The Asian tiger mosquito carries Dengue, Zika and Chikungunya, and traditional control efforts often struggle to keep up. A new genetic trick that literally changes how these mosquitoes look could help tip the balance in your favor. Only female mosquitoes bite and pass on viruses. Males drink nectar, not blood. Many modern control programs release large numbers of males that are sterile or carry a trait that reduces survival in the next generation. When those males mate with wild females, fewer disease-carrying offspring survive. There is one big catch. These programs must release only males. If too many females slip through, they will still bite, still spread disease and may even weaken the program. Today, most facilities separate sexes by size during the pupal stage. That work is tedious, hard to automate and far from perfect. Researchers led by Doron Zaada and Prof. Philippos Papathanos at the Hebrew University of Jerusalem set out to remove that bottleneck. Their idea was simple and bold. Make male and female mosquitoes so visually different that machines, or even the human eye, can sort them at a glance. The team focused on Aedes albopictus, also known as the Asian tiger mosquito. It is aggressive, invasive and a major target for control programs worldwide. In their study, the scientists describe a “Genetic Sexing Strain” that turns sex into a visible trait. They used CRISPR gene editing to break a gene called yellow that controls dark pigment in the mosquito body. When this gene is disrupted, the insects turn pale, almost albino. The group then restored normal dark pigmentation only in males by linking a working copy of the yellow gene to nix, a sex-determining gene. Nix acts like a master switch. When it turns on in a mosquito, the insect develops as a fertile male, even if it started out genetically female. By tying yellow to nix, the team created a line in which all males are dark and all females remain pale. “This produces an engineered sex-linked trait in mosquitoes that uses the insect’s own genes,” said Prof. Papathanos. “By understanding and controlling the sex determination pathway, we were able to create a system were males and females are visually different at the genetic level.”
Scientists in Australia have created a genetically edited cane toad that gets stuck in the tadpole stage and attacks the plague before it spreads.
35365Noel Budeguer, Click Petróleo e Gás, 2026-01-16 10:59:37.
Australia has begun testing an unusual idea to combat one of the country's most persistent biological invasions: creating tadpoles of the cane toad who have never seen adults. The goal is to cut the problem off at the source, before the animals grow, leave the water, and move into new areas, increasing the impact on native wildlife. The proposal is noteworthy because it shifts the focus of control. Instead of targeting adults who have already spread out, the action targets the point where the population begins, the spawning grounds. The cane toad, a species Rhinella marina, it was introduced in Australia in 1935 and spread rapidly through northern regions. The species adapted quickly, encountered few natural barriers, and came to dominate environments where native animals cannot compete on an equal footing. Over time, the problem ceased to be isolated and became a constant threat to entire ecosystems. The adult stage is what allows the cane toad to move long distances and occupy new territories. The idea behind the project is to prevent this transition, keeping the animal confined to the aquatic environment and reducing the arrival of adults in the natural habitat. In practice, the plan attempts to halt the spread of the pest before it "jumps" out of the water. The technique uses CRISPR Cas9 to alter a point related to the hormonal control of metamorphosis. The target is the production of thyroxine, a hormone that triggers the transformation of the tadpole into an adult frog. Without this signaling, the animal remains in the aquatic phase and does not complete the cycle that would make it an even more aggressive terrestrial invader.
Researchers Use Gene Editing to Separate Male and Female Mosquitoes
35367ISAAA Inc., 2026-01-14 11:04:44.
Researchers from the Hebrew University of Jerusalem have developed a new genetic method to separate male and female mosquitoes, which is highly beneficial for large-scale mosquito control programs. Led by Doron Zaada and Prof. Philippos Papathanos, the study aims to improve existing separation strategies that are labor-intensive, difficult to scale, and rely on releasing only male mosquitoes. The study focused on the Asian Tiger mosquito (Aedes albopictus), a major carrier of diseases such as dengue, chikungunya, and Zika. Using CRISPR, the researchers developed a genetically engineered “Genetic Sexing Strain” by disrupting the mosquito's yellow pigmentation gene, then restored dark pigmentation only in males by linking the gene to nix, a “master switch” that converts females into fertile males. This resulted in a stable strain in which males are dark-colored, and females are yellow. The study also found that the yellow females lay eggs that cannot survive dry conditions, unlike wild mosquito eggs that can survive for months. The genetically converted males were shown to behave and reproduce like natural males, indicating their effectiveness for vector control programs. The researchers said that the next step is to improve the female mosquitoes' ability to survive high temperatures or specific additives used in mosquito mass-rearing biofactories.
Florida releases millions of genetically modified mosquitoes from Oxitec in the Florida Keys to try to reduce dengue and Zika by up to 95%, in a real-world experiment that divides residents and ushers in a new era of ecosystem editing.
35351Carla Teles, Click Petróleo e Gás, 2026-01-10 09:57:25.
In a quiet Florida neighborhood, things began with something that seemed mundane. Gray boxes started appearing in backyards and along the edges of mangrove swamps, accompanied by a simple instruction: fill with water and leave. Nobody saw anything special about them, just discreet containers scattered around the neighborhood. What almost nobody realized was that those boxes were capsules for a global experiment: from inside them would emerge millions of mosquitoes. Created in a laboratory, carrying a genetic code designed to attack their own species. In the following months, these boxes became the starting point for waves of millions of mosquitoes A laboratory experiment over the Florida Keys. For some residents, it looked like the beginning of an apocalyptic movie. For others, it was a desperate gamble to contain dengue and Zika outbreaks that had been approaching year after year. And behind it all was Oxitec, a British biotechnology company that transformed a common mosquito into a small flying genetic saboteur.
Researchers develop temperature-controlled gene-editing method to potentially improve efforts to control disease-carrying insects
35356Caliann Ferguson, UT Health Houston School of Public Health, 2026-01-06 09:54:29.
New research presents promising results from an innovative technique that utilizes temperature control to genetically engineer sterile populations of insects, such as mosquitoes responsible for diseases like malaria, dengue, and other vector-borne illnesses. Led by researchers at UTHealth Houston School of Public Health, the Nature Communications publication leverages historical and traditional sterilization insect techniques (SIT) and applies an innovative method that can be scaled for larger population protection. Used for decades, traditional SITs include releasing large numbers of sterile males into mosquito populations so that when they mate with wild females, no viable offspring are produced. CRISPR/Cas9-based methods have proven challenging as they require breeding two separate lines of engineered insects and carefully sorting those insects to produce and release only sterile males. Led by principal investigator Victor Lopez Del Amo, PhD, assistant professor of epidemiology, and Christina Nguyen, a research technician, who carried out most of the experiments, this promising method aims to simplify the traditional SIT by harnessing a gene-editing tool called CRISPR-Cas12a that can generate male sterility and female lethality in a temperature-controlled manner. Cas12a can be engineered to be inactive at lower temperatures and active at higher temperatures. This property enabled the team to develop a single genetically modified insect strain that possesses the genetic composition necessary to disrupt key fertility and reproductive genes.
The ‘mosquito factory’ breeding genetically-engineered insects to fight malaria
35321Rachel Schraer, The Independent, 2025-12-28 11:31:52.
A British company breeding mosquitoes whose offspring cannot spread malaria is set to start releasing the insects into Djibouti city by the end of the year. Genetically-engineered male mosquitoes hatched in boxes placed around the East African capital will produce female babies with genes that cause them to die before they reach adulthood. Only female mosquitoes bite and spread disease. The scheme is designed to slash the number of mosquitoes to reduce cases of malaria, which currently infects up to 10 per cent of the country a year. Malaria is among the world’s biggest killers of children under five. “So much has been achieved with existing tools,” like bed nets and insecticide spraying, says Neil Morrison, chief strategy officer at Oxitec, the British biotech company which produces the altered mosquitoes. “But progress is stalling” as resistance is being built up. As global funding to fight malaria reduces, thanks to cuts by the US, UK and a number of other nations, Morrison adds: “We just need to get a bit smarter in terms of how we think about controlling mosquitoes.”A piece of code is inserted into the genetic material of the mosquitoes at a research facility in the UK, before the “friendly” mosquitoes are transported to a “mosquito factory” in Djibouti, Morrison explains. A chemical antidote is then given to the mosquitoes to “switch off” the code, allowing them to survive and breed within that “factory”.
New Gene Drive Stops the Spread of Malaria—Without Killing Any Mosquitoes
35343Shelly Fan, SingularityHub, 2025-12-18 11:51:00.
Mosquitoes are an uncomfortable, itchy nuisance. But for people in sub-Saharan Africa, a bite could mean death. The pests are living incubators for the parasite that causes malaria. Roughly 600,000 people are killed by the disease each year, with most being children under five years of age. Insecticides, malaria drugs, and mosquito nets saved a million lives globally in 2024 alone. But their efficacy is waning. Mosquitoes and the malaria parasite are becoming resistant to chemical inhibitors. And consistent, perfect use of physical barriers is hard to manage for years on end, especially for children. Realizing this, scientists have turned to a drastic solution: Gene drives, a technology that skews the rules of inheritance. Rather than nature’s fifty-fifty chance of an offspring inheriting a gene from either parent, gene drives raise the possibility of a gene’s inheritance to over 90 percent—if not higher. The tweak allows a gene to rapidly spread across entire populations. In lab tests encoding gene drives that reduce female mosquito fertility, mosquito populations have collapsed. Other experimental gene drives encoding genes that block parasite reproduction have suggested they could replace a natural population with one unable to carry malaria in just a few generations.
Spot the males: New gene-editing method could transform mosquito control
35339Robert Egan, Phys.org, 2025-12-17 11:22:04.
Researchers have developed a new "color-coded" genetic method that makes it easy to distinguish male and female mosquitoes. This innovation can help solve a major bottleneck in mosquito control strategies that rely on releasing only sterile males. The approach uses gene editing to produce dark males and pale females, offering a practical and safer alternative to current sex-separation techniques. A new study led by Doron Zaada and Prof. Philippos Papathanos from the Department of Entomology at Hebrew University, introduces a powerful genetic approach for separating male and female mosquitoes, an essential step for large-scale mosquito control programs aimed at reducing the spread of infectious diseases such as Dengue, Zika, and Chikungunya. Mosquito control strategies based on the mass release of males rely on the complete removal of females, which bite and transmit disease. Existing separation methods, largely based on size differences at the pupal stage, are labor-intensive, difficult to scale, and prone to letting biting females slip through. This new study presents a genetically engineered "Genetic Sexing Strain" (GSS) of the Asian tiger mosquito (Aedes albopictus) that allows sexes to be sorted automatically based on visible pigmentation.
Genetic trick to make mosquitoes malaria resistant passes key test
35307Michael Le Page, New Scientist, 2025-12-10 17:06:06.
A genetic technology known as a gene drive could help prevent malaria by spreading genes in wild mosquitoes that stop them transmitting the parasite. Tests in a lab in Tanzania have now confirmed that one potential gene drive should achieve this if it were released in the country. “It would be a game-changing technology, that’s for sure,” says George Christophides at Imperial College London. A specific piece of DNA in the genome of an animal is normally passed on to only half its offspring, because a parent’s DNA is divided in half among egg or sperm. Gene drives increase this proportion, meaning a bit of DNA can spread rapidly through a population even if it provides no evolutionary benefit. There are many natural gene drives that work via all kinds of mechanisms – perhaps even in some human populations – and in 2013, biologists developed artificial gene drives using CRISPR gene-editing technology, which works by copying pieces of DNA from one chromosome to another. The idea is to use these drives to spread bits of DNA that block malaria transmission – but which bits? Christophides reported in 2022 that the development of malaria parasites inside mosquitoes can be greatly reduced by two tiny proteins, one derived from honeybees and the other from the African clawed frog.
This scientist is breeding billions of mosquitoes to fight disease in Brazil
35301Mariana Lenharo, Nature, 2025-12-08 17:09:18.
nside a massive factory in the industrial district of Curitiba, Brazil, millions of Aedes aegypti mosquitoes are breeding in a climate-controlled room filled with mesh cages. Every week, the facility produces more than 80 million mosquito eggs. At the heart of this effort is Luciano Moreira, a soft-spoken agricultural engineer and entomologist, who opened the factory in July as part of an effort to fight mosquito-borne illnesses in the country. At the Curitiba facility, mosquitoes are infected with a bacterium called Wolbachia, which curbs the transmission of harmful human pathogens. Their offspring are being released in Brazilian cities to help to control dengue, a deadly viral disease transmitted mainly by A. aegypti. Until recently, Wolbachia-carrying mosquitoes were released only as part of small-scale research projects. The new factory marks a shift towards nationwide adoption of the method after Brazil’s federal government recognized it as an official public-health measure to combat dengue and other mosquito-borne diseases. People credit Moreira for making the case. “He has succeeded not only in carrying out the academic work, running experiments to demonstrate the model’s effectiveness, but also in convincing political decision-makers to implement the technology,” says Pedro Lagerblad de Oliveira, a molecular entomologist at Brazil’s Federal University of Rio de Janeiro. “This is a skill that not all scientists have.”
Controversial genetically modified mosquito release paused after backlash in Qld
35305Brandon Long, Australian Broadcasting Corporation, 2025-12-05 17:32:24.
A plan to release genetically modified (GM) mosquitoes in Queensland has been paused, with the organisation behind the idea withdrawing its licence application. Oxitec Australia — a partnership between Australia's CSIRO and US biotech firm Oxitec Ltd — aimed to sell its so-called "friendly" mosquitoes to reduce the spread of diseases like dengue. The plan received backlash from scientists, health experts, and the public, but CSIRO said the step back was not due to concerns about the technology. "This decision was not related to concerns about the technology itself, rather a determination made around the early stage of the company and the necessary financial requirements of holding a licence," a CSIRO spokesperson said.
UCMI partners with Equatorial Guinea to advance the fight against malaria
35265Ana Kormos, Outreach Network for Gene Drive Research, 2025-10-30 17:22:36.
The University of California Malaria Initiative (UCMI) announced a new partnership with the Government of Equatorial Guinea on the sidelines of the United Nations General Assembly (UNGA), which took place in New York City in September. The partnership will support the implementation of Equatorial Guinea’s Vision 2030 strategy for malaria elimination. Despite progress in fighting malaria, the disease remains a major public health concern in the country, particularly in rural and under-resourced areas. Building on over two decades of impact through the MCD Global Health’s (MCD) Bioko Island Malaria Elimination Project (BIMEP), this new collaboration will support the Ministry of Health’s ongoing efforts to eliminate malaria. The long-running BIMEP project has achieved a 78 percent reduction in malaria prevalence and eliminated two major mosquito vectors on Bioko Island. As a scientific partner, UCMI will work with the Ministry of Health, National Malaria Control Program, BIMEP and MCD Global Health to advance research and support implementation of new malaria control strategies including the UCMI genetically modified mosquito. Drawing on its expertise in vector and malaria control research, UCMI will contribute to the advancement of innovative malaria control tools and strategies to ensure that Equatorial Guinea benefits from the latest scientific developments and best practices in full alignment with national priorities and community engagement.
Malaria Know More: Behind the Science of Gene Drive with Krystal Birungi
35271Malaria No More, 2025-10-29 17:39:23.
Congratulations on being named a 2025 Goalkeepers Champion by the Gates Foundation! What does this acknowledgement mean to you personally and professionally as an advocate for malaria elimination? BIRUNGI: It was pretty exciting and also very validating. Malaria has been around for so long that, for many people, it can seem like it’s no longer a big deal. It’s incredible how it can be glossed over that we’re losing over half a million people a year to a disease that we’ve been fighting for decades. You don’t often get recognized for work in this field, so it means a lot to have something I’m working towards be acknowledged. I was also delighted that this brought such a large platform to the fight against malaria. It has helped draw more attention to what we’re doing, why we’re doing it, and the potential it holds to defeat the disease. This year’s Goalkeepers event and being named a champion, is something I’m incredibly grateful for – not just for myself, but for the impact that it can have for malaria.
Innovation under pressure: bold ideas for a changing malaria landscape
35253Epstein, A., Tangena, JA., BMC Glob. Public Health, 3. 2025-10-27 10:36:07.
Innovation has never been more urgent. Encouragingly, the malaria research community is responding. Next-generation insecticide-treated nets (ITNs) [1], new indoor residual sprays (IRS) [2], and spatial emanators are reaching communities [3]. Vaccines such as R21 and RTS,S are moving from trials into wider use [4, 5]. On the treatment front, the pipeline now includes long-lasting antimalarials [6], triple combination therapies (TACTs) [7], and single-dose drugs like tafenoquine [8]. Novel approaches such as ivermectin, recently shown to reduce malaria incidence when deployed in mass drug administration campaigns, are also gaining traction [9]. Looking further ahead, early breakthroughs in gene drive in mosquitoes to bias inheritance of a specific genetic trait (like sterility or resistance to malaria) is passed on to offspring, and monoclonal antibodies, which point to bold new frontiers [10, 11]. Together, these advances represent the most significant broadening of the malaria toolkit in decades. But innovation alone will not be enough. The momentum is colliding with deep structural challenges. Funding cuts threaten to derail the rollout of new tools. Resistance is mounting: mosquitoes have developed resistance to most insecticides used for vector control, and parasites are showing reduced sensitivity to artemisinin and even lumefantrine, a key partner drug to control artemisinin resistance, in East Africa [12]. Climate change is redrawing the risk map by shifting mosquito habitats. Health systems remain fragile, weakened by COVID-19, extreme weather, and political unrest. Even when technologies are available, their potential can be weakened by regulatory delays, fragmented governance, or inequities in access and limited community trust. The path forward requires more than breakthroughs in science. Sustained progress will depend equally on the strength of delivery systems, stable financing, and governance that can translate innovation into equitable impact.
Reactions as IUCN Congress votes to adopt Policy on Synthetic Biology, rejects genetic engineering moratorium
35245EnvironNews Nigeria, 2025-10-15 09:12:00.
Following the vote at the IUCN World Conservation Congress, members have rejected a moratorium on genetic engineering of wild species (Motion 133) and adopted the IUCN Policy on Synthetic Biology (Motion 087), a move observers see as a signal of support for a science-based, case-by-case approach to innovation in conservation. The Outreach Network for Gene Drive Research has welcomed the outcome as a vote of confidence in scientific collaboration and evidence-led policymaking. In a statement, the Outreach Network for Gene Drive Research said: “As a coalition that champions the value of responsible research, we welcome the adoption of IUCN’s Policy on Synthetic Biology as a constructive, balanced and science-based approach towards the potential application of this emerging field for conservation. “The escalating biodiversity crisis poses a grave threat to the future of all life on earth, with more than a million species at risk of extinction. Synthetic biology, including genetic engineering, offers new hope for solutions that can rise to the scale and urgency of the challenge.
Cattle Q&A with Brinda Dass, GeneConvene Global Collaborative
35243Tyrell Marchant, Progressive Cattle, 2025-10-15 08:41:35.
What factors have led to the northward spread of New World screwworm (NWS) over the past year after so many decades of successful eradication in Mexico and the U.S.? DASS: The northward spread of NWS after decades of eradication reflects a convergence of biological, environmental and programmatic factors. Climate change and increasing temperatures have created favorable conditions for pupal survival and year-round reproduction, enabling rapid reinvasion from subtropical regions. NWS biology – especially females’ ability to lay multiple waves of eggs in wounds – allows populations to surge quickly even from small footholds. High-density livestock practices and insufficient inspection of animal trade further accelerate spread, with smuggling through the Darién Gap undermining surveillance. Wildlife, pets and humans act as reservoirs, compounding detection challenges. Sterile insect technique (SIT), historically successful, has been overwhelmed: Production of sterile flies cannot match population growth, forcing control lines northward. Budget constraints, political disputes and reduced funding have further weakened monitoring and response systems. Together, these dynamics explain how a long-maintained eradication barrier collapsed, allowing NWS to expand northward at alarming speed.
Should genetically modified wildlife be banned? Scientists weigh the risks
35235Mariana Lenharo, Nature, 2025-10-10 16:01:10.
The global conservation community is debating whether to ban the release of genetically modified organisms into the wild. Dozens of non-governmental organizations have called for a moratorium on field applications of synthetic biology — a technology being studied as a tool to fight diseases, control pests and help endangered species — saying that the approach has unpredictable consequences. But some researchers argue that an outright ban is too restrictive, and could have negative consequences for human health and biodiversity. A proposal for a ban will face a vote next week at a congress of the International Union for Conservation of Nature (IUCN) in Abu Dhabi. The IUCN brings together governments and civil-society organizations to guide global conservation policy. Although decisions made by its members are not legally binding, they do influence legislation in many countries, says biologist Piero Genovesi, head of the Wildlife Service at the Italian Institute for Environmental Protection and Research in Rome. If members vote in favour of the proposed ban, it “could have stronger impacts in areas like Europe or Australia, where there are many lines of research focused on developing new tools based on synthetic biology for improving the efficacy of conservation action”, Genovesi says. He is among more than 240 scientists who have so far signed an open letter asking IUCN members to reject the moratorium.
UC Malaria Initiative Expands Activities to Equatorial Guinea
35209Andy Fell, UC Davis, 2025-10-01 14:52:44.
The University of California Malaria Initiative, which includes researchers at UC Davis, will partner in the Republic of Equatorial Guinea’s Vision 2030 strategy to eliminate malaria from the Central African country. The plan, which also includes Oxford University, Tsinghua University and a MCD Global Health, was announced Sept. 24 during the United Nations General Assembly in New York. Vision 2030 builds on 20 years of experience in malaria control on Bioko island, Equatorial Guinea. This effort has led to a 78 percent reduction in malaria transmission and eliminated two major mosquitoes that transmit the disease. The program will include R21, a malaria vaccine developed at Oxford. It will also include a range of proven malaria control measures and health interventions. UCMI is focused on using genetically modified mosquitoes to eliminate malaria transmission. It is led by Professor Anthony James, Donald Bren and Distinguished Professor of Microbiology and Molecular Genetics at UC Irvine. Professor Gregory Lanzaro, Department of Pathology, Microbiology and Immunology at UC Davis School of Veterinary Medicine, is leading the translational component of this program and established a field site in the Democratic Republic of São Tomé and Príncipe, and island nation off the coast of Central Africa, where he and his team have been working since 2018. They will now expand this work in Equatorial Guinea. “We are pleased to partner with the Government of Equatorial Guinea in their pioneering malaria elimination program," Lanzaro in a news release. "Our mission is to support countries in achieving malaria elimination through responsible science, deep collaboration, and genuine community engagement. Together, we can help build a future where malaria is no longer a threat to families and communities across the region."
Biotechnology Is a Powerful Tool for Conservation
35205Emma Kovak, The Ecomodernist, 2025-09-30 15:40:23.
What do the American Chestnut tree, the black rat, and the northern white rhinoceros have in common? They are all prime targets for conservation through biotechnology. Genetic engineering could give American chestnut trees disease resistance and restore the keystone species to Eastern forests, gene drives could eliminate rats from islands and save seabirds from the invasive predators, and assisted reproduction technology could rescue the Northern white rhinoceros from the brink of extinction. The U.S. Department of Agriculture is poised to approve an American chestnut engineered to resist the blight that functionally eliminated the species from Eastern forests. Meanwhile, the International Union for Conservation of Nature (IUCN)—the world’s largest conservation network—is voting on whether to ban biotechnology outright or recommend thoughtful case-by-case evaluation. These decisions are important determinants of biotechnology’s role in the conservation toolkit. With extinction rates accelerating, conservation efforts should be able to use as many tools as possible.
From fear to leadership: Africa must embrace innovation instead of blocking it
35187Patricia Nanteza, The Observer, 2025-09-27 08:47:22.
In Burkina Faso, the Target Malaria project, a global research consortium aiming to use genetically modified mosquitoes to combat malaria, has faced a major setback. On August 18, 2025, judicial police raided the Research Institute in Health Sciences (IRSS), a key partner in the project. This raid, which scientists described as “brutal” and “humiliating”, involved sealing off offices and laboratories and treating researchers like criminals, searching even their vehicles for mosquitoes! This event occurred just one week after the project had celebrated a milestone on August 11, releasing about 16,000 genetically modified male mosquitoes in the village of Souroukoudingan, the first such release in Africa. The raid prompted Burkina Faso to announce the immediate suspension of all project activities. The Target Malaria project aims to combat malaria by using a gene drive to spread desirable genetic modifications in mosquitoes. The goal is to reduce the number of female Anopheles gambiae mosquitoes, as they are the ones that transmit malaria to humans. This can be achieved by introducing genes that produce enzymes which disrupt specific genes, such as those controlling fertility or sex determination. Since the genetic changes are self-sustaining and inheritable by a high percentage of offspring, the intervention offers a potentially cost-effective and sustainable solution for malaria control. For a country that records over 40,000 deaths from malaria each year, this pause was more than just a political decision – it was a health crisis delayed. The suspension, which followed years of preparation and a previous release of sterile mosquitoes in 2019, was a sobering reminder that Africa, while being the continent most affected by malaria, can also be the first to step back from promising innovations.
Genetically engineered mice could take the bite out of Lyme disease on Nantucket, scientists say
35149Jon LaPook, Denise Schrier Cetta, Aliza Chasan, Katie Brennan, CBS News, 2025-09-21 10:07:27.
Over the past 40 years, Dr. Timothy Lepore has been the emergency room head, sole surgeon and medical examiner on Nantucket, a small island off Cape Cod, Massachusetts. Today he runs the only private practice, where he treats dozens of patients with Lyme disease each year. About 15% of residents on the island have been afflicted with the disease, which can cause a wide range of symptoms like a fever, rash, facial paralysis, an irregular heartbeat and arthritis. Lepore, 80, may finally be able to retire if a team of scientists' dream to curb the transmission of Lyme disease on the island becomes a reality. The scientists' target is not the deer or ticks often associated with the disease: it's wild mice, the main host of Lyme bacteria. The hope is that by genetically engineering mice to be immune to Lyme and releasing them in Nantucket, the population of mice able to spread Lyme disease on the island will shrink. The problem on Nantucket can be traced back to 1926, when the community voted to import two female deer to the island to give a lone buck company. On top of that, by the 1950s, half the land on the island was put into conservation. The untamed brush and wild grasslands create an ideal ecosystem for Lyme's hosts to thrive. As the deer population grew, so did the population of ticks. Deer don't get Lyme, but female ticks feed on them, and then lay as many as 2,000 eggs in a single batch. Deer also spread the disease as thousands of them carry ticks across Nantucket. Not all ticks carry Lyme disease, and a tick bite doesn't guarantee the transmission. Even if the tick is carrying Lyme, the tick has to be attached for more than 24 hours to infect someone.
How billions of hacked mosquitoes and a vaccine could beat the deadly dengue virus
35143Lucila Pinto, Nature, 645:578-580. 2025-09-17 14:21:03.
Last month, a parade of vehicles wound its way through three cities in Brazil, releasing clouds of mosquitoes into the air. The insects all carry a secret weapon — a bacterium called Wolbachia that lowers the odds that the mosquitoes can transmit the dreaded dengue virus to humans. These infected mosquitoes are the latest weapon in Brazil’s fight against dengue, which infects millions of people in the country each year and can be fatal. A biofactory that opened in the town of Curitiba in July can produce 100 million mosquito eggs per week — making it the largest such facility in the world. The company that runs it, Wolbito do Brasil, aims to protect about 14 million Brazilians per year through its Wolbachia-infected mosquitoes. That will come as welcome news for the Brazilian health officials battling the rapidly growing threat of dengue. In 2024, the country experienced its worst outbreak yet: with 6.6 million probable cases and more than 6,300 related deaths. This year’s outbreak, although less severe, is also one of the highest on record, with 1.6 million probable cases so far (see ‘Dangerous outbreaks’). And the problem is spreading. Argentina, Colombia and Peru also experienced record-breaking outbreaks in 2024 and have seen a sustained increase in cases in recent years. Across Latin America and the Caribbean, deaths from dengue last year totalled more than 8,400 and the global figure reached more than 12,000 — the highest ever recorded for this disease.
Fruit fly tests in Greece target invasive species threat
35161Vassilis Kyriakoulis, Phys.org, 2025-09-15 15:24:50.
In a small persimmon orchard in northern Greece, scientists carefully open paper bags to release thousands of flies, in an experiment aimed at blunting the destructive impact of invasive new species. The insects are sterile male Mediterranean fruit flies (Ceratitis capitata), a pest that annually causes significant damage to crops in Naousa, where a large proportion of Greece's prominent export, the peach, is produced. But the project is ultimately aimed at curbing an even greater threat: fruit fly species from Asia, which have begun to make their appearance in southeastern Europe as climate change increases local temperatures. The four-year, EU-funded project titled REACT brings together researchers from 12 different countries including the UK, Israel and South Africa. The program has a budget of 6.65 million euros ($7.8 million). "Our approach is to locally eradicate Mediterranean fruit fly populations and then apply this knowledge to other species of interest, such as the oriental fruit fly and the peach fruit fly," said project participant Nikos Papadopoulos, a professor of Applied Entomology at the University of Thessaly. The male flies are grown at the University of Patras and are fed a bacterial supplement that makes them more active, resilient, and competitive, said George Tsiamis, the university's Laboratory of Microbiology Systems director, during a media tour organized in Naousa by the research team.
Mosquito gene drive cancellation disrupts Africa’s malaria research
35139Esther Nakkazi, Nature Africa, 2025-09-12 15:46:02.
The abrupt suspension of an anti-malarial gene drive project in Burkina Faso has disrupted plans by scientists in Uganda working on their own modified mosquitoes. The Target Malaria project was put on hold by Burkina Faso’s government in August. Facilities holding genetically modified mosquitoes were sealed, and all samples ordered to be destroyed. Male mosquitoes released in a village were also neutralised with insecticides. A gene drive sees the release of a modified species with the aim of the modification being passed to the next generation, allowing its frequency to increase rapidly in a population. The project’s freeze casts doubt on other programmes across Africa. Jonathan Kayondo, principal investigator at Target Malaria Uganda, said scientists had not anticipated the decision. “It’s surprising, because Burkina Faso scientists had gone through all the regulatory approvals and were given the go-ahead. They were not operating illegally.” For Ugandan researchers, the termination threatens to disrupt timelines, reshape field study plans, increase costs, and denies the opportunity to build on data gathered. Target Malaria is a not-for-profit international research consortium, aiming to develop genetic technologies to reduce populations of malaria-transmitting mosquitoes in Africa. Since 2012, it has operated at the Research Institute in Health Sciences (IRSS) in Bobo Dioulasso, Burkina Faso, with funding from the Gates Foundation. In 20191, the Burkina Faso team had released a small, non-gene-drive strain of genetically modified mosquitoes, whose strains carry useful traits such as reduced fertility. The modifications were not preferentially inherited, and disappear naturally over generations.
After ‘humiliating’ raid, Burkina Faso halts ‘gene drive’ project to fight malaria
35111Kai Kupferschmidt, Science, 2025-09-03 09:35:57.
On 11 August, the international nonprofit Target Malaria celebrated a milestone: In the village of Souroukoudingan, Burkina Faso, its researchers released about 16,000 male mosquitoes genetically modified to produce almost exclusively male offspring. The release, the first of its kind in Africa, was part of a project supported by the Gates Foundation that aims to rid the world of malaria using a so-called gene drive, a controversial technique to help desirable genes spread through a population fast. But a week later, that dream suffered a major setback. On 18 August, judicial police showed up at the Research Institute in Health Sciences (IRSS) in Bobo-Dioulasso, a key partner in Target Malaria, to stage what scientists described as a “brutal, humiliating” raid. According to minutes of a 26 August meeting between researchers and the country’s science minister, IRSS scientists were “treated like criminals, with their offices and laboratories sealed and marked as crime scenes.” The minutes noted that “everyone was searched, including their vehicles, on the grounds that researchers might be carrying mosquitoes in their pockets.” Four days later, the government suspended all of Target Malaria’s activities in Burkina Faso indefinitely. IRSS scientists killed the mosquitoes still living in their insectary, and the government sent a team to spray insecticides in Souroukoudingan to kill the mosquitoes released there.
This is the world’s largest ‘mosquito factory’: its goal is to stop dengue
35109Mariana Lenharo, Nature, 2025-09-03 09:20:02.
When biologist Antonio Brandão tells people that he works at a mosquito factory, they are often baffled. Why would you make more mosquitoes?, he recalls people asking. “We have enough of them.” But once he explains that the laboratory-raised insects can help to stop the spread of dengue — which strikes hundreds of thousands in Brazil each year with fever, headache and bone pain — they come around. Brandão is the production manager, not at just any mosquito factory, but at the world’s largest, located in the southern Brazilian city of Curitiba. Launched in July, the facility is expected to produce 100 million eggs a week from the mosquito Aedes aegypti. However, unlike wild A. aegypti, the main transmitter of dengue virus, those churned out by the factory carry a harmless Wolbachia bacterium that curbs the insects’ ability to spread viruses including dengue and Zika. The idea is to release the modified mosquitoes, which researchers call wolbitos, into cities in Brazil, where they will mate with their wild counterparts and the females will pass the bacterium on to their offspring, gradually converting the local population. The wolbito strategy, which is being spearheaded by the non-profit World Mosquito Program (WMP), has already shown success in Colombia, Indonesia and at home: in the Brazilian city of Niterói in the southeast, dengue cases dropped by 69% in areas where Wolbachia-carrying mosquitoes were released, compared with areas where they weren’t1. Brazil’s federal government has adopted the approach to fight dengue infections — which surged to a record 6.5 million confirmed cases in the country last year — alongside other preventive measures such as vaccines.
Are we winning the war on cane toads?
35089Tom Gurn, Particle, 2025-08-28 19:10:42.
In 1935, a species known as the giant neotropical toad (Rhinella marina) was introduced to Australia. Scientists hoped these amphibians would control native cane beetles, but cane toads quickly colonised the country and had no discernible impact on beetle populations. Many different methods are being tested to remove these warty beasts, including a toad containment zone and turning the toads into sausages. Now, almost a century later, scientists believe they have finally stumbled across a potential solution to one of the worst invasive species ever. Will clever gene-editing techniques finally rid this continent of the dreaded cane toad? Professor Emeritus Rick Shine led the team behind the new idea, based on CRISPR gene-editing techniques. “We seem to have found a chink in the toads’ armour,” says Rick. “If we could only stop their metamorphosing, we could have these eternal tadpoles,” he says. Searching for collaborators to test this cunning plan, Rick happened across molecular biologist Dr Maciej Masielko, who was immediately struck by the beauty of the idea. “We know enough about the biochemistry of metamorphosis to know what we would need to do,” says Maciej. “Like using CRISPR-Cas9 to delete a part of the cane toad’s DNA.”
Target Malaria activities suspended in Burkina Faso
35087Target Malaria, Target Malaria, 2025-08-28 18:52:04.
The National Biosafety Agency (ANB) and the National Environmental Assessment Agency (ANEVE) responded favourably in July 2025 to the authorisation request submitted by the Target Malaria Burkina Faso team based at the Institute of Health Sciences Research (IRSS) to conduct controlled releases of non gene drive genetically modified male bias mosquitoes. As part of this process, the Ethics Committee for Health Research (CERS) also issued its approval. In addition to the regulatory authorisations obtained from the ANB and ANEVE, the project received agreement from the communities of the field sites to proceed with the activities in their villages. On 11 August 2025, one small scale release of non gene drive genetically modified male bias mosquitoes took place successfully, in accord with terms and conditions of the ANB and ANEVE permits. On 18 August, the national authorities requested the Target Malaria team at IRSS to suspend all their activities. The IRSS team complied with the request. On 22 August, the Ministry of Higher Education, Research and Innovation issued a communiqué informing “the Burkinabè public that it has terminated all the activities of the project Target Malaria on its territory”. The IRSS team, as part of the Target Malaria project, has operated since 2012 in compliance with the national laws of Burkina Faso. We have engaged actively with the national authorities and stakeholders of Burkina Faso and remain ready to cooperate.
Burkina Faso says no to Bill Gates’ plan of creating modified species of mosquitoes
35044Chinedu Okafor and BI Africa Contributor, Business Insider Africa, 2025-08-24 17:02:25.
In a statement published on Friday, officials urged Target Malaria, the initiative's principal NGO, to halt "all activities" in the nation. “All samples will be destroyed according to a strict protocol,” Samuel Pare, chief official at the higher education and research ministry, said in a Friday statement. The move is part of a larger crackdown on foreign-backed NGOs functioning under the present junta. The research, which began in Burkina Faso in 2019, released its first swarm of genetically modified male mosquitoes in the hamlet of Bana, a tiny settlement of around 1,000 people in the country's west. These mosquitoes were developed to limit the reproductive rate of malaria-carrying female mosquitoes, with the long-term objective of reducing the transmission of the illness that kills hundreds of thousands of people each year in Africa. Since its first release, the program has expanded its study to other locations, most recently unleashing new batches of mutated mosquitoes only days before the government's abrupt order to suspend operations. As reported by Bloomberg, campaigns in Africa accuse Target Malaria researchers of worsening the spread.
EPA assessing risk of releasing genetically engineered mosquitoes
35046Gary West, Capital Press, 2025-08-22 17:02:34.
The Environmental Protection Agency has convened a scientific panel to help assess whether genetically engineered mosquitoes could pose a risk to humans. In a paper released Aug. 21, the EPA said that as science advances it expects more proposals to control mosquitoes by releasing males with an implanted trait that prevents their offspring from surviving. Male mosquitoes don’t bite humans, only female mosquitoes bite. But if a female mosquito picks up the genetic flaw, such as a new protein, the protein could be passed onto humans, according to the EPA. The EPA expects the number of genetically engineered female mosquitoes to be low, and it hasn’t determined whether the proteins would be hazardous to humans. But it’s looking to identify the best way to confirm a female mosquito’s salvia doesn’t have novel proteins. The test will help the EPA to assess the risk of exposure to humans. “Female mosquitoes bite humans as a means of reproductive survival and, as a result, this interaction results in a plausible pathway of exposure to novel proteins,” the EPA stated.
AUDA-NEPAD Delegation visits Target Malaria at the Uganda Virus Research Institute
35083Richard Linga and Christopher Maiso, Target Malaria, 2025-08-20 16:20:01.
Target Malaria Uganda was honored to host delegates from African member states at the Uganda Virus Research Institute. The delegates were taking part in a benchmarking visit during the East African Regional Engagement on Biosafety and Environmental Regulation for Malaria Elimination, organized by the African Union Development Agency – New Partnership for Africa’s Development (AUDA-NEPAD). The delegates were welcomed by Prof. Pontiano Kaleebu, Director of the Uganda Virus Research Institute (UVRI), who commended their interest in Uganda’s advancing research on genetically modified mosquitoes, and thanked AUDA-NEPAD for supporting regional dialogue on innovative malaria control strategies. In his speech, Dr. Johnson Wiltshire, Programme Coordinator at the AUDA-NEPAD and head of the delegation, emphasized the urgent need for Africa to adopt innovative health solutions to effectively address persistent public health challenges. He noted that for African member states to fully benefit from emerging technologies, such as gene drive, regulatory requirements must be harmonized across the region. He further highlighted the importance of ensuring quality, access, and sustainability in the implementation of such innovations.
Tanzania’s bold step toward malaria elimination
35079Guardian Correspondent, IPP Media, 2025-08-20 12:44:23.
It is both mind-boggling and frustrating that an insect with an average lifespan of just two weeks can cause so much sickness and even deaths. Today, on World Mosquito Day, 20th August, the Ifakara Health Institute (IHI) honours Sir Ronald Ross, whose landmark discovery in 1897 confirmed that mosquitoes transmit malaria. His finding not only transformed medical science but also highlighted the profound impact mosquitoes have on public health. For more than a century, his discovery—made while serving with the Indian Medical Services—has continued to remind the world that defeating malaria requires a deep understanding of parasites and efficient mosquito vectors in order to make a real impact in preventing the disease. Globally, vector control has been instrumental in saving millions of lives, mainly through Long-lasting Insecticidal Nets (LLINs) and Indoor Residual Spraying (IRS). These measures prevented more than 78 million malaria cases between 2000 and 2015.
The buzz stops here
35057Bill Gates, Gates Notes, 2025-08-19 20:44:24.
I've been working on malaria for over two decades. I’ve talked with researchers in labs and parents who’ve lost children to a mosquito bite. I’ve seen promising new tools and surprising setbacks. But I’ve rarely been as excited about a new innovation as I am about this one. In a lab in Tanzania, researchers are studying something incredible: a mosquito that can’t give you malaria. It looks and behaves like any other mosquito. It flies, bites, and breeds. But what it doesn’t do is transmit one of the deadliest diseases on the planet—which means it could save hundreds of thousands of lives a year. This mosquito was developed in 2023 by a team of African scientists at the Ifakara Health Institute in partnership with Imperial College London. It’s the first transgenic mosquito ever created on African soil—meaning that scientists have made a small, targeted change to its DNA. It was both a major scientific milestone and a major moment of African leadership in the global health space. The project is called Transmission Zero, and its goal is as ambitious as its name: to eliminate malaria not by killing mosquitoes, but by making them unable to transmit it to humans.
How biotech helps Florida Keys prevent mosquito-borne diseases
35029Janine Stanwood, Local 10, 2025-08-17 19:49:34.
Biologists with the Florida Keys Mosquito Control District (FKMCD) are releasing lab-modified mosquitoes twice a week in the Middle Keys. It’s part of a pilot program to reduce the population and help stop people from getting bitten. “They’re male Aedes aegypti,” said Dr. Larry Hribar, FKMCD Director of Research. “They’re infected with a mosquito parasite that’s in the genus Wolbachia.” There are dozens of species of blood suckers in South Florida, including the nuisance salt marsh mosquito found in mangroves and in the Everglades. But it’s the Aedes aegypti that carries diseases like Zika and dengue. “That’s the one that vector the diseases we worry about,” said FKMCD spokesperson Chad Huff. The males, shipped from a company called MosquitoMate, have been infected with the Wolbachia bacteria before mating with females after being released. “They’ll find a local female, they’ll mate, but the eggs she produces are not going to be viable,” Hribar said. According to the Centers for Disease Control, the lab-infected mosquitoes can’t make people or animals sick.
CRISPR Mosquitoes That Can’t Bite
35031Science Techniz, 2025-08-09 19:49:44.
Scientists have used CRISPR gene editing to alter female mosquitoes so that their proboscis — the needle-like mouthpart used to pierce skin — develops like a male’s. The consequence is simple and profound: modified females can no longer pierce skin and therefore cannot take a blood meal or transmit human diseases like malaria and dengue. Researchers identified a gene involved in the developmental pathway that produces the female proboscis morphology. Using CRISPR-based edits, they altered that gene’s function so that genetically female mosquitoes develop a male-like mouthpart. Because males naturally do not bite (they feed on nectar), the modification removes the biting behavior without fundamentally disrupting other survival traits in lab tests. It’s important to stress that this is a high-level description intended to explain the concept, not a protocol or “how-to.” The work is complex, tightly regulated, and performed under strict laboratory and ethical oversight.
Millions of genetically modified insects have been released in Brazil, but why didn’t anyone tell you about this before?
35003Noel Budeguer, Click Petroleo e Gas, 2025-08-04 08:29:56.
Few people realize, but Brazil is one of the most advanced countries in the world when it comes to biological pest control. Instead of relying solely on poisons and traps, Brazilian researchers are investing in technological solutions that, at first glance, seem like the stuff of science fiction: releasing modified mosquitoes and flies into the environment to prevent disease outbreaks and agricultural losses. The initiative may sound controversial, but it has already yielded impressive results—and, in some cases, may have prevented entire epidemics without anyone noticing. The logic behind these techniques is simple yet powerful. By releasing sterile or genetically modified males into the environment, they compete with natural males for females. When they win this contest and mate, the offspring born don't survive—or even hatch at all. The result is a drastic decline in the target pest's population. Two main approaches are used: the Sterile Insect Technique (SIT), which uses radiation to sterilize males, and genetic modification, which prevents reproduction through DNA alterations. Both methods eliminate the use of pesticides and have gained traction as sustainable and highly effective alternatives.
