Keywords: genetic incompatibilities
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Transmission distortion and genetic incompatibilities between alleles in a multigenerational mouse advanced intercross lineD. Arends, S. Kärst, S. Heise, P. Korkuc, D. Hesse and G. A. Brockmann, Genetics, 2021.
While direct additive and dominance effects on complex traits have been mapped repeatedly, additional genetic factors contributing to the heterogeneity of complex traits have been scarcely investigated. To assess genetic background effects, we investigated transmission ratio ... |
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A Sterile Solution: How Crispr Could Protect Wild SalmonL. Abend, UNDARK, 2021.
In an attempt to prevent escaped fish from interbreeding with their wild counterparts and threatening the latter’s genetic diversity, molecular biologist Anna Wargelius and her team at the Institute of Marine Research in Norway have spent years working on ways to induce ... |
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Synthetic SPECIES developed for use as a confinable gene driveUniversity of California - San Diego, ScienceDaily, 2021.
CRISPR-based technologies offer enormous potential to benefit human health and safety, from disease eradication to fortified food supplies. As one example, CRISPR-based gene drives, which are engineered to spread specific traits through targeted populations, are being developed ... |
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Engineered reproductively isolated species drive reversible population replacementA. Buchman, I. Shriner, T. Yang, J. Liu, I. Antoshechkin, J. M. Marshall, M. W. Perry and O. S. Akbari, Nature Communications, 12:3281. 2021.
Engineered reproductive species barriers are useful for impeding gene flow and driving desirable genes into wild populations in a reversible threshold-dependent manner. However, methods to generate synthetic barriers are lacking in advanced eukaryotes. Here, to overcome this ... |
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‘Clever Approach’: Scientists Create GM-Free Organisms Using Genetic EngineeringA. Paleja, The WIRE, 2021.
Farther to the north, researchers at the University of Minnesota have developed a novel way to resolve this problem. They used genetic engineering to create organisms for release that are not genetically modified. Maciej Maselko was a postdoctoral associate at the university ... |
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New insect species made via genetic engineeringL. Leffer, SCIENCELINE, 2020.
A biotech fast-forward button for evolution is on the horizon. Researchers say they have used a novel genetic engineering method to create several new species of fruit fly in the lab for the first time — an achievement which might help put a future without malaria and other ... |
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Fruit fly breakthrough puts killer mozzies on noticeV. Tressider, The Lighthouse, 2020.
A new designer fruit fly paves the way for scientists to replace disease-carrying mosquitoes with harmless, genetically modified versions, says Macquarie University researcher Dr Maciej Maselko. |
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The Evolving Arsenal Against Mosquito-Born DiseasesJ. Smith, Labiotech.eu, 2020.
As the global climate continues to warm, disease-spreading mosquitoes such as Aedes aegypti are expected to establish themselves in the US and Europe. |
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Mutant mosquitoes: GM insects ‘engineered’ in ‘new approach to pest control’T. Fish, EXPRESS, 2020.
This cutting-edge research provides the foundations for plans to prevent genetically modified organisms from reproducing with wild organisms. |
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Prospects and Pitfalls: Next-Generation Tools to Control Mosquito-Transmitted DiseaseE. P. Caragata, S. Dong, Y. Dong, M. L. Simões, C. V. Tikhe and G. Dimopoulos, Annual Review of Microbiology, 74:455-475. 2020.
A diverse array of next-generation tools has been designed to eliminate mosquito populations or to replace them with mosquitoes that are less capable of transmitting key pathogens. |
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Non-GMO approach reduces cases of mosquito-borne dengue by 77%GM Watch, GM Watch, 2020.
A randomized field trial found that mosquitoes infected with a natural bacterium called Wolbachia reduced cases of dengue by an "extraordinary" 77%. |
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Bacteria-Laced Mosquitoes Limit Spread of DengueA. Heidt, The Scientist, 2020.
Researchers have infected Aedes aegypti mosquitoes—the species responsible for passing on many diseases—with bacteria called Wolbachia with the intent of reducing the insects’ ability to pass on dengue to people. |
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Scientists infect mosquitoes with bacteria to stop the transmission of dengue fever in Indonesia, dropping infection rates by 77 percentD. Avery, Daily Mail, 2020.
The team found that dengue infections were 77 percent lower in treated neighborhoods, compared to areas not exposed to the infected insects. |
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GeneConvene Global Collaborative Webinar SeriesDavid O'Brochta and Hector Quemada, GeneConvene Global Collaborative, 2020.
This is a series of public scientific and technical seminars by researchers actively involved in the research and development of engineered gene drive and related systems. Presentations will be aimed at other researchers and scientists, highlighting the latest investigations in ... |
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The mosquito strategy that could eliminate dengueE. Callaway, Nature, 2020.
The study, conducted in an Indonesia city, showed that releasing mosquitoes modified to carry a bacterium called Wolbachia, which stops the insects from transmitting some viruses, led to a steep drop in cases of dengue fever. |
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Researchers Find New Approach To Control Dengue, Zika By Genetically Modifying MosquitoesN. Sharma, R. Republicworld.com, 2020.
A new study carried out in Indonesia has shown that dengue infection rates decreased in regions where the genetically modified mosquitoes were introduced. |
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Australian research takes aim at dengue, another killer virusE. Connors, Finanacial Review, 2020.
Australian researchers have teamed up with Indonesian philanthropists to strike a blow against dengue fever, the deadly disease that was a growing scourge in south-east Asia and South America long before COVID-19. |
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Australian scientists slash dengue fever in Indonesia by infecting mosquitoes with bacteriaA. Barker, ABC News, 2020.
Australian scientists may have found the secret to eradicating dengue fever, with a lengthy trial in Indonesia drastically reducing the incidence of the mosquito-borne virus. |
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Engineered Reproductively Isolated Species Drive Reversible Population ReplacementA. Buchman, I. Shriner, T. Yang, J. Liu, I. Antoshechkin, J. M. Marshall, M. W. Perry and O. S. Akbari, bioRxiv, 2020.08.09.242982. 2020.
Engineered reproductive species barriers are useful for impeding gene flow and driving desirable genes into wild populations in a reversible threshold-dependent manner. We engineer multiple reproductively isolated SPECIES and demonstrate their threshold-dependent gene drive ... |
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Engineering multiple species-like genetic incompatibilities in insectsM. Maselko, N. Feltman, A. Upadhyay, A. Hayward, S. Das, N. Myslicki, A. J. Peterson, M. B. O’Connor and M. J. Smanski, bioRxiv, 2020.
Speciation constrains the flow of genetic information between populations of sexually reproducing organisms. Gaining control over mechanisms of speciation would enable new strategies to manage wild populations of disease vectors, agricultural pests, and invasive species. ... |
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The potential cost-effectiveness of controlling dengue in Indonesia using wMel Wolbachia released at scale: a modelling studyO. J. Brady, D. D. Kharisma, N. N. Wilastonegoro, K. M. Reilly, E. Hendricx, L. S. Bastos, L. Yakob and D. S. Shepard, medRxiv, 2020.01.11.20017186. 2020.
Wolbachia releases in high density urban areas is expected to be highly cost-effective and could potentially be the first cost saving intervention for dengue. Sites with strong public health infrastructure, fiscal capacity, and community support should be prioritized. |
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Transmission ratio distortion is frequent in Arabidopsis thaliana controlled crossesSeymour, DKC, E.; Arioz, B. I.; Koenig, D.; Weigel, D., Heredity, 122:294-304. 2019.
The equal probability of transmission of alleles from either parent during sexual reproduction is a central tenet of genetics and evolutionary biology. Yet, there are many cases where this rule is violated. The preferential transmission of alleles or genotypes is termed ... |
