Scholarly Literature
This is an aggregation of scholarly literature from peer-reviewed journals, bioRxiv , medRxiv and arXiv preprint servers focused on natural and engineered selfish genetic elements and genetic biocontrol. New citations are added as they appear. This content is intended for anyone interested in the scholarly literature on gene drive and genetic biocontrol.
A predatory gene drive for targeted control of self-transmissible plasmids
Tags: Gene drive, ModelingRyan Tsoi et al., Science Advances, 11. 2025.
Suppressing plasmid transfer in microbial communities has profound implications due to the role of horizontal gene transfer (HGT) in spreading and maintaining diverse functional traits such as metabolic functions, virulence factors, and antibiotic resistance. However, existing ...
Global asymptotic stability in a delay stage structured model for mosquito population suppression
Tags: Cytoplasmic incompatibility, Modeling, Population suppression, WolbachiaHuang, Mg., Yu, Js., Applied Mathematics, 40:112-136. 2025.
A promising avenue to control mosquito-borne diseases such as dengue, malaria, and Zika involves releasing male mosquitoes carrying the bacterium Wolbachia in wild areas to drive female sterility by a mechanism called cytoplasmic incompatibility (CI). In this work, we initiate ...
Exploiting Wolbachia as a Tool for Mosquito-Borne Disease Control: Pursuing Efficacy, Safety, and Sustainability
Tags: Arbovirus, Cytoplasmic incompatibility, Population modification/replacement, Stakeholder engagement, Vector control, WolbachiaMoretti, R., Lim, J. T., Ferreira, A. G. A., et al, Pathogens, 14:285. 2025.
Despite the application of control measures, mosquito-borne diseases continue to pose a serious threat to human health. In this context, exploiting Wolbachia, a common symbiotic bacterium in insects, may offer effective solutions to suppress vectors or reduce their competence in ...
Adjacent spillover efficacy of Wolbachia for control of dengue: emulation of a cluster randomised target trial
Tags: Asia, Dengue, Incompatible insect technique, WolbachiaLim, J.T., Mailepessov, D., Chong, C.S. et al., BMC Medicine, 23. 2025.
Matings between male Aedes aegypti mosquitoes infected with wAlbB strain of Wolbachia and wild-type females yield non-viable eggs, thereby suppressing Ae. aegypti abundance in the field. We evaluated the spillover efficacy of releasing wAlbB-infected Ae. aegypti male ...
Challenges in developing a split drive targeting dsx for the genetic control of the invasive malaria vector Anopheles stephensi
Tags: Anopheles, CRISPR, Malaria, Population suppression, Sex distorterLarrosa-Godall, M., Ang, J.X.D., Leftwich, P.T. et al., Parasites & Vectors, 18. 2025.
Anopheles stephensi is a competent malaria vector mainly present in southern Asia and the Arabian Peninsula. Since 2012, it has invaded several countries of eastern Africa, creating an emerging risk of urban transmission. Urgent efforts are required to develop novel and more ...
Functional constraints of wtf killer meiotic drivers
Tags: Selfish genetic elements, Toxin-antidoteNidamangala Srinivasa A., Campbell S., Venkatesan S., et al., PLOS Genetics, 21. 2025.
Diploid organisms, such as humans, have two copies of most genes. Only one copy, however, is transmitted through gametes (e.g., sperm and egg) to any given offspring. Alternate copies of the same gene are expected to be equally represented in the gametes, resulting in random ...
Mark-Release-Recapture of Packed and Shipped Aedes aegypti with Wolbachia: Implications for Conducting Remote Incompatible Insect Technique Programs
Tags: Aedes, Incompatible insect technique, Population suppression, WolbachiaOhm, J. R., Lynd, A., McGowan, A., et al., The American Journal of Tropical Medicine and Hygiene, 2025.
Male mosquitoes containing the endosymbiont Wolbachia (Wb+) can be used as a tool to suppress wild mosquito populations through a technique termed incompatible insect technique (IIT). IIT programs reduce wild mosquitoes via incompatible matings between released males and wild ...
Gene drives. Technologies for spreading genetic modifications in populations. TAB-Fokus
Tags: Europe, Gene drive, Policy, Risk and safetyKönig, H., Kolleck, A., Sauter, A., TAB-Fokus, 48. 2025.
Gene drives have the potential to help solve major challenges, including the fight against invasive species or vector-borne diseases such as malaria. These hopes are offset by technical and scientific challenges as well as environmental risks. The policy brief TAB-Fokus no. 48 on ...
Engineering drive–selection balance for localized population suppression with neutral dynamics
Tags: CRISPR, Pest management, Population suppression, Toxin-antidoteWillis, K., and Burt, A., Proceedings of the National Academy of Sciences, 122. 2025.
While the release of sterile males has been highly successful in suppressing some pest populations, it is impractical for many species due to the males disappearing after a single generation, necessitating large, repeated releases to maintain sufficient impact. Synthetic gene ...
Gene drive: communication, hype, and the publics
Tags: Genetic engineering, Malaria, Stakeholder engagementBoëte, C., Journal of Medical Entomology, 2025.
Engineered gene drive (EGD) systems are probably the most high-tech approach considered for their potential role in the control of vector-borne diseases. Interestingly, the rhetoric around it often goes along with a negative presentation of the current “conventional” tools ...
wStri spread dynamics in Nilaparvata lugens via discrete mathematical models
Tags: Cytoplasmic incompatibility, Modeling, Other invertebrates, WolbachiaZheng, B., Yang, H., Elaydi, S. et al., Journal of Mathematical Biology, 90. 2025.
Wolbachia, an intracellular bacterium, is well-known for inducing cytoplasmic incompatibility, which has become a promising and environmentally sustainable strategy for controlling pest populations. The strain wStri, specifically identified in Nilaparvata lugens (brown ...
A comparative assessment of self-limiting genetic control strategies for population suppression
Tags: Population suppression, Self limiting, Sterile insect technique (SIT)Yue Han, Jackson Champer, Molecular Biology and Evolution, 2025.
Genetic control strategies are promising solutions for control of pest populations and invasive species. Methods utilizing repeated releases of males such as Sterile Insect Technique (SIT), Release of Insects carrying a Dominant Lethal (RIDL), self-limiting gene drives, and gene ...
CRISPR/Cas9 Genome Editing in the Diamondback Moth: Current Progress, Challenges, and Prospects
Tags: CRISPR, Gene drive, Genetic biocontrol, MothsAsad, M., Chang, Y., Liao, J., & Yang, G., International Journal of Molecular Sciences, 26:1515. 2025.
The development of site-specific genome-editing tools like CRISPR (clustered regularly interspaced short palindromic repeat) and its associated protein, Cas9, is revolutionizing genetic engineering with its highly efficient mechanism, offering the potential for effective pest ...
Engineering gene drive docking sites in a haplolethal locus in Anopheles gambiae
Tags: Anopheles, CRISPR, Gene drive, ResistanceAndrea L Smidler, Eryney A Marrogi, Sean Scot, et al., bioRxiv, 2025.
Gene drives are selfish genetic elements which promise to be powerful tools in the fight against vector-borne diseases such as malaria. We previously proposed population replacement gene drives designed to better withstand the evolution of resistance by homing through haplolethal ...
Reenacting a mouse genetic evolutionary arms race in yeast reveals that SLXL1/SLX compete with SLY1/2 for binding to Spindlins
Tags: Genetics, Rodents, X chromosome, Y-chromosomeM.F. Arlt,A.N. Kruger,C.M. Swanepoel,& J.L. Mueller, Proceedings of the National Academy of Sciences, 122. 2025.
In the house mouse, an evolutionary arms race between proteins encoded by the X-linked Slxl1/Slx and Y-linked Sly gene families during spermatogenesis can distort offspring sex ratio, but how these proteins compete remains unknown. We report how SLXL1/SLX competes with SLY1/SLY2 ...
RNA-guided nucleases enable a gene drive of insertion sequences in plasmids
Tags: Gene driveKepler S. Mears, Fernando W. Rossine, Natalia Quinones-Olvera, et al., bioRxiv, 2025.
Mobile genetic elements (MGEs) and the interactions between them are a major source of evolutionary innovation. Insertion sequences, the simplest MGEs usually encoding only the necessary genes for transposition and maintenance, are widespread in bacterial genomes, and are ...
Wolbachia-based mosquito control: Environmental perspectives on population suppression and replacement strategies
Tags: Ecology, Modeling, Population modification/replacement, Population suppression, WolbachiaBhattacharyya, J., Roelke, D.L., Acta Tropica, 262. 2025.
Mosquito-borne diseases pose a significant threat to global health, and traditional mosquito control methods often fall short of effectiveness. A promising alternative is the biological control strategy of transinfecting mosquitoes with Wolbachia, a bacterium capable of ...
Exploiting venom toxins in paratransgenesis to prevent mosquito-borne disease
Tags: Aedes, Anopheles, Arbovirus, Dengue, Toxin-antidoteFrench, S., Da Silva, R., Storm, J. et al., Parasites & Vectors, 18. 2025.
Mosquitoes are responsible for the transmission of numerous pathogens, including Plasmodium parasites, arboviruses and filarial worms. They pose a significant risk to public health with over 200 million cases of malaria per annum and approximately 4 billion people at risk of ...
Antagonistic kinesin-14s within a single chromosomal drive haplotype
Tags: Agriculture, Selfish genetic elementsMeghan J. Brady, Anjali Gupta, Jonathan I. Gent, et al., bioRxiv, 2025.
In maize, there are two meiotic drive systems that operate on large tandem repeat arrays called knobs that are found on chromosome arms. One meiotic drive haplotype, Abnormal chromosome 10 (Ab10), encodes two kinesin proteins that interact with two distinct tandem repeat arrays ...
Implications of successive blood feeding on Wolbachia-mediated dengue virus inhibition in Aedes aegypti mosquitoes
Tags: Aedes, Dengue, WolbachiaRebecca M. Johnson, Mallery I. Breban, Braiya L. Nolan, et al., bioRxiv, 2025.
Dengue virus (DENV) is a mosquito-borne virus that poses a continued and increasing threat to public health. A promising strategy to mitigate the burden of DENV is introgression of the virus-inhibiting Wolbachia pipientis bacterium into Aedes aegypti populations in the field. ...
Functional constraints of wtf killer meiotic drivers
Tags: Selfish genetic elements, Toxin-antidoteNidamangala Srinivasa A, Campbell S, Venkatesan S, et al., PLOS Genetics, 21. 2025.
Killer meiotic drivers are selfish DNA loci that sabotage the gametes that do not inherit them from a driver+/driver− heterozygote. These drivers often employ toxic proteins that target essential cellular functions to cause the destruction of driver− gametes. Identifying the ...
Small RNA-mediated suppression of sex chromosome meiotic conflicts during Drosophila male gametogenesis
Tags: Fruit fly, Sex distorterVedanayagam, J., Biochemical Society Transactions, 53:281-291. 2025.
Meiosis is an evolutionarily conserved process in eukaryotes that ensures equal segregation of alleles and chromosomes during reproduction. Although parity in allelic transmission is the norm, selfish genes such as meiotic drivers can violate Mendel’s first law of segregation. ...
Public attitudes to genetic technology for invasive pest control and preferences for engagement and information: a segmentation analysis
Tags: Genetic biocontrol, Pest management, Stakeholder engagementHobman E.V., Mankad A., Carter, L., Collins K., Frontiers in Bioengineering and Biotechnology, 12. 2025.
Advances in genetic technology hold promise in managing the increasing problem of invasive pests. The current study sought to improve our understanding of public perceptions, and potential public engagement pathways and information needs as the technology is researched and ...
Suppression of Aedes aegypti may not affect sympatric Aedes albopictus populations: findings from two years of entomological surveillance in Singapore
Tags: Aedes, Asia, WolbachiaWong, W.J., Tan, C.H., Verkaik, M.G. et al., Scientific Reports, 15:2253. 2025.
Globally, multiple trials have successfully demonstrated the effectiveness of novel tools, such as the sterile and incompatible insect techniques, in suppressing Aedes aegypti populations. However, there is concern that Aedes albopictus, another arbovirus-competent vector, may ...
Controlling the frequency dynamics of homing gene drives for intermediate outcomes
Tags: CRISPR, Modeling, ResistanceCamm B., Fournier-Level A., G3: Genes|Genomes|Genetics, 2025.
Gene drives have enormous potential for solving biological issues by forcing the spread of desired alleles through populations. However, to safeguard from the potentially irreversible consequences on natural populations, gene drives with intermediate outcomes that neither fixate ...
Generating sterile Anopheles mosquitoes to combat malaria transmission
Tags: Anopheles, Malaria, Sex distorter, Vector controlXu, X. and Champer, J., Research Communities by Springer Nature, 2025.
Malaria remains a deadly disease, claiming hundreds of thousands of lives worldwide every year. The primary vectors of malaria are Anopheles mosquitoes, including Anopheles gambiae and Anopheles stephensi. Controlling mosquito populations is crucial for stopping malaria ...
Establishment of pupal color as a screening marker and activity analysis of six U6 promoters in Zeugodacus cucurbitae using the white pupae gene
Tags: CRISPR, Genetic engineering, Pest managementFan Z., Wu Y., Zha X., Ma S., et al., Pest Management Science, 2025.
The genetic control method, which is environmentally friendly and species-specific, has effectively reduced or eliminated pests in many areas. One essential requirement to control a species is the identification of its genetic and molecular elements. Such elements, however, are ...
Upscaling irradiation protocols of Aedes albopictus pupae within an SIT program in Reunion Island
Tags: Aedes albopictus, Irradiation method, Reunion (France), Sterile insect technique, UpscaleLucie Marquereau, Hanano Yamada, David Damiens, Antonin Leclercq, Brice Derepas, Cécile Brengues , Brice William Dain , Quentin Lejarre 1, Mickael Proudhon , Jeremy Bouyer and Louis Clément Gouagna, Scientific Reports, 14:12117. 2025.
The implementation of the sterile insect technique against Aedes albopictus relies on many parameters, in particular on the success of the sterilization of males to be released into the target area in overflooding numbers to mate with wild females. Achieving consistent sterility ...
Life-history traits of a fluorescent Anopheles arabiensis genetic sexing strain introgressed into South African genomic background
Tags: COPAS, Malaria, South Africa, Sterile insect technique (SIT), Vector controlNonhlanhla L. Ntoyi, Thabo Mashatola, Jérémy Bouyer, Carina Kraupa, Hamidou Maiga, Wadaka Mamai, Nanwintoum, Bimbile‑Somda, Thomas Wallner, Danilo O. Carvalho, Givemore Munhenga and Hanano Yamada, Malaria Journal, 21. 2025.
South Africa has set a mandate to eliminate local malaria transmission by 2023. In pursuit of this objective a Sterile Insect Technique programme targeting the main vector Anopheles arabiensis is currently under development. Significant progress has been made towards ...
Animal trypanosomosis eliminated in a major livestock production region in Senegal following the eradication of a tsetse population
Tags: Case-control study, Eradication, Seroprevalence, Sterile insect technique, Sterile insect technique (SIT), TrypanosomeMomar Talla Seck, Assane Guèye Fall, Adji Marème Gaye, Geoffrey Gimonneau, Mamadou Ciss, Mame Thierno Bakhoum, Baba Sall, Mireille Djimangali Bassène1, Renaud Lancelot, Marc J.B., Vreysen, and Jérémy Bouyer, Parasite 31, 31. 2025.
African animal trypanosomosis (AAT) was one of the main disease-related constraints to the development of intensive livestock production systems in the Niayes region of Senegal, a 30 km wide strip of land along the coast between Dakar and Saint-Louis. To overcome this constraint, ...
Integrating malaria vaccine and CRISPR/Cas9 gene drive: a comprehensive strategy for accelerated malaria eradication
Tags: CRISPR, Gene drive, MalariaAbraham, I.C., Aboje, J.E., Ukoaka, B.M. et al., Malaria Journal, 24. 2025.
Malaria remains a significant public health challenge, particularly in low- and middle-income countries, despite ongoing efforts to eradicate the disease. Recent advancements, including the rollout of malaria vaccines, such as RTS,S/AS01 and R21/Matrix-M™, offer new avenues for ...
Gene drive-based population suppression in the malaria vector Anopheles stephensi
Tags: CRISPR, Genetic engineering, Population suppressionXu, X., Chen, J., Wang, Y. et al., Nature Communications, 16:1007. 2025.
Gene drives are alleles that can bias the inheritance of specific traits in target populations for the purpose of modification or suppression. Here, we construct a homing suppression drive in the major urban malaria vector Anopheles stephensi targeting the female-specific exon of ...
Assessing Radiation-Induced Enzyme Activation in Aedes aegypti: Potential Challenges for SIT-Based Vector Management
Tags: Aedes, Sterile insect technique (SIT), Vector controlEdvane Borges da Silva, Sloana Giesta Lemos Florêncio, Ademir Amaral, et al., Acta Tropica, 261. 2025.
This study characterizes the Aedes aegypti population from Fernando de Noronha Island, Pernambuco, Brazil, prior to implementing the Sterile Insect Technique (SIT). The main objective was to assess changes in glutathione S-transferase (GST) enzyme activity, previously linked to ...
A comprehensive review of biological and genetic control approaches for leishmaniasis vector sand flies; emphasis towards promoting tools for integrated vector management
Tags: Genetic engineering, Other arthropods, Vector controlKumari, Y., Gunathilaka, N., Amarasinghe, D., PLOS Neglected Tropical Diseases, 19. 2025.
Leishmaniasis is a health problem in many regions with poor health and poor life resources. According to the World Health Organization (WHO), an estimated 700,000–1 million new cases arise annually. Effective control of sand fly vector populations is crucial for reducing the ...
Assessment of drive efficiency and resistance allele formation of a homing gene drive in the mosquito Aedes aegypti
Tags: Aedes, CRISPR, Gene drive, Mosquitoes, Vector controlYang, X., Xu, X., Chen, Y. et al., Journal of Pest Science, 2025.
Aedes aegypti, known for transmitting viruses such as dengue, Zika and yellow fever, poses a significant public health threat. Conventional insecticides give rise to a range of issues, including ecological contamination and insect resistance. Hence, there is a pressing demand for ...
Identification of novel genes responsible for a pollen killer present in local natural populations of Arabidopsis thaliana
Tags: CRISPR, Genomics, Selfish genetic elements, Toxin-antidoteRicou, A., Simon, M., Duflos, R., et al, PLOS Genetics, 21. 2025.
Gamete killers are genetic loci that distort segregation in the progeny of hybrids because the killer allele promotes the elimination of the gametes that carry the sensitive allele. They are widely distributed in eukaryotes and are important for understanding genome evolution and ...
Escalation of genome defense capacity enables control of an expanding meiotic driver
Tags: Fruit fly, Population genetics/dynamics, Selfish genetic elementsP. Chen, K.C. Pan, E.H. Park, et al., Proceedings of the National Academy of Sciences, 122. 2025.
From RNA interference to chromatin silencing, diverse genome defense pathways silence selfish genetic elements to safeguard genome integrity. Despite their diversity, different defense pathways share a modular organization, where numerous specificity factors identify diverse ...
Wolbachia-Based Approaches to Controlling Mosquito-Borne Viral Threats: Innovations, AI Integration, and Future Directions in the Context of Climate Change
Tags: Ecology, Policy, Vector control, WolbachiaBranda, F., Cella, E., Scarpa, F., et al., Viruses, 16:1868. 2025.
Wolbachia-based mosquito control strategies have gained significant attention as a sustainable approach to reduce the transmission of vector-borne diseases such as dengue, Zika, and chikungunya. These endosymbiotic bacteria can limit the ability of mosquitoes to transmit ...
Recommendations for Implementing Innovative Technologies to Control Aedes aegypti: Population Suppression Using a Combination of the Incompatible and Sterile Insect Techniques (IIT-SIT), Based on the Mexican Experience/Initiative
Tags: Aedes, Incompatible insect technique, South/Central America, Sterile insect technique (SIT), WolbachiaMartín-Park, A., Contreras-Perera, Y., et al., Insects, 15:987. 2025.
The future of Aedes aegypti control emphasizes the transition from traditional insecticides toward more sustainable and multisectoral integrated strategies, like using Wolbachia-carrying mosquitoes for population suppression or replacement. We reviewed the integration of the ...
Mechanisms, Machinery, and Dynamics of Chromosome Segregation in Zea mays
Tags: Agriculture, Chromosomal driveDuffy, Marissa E., Michael Ngaw, Shayna E. Polsky, et al., Genes, 15. 2025.
Zea mays (maize) is both an agronomically important crop and a powerful genetic model system with an extensive molecular toolkit and genomic resources. With these tools, maize is an optimal system for cytogenetic study, particularly in the investigation of chromosome segregation. ...
A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae
Tags: Anopheles, CRISPR, Genetic biocontrol, Genetic engineering, Modeling, Population suppression, Y-chromosomeTolosana, I., Willis, K., Gribble, M. et al., Nature Communications, 16:206. 2025.
Genetic control – the deliberate introduction of genetic traits to control a pest or vector population – offers a powerful tool to augment conventional mosquito control tools that have been successful in reducing malaria burden but that are compromised by a range of ...
Wolbachia-based mosquito control: Environmental perspectives on population suppression and replacement strategies
Tags: Ecology, Modeling, Population modification/replacement, Population suppression, WolbachiaJoydeb Bhattacharyya, Daniel L. Roelke, Acta Tropica, 262. 2025.
Mosquito-borne diseases pose a significant threat to global health, and traditional mosquito control methods often fall short of effectiveness. A promising alternative is the biological control strategy of transinfecting mosquitoes with Wolbachia, a bacterium capable of ...
Meiotic Drive and Speciation
Tags: Fruit fly, Rodents, Sex distorter, X chromosome, Y-chromosomeJeremy B. Searle and Fernando Pardo-Manuel de Villena, Annual Review of Genetics, 58:341-363. 2024.
Meiotic drive is the biased transmission of alleles from heterozygotes, contrary to Mendel's laws, and reflects intragenomic conflict rather than organism-level Darwinian selection. Theory has been developed as to how centromeric properties can promote female meiotic drive and ...
Public attitudes to genetic technology for invasive pest control and preferences for engagement and information: A segmentation analysis
Tags: commu, Genetic biocontrol, Stakeholder engagementElizabeth Virginia Hobman, Aditi Mankad, Lucy Carter, Kerry Collins, Frontiers in Bioengineering and Biotechnology, 12. 2024.
This research focusses on understanding (1) how people perceive genetic technology to control invasive animal pests (feral pigs, cats etc.), and (2) how people would like to be engaged on, and/or informed about, decisions regarding the development of this genetic technology. The ...
Biased social chromosome transmission in males of the fire ant Solenopsis invicta
Tags: Other arthropods, Selfish genetic elementsDaniel R Hettesheimer, Haolin Zeng, Brendan G Hunt, Kenneth G Ross, G3: Genes|Genomes|Genetics, 2024.
Selfish genetic elements subvert the normal rules of inheritance to unfairly propagate themselves, often at the expense of other genomic elements and the fitness of individuals carrying them. Social life provides diverse avenues for the propagation of such elements. In the fire ...
Assessing the Efficacy of Gene-Drive Technology in Reducing Malaria Transmission in Sub-Saharan Africa: Current Progress and Future Prospects
Tags: Africa, Anopheles, Gene drive, MalariaBizimana Rukundo T., IAA Journal of Applied Sciences, 12(1):1-5. 2024.
Malaria continues to pose a significant public health challenge in Sub-Saharan Africa, necessitating innovative solutions to combat its transmission. This review examined the efficacy of gene-drive technology as a novel approach to reducing malaria transmission through genetic ...
A meiotic driver hijacks an epigenetic reader to disrupt mitosis in noncarrier offspring
Tags: Genomics, Selfish genetic elements, Yeast and FungiYu Hua, Jianxiu Zhang, et al., PNAS, 121. 2024.
Killer meiotic drivers (KMDs) are selfish genetic elements that distort Mendelian inheritance by selectively killing meiotic products lacking the KMD element, thereby promoting their own propagation. Although KMDs have been found in diverse eukaryotes, only a limited number of ...
Structural duality enables a single protein to act as a toxin–antidote pair for meiotic drive
Tags: Toxin-antidote, Yeast and FungiYu Hua, Jianxiu Zhang, et al., PNAS, 121. 2024.
In sexual reproduction, selfish genetic elements known as killer meiotic drivers (KMDs) bias inheritance by eliminating gametes that do not carry them. The selective killing behavior of most KMDs can be explained by a toxin–antidote model, where a toxin harms all gametes while ...
Exploring The Dynamics of Gene Drive Mosquitoes Within Wild Populations Using an Agent-Based Simulation
Tags: Africa, Gene drive, Malaria, Modeling, Vector controlS. Wickramasooriya, I. Mahmood, et al., IEEE Xplore, 2024.
Gene drive technology is emerging as a potentially powerful tool in combating vector-borne diseases – notably malaria. This study introduces an agent-based model (ABM) focused on the deployment of genetically engineered mosquitoes with gene drive (GEM) in Príncipe Island, ...
The Meiotic Drive: Intragenomic Competition and Selection
Tags: Chromosomal drive, Fruit fly, Genetics, Rodents, Yeast and FungiI. A. Zakharov, Russian Journal of Genetics, 60:1311-1318. 2024.
The article considers the distribution and mechanisms of the meiotic drive as a phenomenon manifested in unequal transmission of gene alleles and/or homologous chromosomes into gametes during meiosis. The meiotic drive has been studied in the most detail in Drosophila, mice, ...
