Keywords: self limiting
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Modelling the effect of migration on the localisation and spread of a gene driveC. Benjamin and F.-L. Alexandre, bioRxiv, 2023.
Gene drives have the potential to address pressing ecological issues. Through the super-Mendelian inheritance of a gene drive, a trait can be spread through a population even in spite of a fitness cost. This ability to spread is both its greatest quality and detractor. We may not ... |
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Oxitec’s mosquitoes are getting “friendly” with CaliforniaL. Patrick, The Sun Gazette, 2022.
Biotech company Oxitec is buzzing around Visalia, with the hopes of releasing their genetically engineered mosquitoes in Tulare County. Oxitec has one more hurdle to jump over in order to release their “friendly” Aedes aegypti mosquitoes in Tulare County, and that’s to gain ... |
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Turns Out Fighting Mosquitoes With Mosquitoes Actually WorksE. Mullin, Wired, 2022.
In the Brazilian city of Indaiatuba, an effort is underway to eliminate these pests before they have a chance to spread illness. The weapon: more Aedes aegypti mosquitoes—but ones genetically engineered to kill their own kind. Made by British biotechnology firm Oxitec, the ... |
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Genetic control of invasive sea lamprey in the Great LakesD. Ferreira-Martins, J. Champer, D. W. McCauley, Z. Zhang and M. F. Docker, Journal of Great Lakes Research, 2021.
The invasive sea lamprey was a significant factor in the collapse of fish stocks in the Great Lakes, and it continues to threaten the multi-billion-dollar fishing industry. Thus, substantial resources are invested annually on sea lamprey control. Current control strategies have ... |
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Village hears from experts as genetic-mosquito release experiment nears.J. McCarthy, KEYSWEEKLY, 2021.
On March 18, Islamorada Village Council heard from several independent scientists who discussed information and issues behind the genetically modified mosquitoes for population and disease suppression. The scientists collectively said they’re neither for nor against the ... |
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Mosquito anxiety prompts query from congressmanT. Java, Keynews.com, 2021.
Anxiety among some residents over the pending release of hundreds of millions of genetically modified mosquitoes next month in undisclosed locations throughout the Florida Keys has prompted Congressman Carlos Gimenez to seek answers from the U.S. Environmental Protection Agency. ... |
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Gene-Editing Approach To Control the Invasive Gray SquirrelM. Campbell, Technology Networks, 2021.
Biodiversity refers to the extent of the variety of life that is found on planet Earth – and it is currently under threat. Changes in biodiversity have been flagged as "surpassing safe limits" for several years, and world leaders and scientists across the globe are consequently ... |
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Ecology: Gene drives may help control invasive grey squirrel in the UKA. Korn, EurekaAlert, 2021.
Gene drives introduce genes into a population that have been changed to induce infertility in females, allowing for the control of population size. However, they face technical challenges, such as controlling the spread of altered genes as gene drive individuals mate with wild ... |
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Genetically modified squirrels could curb growing population of greysS. Knapton, Telegraph, 2021.
Mutant grey squirrels, genetically modified to spread infertility genes, could be released into the wild to tackle the burgeoning population, |
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Expert reaction to a paper suggesting that gene drives could be used to help control grey squirrel numbers in the UKAnonymous, Science Media Centre, 2021.
This study assesses the prospects for using a gene drive to control invasive grey squirrels in the UK. This is a modelling study exploring the potential for such an approach – no such gene drives currently exist and developing them for grey squirrels would be quite a long-term ... |
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CRISPR gene drives may come to a squirrel near you.Anonymous, NewsBeezer, 2021.
Today’s gene drive technologies could be blended to provide control of the invasive gray squirrel population in the UK – with minimal risk to other populations, according to a new modeling published in the journal Scientific reports. Gene driving introduces altered genes ... |
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Novel combination of CRISPR-based gene drives eliminates resistance and localises spreadN. R. Faber, G. R. McFarlane, R. C. Gaynor, I. Pocrnic, C. B. A. Whitelaw and G. Gorjanc, Scientific Reports, 11:3719. 2021.
As a case study, we model HD-ClvR in the grey squirrel (Sciurus carolinensis), which is an invasive pest in the UK and responsible for both biodiversity and economic losses. HD-ClvR combats resistance allele formation by combining a homing gene drive with a cleave-and-rescue gene ... |
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Tensions rise as GM mosquito release nears in Florida KeysT. O'Hara, Keynews.com, 2021.
Tensions seem to be rising as a planned release of genetically modified mosquitoes nears. The British-based biotech company Oxitec plans to release genetically modified Aedes aegypti mosquitoes in the Florida Keys sometime after April, but has yet to disclose exact locations in ... |
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Florida Keys moves forward with genetically modified mosquitoesH. Vela, local10.com, 2021.
The feared GMO mosquitoes are not going away. Opponents of the technology fear the date of the release in the Florida Keys is getting closer, and they are not ready for the possible repercussions of the experiment. The fight over whether or not to release genetically modified ... |
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When and where will millions of mosquitoes be released? Here are details for Florida KeysD. Goodhue, Miami Herald, 2021.
The Florida Keys Mosquito Control District announced this week a wide and vague planned range of deployment for the lab-designed mosquitoes — neighborhoods from mile marker 10 to 93. The trial is being conducted by British biotech company Oxitec. It’s a method approved by the ... |
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Mosquito trial will begin in April, but Keys locations won’t be disclosedS. Matthis, KEYSWEEKLY, 2021.
FKMCD spokesman Chad Huff wrote in an email, “The physical location of each box is still being finalized. Since most will be situated on private property at owner request, FKMCD-Oxitec will NOT be providing specific addresses due to privacy concerns and protection of project ... |
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Split versions of Cleave and Rescue selfish genetic elements for measured self limiting gene driveG. Oberhofer, T. Ivy and B. A. Hay, PLoS genetics, 17:e1009385. 2021.
Self-sustaining Cleave and Rescue (ClvR) elements include a DNA sequence-modifying enzyme such as Cas9/gRNAs that disrupts endogenous versions of an essential gene, a tightly linked recoded version of the essential gene resistant to cleavage (the Rescue), and a Cargo. ClvR ... |
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Oxitec gears up for test releasesT. O'Hara, Keynews.com, 2021.
The United Kingdom-based biotech company Oxitec will soon announce the test locations and timetable for releasing its genetically modified mosquitoes in the Florida Keys. |
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Self-Deleting Genes Project To Tackle Mosquito-Borne DiseasesD. Ozdemir, INTERESTING ENGINEERING, 2021.
Did you know that mosquitoes kill at least 725,000 persons every year? They truly are one of the world's deadliest animals which is the reason why scientists from all around are trying to find new ways of dealing with them. Controlling mosquito populations and preventing them ... |
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Edit, undo: Temporary gene editing could help solve the mosquito problemL. Dormehl, digitaltrends, 2020.
But if SyFy original movies have taught us anything, it’s that genetically tweaking organisms and then releasing them can… well, not go quite according to plan.With that in mind, a new Texas A&M AgriLife Research project seeks to test out genetic modifications of mosquitos ... |
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Self-deleting genes promise risk-free genetic engineering of mosquitoesD. Quick, New Atlas, 2020.
A new project by Texas A&M AgriLife Research is looking to enable "test runs" of genetic changes to mosquitoes that are automatically deleted. Various angles of attack using genetic engineering to combat mosquitoes have been pursued in recent years, including modifying them so ... |
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Self-deleting genes to be tested as part of mosquito population control conceptB. Hays, UPI, 2020.
Scientists at Texas A&M have developed a new technique for altering the genes of mosquitoes -- the new technology will cause genetic changes to self-delete from the mosquitoes' genome. Thanks to the breakthrough, described Monday in the Philosophical Transactions of the Royal ... |
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$3.9M project on self-deleting genes takes aim at mosquito-borne diseasesO. Kuchment, AGRILIFE Today, 2020.
To control mosquito populations and prevent them from transmitting diseases such as malaria, many researchers are pursuing strategies in mosquito genetic engineering. A new Texas A&M AgriLife Research project aims to enable temporary “test runs” of proposed genetic changes in ... |
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Self-deleting genes tested as part of the concept of mosquito population controlcharlottelarson, NEWYORK NEWS TIMES, 2020.
Most genetic engineering strategies designed to control mosquito populations, and their ability to spread diseases such as malaria, require gene editing to be combined with gene drives. Gene drives allow altered DNA to spread rapidly throughout the population. |
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Making gene drive biodegradableJ. Zapletal, N. Najmitabrizi, M. Erraguntla, M. A. Lawley, K. M. Myles and Z. N. Adelman, Philosophical Transactions of the Royal Society B: Biological Sciences, 376:20190804. 2020.
Here, we consider the inclusion of self-elimination mechanisms into the design of homing-based gene drive transgenes. This approach not only caused the excision of the gene drive transgene, but also generates a transgene-free allele resistant to further action by the gene drive. ... |
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Fighting Mosquito With GMO Mosquito: The Battle Brewing in the Florida KeysS. MacLaughlin, NBC 6 South Florida, 2020.
Scientists are a few months into an experiment to stop the invasive Aedes aegypti mosquito. Their weapon of choice? A genetically modified mosquito. But some environment advocates question the strategy. This year, the Florida Keys had an outbreak of Dengue fever, which was ... |
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Florida will release 750 million genetically modified mosquitoesS. McGlaun, Slash Gear, 2020.
Local officials in Florida have announced that they have approved 750 million genetically modified mosquitoes to be released into the environment to reduce local populations of the bloodsucking creatures. The goal of releasing genetically modified mosquitoes is to help reduce the ... |
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Florida to Release 750 Million GMO Mosquitoes in 2021Seeker, Seeker, 2020.
The U.S. EPA gave the green light to release millions of genetically modified mosquitoes in the Florida Keys in 2021 — here’s what we know. |
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You should be excited that scientists are releasing 750 million genetically modified mosquitoes this yearL. Westreich, Massive Science, 2020.
GM mosquitoes are successful in reducing mosquito populations, and reducing disease spread |
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The Con Job at Mosquito Control BoardE. Russo and B. Wray, keysnews.com, 2020.
Shouldn’t there be a consensus among scholars, scientists, experts and the public that this new technology is safe? |
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GMOs make war on mosquitoesStaff, Kenosha News, 2020.
Given that recent record, we were a bit surprised to read that there was a ruckus over genetically modified mosquitoes going on in the Florida Keys. |
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Why Genetically Modified Mosquitoes Won’t Come to Texas Anytime SoonC. Adams, RA News, 2020.
Talks about releasing genetically modified mosquitoes in Houston began in 2018 between Harris County and Oxitec, a United Kingdom-based company that produces sustainable technologies or transgenic methodologies to stem the impact of disease-spreading insects. Talk also began ... |
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An accident waiting to happen: Tech company to release 750 MILLION GMO mosquitoes in Florida to fight dengue feverZ. Sky, NEWSTARGET, 2020.
Oxitec plans to release 750 million OX5034s into the Florida Keys, something that sounds like the beginning of a doomed science-fiction movie. But the most shocking thing here is the fact that Oxitec received the EPA’s approval in May. |
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Genetically-modified mosquito plan offers hope for Keys, worldP. Goodman, keynews.com, 2020.
The Florida Keys Mosquito Control District Board of Commissioners voted 4-to-1 to approve a trial using Oxitec’s second-generation genetically modified mosquitoes. I |
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The good mosquito versus the badD. Datta, Business Standard, 2020.
Starting 2021, around 750 million genetically modified (GM) Aedes Aegypti mosquitoes will be released in batches into the Florida Keys. |
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Florida Will Release 750 Genetically Modified Mosquitoes to Stop Disease SpreadA. Fahmy, verywell health, 2020.
The hope is to prevent the spread of Dengue fever, a painful virus acquired only by mosquito bite which made a reappearance in the Florida Keys in 2009. |
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Novel combination of CRISPR-based gene drives eliminates resistance and localises spreadN. R. Faber, G. R. McFarlane, R. C. Gaynor, I. Pocrnic, C. B. A. Whitelaw and G. Gorjanc, bioRxiv, 2020.
We present HD-ClvR, a novel combination of CRISPR-based gene drives that eliminates resistance and localises spread. As a case study, we model HD-ClvR in the grey squirrel (Sciurus carolinensis), which is an invasive pest in the UK and responsible for both biodiversity and ... |
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Deep dive: Florida’s GM mosquito experiment aims to rewrite rules of vector-borne diseasesS. Kannan, India Today, 2020.
A pathbreaking bioengineering experiment on mosquito populations that could have massive implications for tropical malaria-affected countries like India has got underway in Florida, US. |
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Fighting mosquito-borne diseases… with mosquitoesN. Gubert and A. Baubeau, Phys Org, 2020.
For decades, researchers have scratched their heads over how to combat deadly mosquito-borne diseases such as dengue fever. |
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Bug board OKs release of genetically modified mosquitoesT. O'Hara, keynews.com, 2020.
After nearly 10 years of debate, the Florida Keys Mosquito Control District board has approved an agreement with biotech company Oxitec to conduct a test release of genetically modified mosquitoes in Monroe County as part of a mosquito limiting or eradication plan. |
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Genetically modified mosquitoes to be released in the Florida Keys to combat dengue, zika, and yellow fever.Yucatan Times, Yucatan Times, 2020.
The Florida Keys will be the scene of the first test in the United States with genetically modified Aedes aegypti mosquitoes, an alternative to insecticides and larvicides to end the transmission of diseases such as dengue, zika and yellow fever that has always been surrounded ... |
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Transgenic moths released to end one of the worst pests on the planetB. Mandalia, Pledge Times, 2020.
Today the results of the first open field experiment with another of the creations of this biotechnology company are published. It is a variant of the moth Plutella xylostella which is one of the worst agricultural pests in the world. |
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750 million genetically modified mosquitoes soon released in the wild!explica, explica, 2020.
Rather frightening mosquitoes will be released on an archipelago in Florida. The goal? Reduce the population of their more dangerous congeners who can transmit certain diseases. |
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US to Use Genetically Modified Mosquitoes to Fight Dengue FeverH. Badr, Asharq Al-Awsat, 2020.
After a decade of discussions, officials in Florida have voted to allow the first test in the United States of free-flying, genetically modified mosquitoes that kill any female offspring, as a way to fight the pests and the diseases they spread. |
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Florida Keys to Use Genetically Modified Mosquitoes to Fight DiseaseB. Lynn, Voice of America, 2020.
Officials in the Florida Keys plan to release genetically modified mosquitoes next year in an effort to fight insect-borne diseases. |
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Florida Approves Controversial Plan to Release 750 Million Genetically Modified MosquitoesD. Rakshit, Swaddle, 2020.
Authorities in Florida have approved a pilot project that will release 750 million genetically modified mosquitoes locally, in a bid to reduce the populations of mosquitoes that cause that cause dengue, Zika, chikungunya, and yellow fever |
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Mutant bugs released to fight diseaseThe Day, The Day, 2020.
Authorities have approved the scheme in Florida but environmental groups are furious, calling it a “Jurassic Park experiment” that will unleash a “mutant bug” into the ecosystem. |
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More than 750 million GMO mosquitoes to be released over Florida Keys – what could go wrong?E. Huff, Natural News, 2020.
The Florida Keys Mosquito Control District (FKMCD) has given Oxitec, a corporation we have reported on in the past, permission to unleash some 750 million GMO mosquitos in Monroe County, Florida, over the next two years. |
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Florida to release genetically modified mosquitoes to prevent diseases like ZikaThe West News, The West News, 2020.
Local authorities on Tuesday gave final approval to release 750 million genetically modified mosquitoes in the Florida Keys over a two-year period, starting in 2021. |
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Genetically modified mosquitoes have been OK’d for a first U.S. test flightS. Milius, ScienceNews, 2020.
After a decade of fits and starts, officials in the Florida Keys have voted to allow the first test in the United States of free-flying, genetically modified mosquitoes as a way to fight the pests and the diseases they spread. |
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Florida Will Release Genetically Modified Mosquitoes to Fight Disease in the KeysS. Harrell, Spectrum News, 2020.
Following lengthy federal and state procedures, the Florida Keys Mosquito Control District this week approved a plan to release more than 750 million genetically modified mosquitoes in the Keys region to combat an invasive, disease-carrying species of the insect. |
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Florida is releasing 750 million genetically modified mosquitoes into the world. Here’s whyH. Schriber, Deseret News, 2020.
Florida officials plan to release 750 million genetically modified mosquitoes into the Florida Keys over the next two years as a way to prevent diseases like the Zika virus. The project will begin in 2021. The Environment Protection Agency approved the idea in May. The project ... |
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Genetically Modified Mosquitoes To Be Released In Florida KeysA. Snow, The Daily Wire, 2020.
CNN reported that the genetically modified bugs, called OX5034, have been “altered to produce female offspring that die in the larval stage, well before hatching and growing large enough to bite and spread disease.” Since it’s the female of the species that bite, they are ... |
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Release 750 Million Genetically Modified Mosquitoes Into the Wild, They SaidC. Delbert, Popular Mechanics, 2020.
Corporate scientists have received final approval from the Environmental Protection Agency (EPA) to release hundreds of millions of genetically altered mosquitoes into the Florida Keys. The goal? To begin reining in the mosquito population, which is only expected to increase as ... |
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Florida releasing genetically modified mosquitoes to prevent diseases like ZikaN. Lanese, LiveScience, 2020.
Hundreds of millions of genetically modified mosquitoes will soon be released in the Florida Keys island chain to wipe out local populations of disease-carrying mosquitoes, according to news reports. |
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750 Million GM Mosquitoes Will Be Released in the Florida KeysL. Winter, The Scientist, 2020.
With the aim of reducing rates of the mosquito-borne illnesses yellow fever and dengue, a pilot program will release 750 million genetically modified mosquitoes into the Florida Keys in 2021, thanks to approval by the barrier islands’ Mosquito Control District Board of ... |
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Hundreds Of Millions Of Genetically Modified Mosquitoes Approved For Release In USJ. Vibes, Anonymous News, 2020.
A Biotech company called Oxitec has received permission from the government to release hundreds of millions of genetically modified male mosquitoes in the Florida Keys. |
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Why Hundreds of Millions of Genetically Engineered Mosquitoes Will Soon Be Released in FloridaK. Gander, Newsweek, 2020.
Hundreds of millions of genetically engineered mosquitoes will soon be released in Florida, in a first for the U.S. On Tuesday, the Florida Keys Mosquito Control District (FKMCD) approved plans to release the insects, who do not bite, as part of a pilot project launching next ... |
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Florida to release genetically modified mosquitoes, detractors blast ‘Jurassic Park’ experimentD. Aaro, Fox News, 2020.
Local authorities on Tuesday gave final approval to release 750 million genetically modified mosquitoes in the Florida Keys over a two-year period, starting in 2021, with the hope of preventing diseases such as the Zika virus but has faced blowback and comparisons to a Steven ... |
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750 million genetically modified mosquitoes to be released across Florida KeysA. Zahid, Sky News, 2020.
Authorities have approved plans for genetically modified mosquitoes to be released across the Florida Keys from next year. British-based firm Oxitec has designed the project to test whether the altered mosquitoes are a viable alternative to pesticides to control and prevent the ... |
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750 million GM mosquitos set for release in Florida Keys.Editorial Staff, E&T, 2020.
Local authorities have approved proposals to release hundreds of millions of genetically modified (GM) modified mosquitos in Florida, in an effort to control populations of diseases spread by the organism. |
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Florida Plans to Fix Its Mosquito Problem With 750 Million More MosquitoesD. Noor, Gizmodo, 2020.
Hundreds of millions of mosquitos will soon be released in Florida. On purpose. The mosquitoes are being released as a form of pest control, but they could wreak havoc on local ecosystems. |
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Florida mosquitoes: 750 million genetically modified insects to be releasedBBC, BBC, 2020.
Local officials in Florida have approved the release of 750 million mosquitoes that have been genetically modified to reduce local populations. The aim is to reduce the number of mosquitoes that carry diseases like dengue or the Zika virus. |
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Florida OKs release of genetically modified mosquitoes in Keys to slow insect disease spreadS. Mann, Just the News, 2020.
Florida officials are authorizing a biotech company to release hundreds of millions of genetically-modified male mosquitoes into the Florida Keys to reduce future mosquito populations that spread diseases including yellow fever and malaria. |
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Florida Keys to release modified mosqutioes to fight illnessC. Anderson, Associated Press, 2020.
Sometime next year, genetically modified mosquitoes will be released in the Florida Keys in an effort to combat persistent insect-borne diseases such as Dengue fever and the Zika virus. The plan approved this week by the Florida Keys Mosquito Control District calls for a pilot ... |
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Florida to Release Millions of Genetically Modified Mosquitoes Against Local Residents’ WishesN. Rice, People, 2020.
A plan to release over 750 million genetically modified mosquitoes in the Florida Keys has received final approval. According to CNN, on Tuesday, local authorities approved a plan to release the genetically modified mosquitoes in the Sunshine State's string of islands, with the ... |
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Plan to Release 750M GMO Mosquitoes Gets Go AheadR. Quinn, newser, 2020.
The plan to release the genetically modified Aedes aegypti mosquitoes received final approval from local authorities Tuesday, causing an outcry from groups opposed to what they call a "Jurassic Park experiment," CNN reports. |
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‘A Jurassic Park Experiment’: Watchdog Groups Denounce Decision to Release Genetically Modified Mosquitoes in FloridaL. Newcomb, Common Dreams, 2020.
Food safety and environmental groups Wednesday condemned a decision by officials in Florida to approve the release of 750 million genetically modified mosquitoes, a pilot project aimed at reducing the spread of mosquito-borne diseases. |
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Florida Keys to release 750M genetically modified mosquitoesD. Haynes, UPI, 2020.
Local authorities in the Florida Keys gave their approval Wednesday to a plan to release genetically modified mosquitoes to prevent the spread of dengue fever and other diseases. The Monroe County Mosquito Control District signed off on the project, which would release about 750 ... |
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To combat disease-spreading mosquitoes in the Keys, leaders vote to unleash lab bugsD. Goodhue, Miami Herald, 2020.
Florida Keys officials have voted to allow the experimental release of millions of genetically modified mosquitoes into a yet-to-be-decided area of the island chain. |
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2-Locus Cleave and Rescue; selfish elements harness a recombination rate-dependent generational clock for self limiting gene driveG. Oberhofer, T. Ivy and B. A. Hay, bioRxiv, 2020.
Self-limiting gene drive allows control over the spread and fate of linked traits. Cleave and Rescue (ClvR) elements create self-sustaining drive and comprise a DNA sequence-modifying enzyme (Cas9-gRNAs, Cleaver) that disrupts an essential gene, and a tightly linked, uncleavable ... |
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Genetically engineered moths may save kale chipsC. Poku, BIOtechNOW, 2020.
Sea salt kale chips, bacon brussels sprouts, and buffalo cauliflower wings are under threat. Environmental activists will have you believe the biggest threat to our food system is pesticides. That’s not true, in fact, it’s insects—the very reason most pesticides are ... |
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Genetically engineered moths have been released into the wild to wipe out pestsK. Rogers, CNN, 2020.
Genetically modified diamondback moths designed to wipe out wild pest populations were released in fields for the first time in New York state. Diamondback moths are migratory pests found in the Americas, Europe, New Zealand and Southeast Asia, but especially in areas where ... |
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GMO diamondback moth shows promise as sustainable pest control tool in first ever open-field releaseCornell University, Genetic Literacy Project, 2020.
A newly published study reports a successful, first-ever open-field release of a self-limiting, genetically engineered diamondback moth, stating that it paves the way for an effective and sustainable approach to pest control. The diamondback moth, also known as Plutella ... |
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Male moths genetically modified to kill females released in the wildM. Le Page, New Scientist, 2020.
Genetically modified male diamondback moths designed to wipe out pest populations have been released in New York state. The field trial shows that these GM moths, whose female offspring die soon after hatching, could help control this major crop pest. Oxitec, the British ... |
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First Field Release of a Genetically Engineered, Self-Limiting Agricultural Pest Insect: Evaluating Its Potential for Future Crop ProtectionA. M. Shelton, S. J. Long, A. S. Walker, M. Bolton, H. L. Collins, L. Revuelta, L. M. Johnson and N. I. Morrison, Frontiers in Bioengineering and Biotechnology, 7:1-15. 2020.
Alternative, biologically-based approaches for pest management are sorely needed and one approach is to use genetically engineered insects. Herein we describe a series of integrated field, laboratory and modeling studies with the diamondback moth, Plutella xylostella, a serious ... |
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‘We don’t want to be guinea pigs’: how one African community is fighting genetically modified mosquitoesA. Pujol-Mazzini, The Telegraph, 2019.
Researchers from the Target Malaria consortium, a not-for-profit research group funded by the Bill & Melinda Gates Foundation and various research institutions, have developed a mosquito in their laboratory that can kill off its own species by spreading a faulty gene. If it ... |
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Split-gene drive system provides flexible application for safe laboratory investigation and potential field deploymentV. L. Del Amo, A. L. Bishop, H. M. Sánchez C, J. B. Bennett, X. Feng, J. M. Marshall, E. Bier and V. M. Gantz, bioRxiv, 684597. 2019.
CRISPR-based gene drives spread through populations bypassing the dictates of Mendelian genetics, offering a population-engineering tool for tackling vector-borne diseases, managing crop pests, and helping island conservation efforts; unfortunately, current technologies raise ... |
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Daisyfield gene drive systems harness repeated genomic elements as a generational clock to limit spreadJ. Min, C. Noble, D. Najjar and K. M. Esvelt, bioRxiv, 104877. 2017.
Here we describe a novel form of gene drive based on the introduction of multiple copies of an engineered ‘daisy’ sequence into repeated elements of the genome. Each introduced copy encodes guide RNAs that target one or more engineered loci carrying the CRISPR nuclease gene ... |
