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Scholarly Literature

This is an aggregation of scholarly literature from peer-reviewed journals,  bioRxiv , medRxiv and arXiv preprint serversfocused on natural and engineered selfish genetic elements and genetic biocontrol. New citations are added as they appear. This content is intended for anyone interested in the scholarly literature on gene drive and genetic biocontrol.

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Curing mosquitoes with genetic approaches for malaria control

Mary Kefi, Victor Cardoso-Jaime, Sally A. Saab, George Dimopoulos,  Trends in Parasitology,  2024.
Malaria remains a persistent global public health challenge because of the limitations of current prevention tools. The use of transgenic mosquitoes incapable of transmitting malaria, in conjunction with existing methods, holds promise for achieving elimination of malaria and ...

Transformation of meiotic drive into hybrid sterility in Drosophila

Jackson Bladen, Hyuck-Jin Nam, Nitin Phadnis,  bioRxiv,  2024.
Hybrid male sterility is one of the fastest evolving intrinsic reproductive barriers between recently isolated populations. A leading explanation for the evolution of hybrid male sterility involves genomic conflicts with meiotic drivers in the male germline. There are, however, ...

A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae

Ignacio Tolosana, Katie Willis, Austin Burt, Matthew Gribble, Tony Nolan, Andrea Crisanti, Federica Bernardini,  bioRxiv,  2024.
Genetic control – the deliberate introduction of genetic traits to control a pest or vector population – offers a powerful tool to augment conventional mosquito control tools that have been successful in reducing malaria burden but that are compromised by a range of ...

A small-molecule approach to restore female sterility phenotype targeted by a homing suppression gene drive in the fruit pest Drosophila suzukii

Ma S, Ni X, Chen S, Qiao X, Xu X, Chen W, et al.,  PLoS Genetics,  2024.
CRISPR-based gene drives offer promising prospects for controlling disease-transmitting vectors and agricultural pests. A significant challenge for successful suppression-type drive is the rapid evolution of resistance alleles. One approach to mitigate the development of ...

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